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| NCT ID | NCT05063786 |
| Title | Trastuzumab + Alpelisib +/- Fulvestrant vs Trastuzumab + CT in Patients With PIK3CA Mutated Previously Treated HER2+ Advanced BrEasT Cancer (ALPHABET) (ALPHABET) |
| Acronym | ALPHABET |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Spanish Breast Cancer Research Group |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | NLD | ITA | FRA | ESP | CHE | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Medizinische Universität Innsbruck - Univ.Klinik f. Frauenheilkunde Innsbruck | Innsbruck | Austria | Details | |||
| LKH Hochsteiermark - Leoben | Leoben | Austria | Details | |||
| Ordensklinikum Linz GmbH - BHS | Linz | Austria | Details | |||
| Universitätsklinikum St. Pölten | Pölten | Austria | Details | |||
| Pyhrn - Eisenwurzen Klinikum Steyr | Steyr | Austria | Details | |||
| Klinik Hietzing Wien | Wien | Austria | Details | |||
| Klinik Ottakring | Wien | Austria | Details | |||
| Medizinische Universität Wien - Univ.klinikum AKH Wien | Wien | Austria | Details | |||
| Centre d'Oncologie et Radiothérapie 37 | Chambray-lès-Tours | France | Details | |||
| Centre Jean Perrin | Clermont-Ferrand | France | Details | |||
| Centre Régional De Lutte Contre Le Cancer Georges-François Leclerc | Dijon | France | Details | |||
| Centre hospitalier universitaire à Limoges | Limoges | France | Details | |||
| Institut Curie Hospital | Paris | France | Details | |||
| Centre hospitalier universitaire de Poitiers | Poitiers | France | Details | |||
| Institute Curie - Site Saint-Cloud | Saint-Cloud | 92210 | France | Details | ||
| A.O. "SS Antonio e Biagio e Cesare Arrigo" | Alessandria | Italy | Details | |||
| Clinica Oncologica, AOU Riuniti | Ancona | Italy | Details | |||
| Ospedale di Bolzano Azienda Sanitaria Alto Adige | Bolzano | Italy | Details | |||
| Ospedale MultiMedica Castellanza | Castellanza | Italy | Details | |||
| Cannizzaro Hospital | Catania | Italy | Details | |||
| ASST Cremona | Cremona | Italy | Details | |||
| Azienda Ospedaliero-Universitaria Careggi, University of Florence | Florence | Italy | Details | |||
| IRCCS Policlinico San Martino | Genoa | Italy | Details | |||
| Mater Salutis Hospital | Legnago | Italy | Details | |||
| ASST-Mantova- Hospital Carlo Poma | Mantova | Italy | Details | |||
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei tumori | Meldola | Italy | Details | |||
| IEO - Istituto Europeo di Oncologia | Milano | Italy | Details | |||
| IRCCS Ospedale San Raffaele | Milan | Italy | Details | |||
| Ospedali Riuniti Monselice Padova | Monselice | Italy | Details | |||
| AOU Maggiore della Caritá | Novara | Italy | Details | |||
| Casa di Cura La Maddalena S.P.A. | Palermo | Italy | Details | |||
| Azienda Ospedaliero-Universitaria di Parma | Parma | Italy | Details | |||
| Istituti Clinici Scientifici Maugeri SpA-SB | Pavia | Italy | Details | |||
| AUSL Romagna/Oncology Department | Rimini | Italy | Details | |||
| Istituti Fisioterapici ospitaliersi - IFO - Istituti Regina Elena | Roma | Italy | Details | |||
| Policlinico Umberto I | Roma | Italy | Details | |||
| UOSD AUSL Modena | Sassuolo | Italy | Details | |||
| Santa Chiara Hospital | Trento | Italy | Details | |||
| Sant'Anna Hospital - Città della salute e della scienza | Turin | Italy | Details | |||
| Department of Oncology, ASUFC, PO Sm Misericordia | Udine | Italy | Details | |||
| Radboud Medical Center | Nijmegen | Güeldres | 6525 GA | Netherlands | Details | |
| Meander Medisch Centrum | Amersfoort | Netherlands | Details | |||
| HagaZiekenhuis | Den Haag | Netherlands | Details | |||
| Adrz Medisch Centrum | Goes | Netherlands | Details | |||
| Martini Ziekenhuis | Groningen | Netherlands | Details | |||
| Maastricht UMC | Maastricht | Netherlands | Details | |||
| ZorgSaam Ziekenhuis | Terneuzen | Netherlands | Details | |||
| Diakonessenhuis Utrecht | Utrecht | Netherlands | Details | |||
| VieCuri Medisch Centrum | Venlo | Netherlands | Details | |||
| Centro Oncoloxico de Galicia | A Coruña | Spain | Details | |||
| Complexo Hospitalario Universitario A Coruña | A Coruña | Spain | Details | |||
| Hospital Clínico Universitario de Santiago CHUS | A Coruña | Spain | Details | |||
| Complejo Hospitalario Universitario de Albacete | Albacete | Spain | Details | |||
| Hospital General Universitario de Alicante | Alicante | Spain | Details | |||
| Hospital Universitario de Badajoz | Badajoz | Spain | Details | |||
| ICO Badalona - Hospital Universitario Germans Trias i Pujol | Badalona | Spain | Details | |||
| Hospital Clínic de Barcelona | Barcelona | Spain | Details | |||
| Hospital de La Santa Creu I Sant Pau | Barcelona | Spain | Details | |||
| Hospital del Mar | Barcelona | Spain | Details | |||
| Hospital Universitario Basurto | Bilbao | 48013 | Spain | Details | ||
| Hospital Galdakao-Usansolo | Bilbao | Spain | Details | |||
| Hospital Universitario de Cruces | Bilbao | Spain | Details | |||
| Hospital Universitario Puerta del Mar | Cadiz | Spain | Details | |||
| Hospital San Pedro de Alcántara | Cáceres | Spain | Details | |||
| Hospital Universitario Donostia | Donostia | Spain | Details | |||
| Hospital General Universitario de Elche | Elche | Spain | Details | |||
| ICO de Girona - Hospital Josep Trueta | Girona | Spain | Details | |||
| Hospital Universitario Clínico San Cecilio | Granada | Spain | Details | |||
| Hospital Universitario Virgen de las Nieves | Granada | Spain | Details | |||
| Hospital Universitario Juan Ramón Jiménez | Huelva | Spain | Details | |||
| Hospital Universitario de Jaen | Jaén | Spain | Details | |||
| Hospital Universitario de Jerez de la Frontera | Jerez De La Frontera | Spain | Details | |||
| Hospital Universitario Arnau de Vilanova de Lleida | Lleida | Spain | Details | |||
| Hospital Universitario Lucus Augusti | Lugo | Spain | Details | |||
| Hospital Universitario Fundación Jiménez Díaz | Madrid | 28040 | Spain | Details | ||
| Hospital Clínico San Carlos | Madrid | Spain | Details | |||
| Hospital General Universitario Gregorio Marañon | Madrid | Spain | Details | |||
| Hospital Universitario de Fuenlabrada | Madrid | Spain | Details | |||
| Hospital Universitario HM Sanchinarro - CIOCC Clara Campal | Madrid | Spain | Details | |||
| Hospital Universitario Puerta de Hierro Majadahonda | Madrid | Spain | Details | |||
| Hospital Universitario Ramon Y Cajal | Madrid | Spain | Details | |||
| Hospital Universitario Severo Ochoa | Madrid | Spain | Details | |||
| Althaia Xarxa Assistencial de Manresa | Manresa | Spain | Details | |||
| Hospital de Mataró | Mataró | Spain | Details | |||
| Hospital Clinico Universitario Virgen de La Arrixaca | Murcia | Spain | Details | |||
| Hospital Universitario Regional de Malaga | Málaga | Spain | Details | |||
| Hospital Universitario Son Espases | Palma De Mallorca | Spain | Details | |||
| Hospital Universitario Son Llatzer | Palma De Mallorca | Spain | Details | |||
| Complejo Hospitalario de Navarra | Pamplona | Spain | Details | |||
| Corporació Sanitaria Parc Taulí | Sabadell | Spain | Details | |||
| Hospital Universitario Virgen de Valme | Sevilla | Spain | Details | |||
| Hospital Universitario Virgen Del Rocio | Sevilla | Spain | Details | |||
| Hospital Universitario Virgen Macarena | Sevilla | Spain | Details | |||
| Hospital Universitario Sant Joan de Reus | Tarragona | Spain | Details | |||
| Hospital Universitario de Canarias | Tenerife | Spain | Details | |||
| Hospital Universitario Nuestra Señora de la Candelaria | Tenerife | Spain | Details | |||
| Hospital de Terrassa - Consorci Sanitari de Terrassa | Terrassa | Spain | Details | |||
| Hospital Virgen de la Salud | Toledo | Spain | Details | |||
| Consorcio Hospital General Universitario de Valencia | Valencia | Spain | Details | |||
| Hospital Clínico Universitario de Valencia | Valencia | Spain | Details | |||
| Hospital Universitario Arnau de Vilanova de Valencia | Valencia | Spain | Details | |||
| Hospital Provincial de Zamora (Complejo Asistencial de Zamora) | Zamora | Spain | Details | |||
| Hospital Universitario Miguel Servet | Zaragoza | Spain | Details | |||
| Tumor Zentrum Aarau | Aarau | Switzerland | Details | |||
| Inselspital, Universitätsspital Bern | Berne | Switzerland | Details | |||
| Centre du sein Fribourg | Fribourg | Switzerland | Details |