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NCT ID NCT04468984
Title Safety, Efficacy, and Assessment of Change in Spleen Volume Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet in Adult Participants With Relapsed/Refractory Myelofibrosis (TRANSFORM-2)
Acronym TRANSFORM-2
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors AbbVie
Indications
Therapies
Age Groups: senior | adult
Covered Countries USA | TUR | SWE | POL | NZL | ITA | ISR | HUN | HRV | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CHE | CAN | BGR | BEL | AUT | AUS

Facility Status City State Zip Country Details
Ironwood Cancer & Res Ctr /ID# 222162 Chandler Arizona 85224-5665 United States Details
Highlands Oncology Group, PA /ID# 221826 Springdale Arkansas 72762 United States Details
Moores Cancer Center at UC San Diego /ID# 219009 La Jolla California 92093 United States Details
Long Beach Memorial Medical Ct /ID# 224542 Long Beach California 90806-1701 United States Details
Icri /Id# 221967 Whittier California 90603 United States Details
St. Mary's Hospital Regional Cancer Center /ID# 224229 Grand Junction Colorado 81501-6132 United States Details
Augusta University Georgia Cancer Center /ID# 219051 Augusta Georgia 30912-0003 United States Details
Columbus Regional Research Institute /ID# 224410 Columbus Georgia 31904-8915 United States Details
Northwest Oncology & Hematology - Elk Grove Village /ID# 222818 Elk Grove Village Illinois 60007-3361 United States Details
Loyola University Medical Ctr /ID# 219048 Maywood Illinois 60153 United States Details
Indiana Blood & Marrow Transpl /ID# 221587 Indianapolis Indiana 46237 United States Details
Tulane Medical Center - New Orleans /ID# 222940 New Orleans Louisiana 70112-2600 United States Details
Ochsner Clinic Foundation-New Orleans /ID# 222777 New Orleans Louisiana 70121 United States Details
American Oncology Partners of Maryland /ID# 222836 Bethesda Maryland 20817 United States Details
Dana-Farber Cancer Institute /ID# 218998 Boston Massachusetts 02215 United States Details
University of Michigan /ID# 218463 Ann Arbor Michigan 48109 United States Details
Henry Ford Health System /ID# 221190 Detroit Michigan 48202 United States Details
William Beaumont Hospital /ID# 222705 Royal Oak Michigan 48073-6710 United States Details
Saint Louis University Cancer Center /ID# 222287 Saint Louis Missouri 63110-2539 United States Details
Summit Medical Group-Florham Park /ID# 222620 Florham Park New Jersey 07932-1049 United States Details
Hackensack Univ Med Ctr /ID# 219047 Hackensack New Jersey 07601 United States Details
The Cancer Institute at St. Francis Hospital /ID# 231782 Greenvale New York 11548-1219 United States Details
Manhattan Hematology Oncology MHO Associates /ID# 223193 New York New York 10016-6028 United States Details
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081 New York New York 10065-6007 United States Details
Atrium Health Wake Forest Baptist Medical Center /ID# 222899 Winston-Salem North Carolina 27157-0001 United States Details
MetroHealth Medical Center /ID# 222650 Cleveland Ohio 44109 United States Details
Hospital of the University of Pennsylvania /ID# 219001 Philadelphia Pennsylvania 19104-4238 United States Details
Fox Chase Cancer Center /ID# 223955 Philadelphia Pennsylvania 19111 United States Details
Duplicate_Houston Methodist Hospital /ID# 223103 Houston Texas 77030 United States Details
University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942 San Antonio Texas 78229 United States Details
Utah Cancer Specialists Salt Lake Clinic /ID# 221962 Salt Lake City Utah 84106 United States Details
Virginia Cancer Specialists - Fairfax /ID# 223016 Fairfax Virginia 22031 United States Details
Providence Everett /ID# 223130 Everett Washington 98201 United States Details
Yakima Valley Memorial Hosp /ID# 224368 Yakima Washington 98902-6388 United States Details
HSHS St. Vincent Hospital /ID# 224468 Green Bay Wisconsin 54301 United States Details
The Kinghorn Cancer Centre /ID# 221097 Darlinghurst New South Wales 2010 Australia Details
Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 223848 East Albury New South Wales 2640 Australia Details
Calvary Mater Newcastle /ID# 224324 Waratah New South Wales 2298 Australia Details
The Alfred Hospital /ID# 221096 Melbourne Victoria 3004 Australia Details
Royal Perth Hospital /ID# 221099 Perth Western Australia 6000 Australia Details
Universitaetsklinikum St. Poelten /ID# 221709 Sankt Poelten Niederoesterreich 3100 Austria Details
Ordensklinikum Linz GmbH Elisabethinen /ID# 220914 Linz Oberoesterreich 4010 Austria Details
Klinikum Wels-Grieskirchen GmbH /ID# 220915 Wels Oberoesterreich 4600 Austria Details
Medizinische Universitaet Graz /ID# 220919 Graz Steiermark 8010 Austria Details
Medizinische Universitaet Wien /ID# 220911 Vienna Wien 1090 Austria Details
Hanusch Krankenhaus /ID# 220912 Wien 1140 Austria Details
ZNA Cadix /ID# 221468 Antwerp Antwerpen 2030 Belgium Details
Cliniques Universitaires UCL Saint-Luc /ID# 224221 Woluwe-Saint-Lambert Bruxelles-Capitale 1200 Belgium Details
Grand Hopital de Charleroi /ID# 224827 Charleroi Hainaut 6000 Belgium Details
UZ Gent /ID# 220841 Gent Oost-Vlaanderen 9000 Belgium Details
AZ-Delta /ID# 221469 Roeselare West-Vlaanderen 8800 Belgium Details
Vitaz /Id# 228150 Sint-Niklaas 9100 Belgium Details
UMHAT Alexandrovska EAD /ID# 231652 Sofiya Sofia 1431 Bulgaria Details
UMHAT Dr Georgi Stranski EAD /ID# 231650 Pleven 5800 Bulgaria Details
Acibadem City Clinic Tokuda University Hospital EAD /ID# 231649 Sofia 1407 Bulgaria Details
UMHAT Sveti Ivan Rilski /ID# 231651 Sofia 1431 Bulgaria Details
UMHAT Sveta Marina /ID# 234119 Varna 9010 Bulgaria Details
Juravinski Cancer Centre /ID# 220887 Hamilton Ontario L8V 1C3 Canada Details
Ottawa Hospital Research Institute /ID# 238858 Ottawa Ontario K1H 8L6 Canada Details
Princess Margaret Cancer Centre /ID# 253942 Toronto Ontario M5G 2M9 Canada Details
CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433 Levis Quebec G6V 3Z1 Canada Details
McGill University Health Center Research Institute /ID# 222614 Montreal Quebec H4A 3J1 Canada Details
Clinical Hospital Dubrava /ID# 230801 Zagreb Grad Zagreb 10000 Croatia Details
Klinicka bolnica Merkur /ID# 230799 Zagreb Grad Zagreb 10000 Croatia Details
Klinicki bolnicki centar Zagreb /ID# 230798 Zagreb Grad Zagreb 10000 Croatia Details
Klinicki Bolnicki Centar (KBC) Split /ID# 230800 Split Splitsko-dalmatinska Zupanija 21000 Croatia Details
Klinicki bolnicki centar Osijek /ID# 231503 Osijek 31000 Croatia Details
Fakultni nemocnice Brno /ID# 220959 Brno 613 00 Czechia Details
Vseobecna fakultni nemocnice v Praze /ID# 220969 Praha 128 08 Czechia Details
Aalborg University Hospital /ID# 224391 Aalborg Nordjylland 9000 Denmark Details
Roskilde Sygehus /ID# 224456 Roskilde Sjælland 4000 Denmark Details
Chu de Nice-Hopital Larchet Ii /Id# 256291 Nice Alpes-Maritimes 06200 France Details
CHU NIMES - Hopital Caremeau /ID# 219128 Nimes CEDEX 9 Gard 30029 France Details
Centre Hospitalier Universitaire de Bordeaux /ID# 222696 Pessac CEDEX Gironde 33604 France Details
Hopital Avicenne - APHP /ID# 221287 Bobigny Ile-de-France 93000 France Details
CHU de Nantes, Hotel Dieu -HME /ID# 219127 Nantes Pays-de-la-Loire 44000 France Details
HCL - Hopital Lyon Sud /ID# 222695 Pierre Benite CEDEX Rhone 69495 France Details
Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 223771 Chambery CEDEX Savoie 73007 France Details
Chu Angers /Id# 219129 Angers 49933 France Details
AP-HP - Hopital Saint-Louis /ID# 221390 Paris 75010 France Details
Universitatsklinikum Mannheim /ID# 221529 Mannheim Baden-Wuerttemberg 68167 Germany Details
Stauferklinikum Schwaebisch Gmuend /ID# 223948 Mutlangen Baden-Wuerttemberg 73557 Germany Details
Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025 Augsburg Bayern 86150 Germany Details
Universitaetsmedizin Rostock /ID# 224157 Rostock Mecklenburg-Vorpommern 18057 Germany Details
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221346 Dresden Sachsen 01307 Germany Details
Augusta-Kranken-Anstalt gGmbH, Bochum-Mitte /ID# 224695 Bochum 44791 Germany Details
Klinikum Chemnitz gGmbH /ID# 224575 Chemnitz 09116 Germany Details
OncoResearch Lerchenfeld GmbH /ID# 225034 Hamburg 22081 Germany Details
Klinikum rechts der Isar /ID# 221526 Munich 81675 Germany Details
Olympion General Clinic /ID# 261423 Patras Achaia 25443 Greece Details
General Hospital of Athens Laiko /ID# 221175 Athens Attiki 11527 Greece Details
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179 Athens 10676 Greece Details
University General Hospital of Patras /ID# 221178 RION Patras Achaia 26504 Greece Details
General Hospital of Thessaloniki George Papanikolaou /ID# 221463 Thessaloniki 57010 Greece Details
Fejér Vármegyei Szent György Egyetemi Oktató Kórház /ID# 220949 Szekesfehervar Fejer 8000 Hungary Details
Debreceni Egyetem-Klinikai Kozpont /ID# 220947 Debrecen Hajdu-Bihar 4032 Hungary Details
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 220948 Kaposvár Somogy 7400 Hungary Details
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 220946 Nyiregyhaza Szabolcs-Szatmar-Bereg 4400 Hungary Details
Szegedi Tudományegyetem /ID# 220955 Szeged 6720 Hungary Details
HaEmek Medical Center /ID# 220839 Afula H_efa 1834111 Israel Details
Rambam Health Care Campus /ID# 219121 Haifa H_efa 3109601 Israel Details
The Lady Davis Carmel Medical Center /ID# 222973 Haifa H_efa 34362 Israel Details
Assuta Ashdod Medical Center /ID# 225281 Ashdod HaDarom 7747629 Israel Details
Yitzhak Shamir Medical Center /ID# 222972 Zerifin HaMerkaz 70300 Israel Details
Galilee Medical Center /ID# 225280 Nahariya HaTsafon 2210001 Israel Details
The Chaim Sheba Medical Center /ID# 219136 Ramat Gan Tel-Aviv 5265601 Israel Details
Tel Aviv Sourasky Medical Center /ID# 219135 Tel Aviv Tel-Aviv 6423906 Israel Details
Hadassah Medical Center-Hebrew University /ID# 219111 Jerusalem Yerushalayim 91120 Israel Details
Hadassah Mt. Scopus /ID# 253394 Jerusalem Yerushalayim 9765400 Israel Details
Rabin Medical Center /ID# 219139 Haifa 4941492 Israel Details
Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 238438 Torette Ancona 60020 Italy Details
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 219087 Rome Lazio 00168 Italy Details
ASST Monza/Ospedale San Gerardo /ID# 225113 Monza Monza E Brianza 20900 Italy Details
AOU Citta della Salute e della Scienza di Torino /ID# 221223 Torino Piemonte 10126 Italy Details
Sapienza University /ID# 225731 Rome Roma 00161 Italy Details
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 221222 Bergamo 24127 Italy Details
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 221077 Bologna 40138 Italy Details
Presidio Ospedaliero Gaspare Rodolico /ID# 219089 Catania 95123 Italy Details
Azienda Ospedaliero Universitaria Careggi /ID# 219090 Florence 50134 Italy Details
Azienda Ospedaliera Universitaria Federico II /ID# 224673 Napoli 80131 Italy Details
Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 221078 Palermo 90127 Italy Details
Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 221220 Reggio Calabria 89124 Italy Details
Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 221241 Udine 33100 Italy Details
ASST Sette Laghi /ID# 234183 Varese 21100 Italy Details
Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 221079 Vicenza 36100 Italy Details
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 221150 Nagoya-shi Aichi 453-8511 Japan Details
Fujita Health University Hospital /ID# 221598 Toyoake Aichi 470-1192 Japan Details
Aomori Prefectural Central Hospital /ID# 221778 Aomori-shi Aomori 030-8553 Japan Details
Chiba University Hospital /ID# 224546 Chiba-shi Chiba 260-8677 Japan Details
National Cancer Center Hospital East /ID# 226653 Kashiwa-shi Chiba 277-8577 Japan Details
Ehime University Hospital /ID# 221158 Toon-shi Ehime 791-0295 Japan Details
Kyushu University Hospital /ID# 221606 Fukuoka-shi Fukuoka 812-8582 Japan Details
Fukushima Medical University Hospital /ID# 221877 Fukushima-shi Fukushima 960-1295 Japan Details
Gifu University Hospital /ID# 224371 Gifu-shi Gifu 501-1194 Japan Details
Sapporo Hokuyu Hospital /ID# 221149 Sapporo-shi Hokkaido 003-0006 Japan Details
Kobe City Medical Center General Hospital /ID# 221156 Kobe-shi Hyogo 650-0047 Japan Details
Kanazawa University Hospital /ID# 223028 Kanazawa-shi Ishikawa 920-8641 Japan Details
Iwate Medical University Hospital /ID# 222044 Shiwa-gun Iwate 028-3695 Japan Details
Shonan Kamakura General Hospital /ID# 223030 Kamakura-shi Kanagawa 247-8533 Japan Details
Kumamoto Shinto General Hospital /ID# 255645 Kumamoto-shi Kumamoto 862-8655 Japan Details
Kyoto University Hospital /ID# 223008 Kyoto-shi Kyoto 606-8507 Japan Details
Mie University Hospital /ID# 221665 Tsu-shi Mie 514-8507 Japan Details
University of Miyazaki Hospital /ID# 221821 Miyazaki-shi Miyazaki 889-1692 Japan Details
Niigata University Medical & Dental Hospital /ID# 223034 Niigata-shi Niigata 951-8520 Japan Details
Kurashiki Central Hospital /ID# 221690 Kurashiki-shi Okayama 710-8602 Japan Details
Kansai Medical University Hospital /ID# 257289 Hirakata-shi Osaka 573-1191 Japan Details
Osaka University Hospital /ID# 221159 Suita-shi Osaka 565-0871 Japan Details
Dokkyo Medical University Saitama Medical Center /ID# 222334 Koshigaya Saitama 343-0845 Japan Details
Juntendo University Shizuoka Hospital /ID# 221780 Izunokuni-shi Shizuoka 410-2295 Japan Details
Juntendo University Hospital /ID# 221154 Bunkyo-ku Tokyo 113-8431 Japan Details
Nippon Medical School Hospital /ID# 221676 Bunkyo-ku Tokyo 113-8602 Japan Details
Tokyo Medical University Hospital /ID# 221540 Shinjuku-ku Tokyo 160-0023 Japan Details
Tokyo Metropolitan Bokutoh Hospital /ID# 254774 Sumida-ku Tokyo 130-8575 Japan Details
University of Yamanashi Hospital /ID# 221706 Chuo-shi Yamanashi 409-3821 Japan Details
IMSUT Hospital, The Institute of Medical Science, The University of Tokyo /ID# 257944 Tokyo 108-8639 Japan Details
Pusan National University Hospital /ID# 220980 Busan Busan Gwang Yeogsi 49241 Korea, Republic of Details
Gachon University Gil Medical Center /ID# 220972 Incheon Gyeonggido 21565 Korea, Republic of Details
Seoul National University Hospital /ID# 219060 Seoul Seoul Teugbyeolsi 03080 Korea, Republic of Details
Samsung Medical Center /ID# 221091 Seoul Seoul Teugbyeolsi 06351 Korea, Republic of Details
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219061 Seoul Seoul Teugbyeolsi 06591 Korea, Republic of Details
Aotearoa Clinical Trials /ID# 232201 Papatoetoe Auckland 2025 New Zealand Details
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopern /ID# 221161 Lodz Lodzkie 93-513 Poland Details
Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie /ID# 221124 Lublin Lubelskie 20-081 Poland Details
SP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160 Krakow Malopolskie 31-501 Poland Details
Lux Med Onkologia - Szpital Szamocka /Id# 221265 Warszawa Mazowieckie 01-748 Poland Details
MTZ Clinical Research Powered by Pratia /ID# 221759 Warszawa Mazowieckie 02-172 Poland Details
Uniwersyteckie Centrum Kliniczne /ID# 221298 Gdansk Pomorskie 80-214 Poland Details
ARS-MEDICAL Sp. z o.o. /ID# 238336 Pila Wielkopolskie 64-920 Poland Details
Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola /ID# 241031 Poznan Wielkopolskie 60-569 Poland Details
Pratia Onkologia Katowice /ID# 224526 Katowice 40-519 Poland Details
Hospital del Centro Comprensivo de Cancer de la UPR /ID# 223281 San Juan 00927 Puerto Rico Details
Moscow State budget healthcare /ID# 221116 Moscow Moskva 125284 Russian Federation Details
Hospital n.a. V.V. Veresaev /ID# 225221 Moscow 127644 Russian Federation Details
Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221115 Sankt-Peterburg 191024 Russian Federation Details
Almazov National Medical Research Centre /ID# 221114 Sankt-Peterburg 197341 Russian Federation Details
Tula Regional Clinical Hospital /ID# 221302 Tula 300053 Russian Federation Details
University Clinical Center Serbia /ID# 231058 Belgrade Beograd 11000 Serbia Details
Clin Hosp Ctr Bezanijska Kosa /ID# 231059 Belgrade Beograd 11080 Serbia Details
University Clinical Center Vojvodina /ID# 231057 Novi Sad 21000 Serbia Details
Duplicate_Wits Clinical Research Site /ID# 231554 Johannesburg Gauteng 2193 South Africa Details
Alberts Cellular Therapy /ID# 231556 Pretoria Gauteng 0044 South Africa Details
Complejo Hospitalario Universitario A Coruña /ID# 224617 A Coruña A Coruna 15006 Spain Details
Hospital Clínico Universitario de Santiago-CHUS /ID# 221616 Santiago de Compostela A Coruna 15706 Spain Details
Hospital Universitario Central de Asturias /ID# 224815 Oviedo Asturias 33011 Spain Details
Hospital Universitario Germans Trias i Pujol /ID# 233727 Badalona Barcelona 08916 Spain Details
Hospital Universitario Dr. Negrin /ID# 220923 Las Palmas de Gran Canaria Las Palmas 35019 Spain Details
Hospital Parc de Salut del Mar /ID# 220922 Barcelona 08003 Spain Details
Hospital Universitario Vall d'Hebron /ID# 240979 Barcelona 08035 Spain Details
Hospital Universitario Virgen de las Nieves /ID# 253936 Granada 18014 Spain Details
Hospital Universitario 12 de Octubre /ID# 233726 Madrid 28041 Spain Details
Hospital Universitario La Paz /ID# 224813 Madrid 28046 Spain Details
Hospital Regional Universitario de Malaga /ID# 221906 Malaga 29011 Spain Details
Hospital Universitario de Salamanca /ID# 221904 Salamanca 37711 Spain Details
Hospital Universitario Virgen del Rocio /ID# 221932 Sevilla 41013 Spain Details
Hospital Clinico Universitario de Valencia /ID# 220920 Valencia 46010 Spain Details
Skane University Hospital Lund /ID# 220834 Lund Skane Lan 224 84 Sweden Details
Duplicate_Universitätsspital Basel /ID# 221261 Basel Basel-Stadt 4031 Switzerland Details
Inselspital, Universitaetsspital Bern /ID# 223439 Bern 3010 Switzerland Details
Kaohsiung Chang Gung Memorial Hospital /ID# 218985 Kaohsiung City Kaohsiung 833 Taiwan Details
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980 Kaohsiung 807 Taiwan Details
China Medical University Hospital /ID# 218979 Taichung 40447 Taiwan Details
Chi Mei Hospital - Liouying /ID# 221144 Tainan City 73657 Taiwan Details
Taipei Veterans General Hosp /ID# 221147 Taipei 11217 Taiwan Details
Linkou Chang Gung Memorial Hospital /ID# 218982 Taoyuan City 333 Taiwan Details
Gulhane Askeri Tip Academy /ID# 224568 Ankara 06010 Turkey Details
Trakya University Medical Facu /ID# 224572 Edirne, Istanbul 22030 Turkey Details
Ege University Medical Faculty /ID# 224570 Izmir 35040 Turkey Details
Mersin University Medical /ID# 224571 Mersin 33343 Turkey Details
Ondokuz mayis University Facul /ID# 224567 Samsun 55200 Turkey Details
United Lincolnshire Hospitals NHS Trust /ID# 224613 Lincoln Lincolnshire LN2 4AX United Kingdom Details
Guys and St Thomas NHS Foundation Trust /ID# 221041 London London, City Of SE1 9RT United Kingdom Details
James Paget University Hospitals NHS Foundation Trust /ID# 221219 Great Yarmouth Norfolk NR31 6LA United Kingdom Details
University Hospitals Birmingham NHS Foundation Trust /ID# 221334 Birmingham B15 2TH United Kingdom Details
NHS Lothian /ID# 224378 Edinburgh EH3 9HE United Kingdom Details
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 221335 Newcastle upon Tyne NE3 3HD United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field