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| NCT ID | NCT04770896 |
| Title | A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab (IMbrave251) |
| Acronym | IMbrave251 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | TUR | SVN | ITA | ISR | HRV | GRC | GBR | FRA | FIN | EST | ESP | DEU | CHE | CAN | BRA | BGR | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Medizinische Universität Innsbruck; Universitätsklinik für Innere Medizin I | Innsbruck | 6020 | Austria | Details | ||
| Uniklinikum Salzburg, LKH; Univ.Klinik f. Innere Medizin III der PMU | Salzburg | 5020 | Austria | Details | ||
| Universitätsklinikum St. Pölten; Innere Medizin 2 | St. Pölten | 3100 | Austria | Details | ||
| Klinik Favoriten; Abteilung für Chirurgie | Wien | 1100 | Austria | Details | ||
| AZ KLINA | Brasschaat | 2930 | Belgium | Details | ||
| Hospital Erasme | Bruxelles | 1070 | Belgium | Details | ||
| Cliniques Universitaires St-Luc | Bruxelles | 1200 | Belgium | Details | ||
| UZ Leuven | Leuven | 3000 | Belgium | Details | ||
| AZ Delta (Campus Rumbeke) | Roeselare | 8800 | Belgium | Details | ||
| Hospital Felicio Rocho | Belo Horizonte | MG | 30110-068 | Brazil | Details | |
| Clinicas Oncologicas Integradas - COI | Rio De Janeiro | RJ | 22290-160 | Brazil | Details | |
| Hospital Moinhos de Vento | Porto Alegre | RS | 90035-001 | Brazil | Details | |
| Hospital Sao Lucas - PUCRS | Porto Alegre | RS | 90610-000 | Brazil | Details | |
| Centro de Pesquisa e Ensino em Oncologia de Santa Catarina - CEPEN | Florianopolis | SC | 88020-210 | Brazil | Details | |
| Beneficencia Portuguesa de Sao Paulo | São Paulo | SP | 01321-00 | Brazil | Details | |
| Multiprofile Hospital for Active Treatment Uni Hospital; Department of medicinal oncology | Panagyurishte | 4500 | Bulgaria | Details | ||
| Complex Oncological Center - Plovdiv, EOOD; Second Internal Department | Plovdiv | 4004 | Bulgaria | Details | ||
| Tom Baker Cancer Centre-Calgary | Calgary | Alberta | T2N 4N2 | Canada | Details | |
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Juravinski Cancer Centre | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| Princess Margaret Cancer Center | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Centro de Estudios Clínicos SAGA | Santiago | 7500653 | Chile | Details | ||
| Hunan Cancer Hospital | Changsha CITY | 410013 | China | Details | ||
| Fujian Provincial Hospital | Fuzhou City | 350001 | China | Details | ||
| The First Affiliated Hospital, Sun Yat-sen University | Guangzhou City | 510080 | China | Details | ||
| Sun Yet-sen University Cancer Center | Guangzhou City | 510663 | China | Details | ||
| Nanfang Hospital, Southern Medical University | Guangzhou | 510515 | China | Details | ||
| Anhui Province Cancer Hospital | Hefei City | 230031 | China | Details | ||
| Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University) | Nanjing City | 210029 | China | Details | ||
| Zhongshan Hospital Fudan University | Shanghai | 200032 | China | Details | ||
| Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | Shanghai | 200127 | China | Details | ||
| Shengjing Hospital of China Medical University | ShenYang | 110004 | China | Details | ||
| Tianjin Cancer Hospital | Tianjin | 300060 | China | Details | ||
| Clinica CIMCA | San José | 10103 | Costa Rica | Details | ||
| ICIMED Instituto de Investigación en Ciencias Médicas | San José | 10108 | Costa Rica | Details | ||
| Clinical Hospital Centre Zagreb | Zagreb | 10000 | Croatia | Details | ||
| AirForce Specialized Hospital; Clinical Oncology | Cairo | 11391 | Egypt | Details | ||
| North Estonia Medical Centre, Oncology and hematology Clinic; Department of Chemotherapy | Tallinn | 13419 | Estonia | Details | ||
| Tartu University Hospital; Clinic of Hematology and Oncology | Tartu | 50406 | Estonia | Details | ||
| TAYS Radius rakennus; onkologinen lääketutkimusyksikkö | Tampere | 33521 | Finland | Details | ||
| CHU Grenoble Sud; Service hépato-gastroentérologie | GRENOBLE Cedex 9 | 38043 | France | Details | ||
| CHRU de Lille - Hopital Claude Huriez | Lille | 59037 | France | Details | ||
| Aphm; Cpcet | Marseille | 13385 | France | Details | ||
| CH Saint Eloi | Montpellier | 34295 | France | Details | ||
| CHU de Nantes - Hotel Dieu | Nantes | 44093 | France | Details | ||
| APHP - Hopital Saint Antoine | Paris | 75571 | France | Details | ||
| CHU Bordeaux | Pessac | 33604 | France | Details | ||
| Centre Eugene Marquis; Service d'oncologie; Direction de la Recherche Clinique | Rennes | 35042 | France | Details | ||
| CHU de Toulouse - Hôpital Rangueil | Toulouse Cedex 09 | 31059 | France | Details | ||
| Hopitaux de Brabois - Gastro-Entereologie | Vandoeuvre-les-nancy | 54511 | France | Details | ||
| Hopital Paul Brousse; Centre Hepatologie Biliaire | Villejuif | 94804 | France | Details | ||
| Klinik Johann Wolfgang von Goethe Uni; Zentrum der Inneren Medizin; Medizinische Klinik I | Frankfurt | 60590 | Germany | Details | ||
| Med. Hochschule Hannover; Gastroenterologie | Hannover | 30625 | Germany | Details | ||
| Uniklinik Mainz; I. Medizinische Klinik | Mainz | 55131 | Germany | Details | ||
| Universität Tübingen; Med. Klinik; Innere Medizin I | Tübingen | 72076 | Germany | Details | ||
| Universitätsklinikum Ulm; Zentrum für Innere Medizin Klinik für Innere Medizin I | Ulm | 89081 | Germany | Details | ||
| Laiko General Hospital Athen; Uni Clinic of Gastrenterology | Athens | 115 27 | Greece | Details | ||
| Agioi Anargiroi Hospital of Kifissia; University Internal Medicine Clinic | Nea Kifissia | 14564 | Greece | Details | ||
| Tata Memorial Hospital; Dept of Medical Oncology | Mumbai | Maharashtra | 400012 | India | Details | |
| Rambam Health Care Campus; Oncology | Haifa | 3109601 | Israel | Details | ||
| Rabin Medical Center; Oncology Dept | Petah Tikva | 4910000 | Israel | Details | ||
| Sourasky Medical Center; Oncology Department | Tel-Aviv | 6423900 | Israel | Details | ||
| Fondazione Pascale; U.O. Sperimentazioni Cliniche | Napoli | Campania | 80100 | Italy | Details | |
| Azienda Osp Uni Seconda Università Degli Studi Di Napoli; Unità Operativa Oncologia Medica | Napoli | Campania | 80131 | Italy | Details | |
| Ospedale del Mare; UOC di Oncologia | Napoli | Campania | 80147 | Italy | Details | |
| A.O. S. Orsola Malpighi; Ambulatorio Epatocarcinoma (Bolondi) | Bologna | Emilia-Romagna | 40138 | Italy | Details | |
| Azienda Ospedaliera San Camillo Forlanini | Roma | Lazio | 151 | Italy | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Rome | Lazio | 00168 | Italy | Details | |
| Fondazione IRCCS Ospedale Maggiore Policlinico; Gastroenterologia | Milano | Lombardia | 20122 | Italy | Details | |
| Azienda Ospedaliera Ordine Mauriziano di Torino | Torino | Piemonte | 10128 | Italy | Details | |
| A.O.U. Policlinico Paolo Giaccone; Gastroenterologia ed Epatologia | Palermo | Sicilia | 90100 | Italy | Details | |
| Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1 | Firenze | Toscana | 50139 | Italy | Details | |
| Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2 | Pisa | Toscana | 56100 | Italy | Details | |
| IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda | Padova | Veneto | 35128 | Italy | Details | |
| Fujita Health University Hospital | Aichi | 470-1192 | Japan | Details | ||
| Chiba University Hospital | Chiba | 260-8677 | Japan | Details | ||
| National Cancer Center Hospital East | Chiba | 277-8577 | Japan | Details | ||
| Kurume University Hospital | Fukuoka | 830-0011 | Japan | Details | ||
| Hiroshima University Hospital | Hiroshima | 734-8551 | Japan | Details | ||
| Japanese Red Cross Society Himeji Hospital | Hyogo | 670-8540 | Japan | Details | ||
| Yokohama City University Medical Center | Kanagawa | 232-0024 | Japan | Details | ||
| Osaka University Hospital | Osaka | 565-0871 | Japan | Details | ||
| Kindai University Hospital | Osaka | 589-8511 | Japan | Details | ||
| Jichi Medical University Hospital | Tochigi | 329-0498 | Japan | Details | ||
| Japanese Red Cross Musashino Hospital | Tokyo | 180-8610 | Japan | Details | ||
| National Cancer Center | Goyang-si | 10408 | Korea, Republic of | Details | ||
| CHA Bundang Medical Center | Gyeonggi-do | 13496 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Uni Malaya Medical Center; Clinical Oncology Unit, Menara Timur | Kuala Lumpur | FED. Territory OF Kuala Lumpur | 59100 | Malaysia | Details | |
| Institute Kanser Negara (IKN) | Putrajaya | FED. Territory OF Kuala Lumpur | 62250 | Malaysia | Details | |
| Beacon International Specialist Centre; Clinical Research Department, Level 2 | Petaling Jaya, Selangor | Selangor | 46050 | Malaysia | Details | |
| Cebu Doctors' University Hospital; Research Office | Cebu City | 6000 | Philippines | Details | ||
| Makati Medical Center | Makati City | 1229 | Philippines | Details | ||
| The Medical City; Cancer Center | Pasig City | 1600 | Philippines | Details | ||
| FSBI "National Medical Research Center of Oncology N.N. Blokhin? | Moscow | Moskovskaja Oblast | 115478 | Russian Federation | Details | |
| Moscow City Oncology Hospital #62; Outpatient Care Center | Moscow | Moskovskaja Oblast | 125134 | Russian Federation | Details | |
| Group of companies "Medci" | Moskva | Moskovskaja Oblast | 105229 | Russian Federation | Details | |
| I.M.Sechenov First Moscow State Medical University (1st MSMU) | Moskva | Moskovskaja Oblast | 119991 | Russian Federation | Details | |
| LLC "Oncology scientific centre" | Pesochny | Sankt Petersburg | 197758 | Russian Federation | Details | |
| University Medical Center Ljubljana; Clinical Dept. of Gastroenterology | Ljubljana | 1000 | Slovenia | Details | ||
| Hospital Son Llatzer; Servicio de Oncologia | Palma de Mallorca | Islas Baleares | 07198 | Spain | Details | |
| Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia | Santiago de Compostela | LA Coruña | 15706 | Spain | Details | |
| Clinica Universitaria de Navarra; Servicio de Hepatologia | Pamplona/iruña | Navarra | 31008 | Spain | Details | |
| Hospital Universitari Vall d'Hebron; Servicio de Hepatologia | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitario Reina Sofia; Servicio de Hepatologia | Cordoba | 14004 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon; Servicio de Aparato Digestivo | Madrid | 28007 | Spain | Details | ||
| Clinica Universidad de Navarra Madrid; Servicio de Oncología | Madrid | 28027 | Spain | Details | ||
| Hospital Clinico San Carlos; Servicio de Oncologia | Madrid | 28040 | Spain | Details | ||
| START Madrid. Centro Integral Oncologico Clara Campal; CIOCC | Madrid | 28050 | Spain | Details | ||
| Hospital Universitario la Fe; Servicio de Oncologia | Valencia | 46026 | Spain | Details | ||
| Hospital Universitario Miguel Servet; Servicio Oncologia | Zaragoza | 50009 | Spain | Details | ||
| Inselspital Bern Medizin Gastroenterologie | Bern | 3010 | Switzerland | Details | ||
| Universitätsspital Zürich Medizin Gastroenterologie; Klinik für Gastroenterologie und Hepatologie | Zürich | 8091 | Switzerland | Details | ||
| Chi-Mei Medical Centre; Hematology & Oncology | Tainan | 710 | Taiwan | Details | ||
| National Taiwan University Hospital; Oncology | Zhongzheng Dist. | 10048 | Taiwan | Details | ||
| Chulalongkorn Hospital; Medical Oncology | Bangkok | 10330 | Thailand | Details | ||
| Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology | Bangkok | 10700 | Thailand | Details | ||
| Adana Ac?badem Hospital Oncology Department | Adana | 01130 | Turkey | Details | ||
| Memorial Ankara Hastanesi | Ankara | 06520 | Turkey | Details | ||
| Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji | Bakirkoy / Istanbul | 34147 | Turkey | Details | ||
| Uludag Uni Hospital; Oncology | Bursa | 16059 | Turkey | Details | ||
| Medipol Mega Üniversite Hastanesi Göztepe | Istanbul | 34214 | Turkey | Details | ||
| Ege Uni Medical Faculty Hospital; Oncology Dept | Izmir | 35100 | Turkey | Details | ||
| Hacettepe Uni Medical Faculty Hospital; Oncology Dept | Sihhiye/Ankara | 06230 | Turkey | Details | ||
| Ac?badem Altunizade Hastanesi; Oncology | Üsküdar | 34662 | Turkey | Details | ||
| Queen Elizabeth Hospital; Hepatobiliary Unit | Birmingham | B15 2TH | United Kingdom | Details | ||
| The Clatterbridge Cancer Centre NHS Foundation Trust | Liverpool | L7 8YA | United Kingdom | Details | ||
| Royal Free Hospital | London | NW3 2QS | United Kingdom | Details | ||
| King College Hospital NHS Foundation Trust | London | SE5 9RS | United Kingdom | Details | ||
| Hammersmith Hospital; Clinical trials unit | London | W12 0HS | United Kingdom | Details | ||
| Christie Hospital Nhs Trust; Medical Oncology | Manchester | M2O 4BX | United Kingdom | Details | ||
| Freeman Hospital; Gastroenterology & Liver Unit | Newcastle Upon Tyne | NE7 7DN | United Kingdom | Details | ||
| Churchill Hospital; Department of Oncology | Oxford | OX3 7LE | United Kingdom | Details |