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| NCT ID | NCT04384484 |
| Title | Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (LOTIS 5) |
| Acronym | LOTIS 5 |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | ADC Therapeutics S.A. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | POL | NLD | ITA | ISR | HUN | GBR | FRA | ESP | CZE | CHE | CAN | BRA | BEL | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of California San Diego Moores Cancer Center | COMPLETED | La Jolla | California | 92093 | United States | Details |
| Redlands Community Hospital | RECRUITING | Redlands | California | 92373 | United States | Details |
| The Oncology Institute of Hope and Innovation | RECRUITING | Whittier | California | 90603 | United States | Details |
| Baptist MD Anderson Cancer Center | RECRUITING | Jacksonville | Florida | 32207 | United States | Details |
| UnityPoint Health - Iowa Oncology Research Association (IORA) | RECRUITING | Des Moines | Iowa | 50309 | United States | Details |
| Norton Cancer Institute | RECRUITING | Louisville | Kentucky | 40207 | United States | Details |
| Comprehensive Cancer Centers of Nevada - Henderson | RECRUITING | Las Vegas | Nevada | 89169 | United States | Details |
| Kaiser Permanente Interstate Medical Office Central | RECRUITING | Portland | Oregon | 97227 | United States | Details |
| Hollings Cancer Center | RECRUITING | Charleston | South Carolina | 29425 | United States | Details |
| Virginia Cancer Specialists | RECRUITING | Gainesville | Virginia | 20155 | United States | Details |
| Medical College of Wisconsin Cancer Center Clinical Trials Office | RECRUITING | Milwaukee | Wisconsin | 53226 | United States | Details |
| Clinica Adventista Belgrano | RECRUITING | Belgrano | Buenos Aires | C1430EGF | Argentina | Details |
| Clínica de Nefrología, Urología y Enfermedades Cardiovasculares S.A. | RECRUITING | Santa Fe | Buenos Aires | 3000 | Argentina | Details |
| Instituto Médico Especializado Alexander Fleming | RECRUITING | Buenos Aires | Distrito Federal | C1426ANZ | Argentina | Details |
| Grupo Gamma - Hospital Privado Rosario | RECRUITING | Rosario | Santa Fe | S2000GAP | Argentina | Details |
| Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan | RECRUITING | Brugge | 8000 | Belgium | Details | |
| Cliniques Universitaires Saint-Luc | RECRUITING | Brussels | 1200 | Belgium | Details | |
| Centre Hospitalier Universitaire Universite Catholique de Louvain | RECRUITING | Namur | B-5530 | Belgium | Details | |
| Algemeen Ziekenhuis Delta - Campus Rumbeke | RECRUITING | Roeselare | 8800 | Belgium | Details | |
| Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer | RECRUITING | Curitiba | Paraná | 81520-060 | Brazil | Details |
| Hospital Moinhos de Vento | RECRUITING | Porto Alegre | Rio Grande Do Sul | 90035-001 | Brazil | Details |
| Hospital de Clínicas de Porto Alegre | RECRUITING | Porto Alegre | Rio Grande Do Sul | 90035-903 | Brazil | Details |
| Hospital Mãe de Deus - Centro Integrado de Oncologia | RECRUITING | Porto Alegre | Rio Grande Do Sul | 90110-270 | Brazil | Details |
| Hospital do Câncer | RECRUITING | Rio De Janeiro | 20230-130 | Brazil | Details | |
| Hemomed Instituto de Oncologia e Hematologia | RECRUITING | São Paulo | 01236-030 | Brazil | Details | |
| A Beneficência Portuguesa de São Paulo - Unidade Mirante | RECRUITING | São Paulo | 01321-001 | Brazil | Details | |
| Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo | RECRUITING | São Paulo | 05403-010 | Brazil | Details | |
| Hospital Israelita Albert Einstein | RECRUITING | São Paulo | 05652-900 | Brazil | Details | |
| Hospital Santa Marcelina | RECRUITING | São Paulo | 08270-120 | Brazil | Details | |
| Cross Cancer Institute | RECRUITING | Edmonton | T6G 1Z2 | Canada | Details | |
| Research Institute of the McGill University Health Centre | RECRUITING | Montréal | H4A 3J1 | Canada | Details | |
| Hôpital Fleurimont | RECRUITING | Sherbrooke | J1H 5H3 | Canada | Details | |
| Centro de Estudios Clínicos SAGA | RECRUITING | Santiago | Región Metropolitana De Santiago | 7500653 | Chile | Details |
| Instituto Oncológico Fundación Arturo López Pérez | RECRUITING | Santiago | Región Metropolitana De Santiago | 8320000 | Chile | Details |
| CeCim - Centro de Estudios Clínicos e Investigaciones Médicas | RECRUITING | Santiago | Región Metropolitana De Santiago | 8330109 | Chile | Details |
| Peking University Third Hospital | ACTIVE_NOT_RECRUITING | Beijing | Beijing | 100191 | China | Details |
| The First Affiliated Hospital of Xiamen University | ACTIVE_NOT_RECRUITING | Xiamen | Fujian | 361001 | China | Details |
| Sun Yat-Sen University Cancer Center | ACTIVE_NOT_RECRUITING | Guangzhou | Guangdong | 510060 | China | Details |
| Guangdong Provincial People's Hospital | ACTIVE_NOT_RECRUITING | Guangzhou | Guangdong | 510080 | China | Details |
| Zhujiang Hospital of Southern Medical University | ACTIVE_NOT_RECRUITING | Guangzhou | Guangdong | 510280 | China | Details |
| Henan Cancer Hospital - Zhengzhou University | ACTIVE_NOT_RECRUITING | Zhengzhou | Henan | 450008 | China | Details |
| Jilin Cancer Hospital | ACTIVE_NOT_RECRUITING | Changchun | Jilin | 130021 | China | Details |
| The First Hospital of Jilin University | ACTIVE_NOT_RECRUITING | Changchun | Jilin | 130021 | China | Details |
| Second Affiliated Hospital of Dalian Medical University | ACTIVE_NOT_RECRUITING | Dalian | Liaoning | 116000 | China | Details |
| Shanghai Cancer Center | ACTIVE_NOT_RECRUITING | Shanghai | Shanghai | 200025 | China | Details |
| West China School of Medicine - West China Hospital of Sichuan University | ACTIVE_NOT_RECRUITING | Chengdu | Sichuan | 610041 | China | Details |
| Tianjin Medical University Cancer Institute & Hospital | ACTIVE_NOT_RECRUITING | Tianjin | Tianjin | 300060 | China | Details |
| The First Affiliated Hospital of Zhejiang University School of Medicine | ACTIVE_NOT_RECRUITING | Hangzhou | Zhejiang | 310003 | China | Details |
| Chongqing University Cancer Hospital - Chongqing Cancer Hospital | ACTIVE_NOT_RECRUITING | Chongqing | 400030 | China | Details | |
| Huizhou Municipal Central Hospital | ACTIVE_NOT_RECRUITING | Huizhou | 516001 | China | Details | |
| The First Affiliated Hospital of Nanchang University | ACTIVE_NOT_RECRUITING | Nanchang | 330006 | China | Details | |
| Institute of Hematology and Blood Diseases Hospital of CAMS - PUMC | ACTIVE_NOT_RECRUITING | Tianjin | 300020 | China | Details | |
| Wuhan Union Hospital | ACTIVE_NOT_RECRUITING | Wuhan | 430023 | China | Details | |
| Tongji Hospital | ACTIVE_NOT_RECRUITING | Wuhan | 430030 | China | Details | |
| Fakultni nemocnice Ostrava | RECRUITING | Ostrava | 708 52 | Czechia | Details | |
| Fakultni Nemocnice Kralovske Vinohrady | RECRUITING | Prague | 100 34 | Czechia | Details | |
| Fakultni nemocnice v Motole | RECRUITING | Prague | 150 06 | Czechia | Details | |
| Centre Hospitalier Regional Universitaire Brest | COMPLETED | Brest | Bretagne | 29200 | France | Details |
| Hôpital Avicenne | RECRUITING | Bobigny | 93000 | France | Details | |
| Centre Hospitalier Regional Universitaire Brest | COMPLETED | Brest | 29200 | France | Details | |
| Hôpital François Mitterrand | COMPLETED | Dijon | 21000 | France | Details | |
| Hôpital Privé du Confluent | RECRUITING | Nantes | 44200 | France | Details | |
| Hopital Universitaire Pitie Salpetriere | RECRUITING | Paris | 75651 | France | Details | |
| Hôpital Haut-Lévêque | RECRUITING | Pessac | 33604 | France | Details | |
| Centre de Lutte Contre le Cancer - Centre Henri-Becquerel | RECRUITING | Rouen | 76038 | France | Details | |
| Heves Varmegyei Markhot Ferenc Oktatokorhaz es Rendelointezet | RECRUITING | Heves | Budapest | 3300 | Hungary | Details |
| Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet - Szent László | RECRUITING | Budapest | Pest | 1097 | Hungary | Details |
| Semmelweis Egyetem | RECRUITING | Budapest | 1088 | Hungary | Details | |
| Orszagos Onkologiai Intezet | RECRUITING | Budapest | 1122 | Hungary | Details | |
| Samson Assuta Ashdod University Hospital | COMPLETED | Ashdod | 7747629 | Israel | Details | |
| Soroka Medical Center | RECRUITING | Be'er Sheva | 8410101 | Israel | Details | |
| Shamir Medical Center (Assaf Harofeh) | RECRUITING | Be'er Ya'aqov | 7030000 | Israel | Details | |
| Carmel Medical Center | RECRUITING | Haifa | 3436212 | Israel | Details | |
| Rabin Medical Center - Beilinson Hospital | COMPLETED | Petah tikva | 4941492 | Israel | Details | |
| The Chaim Sheba Medical Center | COMPLETED | Tel Aviv | 52621 | Israel | Details | |
| Tel Aviv Sourasky Medical Center | ACTIVE_NOT_RECRUITING | Tel Aviv | 6423906 | Israel | Details | |
| Presidio Ospedaliero Universitario Santa Maria della Misericordia | RECRUITING | Udine | Friuli Venezia Giulia | 33100 | Italy | Details |
| Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia | RECRUITING | Brescia | 25123 | Italy | Details | |
| Azienda Ospedaliero - Universitaria Careggi | ACTIVE_NOT_RECRUITING | Florence | 50134 | Italy | Details | |
| Ospedale Casa Sollievo della Sofferenza | RECRUITING | Foggia | 71013 | Italy | Details | |
| Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST | RECRUITING | Meldola | 47014 | Italy | Details | |
| Istituto Europeo di Oncologia | RECRUITING | Milano | 20141 | Italy | Details | |
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas | RECRUITING | Milan | 20089 | Italy | Details | |
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele | RECRUITING | Milan | 20132 | Italy | Details | |
| Fondazione IRCCS Policlinico San Matteo | RECRUITING | Pavia | 27100 | Italy | Details | |
| Sanitaria Locale della Romagna | RECRUITING | Ravenna | 48121 | Italy | Details | |
| National Hospital Organization - Nagoya Medical Center | RECRUITING | Nagoya | Aichi | 460-0001 | Japan | Details |
| Toyohashi Municipal Hospital | RECRUITING | Toyohashi | Aichi | 441-8570 | Japan | Details |
| National Cancer Center Hospital East | RECRUITING | Kashiwa | Chiba | 277-8577 | Japan | Details |
| Matsuyama Red Cross Hospital | RECRUITING | Matsuyama | Ehime | 790-8524 | Japan | Details |
| Gunma Prefectural Cancer Center | RECRUITING | Ota | Gunma | 373-8550 | Japan | Details |
| Sapporo Hokuyu Hospital | RECRUITING | Sapporo | Hokkaido | 003-0006 | Japan | Details |
| Hokkaido Cancer Center | RECRUITING | Sapporo | Hokkaido | 003-0804 | Japan | Details |
| Kobe City Medical Center General Hospital | RECRUITING | Kobe | Hyogo | 650-0047 | Japan | Details |
| Kanagawa Cancer Center | RECRUITING | Yokohama | Kanagawa | 241-8515 | Japan | Details |
| Tohoku University Hospital | RECRUITING | Sendai | Miyagi | 980-8574 | Japan | Details |
| Nagasaki University Hospital | RECRUITING | Nagasaki-city | Nagasaki | 852-8501 | Japan | Details |
| Saitama Medical University - International Medical Center | RECRUITING | Hidaka-Shi | Saitama | 350-1298 | Japan | Details |
| Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital | RECRUITING | Bunkyo-ku | Tokyo | 113-8677 | Japan | Details |
| National Hospital Organization Disaster Medical Center | RECRUITING | Tachikawa | Tokyo | 190-0014 | Japan | Details |
| Fukushima Medical University Hospital | RECRUITING | Fukushima | 960-1295 | Japan | Details | |
| Gifu Municipal Hospital | RECRUITING | Gifu | 500-8323 | Japan | Details | |
| Kagoshima University Hospital | RECRUITING | Kagoshima | 890-8520 | Japan | Details | |
| Niigata University Medical and Dental Hospital | RECRUITING | Niigata | 951-8520 | Japan | Details | |
| National Hospital Organization Okayama Medical Center | RECRUITING | Okayama | 701-1192 | Japan | Details | |
| Osaka Prefectural Hospital Organization - Osaka International Cancer Institute | RECRUITING | Osaka | 541-8567 | Japan | Details | |
| Boca Raton Clinical Research (BRCR) Global Mexico - Guadalajara | RECRUITING | Guadalajara | Jalisco | 44600 | Mexico | Details |
| PanAmerican Clinical Research Mexico - Guadalajara | RECRUITING | Guadalajara | Jalisco | 44670 | Mexico | Details |
| PanAmerican Clinical Research Mexico - Cuernavaca | COMPLETED | Cuernavaca | Morelos | 62290 | Mexico | Details |
| Hospital Universitario Dr. José Eleuterio González | RECRUITING | Monterrey | Nuevo Leon | 64460 | Mexico | Details |
| Hematológica Alta Especialidad | RECRUITING | Huixquilucan | 52787 | Mexico | Details | |
| Boca Raton Clinical Research (BRCR) Global Mexico - Ciudad de México | RECRUITING | Mexico City | 1120 | Mexico | Details | |
| Hagaziekenhuis Van Den Haag - Leyweg | RECRUITING | Den Haag | South Holland | 2545 AA | Netherlands | Details |
| Elisabeth-TweeSteden Ziekenhuis - Elisabeth | RECRUITING | Tilburg | 5022 GC | Netherlands | Details | |
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu | ACTIVE_NOT_RECRUITING | Wroclaw | Dolnoslaskie | 50-367 | Poland | Details |
| Pratia MCM Kraków | RECRUITING | Kraków | Malopolskie | 30-510 | Poland | Details |
| Szpitale Pomorskie Spółka Z Ograniczoną Odpowiedzialnością | RECRUITING | Gdynia | 81-519 | Poland | Details | |
| Pratia Onkologia Katowice | RECRUITING | Katowice | 40-519 | Poland | Details | |
| Szpital Wojewódzki w Opolu | COMPLETED | Opole | 45-061 | Poland | Details | |
| Centrum Medyczne Pratia Poznań | RECRUITING | Skorzewo | 60-185 | Poland | Details | |
| Instytut Hematologii I Transfuzjologii | ACTIVE_NOT_RECRUITING | Warszawa | 02-776 | Poland | Details | |
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi | RECRUITING | Łódź | 93-510 | Poland | Details | |
| Hospital Español Auxilio Mutuo | RECRUITING | San Juan | 00919 | Puerto Rico | Details | |
| Hospital del Mar - Parc de Salut Mar | RECRUITING | Barcelona | 08003 | Spain | Details | |
| Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet) | RECRUITING | Barcelona | 08908 | Spain | Details | |
| Hospital San Pedro de Alcantara | RECRUITING | Cáceres | 10003 | Spain | Details | |
| Hospital Universitario Ramón y Cajal | RECRUITING | Madrid | 28034 | Spain | Details | |
| Hospital Universitario Fundación Jiménez Díaz | RECRUITING | Madrid | 28040 | Spain | Details | |
| Hospital Universitario 12 de Octubre | COMPLETED | Madrid | 28041 | Spain | Details | |
| Hospital Universitario La Paz | RECRUITING | Madrid | 28046 | Spain | Details | |
| Hospital Universitario Marqués de Valdecilla | RECRUITING | Santander | 39008 | Spain | Details | |
| Hospital Universitario Virgen del Rocío | RECRUITING | Sevilla | 41013 | Spain | Details | |
| Hospital Arnau de Vilanova | RECRUITING | Valencia | 25198 | Spain | Details | |
| Istituto Oncologico della Svizzera Italiana | RECRUITING | Bellinzona | 6500 | Switzerland | Details | |
| Özel Koru Hastanesi | RECRUITING | Çukurambar | Ankara | 6510 | Turkey | Details |
| VKV Amerikan Hastanesi | RECRUITING | Şişli | Istanbul | 34365 | Turkey | Details |
| Ege Universitesi Tip Fakultesi Hastanesi | RECRUITING | Bornova | Izmir | 35100 | Turkey | Details |
| Ondokuz Mayis Üniversitesi | RECRUITING | Kurupelit | Samsun | 55270 | Turkey | Details |
| Karadeniz Teknik Üniversitesi Tip Fakültesi | RECRUITING | Ortahisar | Trabzon | 61080 | Turkey | Details |
| Ankara Universitesi Tip Fakultesi - Cebeci Arastirma ve Uygulama Hastanesi | RECRUITING | Ankara | 06100 | Turkey | Details | |
| Mehmet Kemal Dedeman Hematoloji Hastanesi | RECRUITING | Kayseri | 38039 | Turkey | Details | |
| The Royal Marsden NHS Foundation Trust | RECRUITING | Sutton | England | SM2 5PT | United Kingdom | Details |
| NHS Greater Glasgow and Clyde | RECRUITING | Glasgow | G12 0XH | United Kingdom | Details | |
| The Christie NHS Foundation Trust | RECRUITING | Manchester | M20 4BX | United Kingdom | Details |