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| NCT ID | NCT04895722 |
| Title | Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Merck Sharp & Dohme LLC |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | ROU | POL | NLD | LTU | ITA | HUN | GRC | GBR | FRA | EST | ESP | DNK | DEU | CAN | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Mid Florida Cancer Center ( Site 1519) | Orange City | Florida | 32763 | United States | Details | |
| University Cancer & Blood Center, LLC ( Site 1521) | Athens | Georgia | 30607 | United States | Details | |
| University of Chicago Medical Center-Medicine - Section of Hematology/Oncology - Gastrointestinal P | Chicago | Illinois | 60637 | United States | Details | |
| Icahn School of Medicine at Mount Sinai ( Site 1528) | New York | New York | 10029 | United States | Details | |
| Hematology Oncology Associates of Rockland ( Site 1525) | Nyack | New York | 10960 | United States | Details | |
| UPMC Hillman Cancer Center ( Site 1516) | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| The West Clinic, PLLC dba West Cancer Center ( Site 1576) | Germantown | Tennessee | 38138 | United States | Details | |
| Vanderbilt University Medical Center-Vanderbilt-Ingram Cancer Center ( Site 1509) | Nashville | Tennessee | 37232 | United States | Details | |
| UT Southwestern Medical Center ( Site 1551) | Dallas | Texas | 75390 | United States | Details | |
| Baylor Scott & White Medical Center - Temple-Division of Hematology/Oncology ( Site 1549) | Temple | Texas | 76508 | United States | Details | |
| Northwest Medical Specialties, PLLC ( Site 1546) | Tacoma | Washington | 98405 | United States | Details | |
| UZ Brussel ( Site 0105) | Brussels | Bruxelles-Capitale, Region De | 1090 | Belgium | Details | |
| Cliniques universitaires Saint-Luc-Medical Oncology ( Site 0104) | Brussels | Bruxelles-Capitale, Region De | 1200 | Belgium | Details | |
| Université Catholique de Louvain-Namur - Centre Hospitalier -Oncology ( Site 0102) | Yvoir | Namur | 5530 | Belgium | Details | |
| UZ Leuven ( Site 0101) | Leuven | Vlaams-Brabant | 3000 | Belgium | Details | |
| AZ Delta vzw ( Site 0106) | Roeselare | West-Vlaanderen | 8800 | Belgium | Details | |
| The Moncton Hospital-Oncology ( Site 0307) | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Sunnybrook Research Institute - Odette Cancer Centre ( Site 0316) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| McGill University Health Centre-CIM - Oncology ( Site 0306) | Montréal | Quebec | H4A 3J1 | Canada | Details | |
| Instituto de Cancerología ( Site 1610) | Medellin | Antioquia | 050025 | Colombia | Details | |
| Fundación Colombiana de Cancerología Clínica Vida ( Site 1606) | Medellin | Antioquia | 050030 | Colombia | Details | |
| Clinica de la Costa S.A.S. ( Site 1608) | Barranquilla | Atlantico | 080020 | Colombia | Details | |
| Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 1601) | Valledupar | Cesar | 200001 | Colombia | Details | |
| Oncomédica S.A.S ( Site 1602) | Montería | Cordoba | 230002 | Colombia | Details | |
| Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 1611) | Bogota | Distrito Capital De Bogota | 111321 | Colombia | Details | |
| Mediservis del Tolima IPS S.A.S ( Site 1609) | Ibague | Tolima | 730006 | Colombia | Details | |
| CIMCA-Hemato-Oncology ( Site 2101) | San José | San Jose | 1000 | Costa Rica | Details | |
| Hospital Metropolitano - Sede Lindora-Metropolitano Research Institute Sede Lindora ( Site 2102) | Santa Ana | San Jose | 10903 | Costa Rica | Details | |
| Rigshospitalet ( Site 1904) | Copenhagen | Hovedstaden | 2100 | Denmark | Details | |
| Regionshospitalet Gødstrup ( Site 1901) | Herning | Midtjylland | 7400 | Denmark | Details | |
| Aalborg Universitetshospital, Syd ( Site 1903) | Aalborg | Nordjylland | 9000 | Denmark | Details | |
| Odense Universitetshospital ( Site 1902) | Odense | Syddanmark | 5000 | Denmark | Details | |
| North Estonia Medical Centre Foundation-Chemotherapy ( Site 2301) | Tallinn | Harjumaa | 13419 | Estonia | Details | |
| Tartu University Hospital ( Site 2302) | Tartu | Tartumaa | 50406 | Estonia | Details | |
| Assistance Publique Hôpitaux de Marseille - Hôpital de la Ti-Service d'Hepato-Gastro-Enterologie et | Marseille | Bouches-du-Rhone | 13385 | France | Details | |
| Centre Georges François Leclerc ( Site 0506) | Dijon | Cote-d Or | 21079 | France | Details | |
| CHU Rangueil-Digestive oncology department ( Site 0502) | Toulouse | Haute-Garonne | 31059 | France | Details | |
| Hopital Claude Huriez - CHU de Lille ( Site 0510) | Lille | Nord | 59037 | France | Details | |
| Centre Hospitalier Universitaire de Poitiers ( Site 0511) | Poitiers | Vienne | 86021 | France | Details | |
| Hôpital Saint Antoine-Oncologie médicale ( Site 0508) | Paris | 75571 | France | Details | ||
| Muenchen Klinik Neuperlach, Klinik fuer Haematologie und Onkologie ( Site 0612) | Muenchen | Bayern | 81737 | Germany | Details | |
| Universitätsklinikum Marburg ( Site 0610) | Marburg | Hessen | 35043 | Germany | Details | |
| Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 0611) | Essen | Nordrhein-Westfalen | 45136 | Germany | Details | |
| Otto-von-Guericke-Universität Magdeburg-Klinik für Gastroenterologie, Hepatologie und Infektiologie | Magdeburg | Sachsen-Anhalt | 39120 | Germany | Details | |
| Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 0601) | Dresden | Sachsen | 01307 | Germany | Details | |
| Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0604) | Berlin | 10117 | Germany | Details | ||
| Asklepios Altona-Oncology ( Site 0602) | Hamburg | 22763 | Germany | Details | ||
| Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 2704) | Athens | Attiki | 115 28 | Greece | Details | |
| Evgenidion Hospital ( Site 2702) | Athens | Attiki | 115 28 | Greece | Details | |
| University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 2703) | Heraklion | Irakleio | 715 00 | Greece | Details | |
| European Interbalkan Medical Center-Oncology Department ( Site 2701) | Thessaloniki | 57001 | Greece | Details | ||
| CELAN,S.A ( Site 2202) | Guatemala | 01010 | Guatemala | Details | ||
| INTEGRA Cancer Institute-Oncology ( Site 2201) | Guatemala | 01010 | Guatemala | Details | ||
| MEDI-K CAYALA ( Site 2205) | Guatemala | 01016 | Guatemala | Details | ||
| Centro Regional de Sub Especialidades Médicas SA ( Site 2204) | Quetzaltenango | 09001 | Guatemala | Details | ||
| Centro Medico Integral De Cancerología (CEMIC) ( Site 2203) | Quetzaltenango | 09002 | Guatemala | Details | ||
| Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2005) | Kecskemét | Bacs-Kiskun | 6000 | Hungary | Details | |
| Pécsi Tudományegyetem Klinikai Központ-Onkoterápiás Intézet ( Site 2009) | Pécs | Baranya | 7624 | Hungary | Details | |
| Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 2001) | Szolnok | Jasz-Nagykun-Szolnok | 5000 | Hungary | Details | |
| Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 2010) | Kaposvár | Somogy | 7400 | Hungary | Details | |
| Semmelweis Egyetem-Belgyógyászati és Hematológiai Klinika ( Site 2002) | Budapest | 1088 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 2008) | Debrecen | 4032 | Hungary | Details | ||
| Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0802) | Milan | Lombardia | 20133 | Italy | Details | |
| Istituto Nazionale Tumori IRCCS Fondazione Pascale-Department of Abdominal Oncology ( Site 0803) | Napoli | 80131 | Italy | Details | ||
| Istituto Oncologico Veneto IRCCS ( Site 0804) | Padova | 35128 | Italy | Details | ||
| Kyungpook National University Chilgok Hospital-Hematology/oncology ( Site 1103) | Daegu | Taegu-Kwangyokshi | 41404 | Korea, Republic of | Details | |
| Korea University Anam Hospital ( Site 1107) | Seoul | 02841 | Korea, Republic of | Details | ||
| Seoul National University Hospital-Internal Medicine ( Site 1101) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1104) | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center-Department of Oncology ( Site 1105) | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center-Division of Hematology/Oncology ( Site 1102) | Seoul | 06351 | Korea, Republic of | Details | ||
| The Catholic Univ. of Korea Seoul St. Mary's Hospital-Medical Oncology ( Site 1106) | Seoul | 06591 | Korea, Republic of | Details | ||
| Hospital of Lithuanian University of Health Sciences Kauno klinikos ( Site 2402) | Kaunas | Kauno Apskritis | 50161 | Lithuania | Details | |
| National Cancer Institute ( Site 2401) | Vilnius | Vilniaus Miestas | 08660 | Lithuania | Details | |
| VILNIUS UNIVERSITY HOSPITAL SANTAROS KLINIKOS ( Site 2403) | Vilnius | 08460 | Lithuania | Details | ||
| Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL) ( Site 2901) | Amsterdam | Noord-Holland | 1066CX | Netherlands | Details | |
| DOLNOSLASKIE CENTRUM ONKOLOGII PULMONOLOGII I HEMATOLOGII ( Site 0920) | Wroclaw | Dolnoslaskie | 53-413 | Poland | Details | |
| Powiatowe Centrum Zdrowia ( Site 0911) | Brzeziny | Lodzkie | 95-060 | Poland | Details | |
| Luxmed Onkologia sp. z o. o. ( Site 0915) | Warszawa | Mazowieckie | 01-748 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Onkologii i Radioterapii ( Site | Warszawa | Mazowieckie | 02-034 | Poland | Details | |
| Mrukmed-Mrukmed ( Site 0901) | Rzeszow | Podkarpackie | 35-021 | Poland | Details | |
| Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0903) | Koszalin | Zachodniopomorskie | 75-581 | Poland | Details | |
| Spitalul de Oncologie Monza Oncologie Medicala ( Site 2601) | Bucharest | Bucuresti | 013812 | Romania | Details | |
| Fundeni Clinical Institute-Medical Oncology ( Site 2603) | București | Bucuresti | 022328 | Romania | Details | |
| Cardiomed SRL Cluj-Napoca ( Site 2602) | Cluj-Napoca | Cluj | 400015 | Romania | Details | |
| Centrul de Oncologie "Sfântul Nectarie"-Medical Oncology ( Site 2604) | Craiova | Dolj | 200542 | Romania | Details | |
| Saint-Petersburg City Clinical Oncology Dispensary-Department of chemotherapy ( Site 1001) | Saint Petersburg | Leningradskaya Oblast | 198255 | Russian Federation | Details | |
| Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology-Clinical Pharmacology and Chemotherapy | Moscow | Moskva | 115478 | Russian Federation | Details | |
| First Moscow State Medical University I.M. Sechenov-Interhospital Institution Health Management Cl | Moscow | Moskva | 119991 | Russian Federation | Details | |
| Rostov Cancer Research Institute ( Site 1014) | Rostov on Don | Rostovskaya Oblast | 344037 | Russian Federation | Details | |
| GBUZ SPb CRPCstmc(o) ( Site 1005) | Sankt- Peterburg | Sankt-Peterburg | 197758 | Russian Federation | Details | |
| Republican Clinical Oncology Dispensary-Chemotherapy #3 ( Site 1006) | Kazan | Tatarstan, Respublika | 420029 | Russian Federation | Details | |
| Hospital Universitario Central de Asturias-Medical Oncology ( Site 1203) | Oviedo | Asturias | 33011 | Spain | Details | |
| Hospital Universitario Marqués de Valdecilla ( Site 1202) | Santander | Cantabria | 39008 | Spain | Details | |
| Hospital Universitari Vall d'Hebron ( Site 1201) | Barcelona | Cataluna | 08035 | Spain | Details | |
| HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1206) | Madrid | Madrid, Comunidad De | 28007 | Spain | Details | |
| H.R.U Malaga - Hospital General ( Site 1207) | Málaga | Malaga | 29010 | Spain | Details | |
| COMPLEJO HOSPITALARIO DE NAVARRA-oncologia médica ( Site 1210) | Pamplona | Navarra | 31009 | Spain | Details | |
| Fundación Instituto Valenciano de Oncología ( Site 1209) | Valencia | Valenciana, Comunitat | 46009 | Spain | Details | |
| Hospital Clinico San Carlos-Oncology Department ( Site 1204) | Madrid | 28040 | Spain | Details | ||
| Baskent University Dr. Turgut Noyan Research and Training Center ( Site 1303) | Adana | 01250 | Turkey | Details | ||
| Hacettepe Universitesi-oncology hospital ( Site 1301) | Ankara | 06230 | Turkey | Details | ||
| Ankara City Hospital-Medical Oncology ( Site 1306) | Ankara | 06800 | Turkey | Details | ||
| Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1302) | Istanbul | 34668 | Turkey | Details | ||
| TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1305) | Istanbul | 34722 | Turkey | Details | ||
| Beatson West of Scotland Cancer Centre-Clinical Trials Unit ( Site 1401) | Glasgow | Glasgow City | G12 0YN | United Kingdom | Details | |
| UCLH-Cancer Clinical Trials Unit ( Site 1402) | London-Camden | London, City Of | NW1 2PG | United Kingdom | Details | |
| Velindre Cancer Centre-Research and Development ( Site 1415) | Cardiff | CF14 2TL | United Kingdom | Details | ||
| University Hospital Coventry & Warwickshire ( Site 1406) | Coventry | CV2 2DX | United Kingdom | Details |