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| NCT ID | NCT04313881 |
| Title | Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS) (ENHANCE) |
| Acronym | ENHANCE |
| Recruitment | Terminated |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Gilead Sciences |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | POL | NZL | NOR | NLD | ITA | HUN | GBR | FRA | FIN | ESP | DEU | CZE | CHE | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama Birmingham | Birmingham | Alabama | 35294 | United States | Details | |
| University of Arkansas for Medical Sciences IRB | Little Rock | Arkansas | 72205 | United States | Details | |
| City of Hope | Duarte | California | 91010 | United States | Details | |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | United States | Details | |
| UCLA Ronald Reagan Medical Center | Los Angeles | California | 90095 | United States | Details | |
| UC Irvine Health | Orange | California | 92868 | United States | Details | |
| Stanford Cancer Institute | Palo Alto | California | 94305 | United States | Details | |
| University of California, Davis Comprehensive Cancer Center | Sacramento | California | 95817 | United States | Details | |
| University of Miami Hospital and Clinics / Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | United States | Details | |
| Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | United States | Details | |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | United States | Details | |
| The University of Chicago Medical Center | Chicago | Illinois | 60637 | United States | Details | |
| University of Kansas Clinical Research Center | Fairway | Kansas | 66205 | United States | Details | |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | United States | Details | |
| University of Maryland, Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | United States | Details | |
| Johns Hopkins Medicine - The Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21231 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | United States | Details | |
| Dana Farber Cancer Institute (DFCI) | Boston | Massachusetts | 02215 | United States | Details | |
| University of Michigan Medical School | Ann Arbor | Michigan | 48109 | United States | Details | |
| University of Minnesota Medical Center, Fairview | Minneapolis | Minnesota | 55455 | United States | Details | |
| Mid America Division, Inc. | Kansas City | Missouri | 64132 | United States | Details | |
| Washington University School of Medicine - Siteman Cancer Center | Saint Louis | Missouri | 63110 | United States | Details | |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | United States | Details | |
| Weill Cornell Medicine-New York Presbyterian Hospital | New York | New York | 10021 | United States | Details | |
| Mount Sinai Health System | New York | New York | 10029 | United States | Details | |
| Columbia University Medical Center - Herbert Irving Pavilion | New York | New York | 10032 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | United States | Details | |
| DUHS Duke Cancer Center | Durham | North Carolina | 27705 | United States | Details | |
| The Ohio State University Wexner Medical Center / James Cancer Hospital | Columbus | Ohio | 43210 | United States | Details | |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| Oregon Health & Science University Pharmacy Services | Portland | Oregon | 97239 | United States | Details | |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Thomas Jefferson University, Sidney Kimmel Cancer Center; Clinical Research Organization | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| Prisma Health Cancer Center | Greenville | South Carolina | 29615 | United States | Details | |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | United States | Details | |
| UT Southwestern Medical Center | Dallas | Texas | 39090 | United States | Details | |
| Texas Oncology - Baylor Charles A. Simmons Cancer Center | Dallas | Texas | 75246 | United States | Details | |
| Baylor College of Medicine | Houston | Texas | 77030 | United States | Details | |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | United States | Details | |
| Seattle Cancer Care Alliance | Seattle | Washington | 98019 | United States | Details | |
| Swedish Cancer Institute | Seattle | Washington | 98104 | United States | Details | |
| Froedtert Hospital & the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Gosford Hospital | Gosford | New South Wales | 2250 | Australia | Details | |
| Prince of Wales Hospital | Randwick | New South Wales | 2031 | Australia | Details | |
| Royal North Shore Hospital | St Leonards | New South Wales | 2065 | Australia | Details | |
| Westmead Hospital | Westmead | New South Wales | 2145 | Australia | Details | |
| Icon Cancer Foundation | South Brisbane | Queensland | 4101 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Flinders Medical Center | Bedford Park | South Australia | 5042 | Australia | Details | |
| Royal Hobart Hospital | Hobart | Tasmania | 7000 | Australia | Details | |
| Eastern Health | Box Hill | Victoria | 3128 | Australia | Details | |
| Monash Medical Centre | Clayton | Victoria | 3168 | Australia | Details | |
| Peninsula Private Hospital | Frankston | Victoria | 3199 | Australia | Details | |
| Barwon Health, University Hospital Geelong | Geelong | Victoria | 3220 | Australia | Details | |
| Cabrini Hospital Malvern | Malvern | Victoria | 3144 | Australia | Details | |
| The Alfred Hospital | Melbourne | Victoria | 3004 | Australia | Details | |
| Royal Melbourne Hospital | Parkville | Victoria | 3050 | Australia | Details | |
| Sir Charles Gairdner Hospital | Nedlands | Western Australia | 6009 | Australia | Details | |
| Uniklinikum Salzburg | Salzburg | 5020 | Austria | Details | ||
| Hanusch kranhenkaus, 3. Medizinische Abteilung | Vienna | 1140 | Austria | Details | ||
| ZNA Middelheim | Antwerpen | 2060 | Belgium | Details | ||
| ULB Hopital Erasme | Brussels | 1070 | Belgium | Details | ||
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium | Details | ||
| UZ Brussel | Brussels | Belgium | Details | |||
| UZ Leuven | Leuven | 3000 | Belgium | Details | ||
| AZ Turnhout, Campus St. Elisabeth | Turnhout | 2300 | Belgium | Details | ||
| Chu Ucl Namur Site Godinne | Yvoir-Godinne | 5530 | Belgium | Details | ||
| Tom Baker Cancer Centre | Calgary | T2N 4N2 | Canada | Details | ||
| QEII Health Sciences Centre | Halifax | B3H 2Y9 | Canada | Details | ||
| Eastern Regional Health Authority | St. John's | A1B 3V6 | Canada | Details | ||
| University Health Network | Toronto | M5G 2M9 | Canada | Details | ||
| Fakultni nemocnice Olomouc, Hemato-onkologicka klinika | Olomouc | 77520 | Czechia | Details | ||
| Fakultni nemocnice Ostrava, Klinika hemato-onkologicka | Ostrava | 70852 | Czechia | Details | ||
| Helsinki University Central Hospital | Helsinki | 00290 | Finland | Details | ||
| Oulu University Hospital | Oulu | 90220 | Finland | Details | ||
| CHU Amiens-Picardie | Amiens Cedex 1 | 80054 | France | Details | ||
| Hopital Henri Mondor | Creteil | 94010 | France | Details | ||
| CHU de Grenoble Alpes | La Tronche | 38700 | France | Details | ||
| Institut Paoli Calmettes | Marseille | France | Details | |||
| Hopital Saint Eloi | Montpellier | 34295 | France | Details | ||
| CHU de Nantes | Nantes | 44000 | France | Details | ||
| CHU de Nice-l Archet | Nice | 6200 | France | Details | ||
| Hopital Saint Louis | Paris | 75475 | France | Details | ||
| Institut Gustave Roussy | Paris | 94805 | France | Details | ||
| Hopital Haut-Leveque | Pessac Cedex | 33604 | France | Details | ||
| Centre Hospitalier Lyon Sud | Pierre Benite | 69495 | France | Details | ||
| CHU de Poitiers - Hopital de la Miletrie | Poitiers | 86000 | France | Details | ||
| CHU de Rennes- Hopital Pontchaillou | Rennes Cedex 9 | 35033 | France | Details | ||
| Universitatsmedizin der Johannes Gutenberg Universitat Mainz, III. Medizinische Klinik und Poliklinik | Braunschweig | 38114 | Germany | Details | ||
| Universitatsklinikum Carl Gustav Carus | Dresden | 01307 | Germany | Details | ||
| Marien hospital, klinik fur onkologie, hamatologie und palliavmedizin | Duesseldorf | Germany | Details | |||
| Universitatsklinikum Essen | Essen | 45122 | Germany | Details | ||
| Universitat Leipzig | Leipzig | Germany | Details | |||
| Robert-Bosch-Krankenhaus, GmBH, Hamatologie, Onkologie und Palliativmedizin | Stuttgart | 70376 | Germany | Details | ||
| Hong Kong Sanatorium & Hospital | Hong Kong | Hong Kong | Details | |||
| Princess Margaret Hospital | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital | Hong Kong | Hong Kong | Details | |||
| The Chinese University of Hong Kong, Prince of Wales Hospital | Hong Kong | Hong Kong | Details | |||
| Tuen Mun Hospital | Hong Kong | Hong Kong | Details | |||
| Semmelweis Egyetem Belgyógyászati és Hematológiai Kilnika | Budapest | 1125 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Központ | Debrecen | 4032 | Hungary | Details | ||
| Petz Aladar Egyetemi Oktato Korhaz II. Belgyogyaszat - Hematologial Osztaly | Gyor | 9024 | Hungary | Details | ||
| Kaposi Mor Teaching Hospital | Kaposvar | Hungary | Details | |||
| Bács-Kiskun Megyei Kórház | Kecskemet | 6000 | Hungary | Details | ||
| SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz | Nyiregyhaza | 4400 | Hungary | Details | ||
| University of Pecs | Pecs | 7624 | Hungary | Details | ||
| Szent Borbála Hospital | Tatabanya | 2800 | Hungary | Details | ||
| SC Ematologica- Azienda Ospedaliera Nazionale SS. Antonio e Biagio e C. Arrigo | Alessandria | 15100 | Italy | Details | ||
| U.O Ematologica- ASST degli Spedali Civili di Brescia | Brescia | Italy | Details | |||
| Azienda Ospedaliero-Universitaria Careggi | Firenze | 50134 | Italy | Details | ||
| U.O.C Ematologia - Dipartimento di Medicina Interna, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico | Milan | 20122 | Italy | Details | ||
| U.O di Ematologia, Ospedale San Gerardo- ASST Monza | Monza | 20052 | Italy | Details | ||
| S. C. Ematologia Azienda Ospedaliero - Universitaria Maggiore Della Carita | Novara | 28100 | Italy | Details | ||
| Azienda Ospedaliera Ospedali Riuniti Marche Nord | Pesaro | 61100 | Italy | Details | ||
| SC di Oncoematologia - Azienda Ospedaliera Santa Maria | Terni | 05100 | Italy | Details | ||
| SC Ematologica, ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi | Varese | 21100 | Italy | Details | ||
| University Medical Center Groningen | Groningen | 9700 RB | Netherlands | Details | ||
| Medisch Centrum Leeuwarden | Leeuwarden | 8934 AD | Netherlands | Details | ||
| Christchurch Hospital | Christchurch | 8011 | New Zealand | Details | ||
| Southern District Health Board | Dunedin | 9016 | New Zealand | Details | ||
| Auckland City Hospital | Grafton | 1142 | New Zealand | Details | ||
| Waikato Hospital | Hamilton | 3240 | New Zealand | Details | ||
| Midcentral District Health Board | Palmerston North | 4414 | New Zealand | Details | ||
| Haukeland Universitetssjukehus, seksjon for blodsjukdommar- klinisk studieteam | Bergen | 5021 | Norway | Details | ||
| Akershus University Hospital | Loerenskog | 1478 | Norway | Details | ||
| Oslo University Hospital | Oslo | 0372 | Norway | Details | ||
| Stavanger universitetssjukehus | Stavanger | 4068 | Norway | Details | ||
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie, Oddzial Kliniczny Hematologii | Krakow | 31-501 | Poland | Details | ||
| Centrum Onkologii Ziemi Lubelskiej im. św. Jana z Dukli | Lublin | 20090 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu | Wroclaw | 50-367 | Poland | Details | ||
| Centro Clinico Academico de Braga, Hospital de Braga, E.P.E | Braga | 4710 | Portugal | Details | ||
| Champalimaud Foundation | Lisbon | 1400 - 038 | Portugal | Details | ||
| Hospital da Luz | Lisbon | 1500-650 | Portugal | Details | ||
| Centro Hospitalar Universitario Sao Joao. E.P.E | Porto | 4200 319 | Portugal | Details | ||
| Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE | Porto | 4200-072 | Portugal | Details | ||
| Centro Hospitalar Vila Nova de Gaia/Espinho | Porto | 4430-999 | Portugal | Details | ||
| Area Sanitaria de Santiago de Compostela y Barbanza. Complejo Hospitalario Universitario de SantiagoD | A Coruña | Spain | Details | |||
| OSI Araba, Hospital Universitario de Alava, Hospital Txagorritxu | Alava | Spain | Details | |||
| Hospital del Mar | Barcelona | 08003 | Spain | Details | ||
| Hospital Universitari Vall D'Hebron | Barcelona | 08035 | Spain | Details | ||
| Institut Catala d'Oncologia Girona | Girona | 17007 | Spain | Details | ||
| Institut Catala d'Oncologia, Hospital Duran i Reynals | L´Hospitalet de Llobregat | Spain | Details | |||
| MD Anderson Cancer Center Madrid | Madrid | 28033 | Spain | Details | ||
| Hospital Universitario Fundacion Jimenez Diaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario La Paz, Edificio General, 6 Planta. Despacho de Hematologia | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario Quironsalud Madrid. Servico de Hematologica y Hemoterapia | Madrid | Spain | Details | |||
| Hospital Regional Universitario de Malaga | Malaga | Spain | Details | |||
| Centro Hospitalar Universitario Sao Joao | Pamplona | 31008 | Spain | Details | ||
| Complejo Asistencial Universitario de Salamanca- Hospital Clinico Universitario de Salamanca | Salamanca | Spain | Details | |||
| Hospital Universitario Virgen del Rocio | Sevilla | 41013 | Spain | Details | ||
| Hospital Clinico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Istituto Oncologico Della Svizzera Italiana- IOSI, EOC, Clinica di Ematologia | Bellinzona | 6500 | Switzerland | Details | ||
| University of Bern | Bern | 3010 | Switzerland | Details | ||
| Universitaetsspital Zurich - Klinik fur Medizinische Onkologie und Hematologie | Zurich | 8091 | Switzerland | Details | ||
| Hematoloji Bilim Dali, Yenimahalle | Ankara | 06200 | Turkey | Details | ||
| Gazi Universitesi Tip Fakultesi | Ankara | 06560 | Turkey | Details | ||
| Ankara Universitesi Tip Fakultesi Cebeci Hastanesi | Ankara | 06620 | Turkey | Details | ||
| Dokuz Eylul Universitesi Tip Fakultesi Onkoloji Enstitusu | Inciralt | 35340 | Turkey | Details | ||
| Mersin University Medical | Mersin | 33110 | Turkey | Details | ||
| Tekirdag Namik Kemal Universitesi Tip Fakultesi | Tekirdag | 59100 | Turkey | Details | ||
| University Hospitals Birmingham NHS Foundation Trust | Birmingham | B15 2TH | United Kingdom | Details | ||
| United Lincolnshire Hospital NHS Trust | Boston | PE21 9QS | United Kingdom | Details | ||
| Kent and Canterbury Hospital- East Kent Hospitals University NHS Foundation Trust | Canterbury | CT1 3NG | United Kingdom | Details | ||
| Oxford University Hospitals NHS Foundation Trust | Oxford | OX3 9DU | United Kingdom | Details |