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| NCT ID | NCT04266301 |
| Title | Study of Efficacy and Safety of MBG453 in Combination With Azacitidine in Subjects With Intermediate, High or Very High Risk Myelodysplastic Syndrome (MDS) as Per IPSS-R, or Chronic Myelomonocytic Leukemia-2 (CMML-2) (STIMULUS-MDS2) |
| Acronym | STIMULUS-MDS2 |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Novartis Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | NLD | LTU | LBN | ITA | ISR | GRC | GBR | FRA | FIN | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Yuma Regional Cancer Center | Yuma | Arizona | 85364 | United States | Details | |
| University of California LA | Los Angeles | California | 90095 | United States | Details | |
| Yale University School Of Medicine | New Haven | Connecticut | 06520 | United States | Details | |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | United States | Details | |
| University Of Miami | Miami | Florida | 33136 | United States | Details | |
| Northwestern University | Chicago | Illinois | 60611 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Hackensack University Medical Ctr | Hackensack | New Jersey | 07601 | United States | Details | |
| Weill Cornell Medicine NY-Presb | New York | New York | 10021 | United States | Details | |
| University of Rochester Medical Ctr | Rochester | New York | 14642 | United States | Details | |
| University of Virginia | Charlottesville | Virginia | 22903 | United States | Details | |
| Novartis Investigative Site | Pilar | Buenos Aires | B1629AHJ | Argentina | Details | |
| Novartis Investigative Site | Wooloongabba | Queensland | 4102 | Australia | Details | |
| Novartis Investigative Site | Clayton | Victoria | 3168 | Australia | Details | |
| Novartis Investigative Site | Perth | Western Australia | 6000 | Australia | Details | |
| Novartis Investigative Site | Innsbruck | Tyrol | 6020 | Austria | Details | |
| Novartis Investigative Site | Graz | 8036 | Austria | Details | ||
| Novartis Investigative Site | Linz | 4020 | Austria | Details | ||
| Novartis Investigative Site | Brasschaat | 2930 | Belgium | Details | ||
| Novartis Investigative Site | Roeselare | 8800 | Belgium | Details | ||
| Novartis Investigative Site | Florianopolis | SC | 88034-000 | Brazil | Details | |
| Novartis Investigative Site | Sao Paulo | SP | 04014-002 | Brazil | Details | |
| Novartis Investigative Site | Sao Paulo | SP | 05319-000 | Brazil | Details | |
| Novartis Investigative Site | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Novartis Investigative Site | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Novartis Investigative Site | Vina del Mar | Valparaiso | 2540364 | Chile | Details | |
| Novartis Investigative Site | Guangzhou | Guangdong | 510080 | China | Details | |
| Novartis Investigative Site | Guangzhou | Guangdong | 510515 | China | Details | |
| Novartis Investigative Site | Shenzhen | Guangdong | 518037 | China | Details | |
| Novartis Investigative Site | Wuhan | Hubei | 430022 | China | Details | |
| Novartis Investigative Site | Wuhan | Hubei | 430030 | China | Details | |
| Novartis Investigative Site | Suzhou | Jiangsu | 215004 | China | Details | |
| Novartis Investigative Site | Chang Chun | Jilin | 130021 | China | Details | |
| Novartis Investigative Site | Chengdu | Sichuan | 610041 | China | Details | |
| Novartis Investigative Site | Hangzhou | Zhejiang | 310003 | China | Details | |
| Novartis Investigative Site | Beijing | 100029 | China | Details | ||
| Novartis Investigative Site | Beijing | 100730 | China | Details | ||
| Novartis Investigative Site | Jinan | 250012 | China | Details | ||
| Novartis Investigative Site | Shanghai | 200025 | China | Details | ||
| Novartis Investigative Site | Shanghai | 200233 | China | Details | ||
| Novartis Investigative Site | Tianjin | 300020 | China | Details | ||
| Novartis Investigative Site | Tianjin | 300052 | China | Details | ||
| Novartis Investigative Site | Rionegro | Antioquia | 054047 | Colombia | Details | |
| Novartis Investigative Site | Bogota | 110231 | Colombia | Details | ||
| Novartis Investigative Site | Praha 2 | Czech Republic | 128 20 | Czechia | Details | |
| Novartis Investigative Site | Hradec Kralove | CZE | 500 05 | Czechia | Details | |
| Novartis Investigative Site | Brno Bohunice | 625 00 | Czechia | Details | ||
| Novartis Investigative Site | Praha | 12808 | Czechia | Details | ||
| Novartis Investigative Site | Helsinki | FIN 00290 | Finland | Details | ||
| Novartis Investigative Site | Kuopio | 70211 | Finland | Details | ||
| Novartis Investigative Site | Grenoble | 38043 | France | Details | ||
| Novartis Investigative Site | Lille | 59037 | France | Details | ||
| Novartis Investigative Site | Paris 10 | 75475 | France | Details | ||
| Novartis Investigative Site | Toulouse | 31059 | France | Details | ||
| Novartis Investigative Site | Tours | 37044 | France | Details | ||
| Novartis Investigative Site | Vandoeuvre Les Nancy | 54511 | France | Details | ||
| Novartis Investigative Site | Velbert | North Rhine-Westphalia | 42551 | Germany | Details | |
| Novartis Investigative Site | Dresden | Sachsen | 01307 | Germany | Details | |
| Novartis Investigative Site | Augsburg | 86179 | Germany | Details | ||
| Novartis Investigative Site | Duesseldorf | 40479 | Germany | Details | ||
| Novartis Investigative Site | Frankfurt | 60590 | Germany | Details | ||
| Novartis Investigative Site | Greifswald | 17475 | Germany | Details | ||
| Novartis Investigative Site | Jena | 07740 | Germany | Details | ||
| Novartis Investigative Site | Kiel | 24116 | Germany | Details | ||
| Novartis Investigative Site | Ulm | 89081 | Germany | Details | ||
| Novartis Investigative Site | Alexandroupolis | Evros | 681 00 | Greece | Details | |
| Novartis Investigative Site | Patras | 265 00 | Greece | Details | ||
| Novartis Investigative Site | Ahmedabad | Gujrat | 380009 | India | Details | |
| Novartis Investigative Site | Faridabad | Haryana | 121 001 | India | Details | |
| Novartis Investigative Site | Madurai | TamilNadu | 625107 | India | Details | |
| Novartis Investigative Site | Kolkata | West Bengal | 700014 | India | Details | |
| Novartis Investigative Site | Kolkata | West Bengal | 700160 | India | Details | |
| Novartis Investigative Site | Delhi | 110 085 | India | Details | ||
| Novartis Investigative Site | Afula | 1834111 | Israel | Details | ||
| Novartis Investigative Site | Tel Aviv | 6423906 | Israel | Details | ||
| Novartis Investigative Site | Bologna | BO | 40138 | Italy | Details | |
| Novartis Investigative Site | Catania | CT | 95123 | Italy | Details | |
| Novartis Investigative Site | Firenze | FI | 50134 | Italy | Details | |
| Novartis Investigative Site | Genova | GE | 16132 | Italy | Details | |
| Novartis Investigative Site | Milano | MI | 20162 | Italy | Details | |
| Novartis Investigative Site | Rozzano | MI | 20089 | Italy | Details | |
| Novartis Investigative Site | Reggio Calabria | RC | 89100 | Italy | Details | |
| Novartis Investigative Site | Roma | RM | 00133 | Italy | Details | |
| Novartis Investigative Site | Nagoya | Aichi | 464 8681 | Japan | Details | |
| Novartis Investigative Site | Kashiwa | Chiba | 277 8577 | Japan | Details | |
| Novartis Investigative Site | Fukuoka city | Fukuoka | 812-8582 | Japan | Details | |
| Novartis Investigative Site | Sapporo | Hokkaido | 064 0804 | Japan | Details | |
| Novartis Investigative Site | Isehara | Kanagawa | 259-1193 | Japan | Details | |
| Novartis Investigative Site | Sendai city | Miyagi | 980 8574 | Japan | Details | |
| Novartis Investigative Site | Nagasaki-city | Nagasaki | 852-8501 | Japan | Details | |
| Novartis Investigative Site | Osaka Sayama | Osaka | 589 8511 | Japan | Details | |
| Novartis Investigative Site | Bunkyo-ku | Tokyo | 113-8603 | Japan | Details | |
| Novartis Investigative Site | Osaka | 545-8586 | Japan | Details | ||
| Novartis Investigative Site | Yamagata | 990 9585 | Japan | Details | ||
| Novartis Investigative Site | Seoul | Seocho Gu | 06591 | Korea, Republic of | Details | |
| Novartis Investigative Site | Seoul | 03080 | Korea, Republic of | Details | ||
| Novartis Investigative Site | Seoul | 03722 | Korea, Republic of | Details | ||
| Novartis Investigative Site | Seoul | 05505 | Korea, Republic of | Details | ||
| Novartis Investigative Site | Seoul | 06351 | Korea, Republic of | Details | ||
| Novartis Investigative Site | Beirut | 1107 2020 | Lebanon | Details | ||
| Novartis Investigative Site | Vilnius | LT-08661 | Lithuania | Details | ||
| Novartis Investigative Site | Kuching | Sarawak | 93586 | Malaysia | Details | |
| Novartis Investigative Site | Kuala Lumpur | 59100 | Malaysia | Details | ||
| Novartis Investigative Site | Pulau Pinang | 10990 | Malaysia | Details | ||
| Novartis Investigative Site | Selangor | 68000 | Malaysia | Details | ||
| Novartis Investigative Site | Mexico | Distrito Federal | 06726 | Mexico | Details | |
| Novartis Investigative Site | Satelite | Edo Mexico | 53100 | Mexico | Details | |
| Novartis Investigative Site | Morelia | Michoacan | 58260 | Mexico | Details | |
| Novartis Investigative Site | Estado de Mexico | 52787 | Mexico | Details | ||
| Novartis Investigative Site | Groningen | 9713 GZ | Netherlands | Details | ||
| Novartis Investigative Site | Muscat | 123 | Oman | Details | ||
| Novartis Investigative Site | Lisboa | 1099 023 | Portugal | Details | ||
| Novartis Investigative Site | Porto | 4200-072 | Portugal | Details | ||
| Novartis Investigative Site | Saint Petersburg | 191024 | Russian Federation | Details | ||
| Novartis Investigative Site | Saint Petersburg | 197022 | Russian Federation | Details | ||
| Novartis Investigative Site | Riyadh | 11211 | Saudi Arabia | Details | ||
| Novartis Investigative Site | Singapore | 119074 | Singapore | Details | ||
| Novartis Investigative Site | Singapore | 169608 | Singapore | Details | ||
| Novartis Investigative Site | Sevilla | Andalucia | 41013 | Spain | Details | |
| Novartis Investigative Site | Oviedo | Asturias | 33011 | Spain | Details | |
| Novartis Investigative Site | Salamanca | Castilla Y Leon | 37007 | Spain | Details | |
| Novartis Investigative Site | Badalona | Catalunya | 08916 | Spain | Details | |
| Novartis Investigative Site | Barcelona | Catalunya | 08035 | Spain | Details | |
| Novartis Investigative Site | Valencia | Comunidad Valenciana | 46010 | Spain | Details | |
| Novartis Investigative Site | Madrid | 28009 | Spain | Details | ||
| Novartis Investigative Site | Valencia | 46026 | Spain | Details | ||
| Novartis Investigative Site | Bern | 3010 | Switzerland | Details | ||
| Novartis Investigative Site | Zuerich | 8091 | Switzerland | Details | ||
| Novartis Investigative Site | Hualien | 970 | Taiwan | Details | ||
| Novartis Investigative Site | Kaohsiung | 83301 | Taiwan | Details | ||
| Novartis Investigative Site | Liouying Township | 736005 | Taiwan | Details | ||
| Novartis Investigative Site | Taichung | 40447 | Taiwan | Details | ||
| Novartis Investigative Site | Taipei | 10002 | Taiwan | Details | ||
| Novartis Investigative Site | Taoyuan | 33305 | Taiwan | Details | ||
| Novartis Investigative Site | Songkhla | Hat Yai | 90110 | Thailand | Details | |
| Novartis Investigative Site | Khon Kaen | THA | 40002 | Thailand | Details | |
| Novartis Investigative Site | Bangkok | 10330 | Thailand | Details | ||
| Novartis Investigative Site | Bangkok | 10400 | Thailand | Details | ||
| Novartis Investigative Site | Bangkok | 10700 | Thailand | Details | ||
| Novartis Investigative Site | Chiang Mai | 50200 | Thailand | Details | ||
| Novartis Investigative Site | Ankara | 06230 | Turkey | Details | ||
| Novartis Investigative Site | Edirne | 22030 | Turkey | Details | ||
| Novartis Investigative Site | Izmir | 35100 | Turkey | Details | ||
| Novartis Investigative Site | Pendik Istanbul | 34899 | Turkey | Details | ||
| Novartis Investigative Site | Samsun | 55139 | Turkey | Details | ||
| Novartis Investigative Site | Portsmouth | Hants | PO6 3LY | United Kingdom | Details | |
| Novartis Investigative Site | Edinburgh | Scotland | EH4 2XU | United Kingdom | Details | |
| Novartis Investigative Site | Manchester | M20 2BX | United Kingdom | Details | ||
| Novartis Investigative Site | Nottingham | NG5 1PB | United Kingdom | Details |