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| NCT ID | NCT04662710 |
| Title | Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015) (LEAP-015) |
| Acronym | LEAP-015 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | POL | ITA | ISR | IRL | GBR | FRA | ESP | DEU | CAN | BEL | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| UCLA Hematology/Oncology - Santa Monica ( Site 0003) | Los Angeles | California | 90404 | United States | Details | |
| Georgetown University Medical Center ( Site 0009) | Washington | District of Columbia | 20007 | United States | Details | |
| James Graham Brown Cancer Center ( Site 0017) | Louisville | Kentucky | 40202 | United States | Details | |
| Johns Hopkins University ( Site 0052) | Baltimore | Maryland | 21224 | United States | Details | |
| Dana Farber Cancer Center ( Site 0019) | Boston | Massachusetts | 02215 | United States | Details | |
| UMASS Memorial Medical Center ( Site 0020) | Worcester | Massachusetts | 01655 | United States | Details | |
| Henry Ford Health System ( Site 0023) | Detroit | Michigan | 48202 | United States | Details | |
| Cancer and Hematology Centers of Western Michigan ( Site 0025) | Grand Rapids | Michigan | 49503 | United States | Details | |
| Washington University School of Medicine ( Site 0027) | Saint Louis | Missouri | 63110 | United States | Details | |
| Mount Sinai Hospital ( Site 0051) | New York | New York | 10029 | United States | Details | |
| Memorial Sloan Kettering Cancer Center ( Site 0032) | New York | New York | 10065 | United States | Details | |
| AHN West Penn Hospital-AHN Esophageal and Lung Institute ( Site 0058) | Pittsburgh | Pennsylvania | 15224 | United States | Details | |
| IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 0202) | Caba | Buenos Aires | C1012AAR | Argentina | Details | |
| Instituto Medico Alexander Fleming ( Site 0208) | Ciudad Autonoma de Buenos Aires | Buenos Aires | C1426ANZ | Argentina | Details | |
| Fundacion Favaloro ( Site 0201) | Buenos Aires | C1093AAS | Argentina | Details | ||
| Hospital Aleman ( Site 0210) | Buenos Aires | C1118AAT | Argentina | Details | ||
| Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0207) | Buenos Aires | C1264AAA | Argentina | Details | ||
| CEMIC ( Site 0209) | Buenos Aires | C1431FWO | Argentina | Details | ||
| Hospital Privado de Cordoba ( Site 0204) | Cordoba | X5016KEH | Argentina | Details | ||
| Nepean Hospital ( Site 2305) | Kingswood | New South Wales | 2747 | Australia | Details | |
| Wollongong Hospital ( Site 2307) | Wollongong | New South Wales | 2500 | Australia | Details | |
| Royal Brisbane and Women s Hospital ( Site 2304) | Herston | Queensland | 4029 | Australia | Details | |
| Hollywood Private Hospital-Medical Oncology ( Site 2308) | Nedlands | Western Australia | 6009 | Australia | Details | |
| CHU UCL Namur Site de Godinne ( Site 1005) | Yvoir | Namur | 5530 | Belgium | Details | |
| UZ Gent ( Site 1002) | Gent | Oost-Vlaanderen | 9000 | Belgium | Details | |
| UZ Leuven ( Site 1004) | Leuven | Vlaams-Brabant | 3000 | Belgium | Details | |
| AZ Delta ( Site 1006) | Roeselare | West-Vlaanderen | 8800 | Belgium | Details | |
| Queen Elizabeth II Health Sciences Centre ( Site 0101) | Halifax | Nova Scotia | B3H 2Y9 | Canada | Details | |
| Hamilton Health Sciences - Juravinski Site ( Site 0106) | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0103) | Sherbrooke | Quebec | J1H 5N4 | Canada | Details | |
| Centro Investigación del Cáncer James Lind ( Site 0414) | Temuco | Araucania | Temuco | Chile | Details | |
| IC La Serena Research ( Site 0410) | La Serena | Coquimbo | 1720430 | Chile | Details | |
| Clinica Universidad Catolica del Maule ( Site 0411) | Talca | Maule | 3460000 | Chile | Details | |
| Fundacion Arturo Lopez Perez FALP ( Site 0403) | Santiago | Region M. De Santiago | 7500836 | Chile | Details | |
| Clínica San Carlos de Apoquindo Red Salud UC Christus ( Site 0407) | Santiago | Region M. De Santiago | 7550000 | Chile | Details | |
| Bradfordhill ( Site 0404) | Santiago | Region M. De Santiago | 8420383 | Chile | Details | |
| Anhui Provincial Hospital ( Site 2415) | Hefei | Anhui | 230001 | China | Details | |
| Cancer Hospital Chinese Academy of Medical Sciences ( Site 2403) | Beijing | Beijing | 100021 | China | Details | |
| Beijing Cancer Hospital ( Site 2453) | Beijing | Beijing | 100035 | China | Details | |
| Fujian Provincial Cancer Hospital ( Site 2408) | Fuzhou | Fujian | 350014 | China | Details | |
| The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army ( Si | Fuzhou | Fujian | 350025 | China | Details | |
| The First Affiliated Hospital of Xiamen University ( Site 2420) | Xiamen | Fujian | 361003 | China | Details | |
| The First Affiliated Hospital of Xiamen University ( Site 2446) | Xiamen | Fujian | 361003 | China | Details | |
| Zhongshan Hospital Affiliated to Xiamen University ( Site 2421) | Xiamen | Fujian | 361004 | China | Details | |
| First Hospital of Lanzhou University ( Site 2417) | Lanzhou | Gansu | 730000 | China | Details | |
| Nanfang Hospital ( Site 2456) | Guangzhou | Guangdong | 510000 | China | Details | |
| The Affiliated Hospital Of Hainan Medical University-Cancer rehabilitation and palliative treatment | Haikou | Hainan | 570102 | China | Details | |
| Fourth Hospital Of Hebei Medical University ( Site 2441) | Shijiazhuang | Hebei | 050011 | China | Details | |
| Harbin Medical University Cancer Hospital ( Site 2410) | Harbin | Heilongjiang | 150081 | China | Details | |
| Henan Cancer Hospital ( Site 2443) | Zhengzhou | Henan | 450008 | China | Details | |
| Hubei Cancer Hospital ( Site 2429) | Wuhan | Hubei | 430079 | China | Details | |
| Hunan Cancer Hospital ( Site 2440) | Changsha | Hunan | 410006 | China | Details | |
| Changzhou Cancer Hospital-Department of Oncology ( Site 2458) | Changzhou | Jiangsu | 213000 | China | Details | |
| Nanjing Drum Tower Hospital ( Site 2419) | Nanjing | Jiangsu | 210008 | China | Details | |
| Nantong Tumor Hospital-Digestive Oncology ( Site 2464) | Nantong | Jiangsu | 226361 | China | Details | |
| Jilin Cancer Hospital ( Site 2438) | Changchun | Jilin | 130012 | China | Details | |
| Tang Du Hospital ( Site 2432) | XI An | Shaanxi | 710038 | China | Details | |
| LinYi Cancer Hospital-Gastrology department ( Site 2463) | Linyi | Shandong | 276000 | China | Details | |
| Shanghai General Hospital ( Site 2424) | Shanghai | Shanghai | 200080 | China | Details | |
| Shanghai East Hospital ( Site 2455) | Shanghai | Shanghai | 200120 | China | Details | |
| Tianjin Medical University Cancer Institute & Hospital ( Site 2447) | Tianjin | Tianjin | 300060 | China | Details | |
| Cancer Hospital Affiliated to Xinjiang Medical University ( Site 2428) | Urumqi | Xinjiang | 830011 | China | Details | |
| The First Affiliated Hospital of Zhejiang University ( Site 2414) | Hangzhou | Zhejiang | 310009 | China | Details | |
| Sir Run Run Shaw Hospital ( Site 2412) | Hangzhou | Zhejiang | 310016 | China | Details | |
| Clinica de la Costa S.A.S. ( Site 0502) | Barranquilla | Atlantico | 080020 | Colombia | Details | |
| Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0508) | Valledupar | Cesar | 200001 | Colombia | Details | |
| Oncomedica S.A. ( Site 0507) | Monteria | Cordoba | 230002 | Colombia | Details | |
| Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0501) | Bogota | Distrito Capital De Bogota | 111321 | Colombia | Details | |
| Instituto Cancerologico de Narino Ltda ( Site 0504) | Pasto | Narino | 520001 | Colombia | Details | |
| Oncologos del Occidente S.A. ( Site 0525) | Pereira | Risaralda | 660001 | Colombia | Details | |
| CIMCA-Hemato-Oncology ( Site 0601) | San José | San Jose | 10103 | Costa Rica | Details | |
| Hospital Metropolitano - Sede Lindora-Metropolitano Research Institute Sede Lindora ( Site 0602) | Santa Ana | San Jose | 10903 | Costa Rica | Details | |
| Centre Francois Baclesse ( Site 1107) | Caen | Calvados | 14076 | France | Details | |
| Centre Georges Francois Leclerc ( Site 1106) | Dijon | Cote-d Or | 21079 | France | Details | |
| CHU Bordeaux Haut-Leveque ( Site 1110) | Pessac | Gironde | 33604 | France | Details | |
| Centre Hospitalier Annecy Genevois ( Site 1117) | Epagny Metz-Tessy | Haute-Savoie | 74370 | France | Details | |
| CHU Hotel Dieu Nantes ( Site 1101) | Nantes | Pays-de-la-Loire | 44093 | France | Details | |
| Hôpital Edouard Herriot ( Site 1116) | Lyon | Rhone-Alpes | 69003 | France | Details | |
| Hopital Henri Mondor ( Site 1105) | Creteil | Val-de-Marne | 94010 | France | Details | |
| Institut du Cancer Avignon-Provence ( Site 1103) | Avignon | Vaucluse | 84918 | France | Details | |
| Hopital Saint Louis ( Site 1100) | Paris | 75010 | France | Details | ||
| CHU Hopital Saint Antoine ( Site 1102) | Paris | 75012 | France | Details | ||
| Klinikum Rechts der Isar der TU Muenchen ( Site 1200) | Muechen | Bayern | 81675 | Germany | Details | |
| Universitaetsklinikum Regensburg ( Site 1203) | Regensburg | Bayern | 93053 | Germany | Details | |
| Krankenhaus Nordwest ( Site 1205) | Frankfurt am Main | Hessen | 60488 | Germany | Details | |
| Medizinische Hochschule Hannover ( Site 1210) | Hannover | Niedersachsen | 30625 | Germany | Details | |
| Universitaetsklinikum Leipzig ( Site 1211) | Leipzig | Sachsen | 04103 | Germany | Details | |
| Charite Berlin Campus Virchow-Klinikum ( Site 1202) | Berlin | 13353 | Germany | Details | ||
| Facharztzentrum Eppendorf ( Site 1201) | Hamburg | 20249 | Germany | Details | ||
| Clinica Privada Dr Rixci Ramirez Fallas ( Site 0702) | Guatemala | 01010 | Guatemala | Details | ||
| Oncologika S.A. ( Site 0704) | Guatemala | 01010 | Guatemala | Details | ||
| Oncomedica ( Site 0701) | Guatemala | 01010 | Guatemala | Details | ||
| Soluciones Gastrointestinales S.A. ( Site 0706) | Guatemala | 01010 | Guatemala | Details | ||
| Sanatorio Nuestra Senora del Pilar ( Site 0705) | Guatemala | 01015 | Guatemala | Details | ||
| Medi-K Cayala ( Site 0700) | Guatemala | 01016 | Guatemala | Details | ||
| Prince of Wales Hospital ( Site 2503) | Hong Kong | Hong Kong | Details | |||
| Princess Margaret Hospital. ( Site 2502) | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital ( Site 2501) | Hong Kong | Hong Kong | Details | |||
| St James Hospital ( Site 1400) | Dublin | Leinster | Dublin 8 | Ireland | Details | |
| Beaumont Hospital ( Site 1402) | Dublin | Dublin 9 | Ireland | Details | ||
| Soroka Medical Center ( Site 1507) | Be'er Sheva | 8410101 | Israel | Details | ||
| Hillel Yaffe Medical Center ( Site 1503) | Hadera | 3810004 | Israel | Details | ||
| Rambam Health Care Campus-Oncology Division ( Site 1502) | Haifa | 3109601 | Israel | Details | ||
| Hadassah Ein Kerem Medical Center ( Site 1501) | Jerusalem | 9112001 | Israel | Details | ||
| Meir Medical Center ( Site 1504) | Kfar-Saba | 4428164 | Israel | Details | ||
| Rabin Medical Center ( Site 1506) | Petah Tikva | 4941492 | Israel | Details | ||
| Sourasky Medical Center ( Site 1500) | Tel Aviv | 6423906 | Israel | Details | ||
| Istituto Scientifico Romagnolo per Studio e Cura Tumori IRST ( Site 1608) | Meldola | Abruzzo | 47014 | Italy | Details | |
| Presidio Ospedaliero Universitario Santa Maria della Misericordia ( Site 1609) | Udine | Friuli-Venezia Giulia | 33100 | Italy | Details | |
| Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1610) | Milan | Lombardia | 20133 | Italy | Details | |
| Humanitas Research Hospital ( Site 1600) | Rozzano | Lombardia | 20089 | Italy | Details | |
| AULSS8 Berica-Ospedale S.Bortolo ( Site 1607) | Vicenza | Veneto | 36100 | Italy | Details | |
| Azienda Ospedaliera Mater Domini-Translational Oncology Unit ( Site 1611) | Catanzaro | 88100 | Italy | Details | ||
| IRCCS Ospedale San Raffaele di Milano ( Site 1603) | Milano | 20132 | Italy | Details | ||
| A.O.U. Universita degli Studi della Campania-Luigi Vanvitelli ( Site 1604) | Napoli | 80131 | Italy | Details | ||
| Aichi Cancer Center Hospital ( Site 2603) | Nagoya | Aichi | 464-8681 | Japan | Details | |
| National Cancer Center Hospital East ( Site 2601) | Kashiwa | Chiba | 277-8577 | Japan | Details | |
| National Hospital Organization Shikoku Cancer Center ( Site 2610) | Matsuyama | Ehime | 791-0280 | Japan | Details | |
| Hyogo Cancer Center ( Site 2621) | Akashi | Hyogo | 673-8558 | Japan | Details | |
| Kobe City Medical Center General Hospital ( Site 2606) | Kobe | Hyogo | 650-0047 | Japan | Details | |
| Ibaraki Prefectural Central Hospital ( Site 2618) | Kasama | Ibaraki | 309-1793 | Japan | Details | |
| Kagawa University Hospital ( Site 2611) | Kita-gun | Kagawa | 761-0793 | Japan | Details | |
| Kanagawa Cancer Center ( Site 2608) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kansai Medical University Hospital ( Site 2622) | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Kindai University Hospital ( Site 2600) | Osakasayama | Osaka | 5898511 | Japan | Details | |
| Saitama Cancer Center ( Site 2604) | Kitaadachi-gun | Saitama | 362-0806 | Japan | Details | |
| National Hospital Organization Kyushu Cancer Center ( Site 2609) | Fukuoka | 811-1395 | Japan | Details | ||
| Hiroshima City Hiroshima Citizens Hospital ( Site 2612) | Hiroshima | 730-8518 | Japan | Details | ||
| Osaka International Cancer Institute ( Site 2607) | Osaka | 5418567 | Japan | Details | ||
| National Cancer Center Hospital ( Site 2602) | Tokyo | 104-0045 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 2605) | Tokyo | 135-8550 | Japan | Details | ||
| Hallym University Sacred Heart Hospital ( Site 2806) | Anyang-si | Kyonggi-do | 14068 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital ( Site 2804) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 2802) | Songpagu | Seoul | 05505 | Korea, Republic of | Details | |
| Konyang University ( Site 2807) | Daejeon | Taejon-Kwangyokshi | 35365 | Korea, Republic of | Details | |
| Seoul National University Hospital ( Site 2803) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 2800) | Seoul | 03722 | Korea, Republic of | Details | ||
| Gangnam Severance Hospital ( Site 2805) | Seoul | 06273 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 2801) | Seoul | 06351 | Korea, Republic of | Details | ||
| Korea University Guro Hospital ( Site 2808) | Seoul | 08308 | Korea, Republic of | Details | ||
| Dolnoslaskie Centrum Onkologii. ( Site 1712) | Wroclaw | Dolnoslaskie | 53-413 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 1704) | Warszawa | Mazowieckie | 02-034 | Poland | Details | |
| Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1702) | Przemysl | Podkarpackie | 37-700 | Poland | Details | |
| Przychodnia Lekarska KOMED ( Site 1701) | Konin | Wielkopolskie | 62-500 | Poland | Details | |
| Szpital Kliniczny im. Heliodora Swiecickiego Uniwers Medyczn ( Site 1703) | Poznan | Wielkopolskie | 60-780 | Poland | Details | |
| Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1816) | Chelyabinsk | Chelyabinskaya Oblast | 454087 | Russian Federation | Details | |
| National Medical and Surgical Center n.a.N.I.Pirogov ( Site 1805) | Moscow | Moskva | 105203 | Russian Federation | Details | |
| Blokhin National Medical Oncology ( Site 1800) | Moscow | Moskva | 115478 | Russian Federation | Details | |
| Central Clinical Hospital with Polyclinic ( Site 1801) | Moscow | Moskva | 121359 | Russian Federation | Details | |
| Medical University REAVIZ ( Site 1814) | Samara | Samarskaya Oblast | 443011 | Russian Federation | Details | |
| St Petersburg City Clinical Oncology Dispensary ( Site 1808) | Saint Petersburg | Sankt-Peterburg | 198255 | Russian Federation | Details | |
| Leningrad Regional Oncology Center ( Site 1810) | Saint-Petersburg | Sankt-Peterburg | 188663 | Russian Federation | Details | |
| Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1809) | Saint-Petersburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1821) | Yaroslavl | Yaroslavskaya Oblast | 150054 | Russian Federation | Details | |
| Hospital Universitario General de Asturias ( Site 1901) | Oviedo | Asturias | 33011 | Spain | Details | |
| Hospital Universitario Marques de Valdecilla ( Site 1902) | Santander | Cantabria | 39008 | Spain | Details | |
| Hospital General Universitari Vall d Hebron ( Site 1907) | Barcelona | 08035 | Spain | Details | ||
| Hospital General Gregorio Maranon de Madrid ( Site 1904) | Madrid | 28007 | Spain | Details | ||
| China Medical University Hospital ( Site 2903) | Taichung | 40447 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 2904) | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 2901) | Taipei | 10048 | Taiwan | Details | ||
| Chang Gung Medical Foundation. Linkou ( Site 2902) | Taoyuan | 333 | Taiwan | Details | ||
| Sakarya Universitesi Tip Fakultesi ( Site 2007) | Sakarya | Istanbul | 54290 | Turkey | Details | |
| Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 2003) | Ankara | 06100 | Turkey | Details | ||
| Memorial Ankara Hastanesi ( Site 2004) | Ankara | 06520 | Turkey | Details | ||
| Trakya Universitesi Tip Fakultesi ( Site 2000) | Edirne | 22030 | Turkey | Details | ||
| Ataturk Universitesi Tip Fakultesi Hastanesi ( Site 2005) | Erzurum | 25240 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2002) | Istanbul | 34098 | Turkey | Details | ||
| Ege Universitesi Tip Fakultesi Hastanesi ( Site 2001) | Izmir | 35040 | Turkey | Details | ||
| Addenbrooke's Hospital ( Site 2200) | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details | |
| Ninewells Hospital and Medical School ( Site 2207) | Dundee | Dundee City | DD1 9SY | United Kingdom | Details | |
| The Beatson West of Scotland Cancer Centre ( Site 2204) | Glasgow | Glasgow City | G12 0YN | United Kingdom | Details | |
| University College London Hospitals NHS Foundation Trust ( Site 2201) | London | London, City Of | NW1 2BU | United Kingdom | Details | |
| Royal Marsden NHS Foundation Trust ( Site 2202) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
| Royal Marsden NHS Trust ( Site 2203) | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| University Hospital Coventry and Warwickshire NHS Trust ( Site 2205) | Coventry | Warwickshire | CV2 2DX | United Kingdom | Details | |
| The Christie NHS Foundation Trust ( Site 2209) | Manchester | M20 4BX | United Kingdom | Details |