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| NCT ID | NCT04447118 |
| Title | Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy (PYRAMID-1) |
| Acronym | PYRAMID-1 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Jiangsu HengRui Medicine Co., Ltd. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | ITA | FRA | ESP | DEU | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of California - Irvine Medical Center | Orange | California | 92868 | United States | Details | |
| University of California (UC) Davis Comprehensive Cancer Center | Sacramento | California | 95817 | United States | Details | |
| Innovative Clinical Research Institute | Whittier | California | 33756 | United States | Details | |
| Florida Cancer Specialists South Divisio | Fort Myers | Florida | 33901 | United States | Details | |
| Florida Cancer Specialists North Divisio | Saint Petersburg | Florida | 33701 | United States | Details | |
| University of Kansas Medical Center (KUMC) | Kansas City | Kansas | 66160 | United States | Details | |
| David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center | New York | New York | 10021 | United States | Details | |
| Gabrail Cancer Center | Canton | Ohio | 44718 | United States | Details | |
| Tennessee Oncology | Nashville | Tennessee | 33756 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Summit Cancer Centers - North Spokane | Spokane | Washington | 99208 | United States | Details | |
| Royal North Shore Hospital | St Leonards | Saint Leonards | Australia | Details | ||
| Border Medical Oncology | Albury | Australia | Details | |||
| St Vincent's Hospital Melbourne | Fitzroy | Australia | Details | |||
| Sir Charles Gairdner Hospital | Nedlands | Australia | Details | |||
| Calvary North Adelaide Hospital | North Adelaide | Australia | Details | |||
| Antwerp University Hospital (UZA) | Edegem | Belgium | Details | |||
| University Hospital Gent | Gent | Belgium | Details | |||
| University Hospital (UZ) Leuven | Leuven | Belgium | Details | |||
| the Second Affiliated Hospital of Anhui Medical University | Hefei | Anhui | China | Details | ||
| beijing chest hospital,Capital medical university | Beijing | Beijing | China | Details | ||
| Peking university Cancer Hospital | Beijing | Beijing | China | Details | ||
| The second affiliated hospital of ChongQing medical university | Chongqing | Chongqing | China | Details | ||
| The First Affiliated Hospital of Guangdong Pharmaceutical University | Guangzhou | Guangdong | China | Details | ||
| Cangzhou Hospital of Integrated Tcm-Wm.Hebei | Cangzhou | Hebei | China | Details | ||
| Harbin Medical University Cancer Hospital | Ha'erbin | Heilongjiang | China | Details | ||
| First Affiliated Hospital of ZhengzhouUniversity | Zhengzhou | Henan | China | Details | ||
| Henan Cancer Hospital | Zhengzhou | Henan | China | Details | ||
| Hubei cancer hospital WardII | Wuhan | Hubei | China | Details | ||
| Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University | Changsha | Hunan | China | Details | ||
| Jiangsu Cancer Hospital | Nanjing | Jiangsu | China | Details | ||
| Subei People's Hospital of Jiangsu Province | Yangzhou | Jiangsu | China | Details | ||
| The Second Affiliated of Nanchang University | Nanchang | Jiangxi | China | Details | ||
| Jilin Cancer Hospital | Changchun | Jilin | China | Details | ||
| The affiliated hospital of inner mongolia medical univerity | Hohhot | Neimenggu | China | Details | ||
| Shandong Cancer Hospital Affiliated to Shandong University | Jinan | Shandong | China | Details | ||
| Shanghai Pulmonary Hospital, Tongji University | Shanghai | Shanghai | 200433 | China | Details | |
| Fudan University Cancer hospital | Shanghai | Shanghai | China | Details | ||
| Ruijin Hospital, Shanghai Jiaotong University School of Medicine | Shanghai | Shanghai | China | Details | ||
| Shanghai Chest Hospital | Shanghai | Shanghai | China | Details | ||
| Shanxi Provincial Cancer Hospital | Taiyuan | Shanxi | China | Details | ||
| SiChuan Cancer Hospital | Chengdu | Sichuan | China | Details | ||
| West China Hospital,Sichuan University | Chengdu | Sichuan | China | Details | ||
| The Second People's Hosipital of Yibin | Yibin | Sichuan | China | Details | ||
| General Hospital of Tianjin Medical University | Tianjin | Tianjin | China | Details | ||
| Yunnan Provincial Cancer Hospital | Kunming | Yunnan | China | Details | ||
| Sir Run Run Shaw Hospital ZheJiang University School Of Medicine | Hangzhou | Zhejiang | China | Details | ||
| The First Affiliated Hospital，ZheJiang University | Hangzhou | Zhejiang | China | Details | ||
| ZheJiang Cancer Hospital | Hangzhou | Zhejiang | China | Details | ||
| Taizhou Hospital of Zhejiang Province | Taizhou | Zhejiang | China | Details | ||
| Centre Francois Baclesse | CAEN cedex 05 | France | Details | |||
| Centre Hospitalier Intercommunal Creteil | Creteil | France | Details | |||
| AP-HM - Hôpital Nord | Marseille cedex 20 | France | Details | |||
| Hopital Bichat - Claude Bernard - AP-HP | Paris | France | Details | |||
| CHRU Strasbourg | Strasbourg Cedex | France | Details | |||
| CHU Toulouse - Hopital Larrey | Toulouse | France | Details | |||
| Universitaetsklinikum Carl Gustav Carus Dresden | Dresden | Germany | Details | |||
| Uniklinikum Giessen und Marburg | Giessen | Germany | Details | |||
| Klinikverbund Kempten-Oberallgäu gGmbH | Kempten | Germany | Details | |||
| POIS Leipzig GbR | Leipzig | Germany | Details | |||
| Pius-Hospital Oldenburg, Centre of Radiotherapy and Medical Oncology, Dept. Medical Oncology | Oldenburg | Germany | Details | |||
| Centro Riferimento Oncologico - Aviano | Aviano | Italy | Details | |||
| Azienda Ospedaliero Universitaria Policlinico G. Rodolico-San Marco - Presidio Ospedaliero G. Rodolico | Catania | Italy | Details | |||
| Istituto Romagnolo per lo Studio dei Tumori Dino Amadori | Meldola (fc) | Italy | Details | |||
| Istituto Europeo di Oncologia | Milano | Italy | Details | |||
| ASST dei Sette Laghi-Ospedale di Circolo e Fondazione Macchi di Varese | Varese | Italy | Details | |||
| Seoul National University Bundang Hospital | Seoul | Bundang | Korea, Republic of | Details | ||
| Ajou University Hospital | Gyeonggi-do | Korea, Republic of | Details | |||
| Asan Medical Center | Seoul | Korea, Republic of | Details | |||
| Korea University Anam Hospital | Seoul | Korea, Republic of | Details | |||
| Samsung Medical Center | Seoul | Korea, Republic of | Details | |||
| Seoul St. Mary's Hospital, The Catholic University of Korea | Seoul | Korea, Republic of | Details | |||
| Severance Hospital, Yonsei University Health System | Seoul | Korea, Republic of | Details | |||
| Centrum Onkologii KOMED | Konin | Poland | Details | |||
| Salve-Medica | Lodz | Poland | Details | |||
| Instytut Genetyki i Immunologii GENIM | Lublin | Poland | Details | |||
| Med Polonia Sp. z o.o. | Poznan | Poland | Details | |||
| Petrov National Medical Research Center of Oncology | St. Petersburg | Saint Petersburg | Russian Federation | Details | ||
| Arkhangelsk Clinical Oncological Dispensary | Arkhangelsk | Russian Federation | Details | |||
| JSC Group of companies Medsi | Moscow | Russian Federation | Details | |||
| Clinical hospital RZD-Medicine of St. Petersburg | Saint Petersburg | Russian Federation | Details | |||
| Eurocityclinic LLC | Saint Petersburg | Russian Federation | Details | |||
| Saint-Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology) | Saint Petersburg | Russian Federation | Details | |||
| Hospital Germans Trias i Pujol | Barcelona | Badalona | Spain | Details | ||
| Hospital Universitario Vall d'Hebron | Barcelona | Badalona | Spain | Details | ||
| Hospital Clinic Barcelona | Barcelona | Spain | Details | |||
| Hospital Fundación Jiménez Díaz | Madrid | Spain | Details | |||
| Hospital Universitario 12 de Octubre | Madrid | Spain | Details | |||
| Hospital Regional Universitario de Malaga | Malaga | Spain | Details | |||
| Complejo Hospitalario de Navarra | Pamplona | Spain | Details | |||
| Hospital Universitario Virgen del Rocio | Sevilla | Spain | Details | |||
| Instituto Valenciano de Oncologia | Valencia | Spain | Details | |||
| China Medical University Hospital | Taichung | Taiwan | Details | |||
| Taipei Veterans General Hospital | Taipei | Taiwan | Details | |||
| Linkou Chang Gung Memorial Hospital (CGMHLK) | Taoyuan City | Taiwan | Details | |||
| Baskent University Adana Application and Research Center | Adana | Turkey | Details | |||
| Ankara Sehir Hastanesi | Ankara | Turkey | Details | |||
| Istanbul University Cerrahpasa Medical Faculty | Istanbul | Turkey | Details | |||
| Izmir Medical Park Hospital | Izmir | Turkey | Details | |||
| Gulhane Training and Research Hospital | Keçiören | Turkey | Details | |||
| Necmettin Erbakan University Selcuklu Faculty of Medicine | Konya | Turkey | Details | |||
| Trakya University Medical Faculty | Merkez | Turkey | Details |