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| NCT ID | NCT05020665 |
| Title | A Study to Assess the Efficacy and Safety of Entospletinib in Combination With Intensive Induction and Consolidation Chemotherapy in Adults With Newly Diagnosed Nucleophosmin 1-mutated Acute Myeloid Leukemia |
| Recruitment | Terminated |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Kronos Bio |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | POL | ITA | ISR | HUN | FRA | ESP | DEU | CZE | CAN | BRA |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| City of Hope | Duarte | California | 91010 | United States | Details | |
| UCLA - Jonsson Comprehensive Cancer Center | Los Angeles | California | 90095 | United States | Details | |
| Indiana Blood & Marrow Transplantation | Indianapolis | Indiana | 46237 | United States | Details | |
| University of Michigan Medical School | Ann Arbor | Michigan | 48109 | United States | Details | |
| Henry Ford Health System | Detroit | Michigan | 48202 | United States | Details | |
| Mount Sinai Health System | New York | New York | 10029 | United States | Details | |
| Duke Cancer Institute | Durham | North Carolina | 27710 | United States | Details | |
| Hollings Cancer Center | Charleston | South Carolina | 29425 | United States | Details | |
| Bon Secours St. Francis Cancer Center | Greenville | South Carolina | 29607 | United States | Details | |
| Baylor University Medical Center | Dallas | Texas | 75246 | United States | Details | |
| Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer | Curitiba | 81520-060 | Brazil | Details | ||
| Hospital Universitário Walter Cantídio | Fortaleza | 60430-372 | Brazil | Details | ||
| Hospital Amaral Carvalho | Jaú | 17210-120 | Brazil | Details | ||
| Hospital de Clínicas de Porto Alegre | Porto Alegre | 90035-903 | Brazil | Details | ||
| Irmandade da Santa Casa de Misericórdia Hospital - Porto Alegre | Porto Alegre | 90050-170 | Brazil | Details | ||
| Instituto Nacional de Câncer - Brazil | Rio De Janeiro | 20 580-120 | Brazil | Details | ||
| Hospital de Base - São José do Rio Preto | Rio Preto | 15090-000 | Brazil | Details | ||
| A Beneficência Portuguesa de São Paulo - Unidade Mirante | São Paulo | 01321001 | Brazil | Details | ||
| Instituto Brasileiro de Controle do Câncer - São Camilo Oncologia - Unidade Mooca | São Paulo | 03102-002 | Brazil | Details | ||
| Juravinski Hospital | Hamilton | L8V 5C2 | Canada | Details | ||
| Saskatchewan Cancer Agency | Saskatoon | S7N 4H4 | Canada | Details | ||
| Princess Margaret Cancer Centre | Toronto | M5G 1X6 | Canada | Details | ||
| Fakultni Nemocnice Brno | Brno | 625 00 | Czechia | Details | ||
| Fakultní Nemocnice Hradec Králové | Hradec Králové | 500 05 | Czechia | Details | ||
| Fakultní Nemocnice Královské Vinohrady | Praha | 100 34 | Czechia | Details | ||
| Hôpital Côte De Nacre | Caen | Calvados | 14000 | France | Details | |
| Centre Hosptitalier Universitaire d'Angers | Angers | 49933 | France | Details | ||
| Hôpital Claude Huriez | Lille | 59000 | France | Details | ||
| Hôpital l'Archet | Nice | CS23079 - 06202 | France | Details | ||
| Hôpital Saint-Antoine | Paris | 75012 | France | Details | ||
| Hôpital Saint-Louis | Paris | 75475 | France | Details | ||
| Hôpital Necker-Enfants Malades | Paris | 75743 | France | Details | ||
| Centre Hospitalier Lyon-Sud | Pierre-Bénite | 69310 | France | Details | ||
| Centre de Lutte Contre le Cancer - Centre Henri-Becquerel | Rouen | 76038 | France | Details | ||
| Städtisches Klinikum Braunschweig | Braunschweig | 38114 | Germany | Details | ||
| Helios St. Johannes Klinik | Duisburg | 47166 | Germany | Details | ||
| Marien Hospital Düsseldorf | Düsseldorf | 40479 | Germany | Details | ||
| Medizinische Hochschule Hannover | Hanover | 30625 | Germany | Details | ||
| Universitätsmedizin Mannheim | Mannheim | 68167 | Germany | Details | ||
| Universitätsklinikum Münster | Münster | 48149 | Germany | Details | ||
| Semmelweis Egyetem | Budapest | 1083 | Hungary | Details | ||
| Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet | Budapest | 1097 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Központ | Debrecen | 4032 | Hungary | Details | ||
| Jósa András Oktatókórház | Nyíregyháza | 4400 | Hungary | Details | ||
| Szent-Györgyi Albert Klinikai Központ | Szeged | 6725 | Hungary | Details | ||
| Samson Assuta Ashdod University Hospital | Ashdod | 7747629 | Israel | Details | ||
| Shamir Medical Center (Assaf Harofeh) | Be'er Ya'aqov | 7030000 | Israel | Details | ||
| Rambam Health Care Campus | Haifa | 3109601 | Israel | Details | ||
| Hadassah University Hospital Ein Kerem | Jerusalem | 9112001 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 62431 | Israel | Details | ||
| Assuta Hospital - Ramat HaHayal | Tel Aviv | 69710 | Israel | Details | ||
| Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele | Catania | Sicily | 95123 | Italy | Details | |
| Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari | Bari | 70124 | Italy | Details | ||
| Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi | Bologna | 40138 | Italy | Details | ||
| Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico | Milano | 20122 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda | Milan | 20162 | Italy | Details | ||
| Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara | Novara | 28100 | Italy | Details | ||
| Ospedale Santa Maria delle Croci di Ravenna | Ravenna | 48121 | Italy | Details | ||
| Kyungpook National University Hospital | Daegu | 41944 | Korea, Republic of | Details | ||
| Daegu Catholic University Medical Center | Daegu | 42472 | Korea, Republic of | Details | ||
| Keimyung University Dongsan Hospital | Daegu | 42601 | Korea, Republic of | Details | ||
| Chungnam National University Hospital | Daejeon | 35015 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Incheon | 03080 | Korea, Republic of | Details | ||
| Gachon University Gil Medical Center | Incheon | 21565 | Korea, Republic of | Details | ||
| Severance Hospital | Seoul | 03722 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Catholic University of Korea Seoul Saint Mary's Hospital | Seoul | 06591 | Korea, Republic of | Details | ||
| Korea University Guro Hospital | Seoul | 08308 | Korea, Republic of | Details | ||
| Uniwersyteckie Centrum Kliniczne w Gdańsku | Gdańsk | 80-214 | Poland | Details | ||
| Samodzielny Publiczny Szpital Kliniczny Nr im. Prof. Tadeusza Sokołowskiego | Szczecin | 71-252 | Poland | Details | ||
| Uniwersyteckie Centrum Kliniczne WUM - Centralny Szpital Kliniczny | Warsaw | 02-097 | Poland | Details | ||
| Instytut Hematologii I Transfuzjologii | Warsaw | 02-776 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu | Wrocław | 50-367 | Poland | Details | ||
| Hospital Germans Trias i Pujol | Badalona | Catalonia | 08916 | Spain | Details | |
| Institut D'Investigacions Biomédiques August Pi I Sunyer | Barcelona | 08036 | Spain | Details | ||
| Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet) | Barcelona | 08908 | Spain | Details | ||
| Hospital San Pedro de Alcantara | Cáceres | 10003 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañón | Madrid | 28007 | Spain | Details | ||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Central de Asturias | Oviedo | 33011 | Spain | Details | ||
| Hospital Son Llàtzer | Palma De Mallorca | 07198 | Spain | Details | ||
| Hospital Clínico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Hospital Universitari I Politecnic La Fe | Valencia | 46026 | Spain | Details |