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| NCT ID | NCT04778397 |
| Title | Study of Magrolimab in Combination With Azacitidine Versus Physician's Choice of Venetoclax in Combination With Azacitidine or Intensive Chemotherapy in Patients With TP53 Mutant Acute Myeloid Leukemia That Have Not Been Treated (ENHANCE-2) |
| Acronym | ENHANCE-2 |
| Recruitment | Terminated |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Gilead Sciences |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | SWE | ITA | GBR | FRA | ESP | DNK | DEU | CHE | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States | Details | |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | United States | Details | |
| USC/ Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | United States | Details | |
| UC Irvine Health | Orange | California | 92868 | United States | Details | |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | United States | Details | |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | United States | Details | |
| Miami Cancer Institute | Miami | Florida | 33176 | United States | Details | |
| AdventHealth Orlando | Orlando | Florida | 32804 | United States | Details | |
| Memorial Cancer Institute | Pembroke Pines | Florida | 33028 | United States | Details | |
| Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | United States | Details | |
| Northwestern Memorial Hospital/Main Lab | Chicago | Illinois | 60611 | United States | Details | |
| The University of Chicago Medical Centre | Chicago | Illinois | 60637 | United States | Details | |
| University of Kansas Hospital | Fairway | Kansas | 66205 | United States | Details | |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536 | United States | Details | |
| Tulane Medical center | New Orleans | Louisiana | 70112 | United States | Details | |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21231 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Mayo Clinic Cancer Center Outpatient Pharmacy | Rochester | Minnesota | 55905 | United States | Details | |
| MidAmerica Division, Inc., c/o Research Medical Center | Kansas City | Missouri | 64132 | United States | Details | |
| SSM Health Saint Louis University Hospital | Saint Louis | Missouri | 63110 | United States | Details | |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | United States | Details | |
| Columbia University Medical Center - Herbert Irving Pavilion | New York | New York | 10032 | United States | Details | |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | United States | Details | |
| Duke Blood Cancer Center | Durham | North Carolina | 27705 | United States | Details | |
| The Ohio State University Wexner Medical Center/ James Cancer Hospital | Columbus | Ohio | 43210 | United States | Details | |
| University of Oklahoma Health Sciences Center - OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Research Organization | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| St. Francis Cancer Center | Greenville | South Carolina | 29607 | United States | Details | |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29615 | United States | Details | |
| Baylor College of Medicine Medical Center | Houston | Texas | 77030 | United States | Details | |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Huntsman Cancer Institute ,The University of Utah | Salt Lake City | Utah | 84112 | United States | Details | |
| Froedtert Hospital / Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Canberra Hospital | Garran | Australian Capital Territory | 2605 | Australia | Details | |
| Calvary Master Newcastle | Waratah | New South Wales | 2298 | Australia | Details | |
| Westmead Hospital / Department of Haematology and Bone Marrow Transplantation | Westmead | New South Wales | 2145 | Australia | Details | |
| Princess Alexandra Hospital | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Andrew Love Cancer Centre, University Hospital Geelong | Geelong | Victoria | 3220 | Australia | Details | |
| The Alfred | Melbourne | Victoria | 3004 | Australia | Details | |
| St Vincents Hospital Melbourne | Melbourne | Victoria | 3122 | Australia | Details | |
| Fiona Stanley Hospital | Murdoch | Western Australia | 6150 | Australia | Details | |
| Royal Perth Hospital | Perth | Western Australia | 6000 | Australia | Details | |
| Univ. -Klinik für Hämatologie und Internistische Onkologie, Kepler Universitätskilkun GmbHMed | Linz | 4021 | Austria | Details | ||
| Uniklinikum Salzburg, Universitatsklinik f. Innere Medizin III der PMU | Salzburg | 5020 | Austria | Details | ||
| Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV | Brugge | 8000 | Belgium | Details | ||
| Universitair Ziekenhuis Brussel | Brussels | Belgium | Details | |||
| Grand Hôpital De Charleroi - Notre Dame | Charleroi | 6000 | Belgium | Details | ||
| Universitaire Ziekenhuis Antwerpen | Edegem | Belgium | Details | |||
| Universitair Ziekenhuis Gent | Gent | 9000 | Belgium | Details | ||
| AZ Delta vzw | Roeselare | 8800 | Belgium | Details | ||
| Tom Baker Cancer Center | Calgary | T2N 4N2 | Canada | Details | ||
| Queen Elizabeth II Health Sciences Centre | Halifax | B3H 1V7 | Canada | Details | ||
| CIUSSS de L'Est-de-L'Ile-de- Montreal - Hopital Maisonneuve-Rosemont | Montreal | H1T 2M4 | Canada | Details | ||
| McGill University Health Centre | Montreal | H4A 3J1 | Canada | Details | ||
| Sunnybrook Research Institute | Toronto | M4N 3M5 | Canada | Details | ||
| Princess Margaret Cancer Centre | Toronto | M5G 2M9 | Canada | Details | ||
| Aalborg University Hospital | Aalborg | 9000 | Denmark | Details | ||
| Odense University Hospital | Odense C | 5000 | Denmark | Details | ||
| CHU d'Angers | Angers cedex | 49933 | France | Details | ||
| CHU de Caen | Caen cedex | 14033 | France | Details | ||
| CHRU Lille - Hospital Claude Huriez | Lille | 59037 | France | Details | ||
| CHU Limoges | Limoges | 87042 | France | Details | ||
| Central Hospital Lyon Sud | Lyon | 69495 | France | Details | ||
| Institut Paoli Calmettes | Marseille | 13009 | France | Details | ||
| CHU de Nantes, Hotel Dieu | Nantes | 44093 | France | Details | ||
| CHU Nice - Hopital Archet 1 | Nice | 6200 | France | Details | ||
| Gustave Roussy | Paris | 94805 | France | Details | ||
| Hopital Haut-Leveque | Pessac | 33604 | France | Details | ||
| IUCT Oncopole | Toulouse | 31059 | France | Details | ||
| Hopitaux de Brabois | Vandoeuvre-lès-Nancy | France | Details | |||
| Uniklinik RWTH Aachen, Medizinische Klunuk IV - Klinik fur Hamatologie, Onkologie, Hamastaseologie und Srammzelltransplantation | Aachen | 52074 | Germany | Details | ||
| Dept. of Hematology, Oncology and Tumor Immunology, Charite- University Medicine Berlin, Campus Virchow Klinikum | Berlin | 13353 | Germany | Details | ||
| Department of Hematology and Oncology, Braunschweig Community Hospital | Braunschweig | 38114 | Germany | Details | ||
| Universitatsklinikum Carl Gustav Carus Dresden an der Technische Universitat Dresden, Medizinische Klinik und Poliklinik 1, Bereich Hamatologie | Dresden | 01307 | Germany | Details | ||
| Universitätsklinikum Düsseldorf -Klinik für Hämatologie, Onkologie und Klinische Immunologie | Dusseldorf | 40225 | Germany | Details | ||
| Dept. of Medicine II, University Hospital Hamburg-Eppendorf | Hamburg | 20246 | Germany | Details | ||
| Universitatsklinikum Heidelberg, Innere Medizin V, Hamatologie, Onkologie und Rheumatologie | Heidelberg | 69120 | Germany | Details | ||
| Universitatsklinikum Schleswig-Holstein | Kiel | 24105 | Germany | Details | ||
| Universitatsklinikum Koln | Köln | 50937 | Germany | Details | ||
| Klinikum Ludwigshafen Medizinische Klinik A | Ludwigshafen | 67063 | Germany | Details | ||
| Klinikum rechts der Isar der Technischen Universitat Munchen, Klinik und Poliklinik fur Innere Medizin III | Muenchen | 81675 | Germany | Details | ||
| LMU - Klinikum der Universitat Munchen, Medizinische Klinik und Poliklinik III, Campus Grosshadern | München | 81377 | Germany | Details | ||
| Universitatsklinikum Ulm, Zentrum fur Innere Medizin, Innere Medizin III | Ulm | 89081 | Germany | Details | ||
| Prince of Wales Hospital, The Chinese University of Hong Kong | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital | Hong Kong | Hong Kong | Details | |||
| Azienda Ospedaliero Universitaria delle Marche | Ancona | I-60126 | Italy | Details | ||
| AOU Consorziale Policlinico Bari | Bari | 70124 | Italy | Details | ||
| Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant'Orsola-Malphigi U.O Ematologia | Bologna | 40138 | Italy | Details | ||
| Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRS - Oncologia Medica | Meldola | 40174 | Italy | Details | ||
| Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli U.O.S.C. di Ematologia con Trapianto di Midollo Osseo | Napoli | 80131 | Italy | Details | ||
| SC Ematologia, Azienda Ospedaliera di Perugia - Santa Maria della Misericordia | Perugia | 06129 | Italy | Details | ||
| AORM - AO Riuniti Marche Norde - Pesaro Presidio "San Salvatore" - Muraglia | Pesaro | 61122 | Italy | Details | ||
| Fondazione PTV Policinico Tor Vergata | Roma | 00133 | Italy | Details | ||
| SCDU Ematologia e Terrapie cellulari AO O Ordine Mauriziano Torino | Torino | 10122 | Italy | Details | ||
| ASST Sette Laghi - Ospedale di Circolo e Fondazione Macchi | Varese | 21100 | Italy | Details | ||
| Hyogo Prefectural Amagasaki General Medical Center | Amagasaki | 660-8550 | Japan | Details | ||
| Chiba Aoba Municipal Hospital | Chiba | 260-0852 | Japan | Details | ||
| University of Yamanashi Hospital | Chuo-City | 409-3898 | Japan | Details | ||
| Kyushu University Hospital | Fukuoka | 812-8582 | Japan | Details | ||
| Fukushima Medical University Hospital | Fukushima-Shi | 960-1295 | Japan | Details | ||
| Aiiku Hospital | Hokkaido | 064-0804 | Japan | Details | ||
| Tokai University School of Medicine | Isehara | 259-1193 | Japan | Details | ||
| Kanazawa University Hospital | Kanazawa | 920-8641 | Japan | Details | ||
| National Cancer Center Hospital East | Kashiwa | 277-8577 | Japan | Details | ||
| Hospital of the University of Occupational and Environmental Health, Japan | Kitakyushu-shi | 807-8555 | Japan | Details | ||
| Kobe City Medical Center General Hospital | Kobe-city | 650-0047 | Japan | Details | ||
| Gunmaken Saiseikai Maebashi Hospital | Maebashi | 371-0821 | Japan | Details | ||
| Ehime Prefectural Center Hospital | Matsuyama | 790-0024 | Japan | Details | ||
| Nagasaki University Hospital | Nagasaki | 852-8501 | Japan | Details | ||
| Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital | Nagoya-Shi | 466-8650 | Japan | Details | ||
| Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital | Nagoya | 453-8511 | Japan | Details | ||
| Okayama University Hospital | Okayama-Shi | 700-8558 | Japan | Details | ||
| Osaka Metropolitan University Hospital | Osaka-Shi | 545-8586 | Japan | Details | ||
| Kindai University Hospital | Osakasayama | 589-8511 | Japan | Details | ||
| National University Corporation Tohoku University Tohoku University Hospital | Sendai | 980-8574 | Japan | Details | ||
| NTT Medical Center Tokyo | Shinagawa-Ku | 141-8625 | Japan | Details | ||
| Yamagata University Hospital | Yamagata | 990-9585 | Japan | Details | ||
| University of Fukui Hospital | Yoshida-gun | 910-1193 | Japan | Details | ||
| Hospital General Universitario de Alicante | Alicante | 3010 | Spain | Details | ||
| Hospital del la Santa Creu i Sant Pau | Barcelona | 08025 | Spain | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Institut Catala d'Oncologia | Barcelona | 08907 | Spain | Details | ||
| Complejo Asistencial Universitario de Burgos/H.U. de Burgos | Burgos | 09006 | Spain | Details | ||
| Hospital Universitario Reina Sofia | Cordoba | 14004 | Spain | Details | ||
| Complejo Hospitalario San Pedro de Alcantara | Cáceres | 10001 | Spain | Details | ||
| Hospital Universitario de Gran Canaria Doctor Negrin | Las Palmas de Gran Canaria | 35010 | Spain | Details | ||
| Hospital Universitario de La Princesa | Madrid | 28006 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon | Madrid | 28007 | Spain | Details | ||
| MD Anderson Cancer Center Madrid | Madrid | 28033 | Spain | Details | ||
| Hospital Regional Universitario de Malaga | Malaga | 29010 | Spain | Details | ||
| Hospital Universitario Central de Asturias | Oviedo | 33011 | Spain | Details | ||
| Clinica Universidad de Navarra - Pamplona (Main Site) | Pamplona | 31008 | Spain | Details | ||
| Complejo Asistencial Universitario de Salamanca - Hsopital Clinico | Salamanca | 37007 | Spain | Details | ||
| Hospital U. Marques de Valdecilla | Santander | 39008 | Spain | Details | ||
| Hospital Clinico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Hospital Universitari I Politècnic La Fe | Valencia | 46026 | Spain | Details | ||
| Universitetssjukhus, Hematologimottagnungen | Lund | 221 85 | Sweden | Details | ||
| Universitatsspital Basel - Klinik fur Hamatrologie, Bereich Innere Medizin | Basel | 4031 | Switzerland | Details | ||
| Inselspital, Universitatsspital Bern - Universitatsklinik fur Medizinisch Onkologie | Berne | CH 3010 | Switzerland | Details | ||
| University Hospitals Birmingham NHS Foundation Trust | Birmingham | B15 2GW | United Kingdom | Details | ||
| United Lincolnshire Hospitals NHS Trust, Pilgrim Hospital, Sibsey Road | Boston | PE21 9QS | United Kingdom | Details | ||
| Cambridge University Hospital NHS Foundation Trust | Cambridge | CB2 0QQ | United Kingdom | Details | ||
| Cardiff and Vale University Health Board | Cardiff Wales | CF14 4XW | United Kingdom | Details | ||
| Barts Health NHS Trust | City of London | EC1A 7BE | United Kingdom | Details | ||
| NHS Tayside | Dundee | DD1 9SY | United Kingdom | Details | ||
| Beatson West of Scotland Cancer Centre | Glasgow | G12 0YN | United Kingdom | Details | ||
| University College London Hospitals NHS Foundation Trust | London | NW1 2PG | United Kingdom | Details | ||
| King's College NHS Foundation Trust | London | SE5 9RS | United Kingdom | Details | ||
| Oxford University Hospital NHS Foundation Trust | Oxford | OX3 7LE | United Kingdom | Details | ||
| The Royal Marsden NHS Foundation Trust | Sutton | SM2 5PT | United Kingdom | Details | ||
| The Christie NHS Foundation Trust | Withington | M20 4BX | United Kingdom | Details |