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| NCT ID | NCT04965493 |
| Title | A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (BRUIN CLL-322) |
| Acronym | BRUIN CLL-322 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | SWE | POL | ITA | ISR | IRL | HUN | GBR | FRA | ESP | DNK | DEU | CZE | CHE | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Mitchell Cancer Institute -University of South Alabama | Mobile | Alabama | 36604 | United States | Details | |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | United States | Details | |
| Arizona Oncology Associates, P.C. - HOPE | Tucson | Arizona | 85711 | United States | Details | |
| University of Arizona Cancer Center | Tucson | Arizona | 85724 | United States | Details | |
| Marin Specialty Care, Inc | Greenbrae | California | 94904 | United States | Details | |
| University of California Irvine Medical Center | Orange | California | 92868 | United States | Details | |
| Scripps Mercy Hospital | San Diego | California | 92103 | United States | Details | |
| Sharp Memorial Hospital | San Diego | California | 92123 | United States | Details | |
| Providence Medical Foundation | Santa Rosa | California | 95403 | United States | Details | |
| Stamford Hospital | Stamford | Connecticut | 06904 | United States | Details | |
| Cancer Specialists of North Florida -St Augustine | Jacksonville | Florida | 32256 | United States | Details | |
| BRCR Medical Center, Inc. | Plantation | Florida | 33322 | United States | Details | |
| Florida Cancer Specialists | Tallahassee | Florida | 32308 | United States | Details | |
| Carle Cancer Center | Urbana | Illinois | 61801 | United States | Details | |
| Mission Cancer and Blood | Des Moines | Iowa | 50309 | United States | Details | |
| Central Care Cancer Center - Garden City | Garden City | Kansas | 67846 | United States | Details | |
| Pikeville Medical Center, Inc. | Pikeville | Kentucky | 41501 | United States | Details | |
| American Oncology Partners of Maryland, PA | Bethesda | Maryland | 20817 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | Details | |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details | |
| Mayo Clinic- Rochester | Rochester | Minnesota | 55905 | United States | Details | |
| Central Care Cancer Center | Bolivar | Missouri | 65613 | United States | Details | |
| Summit Health | Florham Park | New Jersey | 07932 | United States | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Morristown Medical Center | Morristown | New Jersey | 07962 | United States | Details | |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10021 | United States | Details | |
| The Mount Sinai Hospital | New York | New York | 10029 | United States | Details | |
| Columbia University Medical Center | New York | New York | 10032 | United States | Details | |
| Westchester Medical College | New York | New York | 10532 | United States | Details | |
| SUNY Upstate Medical Center | Syracuse | New York | 13210 | United States | Details | |
| Clinical Research Alliance | Westbury | New York | 11590 | United States | Details | |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | United States | Details | |
| Novant Cancer Institute - Charlotte | Charlotte | North Carolina | 28204 | United States | Details | |
| Duke University Medical Center | Durham | North Carolina | 27705 | United States | Details | |
| Regional Medical Oncology Center | Wilson | North Carolina | 27893 | United States | Details | |
| Oncology Hematology Care Inc | Cincinnati | Ohio | 45242 | United States | Details | |
| The James Cancer Hospital | Columbus | Ohio | 43210 | United States | Details | |
| Oklahoma Cancer Specialists & Research Institute, LLC | Tulsa | Oklahoma | 74146 | United States | Details | |
| Oncology Associates of Bridgeport P.C. | Eugene | Oregon | 97401 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111-2497 | United States | Details | |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | United States | Details | |
| Houston Methodist Hospital | Houston | Texas | 77030 | United States | Details | |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Baylor Scott and White Medical Center Round Rock | Round Rock | Texas | 78665 | United States | Details | |
| USO - Texas Oncology - San Antonio | San Antonio | Texas | 78240 | United States | Details | |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | United States | Details | |
| Virginia Cancer Specialists, PC - Lee Highway | Fairfax | Virginia | 22031 | United States | Details | |
| Virginia Oncology Associates-Virginia Beach | Norfolk | Virginia | 23502 | United States | Details | |
| Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | 23298-0070 | United States | Details | |
| Virginia Commonwealth University (VCU) Massey Cancer Center | Richmond | Virginia | 843042 | United States | Details | |
| Swedish Cancer Institute; STE 1020 | Seattle | Washington | 98104 | United States | Details | |
| MultiCare Health System Institute for Research and Innovation | Spokane | Washington | 99218 | United States | Details | |
| Northwest Cancer Specialists PC | Vancouver | Washington | 98684 | United States | Details | |
| The Richland Hospital | Waukesha | Wisconsin | 53188 | United States | Details | |
| Border Medical Oncology | Albury | New South Wales | 2640 | Australia | Details | |
| Concord Repatriation General Hospital | Concord | New South Wales | 2139 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia | Details | |
| Flinders Medical Centre | Adelaide | South Australia | 5042 | Australia | Details | |
| Royal Hobart Hospital | Hobart | Tasmania | 7000 | Australia | Details | |
| St. Vincent's Hospital | Fitzroy | Victoria | 3065 | Australia | Details | |
| Peninsula Private Hospital | Frankston | Victoria | 3199 | Australia | Details | |
| The Alfred Hospital | Melbourne | Victoria | 3004 | Australia | Details | |
| Fiona Stanley Hospital | Murdoch | Western Australia | 6150 | Australia | Details | |
| Sir Charles Gairdner Hospital | Nedlands | Western Australia | 6009 | Australia | Details | |
| Universitair Ziekenhuis Gent | Gent | 900 | Belgium | Details | ||
| Groupe Jolimont | Haine-Saint-Paul | 7100 | Belgium | Details | ||
| CHU UCL Namur | Yvoir | 5530 | Belgium | Details | ||
| Foothills Medical Centre | Calgary | Alberta | T2N4N2 | Canada | Details | |
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| BC Cancer Vancouver | Vancouver | British Columbia | V5Z4E6 | Canada | Details | |
| CancerCare Manitoba | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Sunnybrook Research Institute | Toronto | Ontario | M4N3M5 | Canada | Details | |
| Jewish General Hospital | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| The First Affiliated Hospital of Anhui Medical University | Hefei | Anhui | 230022 | China | Details | |
| Peking University First Hospital | Beijing | Beijing | 100034 | China | Details | |
| Fujian Provincial Cancer Hospial | Fuzhou | Fujian | 350014 | China | Details | |
| Cancer Center of Guangzhou Medical University | Guangzhou | Guangdong | 510000 | China | Details | |
| Zhongshan City People's Hospital | Zhongshan | Guangdong | 528403 | China | Details | |
| Guangxi Medical University Cancer Hospital | Nanning | Guangxi | 530021 | China | Details | |
| Henan Provincial People's Hospital | Zhengzhou | Henan | 450003 | China | Details | |
| Henan Cancer Hospital | Zhengzhou | Henan | 450008 | China | Details | |
| Wu Han Tongji Hospital | Wuhan City | Hubei | 430030 | China | Details | |
| Wuhan Union Hospital | Wuhan | Hubei | 430022 | China | Details | |
| Yichang Central People's Hospital | Yichang | Hubei | 443003 | China | Details | |
| The Second Xiangya Hospital of Central South University | Changsha | Hunan | 410011 | China | Details | |
| The First Affiliated Hospital Of University Of South China | Hengshan | Hunan | 421001 | China | Details | |
| The Affiliated Hospital of Inner Mongolia Medical University | Hohhot | Inner Mongolia | 10050 | China | Details | |
| Nantong Tumor Hospital | Nantong | Jiangsu | 226000 | China | Details | |
| Wuxi People's Hospital | Wuxi | Jiangsu | 214023 | China | Details | |
| Jiangxi Provincial Cancer Hospital | Nanchang | Jiangxi | 330029 | China | Details | |
| Shengjing Hospital of China Medical University | Shenyang | Liaoning | 110022 | China | Details | |
| Jiangsu Province Hospital | Nanjing | Nanjing | 210029 | China | Details | |
| The Affiliated Hospital of Qingdao University | Qingdao City | Shandong | 266555 | China | Details | |
| Shanghai Tongren Hospital | Changning District | Shanghai | 200050 | China | Details | |
| Shanghai Jiaotong University School of Medicine Ruijin Hospital | Shanghai | Shanghai | 200025 | China | Details | |
| Tianjin Medical University Cancer Institute and Hospital | Tianjin | Tianjin | 300060 | China | Details | |
| Peking University People's Hospital | Beijing | Xicheng District | 100044 | China | Details | |
| The First People's Hospital of Yunnan Province | Kunming | Yunnan | 650034 | China | Details | |
| First Affiliated Hosp of College of Med, Zhejiang University | Hangzhou | Zhejiang | 310003 | China | Details | |
| Chongqing Cancer Hospital | Chongqing | 400030 | China | Details | ||
| Fakultni nemocnice Brno | Brno | 62500 | Czechia | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | 500 05 | Czechia | Details | ||
| Fakultni nemocnice Kralovske Vinohrady | Praha 10 | 100 34 | Czechia | Details | ||
| Vseobecna fakultni nemocnice v Praze | Praha 2 | 12808 | Czechia | Details | ||
| Rigshospitalet | Copenhagen | 2100 | Denmark | Details | ||
| Institut de Cancérologie de Strasbourg Europe - ICANS | Strasbourg Cedex | Bas Rhin | 67033 | France | Details | |
| Hopital de la Pitie Salpetriere | Paris | Cedex 13 | 75651 | France | Details | |
| CHU de Nantes - Hôtel-Dieu | Nantes | Cedex 1 | 44093 | France | Details | |
| CHU Rennes - Hopital Pontchaillou | Rennes | Cedex 9 | 35033 | France | Details | |
| L'Institut Universitaire du Cancer de Toulouse Oncopole | Toulouse | Cedex 9 | 31100 | France | Details | |
| Centre Hospitalier Lyon Sud | Pierre-Bénite | Cedex | 69495 | France | Details | |
| CHU Limoges | Limoges | France Cédex | 87042 | France | Details | |
| Hopital Saint Eloi | Montpellier Cedex 5 | Herault | 34295 | France | Details | |
| Hôpital Saint-Louis | Paris cedex 10 | Paris | 75010 | France | Details | |
| Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen | Rouen | Seine-Maritime | 76038 | France | Details | |
| CHRU De Tours | Tours | Tours Cedex 9 | 37044 | France | Details | |
| Pole Regionalde Cancérologie(CHU de Poitiers) | Politiers | Vienne | 86021 | France | Details | |
| Centre Hospitalier du Mans | Le Mans | 72000 | France | Details | ||
| CHU de Nancy - Hôpital de Brabois Adultes | Vandœuvre-lès-Nancy | 54500 | France | Details | ||
| Muenchen Klinikum Schwabing | München | Bayern | 80804 | Germany | Details | |
| Unimedizin RostockZIM III -Haemtologie | Rostock | Mecklenburg Vorpommern | 18057 | Germany | Details | |
| Universitaetsklinikum Koeln | Koeln | Nordrhein Westfalen | 50937 | Germany | Details | |
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz | Mainz | Rheinland Pfalz | 55131 | Germany | Details | |
| Klinikum Chemnitz gGmbH | Chemnitz | Sachsen | 09116 | Germany | Details | |
| Universitätsklinikum Leipzig AöR Klinik und Poliklinik für Hämatologie | Leipzig | Sachsen | 4103 | Germany | Details | |
| Universitätsklinikum Schleswig-Holstein | Kiel | Schleswig-Holstein | 24105 | Germany | Details | |
| Charité - Hämatologie - Onkologie - Tumorimmunologie, CC14 - Campus Benjamin Franklin | Berlin | 12203 | Germany | Details | ||
| Universtitätsklinikum Essen AöR | Essen | 45147 | Germany | Details | ||
| Gemeinschaftspraxis Dres. Schöttker & Pretscher, z.Hd. Sophie Enz | Würzburg | 97080 | Germany | Details | ||
| National Institute of Oncology | Budapest | 1122 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Kozpont | Debrecen | 4032 | Hungary | Details | ||
| Kaposi Mor Oktato Korhaz | Kaposvar | 7400 | Hungary | Details | ||
| Mater Misericordiae University Hospital | Dublin | D07 R2WY | Ireland | Details | ||
| University Hospital Waterford | Waterford | X91 ER8E | Ireland | Details | ||
| Bnai Zion Medical Center | Haifa | 3339419 | Israel | Details | ||
| Galilee Medical Center | Naharia | 2210010 | Israel | Details | ||
| Rabin Medical Center-Beilinson Campus | Petah-Tikva | 4941492 | Israel | Details | ||
| Kaplan Medical Center | Reẖovot | 76100 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS | Bologna | 40138 | Italy | Details | ||
| Azienda Ospedaliera di Catanzaro "Pugliese-Ciaccio" | Catanzaro | 88100 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Arcispedale Sant'Anna | Cona | 44124 | Italy | Details | ||
| Azienda Ospedaliera Santa Croce e Carle | Cuneo | 12100 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Careggi | Firenze | 50134 | Italy | Details | ||
| IRCCS Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" - IRST | Meldola | 47014 | Italy | Details | ||
| Ospedale San Raffaele | Milano | 20132 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda) | Milano | 20162 | Italy | Details | ||
| A.O.U. Policlinico di Modena | Modena | 41124 | Italy | Details | ||
| Azienda Ospedale Maggiore Della Carita | Novara | 28100 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza | Roma | 00161 | Italy | Details | ||
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore | Roma | 00168 | Italy | Details | ||
| Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino | Torino | 10126 | Italy | Details | ||
| Nagoya City University Hospital | Nagoya-shi | Aichi-Ken | 467-8602 | Japan | Details | |
| NHO Nagoya Medical Center | Nagoya | Aichi | 460-0001 | Japan | Details | |
| Hokkaido University Hospital | Sapporo | Hokkaido | 060-8648 | Japan | Details | |
| Kanagawa cancer center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Kochi Medical School Hospital | Nankoku | Kochi | 783-8505 | Japan | Details | |
| Kyoto Furitsu Medical University Hospital | Kyoto-shi | Kyoto | 602-8566 | Japan | Details | |
| Tohoku University Hospital | Sendai-shi | Miyagi | 980-8574 | Japan | Details | |
| Kindai University Hospital | Osaka Sayama-shi | Osaka | 589 8511 | Japan | Details | |
| Saitama Medical Center | Kawagoe-shi | Saitama-Ken | 350-8550 | Japan | Details | |
| National Cancer Center Hospital | Chuo-ku | Tokyo | 104-0045 | Japan | Details | |
| Japanese Foundation for Cancer Research | Koto | Tokyo | 135-8550 | Japan | Details | |
| Ome Municipal General Hospital | Ome | Tokyo | 198-0042 | Japan | Details | |
| NTT Medical Center Tokyo | Shinagawa-Ku | Tokyo | 141-8625 | Japan | Details | |
| University of Yamanashi Hospital | Chuo | Yamanshi | 409-3821 | Japan | Details | |
| National Cancer Center Hospital East | Chiba-Ken | 277 8577 | Japan | Details | ||
| University of Fukui Hospital | Fukui | 9101193 | Japan | Details | ||
| Kumamoto University Hospital | Kumamoto | 860-8556 | Japan | Details | ||
| Niigata University Medical & Dental Hospital | Niigata | 951-8520 | Japan | Details | ||
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| Osaka City General Hospital | Osaka | 534-0021 | Japan | Details | ||
| KKR Mishuku Hospital | Tokyo-To | 153 0051 | Japan | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | Seoul-teukbyeolsi [Seoul] | 03722 | Korea, Republic of | Details | |
| The Catholic University of Korea-Seoul St. Mary's Hospital | Seocho-Gu | Seoul | 06591 | Korea, Republic of | Details | |
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| MICS Centrum Medyczne Torun | Torun | Kujawsko-pomorskie | 87-100 | Poland | Details | |
| Szpitale Pomorskie spółka z ograniczoną odpowiedzialnością | Gdynia | Pomorskie | 81-519 | Poland | Details | |
| Pratia Onkologia Katowice | Katowice | 40519 | Poland | Details | ||
| Pratia MCM Krakow | Krakow | 30-510 | Poland | Details | ||
| Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1 | Lublin | 20-081 | Poland | Details | ||
| Instytut Hematologii i Transfuzjologii | Warszawa | 02-776 | Poland | Details | ||
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi | Łódź | 93510 | Poland | Details | ||
| Auxilio Mutuo Cancer Center | San Juan | 00917 | Puerto Rico | Details | ||
| Singapore General Hospital | Singapore | 169608 | Singapore | Details | ||
| National Cancer Centre Singapore | Singapore | 169610 | Singapore | Details | ||
| Hospital Universitario Central de Asturias | Oviedo | Asturias | 33011 | Spain | Details | |
| Hospital de la Santa Creu i Sant Pau | Barcelona | Barcelona [Barcelona] | 8041 | Spain | Details | |
| Hospital Universitario de Toledo | Toledo | Castilla La Mancha | 45004 | Spain | Details | |
| Hospital Universitario Puerta de Hierro Majadahonda | Majadahonda | Madrid | 28222 | Spain | Details | |
| Hospital Costa Del Sol | Marbella | Malaga | 29603 | Spain | Details | |
| CEIC Área 2 - Hospital Universitario de La Princesa | Salamanca | Mandrid | 28006 | Spain | Details | |
| Hospital Universitario Quironsalud Madrid | Madrid | Pozuelo De Alarcón | 28223 | Spain | Details | |
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital Universitari Vall d'Hebron | Barcelona | 8035 | Spain | Details | ||
| Hospital Universitario Infanta Leonor | Madrid | 28031 | Spain | Details | ||
| MD Anderson Cancer Center | Madrid | 28033 | Spain | Details | ||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hospital Universitario Virgen del Rocío | Sevilla | 41013 | Spain | Details | ||
| Hospital Universitari i Politecnic La Fe | Valencia | 46026 | Spain | Details | ||
| Skanes Universitetssjukhus, Hematoloaimottagningen | Lund | 22185 | Sweden | Details | ||
| Karolinska Universitetssjukhuset i Solna | Stockholm | 17164 | Sweden | Details | ||
| Kliniska forsknings- och utvecklingsenheten | Uppsala | 75185 | Sweden | Details | ||
| Ospedale Regionale Bellinzona e Valli | Bellinzona | Ticino | 6500 | Switzerland | Details | |
| Luzerner Kantonsspital - Luzern | Luzern | 6000 | Switzerland | Details | ||
| Chang Gung Memorial Hospital - Linkou | Guei Shan Township | Taoyuan City | 333 | Taiwan | Details | |
| National Taiwan University Hospital | Taipei | 10002 | Taiwan | Details | ||
| Derriford Hospital | Plymouth | Devon | PL6 8DH | United Kingdom | Details | |
| Leicester Royal Infirmary | Leicester | England | LE15WW | United Kingdom | Details | |
| Birmingham Heartlands Hospital | Birmingham | West Midlands | B9 5SS | United Kingdom | Details | |
| St James's University Hospital | Leeds | West Yorkshire | LS97TF | United Kingdom | Details | |
| Churchill Hospital | Oxford | OX3 7LJ | United Kingdom | Details | ||
| Royal Marsden Hospital | Surrey | SM2 5PT | United Kingdom | Details |