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| NCT ID | NCT04384484 |
| Title | Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (LOTIS 5) |
| Acronym | LOTIS 5 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | ADC Therapeutics S.A. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | POL | NLD | ITA | ISR | HUN | GBR | FRA | ESP | CZE | CHE | CAN | BRA | BEL | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of California San Diego Moores Cancer Center | La Jolla | California | 92093 | United States | Details | |
| Redlands Community Hospital | Redlands | California | 92373 | United States | Details | |
| The Oncology Institute of Hope and Innovation | Whittier | California | 90603 | United States | Details | |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | United States | Details | |
| UnityPoint Health - Iowa Oncology Research Association (IORA) | Des Moines | Iowa | 50309 | United States | Details | |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | United States | Details | |
| Comprehensive Cancer Centers of Nevada - Henderson | Las Vegas | Nevada | 89169 | United States | Details | |
| Kaiser Permanente Interstate Medical Office Central | Portland | Oregon | 97227 | United States | Details | |
| Hollings Cancer Center | Charleston | South Carolina | 29425 | United States | Details | |
| Virginia Cancer Specialists | Gainesville | Virginia | 20155 | United States | Details | |
| Medical College of Wisconsin Cancer Center Clinical Trials Office | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Clinica Adventista Belgrano | Belgrano | Buenos Aires | C1430EGF | Argentina | Details | |
| Clínica de Nefrología, Urología y Enfermedades Cardiovasculares S.A. | Santa Fe | Buenos Aires | 3000 | Argentina | Details | |
| Instituto Médico Especializado Alexander Fleming | Buenos Aires | Distrito Federal | C1426ANZ | Argentina | Details | |
| Grupo Gamma - Hospital Privado Rosario | Rosario | Santa Fe | S2000GAP | Argentina | Details | |
| Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan | Brugge | 8000 | Belgium | Details | ||
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium | Details | ||
| Centre Hospitalier Universitaire Universite Catholique de Louvain | Namur | B-5530 | Belgium | Details | ||
| Algemeen Ziekenhuis Delta - Campus Rumbeke | Roeselare | 8800 | Belgium | Details | ||
| Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer | Curitiba | Paraná | 81520-060 | Brazil | Details | |
| Hospital Moinhos de Vento | Porto Alegre | Rio Grande Do Sul | 90035-001 | Brazil | Details | |
| Hospital de Clínicas de Porto Alegre | Porto Alegre | Rio Grande Do Sul | 90035-903 | Brazil | Details | |
| Hospital Mãe de Deus - Centro Integrado de Oncologia | Porto Alegre | Rio Grande Do Sul | 90110-270 | Brazil | Details | |
| Hospital do Câncer | Rio De Janeiro | 20230-130 | Brazil | Details | ||
| Hemomed Instituto de Oncologia e Hematologia | São Paulo | 01236-030 | Brazil | Details | ||
| A Beneficência Portuguesa de São Paulo - Unidade Mirante | São Paulo | 01321-001 | Brazil | Details | ||
| Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo | São Paulo | 05403-010 | Brazil | Details | ||
| Hospital Israelita Albert Einstein | São Paulo | 05652-900 | Brazil | Details | ||
| Hospital Santa Marcelina | São Paulo | 08270-120 | Brazil | Details | ||
| Cross Cancer Institute | Edmonton | T6G 1Z2 | Canada | Details | ||
| Research Institute of the McGill University Health Centre | Montréal | H4A 3J1 | Canada | Details | ||
| Hôpital Fleurimont | Sherbrooke | J1H 5H3 | Canada | Details | ||
| Centro de Estudios Clínicos SAGA | Santiago | Región Metropolitana De Santiago | 7500653 | Chile | Details | |
| Instituto Oncológico Fundación Arturo López Pérez | Santiago | Región Metropolitana De Santiago | 8320000 | Chile | Details | |
| CeCim - Centro de Estudios Clínicos e Investigaciones Médicas | Santiago | Región Metropolitana De Santiago | 8330109 | Chile | Details | |
| Peking University Third Hospital | Beijing | Beijing | 100191 | China | Details | |
| The First Affiliated Hospital of Xiamen University | Xiamen | Fujian | 361001 | China | Details | |
| Sun Yat-Sen University Cancer Center | Guangzhou | Guangdong | 510060 | China | Details | |
| Guangdong Provincial People's Hospital | Guangzhou | Guangdong | 510080 | China | Details | |
| Zhujiang Hospital of Southern Medical University | Guangzhou | Guangdong | 510280 | China | Details | |
| Henan Cancer Hospital - Zhengzhou University | Zhengzhou | Henan | 450008 | China | Details | |
| Jilin Cancer Hospital | Changchun | Jilin | 130021 | China | Details | |
| The First Hospital of Jilin University | Changchun | Jilin | 130021 | China | Details | |
| Second Affiliated Hospital of Dalian Medical University | Dalian | Liaoning | 116000 | China | Details | |
| Shanghai Cancer Center | Shanghai | Shanghai | 200025 | China | Details | |
| West China School of Medicine - West China Hospital of Sichuan University | Chengdu | Sichuan | 610041 | China | Details | |
| Tianjin Medical University Cancer Institute & Hospital | Tianjin | Tianjin | 300060 | China | Details | |
| The First Affiliated Hospital of Zhejiang University School of Medicine | Hangzhou | Zhejiang | 310003 | China | Details | |
| Chongqing University Cancer Hospital - Chongqing Cancer Hospital | Chongqing | 400030 | China | Details | ||
| Huizhou Municipal Central Hospital | Huizhou | 516001 | China | Details | ||
| The First Affiliated Hospital of Nanchang University | Nanchang | 330006 | China | Details | ||
| Institute of Hematology and Blood Diseases Hospital of CAMS - PUMC | Tianjin | 300020 | China | Details | ||
| Wuhan Union Hospital | Wuhan | 430023 | China | Details | ||
| Tongji Hospital | Wuhan | 430030 | China | Details | ||
| Fakultni nemocnice Ostrava | Ostrava | 708 52 | Czechia | Details | ||
| Fakultni Nemocnice Kralovske Vinohrady | Prague | 100 34 | Czechia | Details | ||
| Fakultni nemocnice v Motole | Prague | 150 06 | Czechia | Details | ||
| Centre Hospitalier Regional Universitaire Brest | Brest | Bretagne | 29200 | France | Details | |
| Hôpital Avicenne | Bobigny | 93000 | France | Details | ||
| Centre Hospitalier Regional Universitaire Brest | Brest | 29200 | France | Details | ||
| Hôpital François Mitterrand | Dijon | 21000 | France | Details | ||
| Hôpital Privé du Confluent | Nantes | 44200 | France | Details | ||
| Hopital Universitaire Pitie Salpetriere | Paris | 75651 | France | Details | ||
| Hôpital Haut-Lévêque | Pessac | 33604 | France | Details | ||
| Centre de Lutte Contre le Cancer - Centre Henri-Becquerel | Rouen | 76038 | France | Details | ||
| Heves Varmegyei Markhot Ferenc Oktatokorhaz es Rendelointezet | Heves | Budapest | 3300 | Hungary | Details | |
| Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet - Szent László | Budapest | Pest | 1097 | Hungary | Details | |
| Semmelweis Egyetem | Budapest | 1088 | Hungary | Details | ||
| Orszagos Onkologiai Intezet | Budapest | 1122 | Hungary | Details | ||
| Samson Assuta Ashdod University Hospital | Ashdod | 7747629 | Israel | Details | ||
| Soroka Medical Center | Be'er Sheva | 8410101 | Israel | Details | ||
| Shamir Medical Center (Assaf Harofeh) | Be'er Ya'aqov | 7030000 | Israel | Details | ||
| Carmel Medical Center | Haifa | 3436212 | Israel | Details | ||
| Rabin Medical Center - Beilinson Hospital | Petah tikva | 4941492 | Israel | Details | ||
| The Chaim Sheba Medical Center | Tel Aviv | 52621 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| Presidio Ospedaliero Universitario Santa Maria della Misericordia | Udine | Friuli Venezia Giulia | 33100 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia | Brescia | 25123 | Italy | Details | ||
| Azienda Ospedaliero - Universitaria Careggi | Florence | 50134 | Italy | Details | ||
| Ospedale Casa Sollievo della Sofferenza | Foggia | 71013 | Italy | Details | ||
| Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST | Meldola | 47014 | Italy | Details | ||
| Istituto Europeo di Oncologia | Milano | 20141 | Italy | Details | ||
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas | Milan | 20089 | Italy | Details | ||
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele | Milan | 20132 | Italy | Details | ||
| Fondazione IRCCS Policlinico San Matteo | Pavia | 27100 | Italy | Details | ||
| Sanitaria Locale della Romagna | Ravenna | 48121 | Italy | Details | ||
| National Hospital Organization - Nagoya Medical Center | Nagoya | Aichi | 460-0001 | Japan | Details | |
| Toyohashi Municipal Hospital | Toyohashi | Aichi | 441-8570 | Japan | Details | |
| National Cancer Center Hospital East | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| Matsuyama Red Cross Hospital | Matsuyama | Ehime | 790-8524 | Japan | Details | |
| Gunma Prefectural Cancer Center | Ota | Gunma | 373-8550 | Japan | Details | |
| Sapporo Hokuyu Hospital | Sapporo | Hokkaido | 003-0006 | Japan | Details | |
| Hokkaido Cancer Center | Sapporo | Hokkaido | 003-0804 | Japan | Details | |
| Kobe City Medical Center General Hospital | Kobe | Hyogo | 650-0047 | Japan | Details | |
| Kanagawa Cancer Center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Tohoku University Hospital | Sendai | Miyagi | 980-8574 | Japan | Details | |
| Nagasaki University Hospital | Nagasaki-city | Nagasaki | 852-8501 | Japan | Details | |
| Saitama Medical University - International Medical Center | Hidaka-Shi | Saitama | 350-1298 | Japan | Details | |
| Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital | Bunkyo-ku | Tokyo | 113-8677 | Japan | Details | |
| National Hospital Organization Disaster Medical Center | Tachikawa | Tokyo | 190-0014 | Japan | Details | |
| Fukushima Medical University Hospital | Fukushima | 960-1295 | Japan | Details | ||
| Gifu Municipal Hospital | Gifu | 500-8323 | Japan | Details | ||
| Kagoshima University Hospital | Kagoshima | 890-8520 | Japan | Details | ||
| Niigata University Medical and Dental Hospital | Niigata | 951-8520 | Japan | Details | ||
| National Hospital Organization Okayama Medical Center | Okayama | 701-1192 | Japan | Details | ||
| Osaka Prefectural Hospital Organization - Osaka International Cancer Institute | Osaka | 541-8567 | Japan | Details | ||
| Boca Raton Clinical Research (BRCR) Global Mexico - Guadalajara | Guadalajara | Jalisco | 44600 | Mexico | Details | |
| PanAmerican Clinical Research Mexico - Guadalajara | Guadalajara | Jalisco | 44670 | Mexico | Details | |
| PanAmerican Clinical Research Mexico - Cuernavaca | Cuernavaca | Morelos | 62290 | Mexico | Details | |
| Hospital Universitario Dr. José Eleuterio González | Monterrey | Nuevo Leon | 64460 | Mexico | Details | |
| Hematológica Alta Especialidad | Huixquilucan | 52787 | Mexico | Details | ||
| Boca Raton Clinical Research (BRCR) Global Mexico - Ciudad de México | Mexico City | 1120 | Mexico | Details | ||
| Hagaziekenhuis Van Den Haag - Leyweg | Den Haag | South Holland | 2545 AA | Netherlands | Details | |
| Elisabeth-TweeSteden Ziekenhuis - Elisabeth | Tilburg | 5022 GC | Netherlands | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu | Wroclaw | Dolnoslaskie | 50-367 | Poland | Details | |
| Pratia MCM Kraków | Kraków | Malopolskie | 30-510 | Poland | Details | |
| Szpitale Pomorskie Spółka Z Ograniczoną Odpowiedzialnością | Gdynia | 81-519 | Poland | Details | ||
| Pratia Onkologia Katowice | Katowice | 40-519 | Poland | Details | ||
| Szpital Wojewódzki w Opolu | Opole | 45-061 | Poland | Details | ||
| Centrum Medyczne Pratia Poznań | Skorzewo | 60-185 | Poland | Details | ||
| Instytut Hematologii I Transfuzjologii | Warszawa | 02-776 | Poland | Details | ||
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi | Łódź | 93-510 | Poland | Details | ||
| Hospital Español Auxilio Mutuo | San Juan | 00919 | Puerto Rico | Details | ||
| Hospital del Mar - Parc de Salut Mar | Barcelona | 08003 | Spain | Details | ||
| Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet) | Barcelona | 08908 | Spain | Details | ||
| Hospital San Pedro de Alcantara | Cáceres | 10003 | Spain | Details | ||
| Hospital Universitario Ramón y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario La Paz | Madrid | 28046 | Spain | Details | ||
| Hospital Universitario Marqués de Valdecilla | Santander | 39008 | Spain | Details | ||
| Hospital Universitario Virgen del Rocío | Sevilla | 41013 | Spain | Details | ||
| Hospital Arnau de Vilanova | Valencia | 25198 | Spain | Details | ||
| Istituto Oncologico della Svizzera Italiana | Bellinzona | 6500 | Switzerland | Details | ||
| Özel Koru Hastanesi | Çukurambar | Ankara | 6510 | Turkey | Details | |
| VKV Amerikan Hastanesi | Şişli | Istanbul | 34365 | Turkey | Details | |
| Ege Universitesi Tip Fakultesi Hastanesi | Bornova | Izmir | 35100 | Turkey | Details | |
| Ondokuz Mayis Üniversitesi | Kurupelit | Samsun | 55270 | Turkey | Details | |
| Karadeniz Teknik Üniversitesi Tip Fakültesi | Ortahisar | Trabzon | 61080 | Turkey | Details | |
| Ankara Universitesi Tip Fakultesi - Cebeci Arastirma ve Uygulama Hastanesi | Ankara | 06100 | Turkey | Details | ||
| Mehmet Kemal Dedeman Hematoloji Hastanesi | Kayseri | 38039 | Turkey | Details | ||
| The Royal Marsden NHS Foundation Trust | Sutton | England | SM2 5PT | United Kingdom | Details | |
| NHS Greater Glasgow and Clyde | Glasgow | G12 0XH | United Kingdom | Details | ||
| The Christie NHS Foundation Trust | Manchester | M20 4BX | United Kingdom | Details |