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| NCT ID | NCT04965493 |
| Title | A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (BRUIN CLL-322) |
| Acronym | BRUIN CLL-322 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | SWE | POL | NOR | ITA | ISR | IRL | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CHE | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| A.O.U. Citta' della Salute e della Scienza di Torino | Torino | 10126 | Italy | Details | ||
| A.O.U. di Modena | Modena | 41224 | Italy | Details | ||
| Akershus Universitetssykehus | Nordbyhagen | 1474 | Norway | Details | ||
| American Oncology Partners of Maryland, PA | Bethesda | Maryland | 20817 | United States | Details | |
| AOU Arcispedale Sant'Anna | Cona | 44124 | Italy | Details | ||
| ASST Grande Ospedale Metropolitano Niguarda Comitato Etico Milano Area C | Milan | Milano | 20162 | Italy | Details | |
| Azienda Ospedale Maggiore Della Carita | Novara | 28100 | Italy | Details | ||
| Azienda Ospedaliera Pugliese Ciaccio | Catanzaro | 88100 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Careggi | Firenze | Florence | 50134 | Italy | Details | |
| BC Cancer Vancouver | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| Birmingham Heartlands Hospital | Birmingham | England | B9 5SS | United Kingdom | Details | |
| Bnai Zion Medical Center | Haifa | 3339419 | Israel | Details | ||
| Cancer Care Manitoba | Winnipeg | Manitoba | R3A 1M3 | Canada | Details | |
| Cancer Center of Guangzhou Medical University | Guangzhou | Guangdong | 510000 | China | Details | |
| Cancer Specialists of North Florida -St Augustine | Saint Augustine | Florida | 32086 | United States | Details | |
| Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen | Rouen | Seine-Maritime | 76038 | France | Details | |
| Centre Hospitalier du Mans | Le Mans | 72000 | France | Details | ||
| Centre Hospitalier Lyon Sud | Pierre Benite Cedex | 69495 | France | Details | ||
| Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois | Morvan | Vandoeuvre Les Nancy | 54511 | France | Details | |
| Charité - Hämatologie - Onkologie - Tumorimmunologie, CC14 - Campus Benjamin Franklin | Berlin | 12203 | Germany | Details | ||
| Chongqing Cancer Hospital | Chongqing | 400030 | China | Details | ||
| CHRU De Tours | Tours Cedex | 37044 | France | Details | ||
| CHU de Nantes - Hotel Dieu | Nantes | Cedex 1 | 44093 | France | Details | |
| CHU UCL Namur site Godinne | Yvoir | 5530 | Belgium | Details | ||
| Churchill Hospital | Oxford | OX3 7LJ | United Kingdom | Details | ||
| Columbia University Medical Center | New York | New York | 10032 | United States | Details | |
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Debreceni Egyetem Klinikai Kozpont | Debrecen | 4032 | Hungary | Details | ||
| Derriford Hospital | Plymouth | Devon | PL6 8DH | United Kingdom | Details | |
| Duke University Medical Center | Durham | North Carolina | 27710 | United States | Details | |
| Fakultni nemocnice Brno | Brno | 62500 | Czechia | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | Hradec Králové | 500 05 | Czechia | Details | |
| Fakultni nemocnice Kralovske Vinohrady | Praha 10 | 10034 | Czechia | Details | ||
| First Affiliated Hosp of College of Med, Zhejiang University | Hangzhou | Zhejiang | 310003 | China | Details | |
| Florida Cancer Specialists | Fort Myers | Florida | 33916-2233 | United States | Details | |
| Florida Cancer Specialists East | West Palm Beach | Florida | 33401 | United States | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore | Roma | 00168 | Italy | Details | ||
| Foothills Medical Centre | Calgary | Alberta | T2N 2T9 | Canada | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98104-2092 | United States | Details | |
| Fujian Provincial Cancer Hospial | Fuzhou | Fujian | 350014 | China | Details | |
| Galilee Medical Center | Nahariya | 22100 | Israel | Details | ||
| Gemeinschaftspraxis Dres. Schöttker & Pretscher, z.Hd. Sophie Enz | Würzburg | 97080 | Germany | Details | ||
| Groupe Jolimont | La Louvière | Hainaut | 7100 | Belgium | Details | |
| Guangxi Medical University Affiliated Tumor Hospital | Nanning | Guangxi | 530021 | China | Details | |
| Henan Cancer Hospital | Zhengzhou | Henan | 450008 | China | Details | |
| Henan Provincial People's Hospital | Zhengzhou | Henan | 450003 | China | Details | |
| Hopital de la Pitie Salpetriere | Paris CEDEX 13 | 75651 | France | Details | ||
| Hopital Saint Eloi | Montpellier Cedex | 34295 | France | Details | ||
| Hopital Saint Louis | Paris | 75010 | France | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital Costa Del Sol | Marbella | Malaga | 29600 | Spain | Details | |
| Hospital de la Santa Creu i Sant Pau | Barcelona | Barcelona [Barcelona] | 8041 | Spain | Details | |
| Hospital Puerta De Hierro | Majadahonda | Madrid | 28222 | Spain | Details | |
| Hospital Universitari i Politecnic La Fe | Valencia | 46026 | Spain | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | Barcelona [Barcelona] | 8035 | Spain | Details | |
| Hospital Universitario Central de Asturias | Oviedo | Asturias | 33011 | Spain | Details | |
| Hospital Universitario de Toledo | Toledo | 45007 | Spain | Details | ||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Infanta Leonor | Madrid | 28031 | Spain | Details | ||
| Hospital Universitario Quironsalud Madrid | Pozuelo de Alarcon | Madrid | 28223 | Spain | Details | |
| Hospital Universitario Virgen Del Rocio | Sevilla | 41013 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hôpital de Pontchaillou | Rennes | Cedex 9 | 35033 | France | Details | |
| ICANS_Institut de Cancerologie Strasbourg Europe | Strasbourg | 67033 | France | Details | ||
| Instytut Hermatologii I Transfuzjologii | Warszawa | Poland | Details | |||
| IRCCS - AOU di Bologna | Bologna | 40138 | Italy | Details | ||
| IRCCS Ospedale San Raffaele | Milano | 20132 | Italy | Details | ||
| Ironwood Physicians, Ironwood Cancer and Research Centers | Chandler | Arizona | 85224 | United States | Details | |
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori | Meldola | Emilia-Romagna | 47014 | Italy | Details | |
| Japanese Foundation for Cancer Research | Koto | Tokyo | 135-8550 | Japan | Details | |
| Jewish General Hospital | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Jiangsu Province Hospital | Nanjing | Nanjing | 210029 | China | Details | |
| Jiangxi Provincial Cancer Hospital | Nanchang | Jiangxi | 330029 | China | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Kaplan Medical Center | Rehovot | HaMerkaz | 7610001 | Israel | Details | |
| Karolinska Universitetssjukhuset i Solna | Stockholm | 17176 | Sweden | Details | ||
| Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1 | Lublin | 20-081 | Poland | Details | ||
| Klinikum Chemnitz GmbH | Chemnitz | Sachsen | 09131 | Germany | Details | |
| Kochi Medical School Hospital | Nankoku | Kochi | 783-8505 | Japan | Details | |
| Kyoto Furitsu Medical University Hospital | Kyoto | 602-8566 | Japan | Details | ||
| Leicester Royal Infirmary | Leicester | LE1 5WW | United Kingdom | Details | ||
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | United States | Details | |
| Luzerner Kantonsspital | Luzern | 6000 | Switzerland | Details | ||
| Mater Misericordiae Hospital | Dublin 7 | Ireland | Details | |||
| Mayo Clinic | Rochester | Minnesota | 55905-0002 | United States | Details | |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | United States | Details | |
| MD Anderson Cancer Center | Madrid | 28033 | Spain | Details | ||
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | Details | |
| MICS Centrum Medyczne Torun | Torun | Pomorskie | 87-100 | Poland | Details | |
| Mission Cancer and Blood | Des Moines | Iowa | 50309 | United States | Details | |
| München Klinik Schwabing | Koelner Platz 1 | München | 80804 | Germany | Details | |
| Nantong Tumor Hospital | Nantong | Jiangsu | 226000 | China | Details | |
| National Cancer Center Hospital | Chuo-ku | Tokyo | 104-0045 | Japan | Details | |
| National Cancer Center Hospital East | Chiba-Ken | 277 8577 | Japan | Details | ||
| National Institute of Oncology | Budapest | 1122 | Hungary | Details | ||
| National Taiwan University Hospital | Taipei | 10002 | Taiwan | Details | ||
| Northwest Cancer Specialists PC | Vancouver | Washington | 98684 | United States | Details | |
| Novant Cancer Institute Charlotte | Charlotte | North Carolina | 28204 | United States | Details | |
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| Oncology Associates of Bridgeport P.C. | Eugene | Oregon | 97401 | United States | Details | |
| Oncology Hematology Care Inc | Cincinnati | Ohio | 45242 | United States | Details | |
| Osaka City General Hospital | Osaka | 534-0021 | Japan | Details | ||
| Ospedale Regionale Bellinzona e Valli | Bellinzona | Ticino | 6500 | Switzerland | Details | |
| Ospedale Santa Croce e Carle | Cuneo | 12100 | Italy | Details | ||
| Peking University First Hospital | Beijing | Beijing | 100034 | China | Details | |
| Peking University People's Hospital | Beijing | Xicheng District | 100044 | China | Details | |
| Peninsula Private Hospital | Frankston | Victoria | 3199 | Australia | Details | |
| Pikeville Medical Center, Inc. | Pikeville | Kentucky | 41501 | United States | Details | |
| Pole Regionalde Cancérologie(CHU de Poitiers) | Politiers | 86021 | France | Details | ||
| Policlinico Umberto I - Haematology | Rome | 00161 | Italy | Details | ||
| Pratia MCM Krakow | Krakow | 30-510 | Poland | Details | ||
| Pratia Onkologia Katowice | Katowice | 40519 | Poland | Details | ||
| Providence Medical Foundation | Santa Rosa | California | 95403 | United States | Details | |
| Rabin Medical Center | Petah Tikva | HaMerkaz | 4941492 | Israel | Details | |
| Regional Medical Oncology Center | Wilson | North Carolina | 27893 | United States | Details | |
| Research Medical Center | Kansas City | Missouri | 64132 | United States | Details | |
| Rigshospitalet | Copenhagen | 2200 | Denmark | Details | ||
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Royal Hobart Hospital | Hobart | Tasmania | 7000 | Australia | Details | |
| Royal Marsden Hospital | London | SW3 6JJ | United Kingdom | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Sarah Cannon Research Institute SCRI | Nashville | Tennessee | 37203 | United States | Details | |
| Scripps Mercy Hospital | San Diego | California | 92111 | United States | Details | |
| Seoul National University Hospital | Seoul | Korea | 03080 | Korea, Republic of | Details | |
| Shanghai Jiaotong University School of Medicine Ruijin Hospital | Shanghai | Shanghai | 200025 | China | Details | |
| Shanghai Tongren Hospital | Shanghai | Shanghai | 200336 | China | Details | |
| Shengjing Hospital of China Medical University | Shenyang | Liaoning | 110004 | China | Details | |
| Singapore General Hospital | Singapore | 169078 | Singapore | Details | ||
| Sir Charles Gairdner Hospital | Perth | Western Australia | 6009 | Australia | Details | |
| Skanes Universitetssjukhus, Hematoloaimottagningen | Lund | 22185 | Sweden | Details | ||
| St James's University Hospital | Leeds | West Yorkshire | LS9 7TF | United Kingdom | Details | |
| St Vincent's Hospital | Melbourne | Victoria | 3065 | Australia | Details | |
| St-Olavs Hospital | Trondheim | 7006 | Norway | Details | ||
| St. Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | United States | Details | |
| Stamford Hospital | Stamford | Connecticut | 06902 | United States | Details | |
| Sunnybrook Research Institute | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Swedish Cancer Institute; STE 1020 | Seattle | Washington | 98104 | United States | Details | |
| Szpitale Pomorskie Sp. z o. o. | Gdynia | Pomorskie | 81-519 | Poland | Details | |
| Tel Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| Tennessee Oncology PLLC | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | United States | Details | |
| The Affiliated Hospital of Inner Mongolia Medical University | Hohhot | Inner Mongolia | 010050 | China | Details | |
| The Affiliated Hospital of Qingdao University | Qingdao City | Shandong | 266555 | China | Details | |
| The Alfred Hospital | Melbourne | Victoria | 3004 | Australia | Details | |
| The First Affiliated Hospital of Anhui Medical University | Hefei | Anhui | 230022 | China | Details | |
| The First Affiliated Hospital Of University Of South China | Hengyang | Hunan | 421001 | China | Details | |
| The First People's Hospital of Yunnan Province | Kunming | Yunnan | 650034 | China | Details | |
| The James Cancer Hospital | Columbus | Ohio | 43210 | United States | Details | |
| The Mount Sinai Hospital | New York | New York | 10029 | United States | Details | |
| The Second Xiangya Hospital of Central South University | Changsha | Hunan | 410008 | China | Details | |
| Tianjin Medical University Cancer Institute and Hospital | Tianjin | Tianjin | 300060 | China | Details | |
| Tokyo Medical and Dental University Hospital | Bunkyo-ku | 113-8519 | Japan | Details | ||
| Uniklinik Köln | Kerpener | Köln | 50937 | Germany | Details | |
| Unimedizin RostockZIM III -Haemtologie | Rostock | 18057 | Germany | Details | ||
| Universitair Ziekenhuis Gent | Gent | Oost-Vlaanderen | 9000 | Belgium | Details | |
| University Hospital Waterford | Waterford | X91 ER8E | Ireland | Details | ||
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| University of California Irvine Medical Center | Orange | California | 92868 | United States | Details | |
| University of Fukui Hospital | Fukui | 9101193 | Japan | Details | ||
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | Details | |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| University of Virginia Health System | Charlottesville | Virginia | 22908-0816 | United States | Details | |
| University of Yamanashi Hospital | Chuo | Yamanshi | 409-3821 | Japan | Details | |
| Universitätsklinikum Leipzig AöR Klinik und Poliklinik für Hämatologie | Leipzig | Saxony | 04103 | Germany | Details | |
| Universtitätsklinikum Essen AöR | Essen | 45147 | Germany | Details | ||
| USO - Texas Oncology - San Antonio | San Antonio | Texas | 78240 | United States | Details | |
| Virginia Cancer Specialists, PC - Lee Highway | Fairfax | Virginia | 22031 | United States | Details | |
| Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | 23298-0070 | United States | Details | |
| Vseobecna fakultni nemocnice v Praze | Praha 2 | 12808 | Czechia | Details | ||
| Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii | Łódź | 93510 | Poland | Details | ||
| Wu Han Tongji Hospital | Wu Han | Hu Bei | 430030 | China | Details | |
| Wuhan Union Hospital | Wuhan | Hubei | 430022 | China | Details | |
| Wuxi People's Hospital | Wuxi | Jiangsu | 214023 | China | Details | |
| Yichang Central People's Hospital | Yichang | Hubei | 443003 | China | Details | |
| Zhongshan City People's Hospital | Zhongshan | Guangdong | 528403 | China | Details |
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