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| NCT ID | NCT04777851 |
| Title | Regorafenib-pembrolizumab vs. TACE/TARE in Intermediate Stage HCC Beyond Up-to-7 (REPLACE) |
| Acronym | REPLACE |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Translational Research in Oncology |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | ROU | ITA | FRA | ESP | DEU | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| UCLA Santa Monica Hematology Oncology | RECRUITING | Santa Monica | California | 90404 | United States | Details |
| University of Florida College of Medicine Jacksonville | NOT_YET_RECRUITING | Jacksonville | Florida | 32209 | United States | Details |
| Miami Cancer Institute | WITHDRAWN | Miami | Florida | 33176 | United States | Details |
| Icahn School of Medicine at Mount Sinai | NOT_YET_RECRUITING | New York | New York | 10029 | United States | Details |
| University Hospitals Cleveland Medical Center | RECRUITING | Cleveland | Ohio | 44106 | United States | Details |
| Hôpital Erasme | WITHDRAWN | Brussels | 1070 | Belgium | Details | |
| UCL SAINT LUC - UC Louvain | RECRUITING | Brussels | 1200 | Belgium | Details | |
| Antwerp University Hospital | RECRUITING | Edegem | 2650 | Belgium | Details | |
| CHU Amiens-Picardie | RECRUITING | Amiens | 80054 | France | Details | |
| CHU Jean Minjoz | RECRUITING | Besançon | 25000 | France | Details | |
| Hôpital Avicenne - APHP | RECRUITING | Bobigny | 93000 | France | Details | |
| Hôpital Beaujon - APHP | RECRUITING | Clichy | 92110 | France | Details | |
| Hôpital Henri Mondor | RECRUITING | Créteil | 94010 | France | Details | |
| CHU Grenoble Alpes - Site Nord | RECRUITING | La Tronche | 38700 | France | Details | |
| CHU de Nantes - Hôtel-Dieu | RECRUITING | Nantes | 44093 | France | Details | |
| JSC VIANI Batumi Referral Hospital | RECRUITING | Batumi | 6010 | Georgia | Details | |
| Israel-Georgian Medical Research Clinic Healthycore | RECRUITING | Tbilisi | 0112 | Georgia | Details | |
| New Hospitals | RECRUITING | Tbilisi | 0114 | Georgia | Details | |
| University Hospital Bonn | RECRUITING | Bonn | 53127 | Germany | Details | |
| University Hospital Carl Gustav Carus Dresden | RECRUITING | Dresden | 1307 | Germany | Details | |
| Universitätsklinikum des Saarlandes | NOT_YET_RECRUITING | Homburg | 66421 | Germany | Details | |
| Universitätsklinikum Schleswig-Holstein -Kiel | RECRUITING | Kiel | 24105 | Germany | Details | |
| Universitätsmedizin: Medizinische Klinik und Poliklinik I | RECRUITING | Mainz | D-55131 | Germany | Details | |
| Department Of Clinical Oncology, Queen Mary Hospital, University of Hong Kong | NOT_YET_RECRUITING | Hong Kong | 999077 | Hong Kong | Details | |
| Humanity and Health Clinical Trial Center | NOT_YET_RECRUITING | Hong Kong | 999077 | Hong Kong | Details | |
| Prince of Wales Hospital, The Chinese University of Hong Kong | RECRUITING | Hong Kong | 999077 | Hong Kong | Details | |
| Queen Mary Hospital, University of Hong Kong Department of Medicine, Medical Oncology | NOT_YET_RECRUITING | Hong Kong | 999077 | Hong Kong | Details | |
| ASST Papa Giovanni XXIII Hospital | NOT_YET_RECRUITING | Bergamo | 24127 | Italy | Details | |
| Ospedale Garibaldi Nesima | RECRUITING | Catania | 95122 | Italy | Details | |
| San Raffaele Hospital | NOT_YET_RECRUITING | Milan | 20132 | Italy | Details | |
| ASST Grande Ospedale Metropolitano Niguarda | NOT_YET_RECRUITING | Milan | 20162 | Italy | Details | |
| Azienda Ospedaliera Universitaria Federico II di Napoli | RECRUITING | Napoli | 80131 | Italy | Details | |
| Ehime University Hospital | NOT_YET_RECRUITING | Tōon | Ehime | 791-0295 | Japan | Details |
| Fujita Health University Hospital Department of Gastroenterology and Hepatology | NOT_YET_RECRUITING | Kutsukake | Toyoake | 470-1101 | Japan | Details |
| Chiba University Hospital | NOT_YET_RECRUITING | Chiba | 260-8677 | Japan | Details | |
| Kurume University Hospital | NOT_YET_RECRUITING | Fukuoka | 830-0011 | Japan | Details | |
| Kanazawa University Hospital | NOT_YET_RECRUITING | Kanazawa | 920-8642 | Japan | Details | |
| Nagoya University Hospital | NOT_YET_RECRUITING | Nagoya | 466-8560 | Japan | Details | |
| Kindai University Hospital | NOT_YET_RECRUITING | Osaka sayama-shi, Osaka | 589-8511 | Japan | Details | |
| Jichi Medical University Hospital | NOT_YET_RECRUITING | Shimotsuke-shi | 329-0498 | Japan | Details | |
| University of Tokyo Hospital | NOT_YET_RECRUITING | Tokyo | 113-8655 | Japan | Details | |
| Toyama University Hospital | NOT_YET_RECRUITING | Toyama | 930-0194 | Japan | Details | |
| Kanagawa Cancer Center | NOT_YET_RECRUITING | Yokohama | 241-8515 | Japan | Details | |
| Inje University Haeundae Paik Hospital | RECRUITING | Busan | Korea, Republic of | Details | ||
| National Cancer Center | NOT_YET_RECRUITING | Goyang-si | 10408 | Korea, Republic of | Details | |
| Cha Bundang Medical Center | RECRUITING | Seongnam-si | Korea, Republic of | Details | ||
| Asan Medical Center | RECRUITING | Seoul | Korea, Republic of | Details | ||
| Seoul National University Hospital | NOT_YET_RECRUITING | Seoul | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | RECRUITING | Seoul | Korea, Republic of | Details | ||
| Institutul Clinic Fundeni | RECRUITING | Bucharest | 22328 | Romania | Details | |
| Regional Institute of Gastroenterology and Hepatology "Dr Octavian Fodor" | RECRUITING | Cluj-Napoca | 400394 | Romania | Details | |
| Center of Oncology Euroclinic Victoria Hospital | RECRUITING | Iaşi | 700106 | Romania | Details | |
| Oncohelp Medical Center | RECRUITING | Timişoara | 300239 | Romania | Details | |
| Clinic for Digestive Surgery, University Clinical Center of Serbia | RECRUITING | Belgrade | Serbia | Details | ||
| Military Medical Academy | NOT_YET_RECRUITING | Belgrade | Serbia | Details | ||
| Clinical Center Nis | NOT_YET_RECRUITING | Niš | Serbia | Details | ||
| Institue of Oncology Vojvodine Sremska Kamenica (Oncology Institute of Volvodina) | RECRUITING | Sremska Kamenica | 21204 | Serbia | Details | |
| Hospital Universitario Vall d'Hebron | NOT_YET_RECRUITING | Barcelona | 8035 | Spain | Details | |
| Hospital Reina Sofía | RECRUITING | Córdoba | 14004 | Spain | Details | |
| Instituto Catalán de Oncología L'Hospitalet | RECRUITING | L'Hospitalet De Llobregat | 08908 | Spain | Details | |
| Hospital Ramón y Cajal | RECRUITING | Madrid | 28034 | Spain | Details | |
| Hospital Universitario La Paz | RECRUITING | Madrid | 28046 | Spain | Details | |
| Hospital Puerta de Hierro | RECRUITING | Majadahonda | 28222 | Spain | Details | |
| Hospital Universitario Virgen del Rocío | RECRUITING | Sevilla | 41013 | Spain | Details | |
| Hospital Universitario Miguel Servet | RECRUITING | Zaragoza | 50009 | Spain | Details | |
| Kaohsiung Chang Gung Memorial Hospital | NOT_YET_RECRUITING | Kaohsiung | 800-852 | Taiwan | Details | |
| China Medical University Hospital | RECRUITING | Taichung | 404332 | Taiwan | Details | |
| Taichung Veterans General Hospital | NOT_YET_RECRUITING | Taichung | 40705 | Taiwan | Details | |
| National Cheng Kung University Hospital | RECRUITING | Tainan | 704 | Taiwan | Details | |
| Chi Mei Medical Center-Liuying | RECRUITING | Tainan | 73657 | Taiwan | Details | |
| National Taiwan University Hospital | RECRUITING | Taipei | 10041 | Taiwan | Details | |
| Chang Gung Memorial Hospital - Linkou | RECRUITING | Taoyuan | 333 | Taiwan | Details | |
| Taipei Veterans General Hospital | NOT_YET_RECRUITING | Tapei | 11217 | Taiwan | Details | |
| Gülhane Eğitim ve Araştırma Hastanesi | RECRUITING | Ankara | 6010 | Turkey | Details | |
| Gazi University MF | RECRUITING | Ankara | 6560 | Turkey | Details | |
| Ankara City Hospital | RECRUITING | Ankara | 6800 | Turkey | Details | |
| Dicle University MF | RECRUITING | Diyarbakır | 21280 | Turkey | Details | |
| Koc University Hospital | RECRUITING | Istanbul | 34010 | Turkey | Details |