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NCT ID NCT04949256
Title Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014)
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications
Therapies
Age Groups: adult | senior
Covered Countries USA | TUR | ROU | ITA | HUN | GBR | FRA | ESP | DNK | CAN | ARG

Facility Status City State Zip Country Details
City of Hope ( Site 0102) Duarte California 91010 United States Details
MedStar Washington Hospital Center ( Site 0186) Washington District of Columbia 20010 United States Details
James Graham Brown Cancer Center ( Site 0117) Louisville Kentucky 40202 United States Details
Norton Cancer Institute ( Site 0116) Louisville Kentucky 40217 United States Details
Johns Hopkins Bayview Medical Center ( Site 0152) Baltimore Maryland 21224 United States Details
UMASS Memorial Medical Center ( Site 0120) Worcester Massachusetts 01655 United States Details
Capital Health Medical Center - Hopewell ( Site 0189) Pennington New Jersey 08534 United States Details
Hematology-Oncology Associates of CNY ( Site 0173) East Syracuse New York 13057 United States Details
Memorial Sloan Kettering Cancer Center ( Site 0132) New York New York 10065 United States Details
Weill Cornell Medical College ( Site 0133) New York New York 10065 United States Details
St. Luke's University Health Network ( Site 0185) Bethlehem Pennsylvania 18015 United States Details
AHN Allegheny General Hospital ( Site 0164) Pittsburgh Pennsylvania 15212 United States Details
Medical University of South Carolina-Hollings Cancer Center ( Site 0177) Charleston South Carolina 29425 United States Details
VCU Health Adult Outpatient Pavillion ( Site 0160) Richmond Virginia 23219 United States Details
Seattle Cancer Care Alliance ( Site 0145) Seattle Washington 98109 United States Details
Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0203) Berazategui Buenos Aires B1884BBF Argentina Details
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 0202) Caba Buenos Aires C1012AAR Argentina Details
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0205) Mar del Plata. Buenos Aires B7600FZO Argentina Details
Fundacion Estudios Clinicos-Oncology ( Site 0215) Rosario Santa Fe S2000DEJ Argentina Details
Sanatorio Parque ( Site 0206) Rosario Santa Fe S2000DSV Argentina Details
Hospital Provincial del Centenario ( Site 0217) Rosario Santa Fe S2002KDS Argentina Details
Fundacion Favaloro ( Site 0201) Buenos Aires C1093AAS Argentina Details
Fundación Respirar ( Site 0216) Buenos Aires C1426ABP Argentina Details
Hospital Italiano de Córdoba ( Site 0218) Cordoba X5004BAL Argentina Details
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0221) La Rioja F5300COE Argentina Details
Instituto San Marcos ( Site 0213) San Juan J5400EBB Argentina Details
CancerCare Manitoba ( Site 0001) Winnipeg Manitoba R3E 0V9 Canada Details
Princess Margaret Cancer Centre ( Site 0004) Toronto Ontario M5G 2M9 Canada Details
Hotel-Dieu de Levis ( Site 0013) Levis Quebec G6V 3Z1 Canada Details
Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0401) Temuco. Araucania 4810218 Chile Details
James Lind Centro de Investigacion del Cancer ( Site 0412) Temuco Araucania 4800827 Chile Details
Fundacion Arturo Lopez Perez FALP ( Site 0403) Santiago Region M. De Santiago 7500836 Chile Details
Oncovida ( Site 0413) Santiago Region M. De Santiago 7510032 Chile Details
Clínica San Carlos de Apoquindo Red Salud UC Christus ( Site 0407) Santiago Region M. De Santiago 7550000 Chile Details
Bradford Hill Centro de Investigaciones Clinicas ( Site 0404) Santiago Region M. De Santiago 8420383 Chile Details
Anhui Provincial Cancer Hospital ( Site 8058) Hefei Anhui 230031 China Details
The Second Affiliated Hospital of Anhui Medical University ( Site 8026) Hefei Anhui 230031 China Details
Beijing Cancer Hospital ( Site 8001) Beijing Beijing 100142 China Details
Fujian Provincial Cancer Hospital ( Site 8029) Fuzhou Fujian 350014 China Details
The First Affiliated Hospital of Xiamen University ( Site 8003) Xiamen City, Fujian Province Fujian 361003 China Details
Zhongshan Hospital Affiliated to Xiamen University ( Site 8055) Xiamen Fujian 361004 China Details
The First Affiliated Hospital.Sun Yat-sen University ( Site 8047) Guangzhou Guangdong 510080 China Details
Southern Medical University Nanfang Hospital ( Site 8031) Guangzhou Guangdong 510515 China Details
The Third Xiangya Hospital of Central South University ( Site 8046) Changsha Hainan 410013 China Details
The First Affiliated Hospital of Hainan Medical University ( Site 8042) Haikou Hainan 570102 China Details
Affiliated Hospital of Chengde Medical Univeristy ( Site 8053) Chengde Hebei 067055 China Details
Harbin Medical University Cancer Hospital ( Site 8009) Harbin Heilongjiang China Details
Anyang Cancer Hospital ( Site 8006) Anyang Henan 455000 China Details
The First Affiliated Hospital of Henan University of Science &Technology-Tumor ( Site 8036) Luoyang Henan 471003 China Details
The First Affiliated Hospital of Xinxiang Medical University ( Site 8018) Xinxiang Henan 453100 China Details
Tongji Medical College Huazhong Uinversity Of Science and Technology ( Site 8025) Wuhan Hubei 430030 China Details
Hubei Cancer Hospital ( Site 8014) Wuhan Hubei 430079 China Details
Affiliated hospital of Jiangnan university ( Site 8049) Wuxi Jiangsu 214122 China Details
The Affiliated Hospital of Xuzhou Medical University ( Site 8015) Xuzhou Jiangsu 221000 China Details
Jilin Cancer Hospital ( Site 8016) Changchun Jilin 130012 China Details
Jinan Central Hospital ( Site 8052) Jinan Shandong 250013 China Details
Shandong Cancer Hospital ( Site 8060) Jinan Shandong 250117 China Details
Affiliated Hospital of Jining Medical University ( Site 8017) Jining Shandong 272000 China Details
Linyi Cancer Hospital- Medical Oncology Department ( Site 8051) Linyi Shandong 276000 China Details
Shanxi Provincial Cancer Hospital ( Site 8019) Taiyuan Shanxi 030000 China Details
West China Hospital of Sichuan University ( Site 8048) Chengdu Sichuan 610041 China Details
Tianjin Medical University Cancer Institute & Hospital ( Site 8035) Tianjin Tianjin 300060 China Details
The Affiliated Cancer Hospital of Xinjiang Medical University. ( Site 8041) Urumqi Xinjiang 830000 China Details
Sir Run Run Shaw Hospital ( Site 8021) Hangzhou Zhejiang 310016 China Details
ICIMED-Oncology Research Unit ( Site 0903) San José San Jose 10108 Costa Rica Details
PROCLINICAL Pharma ( Site 0904) San José San Jose 11303 Costa Rica Details
CIMCA Centro de Investigacion y Manejo del Cancer ( Site 0902) San Jose 10103 Costa Rica Details
Onco Tech S A ( Site 0901) San Jose 10103 Costa Rica Details
Rigshospitalet ( Site 2102) Copenhagen Hovedstaden 2100 Denmark Details
Odense University Hospital ( Site 2101) Odense Syddanmark 5000 Denmark Details
Institut De Cancerologie De Lorraine ( Site 1010) Vandoeuvre les Nancy Ain 54519 France Details
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1014) Strasbourg Alsace 67200 France Details
Centre François Baclesse ( Site 1009) Caen Calvados 14076 France Details
Centre Georges Francois Leclerc ( Site 1008) Dijon Cote-d Or 21000 France Details
C.H. regional Unv. de Brest - Hopital La Cavale Blanche - Institut de Cancerologie et d Imagerie ( S Brest Finistere 29200 France Details
CHU Besançon ( Site 1015) Besançon Franche-Comte 25000 France Details
CHU Bordeaux Haut-Leveque ( Site 1012) Pessac Gironde 33604 France Details
Institut du Cancer de Montpellier ( Site 1002) Montpellier Herault 34298 France Details
CHRU de Tours - Hopital Bretonneau ( Site 1018) Tours Indre-et-Loire 37044 France Details
Institut De Cancerologie De L Ouest ( Site 1003) Saint Herblain Loire-Atlantique 44805 France Details
Hôpital Claude Huriez ( Site 1030) Lille Nord 59000 France Details
Hopital Henri Mondor ( Site 1007) Creteil Val-de-Marne 94010 France Details
Hopital Saint Louis ( Site 1029) Paris 75010 France Details
Centro Regional de Sub Especialidades Medicas SA ( Site 0604) Guatemala Quetzaltenango 09001 Guatemala Details
MEDI-K ( Site 0601) Guatemala 01009 Guatemala Details
Oncomedica ( Site 0602) Guatemala 01010 Guatemala Details
Soluciones Gastrointestinales S.A. ( Site 0607) Guatemala 01010 Guatemala Details
Queen Mary Hospital ( Site 4001) Hong Kong Hong Kong Details
Queen Elizabeth Hospital. ( Site 4004) Kowloon Hong Kong Details
Pecsi Tudomanyegyetem AOK ( Site 1204) Pecs Baranya 7624 Hungary Details
Petz Aladar Egyetemi Oktato Korhaz ( Site 1210) Gyor Gyor-Moson-Sopron 9024 Hungary Details
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1203) Szolnok Jasz-Nagykun-Szolnok 5000 Hungary Details
Orszagos Onkologiai Intezet ( Site 1207) Budapest 1122 Hungary Details
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 1313) Meldola Emilia-Romagna 47014 Italy Details
A.O.U. Santa Maria della Misericordia di Udine ( Site 1302) Udine Friuli-Venezia Giulia 33100 Italy Details
Humanitas Research Hospital ( Site 1309) Rozzano Lombardia 20089 Italy Details
Azienda Ospedaliera Universitaria Pisana ( Site 1312) Pisa Toscana 56126 Italy Details
Istituto Oncologico Veneto IRCCS-Oncologia Medica 1 ( Site 1311) Padova Veneto 35128 Italy Details
Azienda Ospedaliera Mater Domini-Translational Oncology Unit ( Site 1314) Catanzaro 88100 Italy Details
Azienda Ospedaliero Universitaria Careggi ( Site 1301) Firenze 50134 Italy Details
IRCCS Ospedale San Raffaele di Milano ( Site 1304) Milano 20132 Italy Details
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1306) Milano 20133 Italy Details
A.O. Universitaria di Modena ( Site 1307) Modena 41124 Italy Details
A.O.U. Universita degli Studi della Campania-Luigi Vanvitelli ( Site 1305) Napoli 80131 Italy Details
Universita Cattolica del Sacro Cuore - Policlinico Gemelli ( Site 1310) Roma 00168 Italy Details
Aichi Cancer Center Hospital ( Site 9006) Nagoya Aichi 464-8681 Japan Details
Chiba Cancer Center ( Site 9023) Chiba-shi Chiba 260-8717 Japan Details
National Cancer Center Hospital East ( Site 9002) Kashiwa Chiba 277-8577 Japan Details
National Hospital Organization Shikoku Cancer Center ( Site 9019) Matsuyama Ehime 791-0280 Japan Details
Hyogo Cancer Center ( Site 9014) Akashi Hyogo 673-8558 Japan Details
Ibaraki Prefectural Central Hospital ( Site 9007) Kasama Ibaraki 309-1793 Japan Details
Kagawa University Hospital ( Site 9015) Kita-gun Kagawa 761-0793 Japan Details
Kanagawa Cancer Center ( Site 9004) Yokohama Kanagawa 241-8515 Japan Details
Tohoku University Hospital ( Site 9013) Sendai-shi Miyagi 980-8574 Japan Details
Niigata Cancer Center Hospital ( Site 9022) Niigata-shi Niigata 951-8566 Japan Details
Kindai University Hospital ( Site 9017) Sayama Osaka 589-8511 Japan Details
Osaka University Hospital ( Site 9021) Suita Osaka 565-0871 Japan Details
Osaka Medical and Pharmaceutical University Hospital ( Site 9008) Takatsuki Osaka 569-8686 Japan Details
Saitama Prefectural Cancer Center ( Site 9003) Kitaadachi-gun Saitama 362-0806 Japan Details
Shizuoka Cancer Center ( Site 9016) Nagaizumi Shizuoka 411-8777 Japan Details
Tokyo Metropolitan Komagome Hospital ( Site 9028) Bunkyo ku Tokyo 113-8677 Japan Details
Toranomon Hospital ( Site 9026) Minato-ku Tokyo 105-8470 Japan Details
Showa University Hospital ( Site 9025) Shinagawa Tokyo 142-8666 Japan Details
National Hospital Organization Kyushu Cancer Center ( Site 9010) Fukuoka 811-1395 Japan Details
University Hospital,Kyoto Prefectural University of Medicine ( Site 9027) Kyoto 602-8566 Japan Details
Kyoto University Hospital ( Site 9011) Kyoto Japan Details
Okayama University Hospital ( Site 9024) Okayama 700-8558 Japan Details
Osaka International Cancer Institute ( Site 9009) Osaka 541-8567 Japan Details
Osaka General Medical Center ( Site 9018) Osaka 558-8558 Japan Details
National Cancer Center Hospital ( Site 9001) Tokyo 104-0045 Japan Details
The Cancer Institute Hospital of JFCR ( Site 9005) Tokyo 135-8550 Japan Details
Keio University Hospital ( Site 9020) Tokyo 160-8582 Japan Details
Seoul National University Bundang Hospital ( Site 5006) Seongnam-si Kyonggi-do 13605 Korea, Republic of Details
Asan Medical Center ( Site 5002) Songpagu Seoul 05505 Korea, Republic of Details
Severance Hospital ( Site 5003) Seoul 03722 Korea, Republic of Details
Samsung Medical Center ( Site 5005) Seoul 06351 Korea, Republic of Details
Korea University Guro Hospital ( Site 5001) Seoul 08308 Korea, Republic of Details
University Malaya Medical Centre ( Site 9101) Lembah Pantai Kuala Lumpur 59100 Malaysia Details
Sarawak General Hospital-Radiotherapy Unit ( Site 9100) Kuching Sarawak 93586 Malaysia Details
Hospital Kuala Lumpur ( Site 9104) Kuala Lumpur 50586 Malaysia Details
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2201) Bucharest Bucuresti 013812 Romania Details
Cardiomed SRL Cluj-Napoca-Medical Oncology ( Site 2207) Cluj-Napoca Cluj 400015 Romania Details
SC Radiotherapy Center Cluj SRL ( Site 2202) Comuna Floresti Cluj 407280 Romania Details
Ovidius Clinical Hospital OCH-Oncology and Hematology ( Site 2203) Ovidiu Constanta 905900 Romania Details
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2204) Craiova Dolj 200542 Romania Details
Policlinica Oncomed SRL ( Site 2206) Timisoara Timis 300239 Romania Details
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1507) Ufa Baskortostan, Respublika 450054 Russian Federation Details
GBUZ LOKB ( Site 1502) Saint-Petersburg Leningradskaya Oblast 194291 Russian Federation Details
FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1510) Moscow Moskva 115478 Russian Federation Details
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1503) Saint Petersburg Sankt-Peterburg 197758 Russian Federation Details
Academician I.P. Pavlov First St. Petersburg State Medical University ( Site 1519) Saint-Petersburg Sankt-Peterburg 197022 Russian Federation Details
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 150 Kazan Tatarstan, Respublika 420029 Russian Federation Details
SAIH of Tyumen reg "Multifield clinical medical center "Medical city" ( Site 1520) Tyumen Tyumenskaya Oblast 625041 Russian Federation Details
National Cancer Centre Singapore ( Site 9201) Singapore Central Singapore 168583 Singapore Details
Wits Clinical Research ( Site 9502) Johannesburg Gauteng 2193 South Africa Details
The Oncology Centre ( Site 9505) Durban Kwazulu-Natal 4091 South Africa Details
Hospital Universitario General de Asturias ( Site 1601) Oviedo Asturias 33011 Spain Details
Hospital Universitario Marques de Valdecilla ( Site 1602) Santander Cantabria 39008 Spain Details
Complexo Hospitalario Universitario de Ourense-MEDICAL ONCOLOGY ( Site 1609) Ourense Orense 32005 Spain Details
Hospital General Universitari Vall d Hebron ( Site 1607) Barcelona 08035 Spain Details
Hospital General Universitario Gregorio Maranon ( Site 1604) Madrid 28007 Spain Details
Hospital Virgen del Rocio ( Site 1606) Sevilla 41013 Spain Details
Chi Mei Hospital - Liouying Branch-Clinical Trial Center ( Site 6007) Tainan City Tainan 73657 Taiwan Details
Chang Gung Med Foundation. Kaohsiung Branch ( Site 6005) Kaohsiung 833 Taiwan Details
China Medical University Hospital ( Site 6003) Taichung 40447 Taiwan Details
National Cheng Kung University Hospital ( Site 6004) Tainan 704 Taiwan Details
National Taiwan University Hospital ( Site 6001) Taipei 10002 Taiwan Details
Taipei Veterans General Hospital ( Site 6006) Taipei 11217 Taiwan Details
Faculty of Medicine Siriraj Hospital ( Site 7002) Bangkok Krung Thep Maha Nakhon 10700 Thailand Details
Songklanagarind hospital ( Site 7001) HatYai Songkhla 90110 Thailand Details
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 1714) Adana 01140 Turkey Details
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1701) Ankara 06230 Turkey Details
Memorial Ankara Hastanesi ( Site 1702) Ankara 06520 Turkey Details
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1715) Ankara 06800 Turkey Details
Atatürk Üniversitesi-onkoloji ( Site 1712) Erzurum 25070 Turkey Details
Acibadem Universitesi Atakent Hastanesi-Medical Oncology ( Site 1716) Istanbul 34303 Turkey Details
Istanbul Okmeydanı Egitim ve Arastirma Hastanesi ( Site 1711) Istanbul 34384 Turkey Details
Medeniyet Universitesi Tip Fakultesi ( Site 1703) İstanbul 34732 Turkey Details
Chernihiv Medical Center of Modern Oncology ( Site 1811) Chernihiv Chernihivska Oblast 14029 Ukraine Details
Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 1819) Chernivtsi Chernivetska Oblast 58013 Ukraine Details
MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council ( Site 1804) Kryviy Rih Dnipropetrovska Oblast 50048 Ukraine Details
Kharkiv Regional Clinical Oncology Center ( Site 1812) Kharkiv Kharkivska Oblast 61000 Ukraine Details
Institute of General and Emergency Surgery n.a Zaitsev NAMS of Ukraine ( Site 1813) Kharkiv Kharkivska Oblast 61103 Ukraine Details
Communal nonprofit enterprise "Kherson Regional Oncology Dispensary" of Kherson Regional Council ( Antonivka Village Khersonska Oblast 73000 Ukraine Details
SNPE National Cancer Institute ( Site 1806) Kyiv Kyivska Oblast 03022 Ukraine Details
Rivne Regional Clinical Hospital ( Site 1817) Rivne Rivnenska Oblast 33007 Ukraine Details
Podillya Regional Center of Oncology ( Site 1809) Vinnytsia Vinnytska Oblast 21029 Ukraine Details
Volyn Regional Oncological Dispensary ( Site 1816) Lutsk Volynska Oblast 43018 Ukraine Details
Shalimov Institute of Surgery and Transplantation ( Site 1818) Kyiv 03126 Ukraine Details
Cambridge University Hospitals NHSFT ( Site 1908) Cambridge Cambridgeshire CB2 2QQ United Kingdom Details
Ninewells Hospital and Medical School ( Site 1907) Dundee Dundee City DD2 1SG United Kingdom Details
Nottingham University Hospital NHS Trust ( Site 1910) Nottingham England NG5 1PF United Kingdom Details
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1915) London London, City Of EC1A 7BE United Kingdom Details
University College London Hospitals NHS Foundation Trust ( Site 1901) London London, City Of NW1 2BU United Kingdom Details
Royal Marsden NHS Foundation Trust ( Site 1905) London London, City Of SW3 6JJ United Kingdom Details
Royal Marsden NHS Trust. ( Site 1906) Sutton London, City Of SM2 5PT United Kingdom Details
Western General Hospital ( Site 1912) Edinburgh Midlothian EH4 2XU United Kingdom Details
The Christie NHS Foundation Trust ( Site 1909) Manchester M20 4BX United Kingdom Details
*Shaded cells indicate that there was no data available from clinicaltrials.gov for the field