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| NCT ID | NCT05079230 |
| Title | Study Evaluating the Safety and Effectiveness Magrolimab Versus Placebo in Combination With Venetoclax and Azacitidine in Participants With Acute Myeloid Leukemia (AML) (ENHANCE-3) |
| Acronym | ENHANCE-3 |
| Recruitment | Terminated |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Gilead Sciences |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | POL | NOR | NLD | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | United States | Details | |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | United States | Details | |
| Community Cancer Institute | Fresno | California | 93730 | United States | Details | |
| UC Irvine Health- Chao Family Comprehensive Cancer Center | Orange | California | 92868 | United States | Details | |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | United States | Details | |
| Moffitt Cancer Center | Tampa | Florida | 33612 | United States | Details | |
| Loyola University Medical Center | Maywood | Illinois | 60153 | United States | Details | |
| Parkview Research Center | Fort Wayne | Indiana | 46845 | United States | Details | |
| Indiana Blood and Marrow Transplantation - Clinic | Indianapolis | Indiana | 46237 | United States | Details | |
| The University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | United States | Details | |
| University of Maryland, Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | United States | Details | |
| University of Massachusetts Worcester | Worcester | Massachusetts | 01655 | United States | Details | |
| MidAmerica Division, Inc., c/o Research Medical Center | Kansas City | Missouri | 64132 | United States | Details | |
| SSM Health Saint Louis University Hospital | Saint Louis | Missouri | 63110 | United States | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | United States | Details | |
| New York-Presbyterian/Weill Cornell Medical Center | New York | New York | 10021 | United States | Details | |
| Icahn School of Medicine at Mount Sinai and The Mount Sinai Hospital | New York | New York | 10029 | United States | Details | |
| University of Rochester Medical Center | Rochester | New York | 14642 | United States | Details | |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | United States | Details | |
| Novant Health Cancer Institute Hematology- Charlotte | Charlotte | North Carolina | 28204 | United States | Details | |
| Novant Health Cancer Institute Hematology - Forsyth | Winston-Salem | North Carolina | 27103 | United States | Details | |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27103 | United States | Details | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | United States | Details | |
| OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | United States | Details | |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | United States | Details | |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | United States | Details | |
| West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | United States | Details | |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | United States | Details | |
| Baylor University Medical Center | Dallas | Texas | 75246 | United States | Details | |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | United States | Details | |
| Houston Methodist Hospital Cancer Center | Houston | Texas | 77030 | United States | Details | |
| MD Anderson Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Intermountain Health - LDS Hospital | Salt Lake City | Utah | 84143 | United States | Details | |
| Virginia Mason Franciscan Health | Seattle | Washington | 98101 | United States | Details | |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | United States | Details | |
| Froedtert Hospital and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Canberra Hospital | Woden | Australian Capital Territory | 2606 | Australia | Details | |
| Border Medical Oncology Research Unit | Albury | New South Wales | 2640 | Australia | Details | |
| Concord Repatriation General Hospital | Concord | New South Wales | 2139 | Australia | Details | |
| Liverpool Hospital | Liverpool | New South Wales | 2170 | Australia | Details | |
| St George Hospital, Clinical Research Unit Haemotology, Division of Cancer Services | Sydney | New South Wales | 2217 | Australia | Details | |
| Gold Coast University Hospital | Southport | Queensland | 4215 | Australia | Details | |
| Monash University, Eastern Health-Box Hill Hospital | Box Hill | Victoria | 3128 | Australia | Details | |
| Northern Health | Epping | Victoria | 3076 | Australia | Details | |
| Peter MacCallum Cancer Centre | Melbourne | Victoria | 3000 | Australia | Details | |
| Ordensklinikum Linz GmbH Elisabethinen | Linz | Austria | Details | |||
| Hanusch Krankenhaus | Vienna | 1140 | Austria | Details | ||
| Wiener Gesundheitsverbund, Klinik Hietzing | Wien | 1130 | Austria | Details | ||
| Ziekenhuis Netwerk Antwerp (ZNA) - Stuivenberg | Antwerp | 2060 | Belgium | Details | ||
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium | Details | ||
| University Hospital Gent | Gent | 9000 | Belgium | Details | ||
| Hopital de Jolimont | Haine-Saint-Paul | 7100 | Belgium | Details | ||
| University Hospital Leuven (UZ Leuven) - Campus Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| Centre Hospitalier Universitaire de Liege | Liege | 4000 | Belgium | Details | ||
| Queen Elizabeth II (QEII) Health Sciences Centre | Halifax | B3H 1V7 | Canada | Details | ||
| Centre Integre Universitaire de Sante et de Services Sociaux(CIUSSS) de l'Est-de-L'Ile-de- Montreal - Hopital Maisonneuve-Rosemont | Montreal | H1T 2M4 | Canada | Details | ||
| Princess Margaret Cancer Centre - University Health Network | Toronto | M5G 2M9 | Canada | Details | ||
| CancerCare Manitoba | Winnipeg | R3E 0V9 | Canada | Details | ||
| Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika FN Brno a LF MU | Jihormoravsky KRAJ | 625 00 | Czechia | Details | ||
| Fakultni nemocine Olomouc, Hemato-onkologicka klinika | Olomouc | 77520 | Czechia | Details | ||
| Fakultni nemocnice Ostrava, Klinika hematoonkologie | Ostrava | 70852 | Czechia | Details | ||
| Fakulti nemocnice Kralovske Vinohrady, Internf hematologicka klinika FNKV a 3. LF UK | Prague | 100 34 | Czechia | Details | ||
| Vseobecna fakultni nemocnice v Praze, Fakultni poliklinika, Hematologicka ambulance | Praha 2 | 128 08 | Czechia | Details | ||
| CHU Amiens Picardie | Amiens Cedex 1 | 80054 | France | Details | ||
| CHU d'Angers | Angers | 49033 | France | Details | ||
| Hopital Avicenne | Bobigny | 93000 | France | Details | ||
| Hopitaux Universitaires Henri Mondor | Creteil | 94010 | France | Details | ||
| Centre Hospitalier Universitaire Grenoble Alpes | La Tronche | 38700 | France | Details | ||
| Centre Hospitalier de Versailles | Le Chesnay Cedex | 78157 | France | Details | ||
| Hôpital Claude Huriez (CHRU de Lillle) | Lille Cedex | 59037 | France | Details | ||
| Centre Leon Berard | Lyon Cedex 08 | 69373 | France | Details | ||
| Centre Hospitalier Universitaire Nantes - Hotel Dieu | Nantes | 44093 | France | Details | ||
| Hopital Saint-Louis | Paris | 75010 | France | Details | ||
| Centre Hospitalier Lyon-Sud (CHLS) | Pierre-Bénite | 69495 | France | Details | ||
| Institut de Cancérologie Strasbourg Europe (ICANS) | Strasbourg | 67033 | France | Details | ||
| Institut Universitaire du Cancer de Toulouse (IUCT)-Oncopole | Toulouse | 31059 | France | Details | ||
| CHU de Nancy - Hopitaux de Brabois | Vandoeuvre-les-Nancy | 54500 | France | Details | ||
| Charite - Universitatsmedizin Berlin, Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt Hamatologie, Onkologie und Tumorimmunologie | Berlin | 13353 | Germany | Details | ||
| Universitätsklinikum Bonn | Bonn | 53127 | Germany | Details | ||
| Städtisches Klinikum Braunschweig GmbH Medizinische Klinik III/Hämatologie und Onkologie | Braunschweig | 38114 | Germany | Details | ||
| Universitatsklinikum Dusseldorf, Klink fur Hamatologie, Onkologie und Klinische Immunologie | Dusseldorf | 40225 | Germany | Details | ||
| Marien Hospital Dusseldorf GmbH, Klinik Fur Onkologie, Hamatologie Und Palliativmedizin | Düsseldorf | 40479 | Germany | Details | ||
| Malteser Krankenhaus St. Franziskus Hospital,Med.Klinik I | Flensburg | 24939 | Germany | Details | ||
| Universitatsklinikum Frankfurt Goethe Universitat Med. Klink II | Frankfurt | 60590 | Germany | Details | ||
| Asklepios Klink St.Georg | Hamburg | 20099 | Germany | Details | ||
| Medizinische Hochschule Hannover, Hamatologie, Hamostaseologie, Onkologie und Stammzelltrandsplantation | Hannover | 30625 | Germany | Details | ||
| Universitätsklinikum Magdeburg | Magdeburg | 39120 | Germany | Details | ||
| Johannes Wesling Klinikum Minden Universitätsklinik fur Hämatologie, Onkologie, Hämostaseologie und Pastativrndezin, Universitatsklinik der Ruhr-Unive | Minden | 32429 | Germany | Details | ||
| Klinikum rechts der Isar Technischen Universitat Munchen | Muenchen | 81675 | Germany | Details | ||
| Klinikum Oldenburg, Rahel-Straus-Straße 10 | Oldenburg | 26133 | Germany | Details | ||
| Universitatsklinikum Regensburg, Klink fur Innere Medizin III | Regensburg | 93053 | Germany | Details | ||
| Universitatsklinikum Ulm, Zentrum fur Innere Medizin, Klinik fur Innere Medizin III | Ulm | 89070 | Germany | Details | ||
| Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital | Hong Kong | Hong Kong | Details | |||
| Princess Margaret Hospital | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital | Hong Kong | Hong Kong | Details | |||
| Tuen Mun Hospital | Hong Kong | Hong Kong | Details | |||
| Semmelweis Egyetem Belgyogyaszati es Hematologiai Klinika | Budapest | 1083 | Hungary | Details | ||
| Petz Aladár Egyetemi Oktató Kórház II. Belgyógyaszat - Haematológia | Gyor | 9024 | Hungary | Details | ||
| Debreceni Egyetem Klinikai Központ Belgyogyaszati Klinika B epulet Hematologia | Hajdu-bihar | 4032 | Hungary | Details | ||
| Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Kozpont | Szeged | 6725 | Hungary | Details | ||
| Rambam Health Care Campus | Haifa | 31096 | Israel | Details | ||
| Shaare Zedek Medical Center | Jerusalem | 9103102 | Israel | Details | ||
| Hadassah University Hospital Ein Kerem | Jerusalem | 91120 | Israel | Details | ||
| Rabin Medical Center | Petah Tikva | 49100 | Israel | Details | ||
| The Chaim Sheba Medical Center | Ramat Gan | 52621 | Israel | Details | ||
| Azienda Ospedaliero Universitaria delle Marche - SOD Clinica di Ematologia | Ancona | I-60126 | Italy | Details | ||
| ASST Papa Giovanni XXIII | Bergamo | 24127 | Italy | Details | ||
| Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi | Bologna | 40138 | Italy | Details | ||
| IRCCS Istituto Clinico Humanitas | Milano | 20089 | Italy | Details | ||
| ASST Monza-Ospedale San Gerardo | Monza | 20052 | Italy | Details | ||
| Azienda Ospedaliera di Perugia - Santa Maria della Misericordia | Perugia | Italy | Details | |||
| Azienda Sanitaria Territoriale Pesaro e Urbino - "Stabilimento Ospedaliero San Salvatore - Muraglia" - U.O. Ematologia e Centro Trapianti | Pesaro | 61122 | Italy | Details | ||
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Severance Hospital | Seoul | 120-752 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 138-736 | Korea, Republic of | Details | ||
| The Catholic University of Korea Seoul Saint Mary's Hospital | Seoul | 6591 | Korea, Republic of | Details | ||
| Jeroen Bosch Ziekenhuis | 's-Hertogenbosch | 5223GZ | Netherlands | Details | ||
| Meander Medisch Centrum | Amersfoort | 3813 TZ | Netherlands | Details | ||
| Amsterdam Universitair Medische Centra-Locatie Vrije Universiteit Medisch Centrum | Amsterdam | 1081 HV | Netherlands | Details | ||
| Amphia Hospital, department Oncologie, Route 43 | Breda | 4818 CK | Netherlands | Details | ||
| HagaZiekenhuis | Den Haag | 2545AA | Netherlands | Details | ||
| Medisch Spectrum Twente - Enschede Koningsplein | Enschede | 7512 KZ | Netherlands | Details | ||
| Universitair Medisch Centrum Groningen | Groningen | 9700 RB | Netherlands | Details | ||
| Medisch Centrum Leeuwarden | Leeuwarden | 8934 AD | Netherlands | Details | ||
| Masstricht Universitair Medisch Centrum | Maastricht | 62002 | Netherlands | Details | ||
| St. Antonius Ziekenhuis, Nieuwegein | Nieuwegein | 3435 CM | Netherlands | Details | ||
| Canisius Wilhelmina Ziekenhuis | Nijmegen | 6532 SZ | Netherlands | Details | ||
| Erasmus Medisch Centrum | Rotterdam | 3000 CA | Netherlands | Details | ||
| Oslo University Hospital, Department of Hematology | Oslo | 0424 | Norway | Details | ||
| Centrum Onkologii Ziemi Lubelskiej im. Sw. Jana z Dukli, Oddzial Hematologiczny | Lublin | 20090 | Poland | Details | ||
| Szpital Wojewodozki w Opolu Sp. z 0.0. Oddzial Klinixzny Hematologii, Onkologii Hematologicznej i Chorob Wemnetrznych | Opole | 45-372 | Poland | Details | ||
| Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M.Kopernika w Lodzi, Oddzial Hematologii Ogolnej | Łódź | 93-510 | Poland | Details | ||
| Hospital Universitario Araba | Alava | Spain | Details | |||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital Universitario Reina Sofia | Cordoba | 14004 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon | Madrid | 28009 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario La Paz | Madrid | 28041 | Spain | Details | ||
| Hospital Universitario Quironsalud Madrid | Madrid | Spain | Details | |||
| Hospital Universitario Ramon y Cajal | Madrid | Spain | Details | |||
| Hospital Regional Universitario de Malaga | Malaga | 29010 | Spain | Details | ||
| Complejo Asistencial Universitario de Salamanca - Hospital Clinico | Salamanca | 37007 | Spain | Details | ||
| Complejo Hospitalario Universitario de Santiago de Compostela | Santiago de Compostela | 15706 | Spain | Details | ||
| Hospital Universitari I Politecnic La Fe | Valencia | 46026 | Spain | Details | ||
| Inselspital Universitätsspital Bern | Berne | 3010 | Switzerland | Details | ||
| Kaohsiung Chang Gung Memorial Hospital | Kaohsiung | 83301 | Taiwan | Details | ||
| China Medical University Hospital | Taichung | 404 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 10002 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Taipei | 11490 | Taiwan | Details | ||
| Blackpool Teaching Hospitals NHS Foundation Trust | Blackpool | FY3 8NR | United Kingdom | Details | ||
| University Hospitals Bristol and Weston NHS Foundation Trust | Bristol | BS2 8ED | United Kingdom | Details | ||
| Leeds Teaching Hospitals NHS Trust | Leeds | LS9 7TF | United Kingdom | Details | ||
| Clatterbridge Cancer Centre NHS Foundation Trust | Liverpool | L7 8YA | United Kingdom | Details | ||
| Barts Health NHS Trust | London | EC1A 7BE | United Kingdom | Details | ||
| King's College Hospital | London | SE5 9RS | United Kingdom | Details | ||
| The Christie NHS Foundation Trust | Manchester | M20 4BX | United Kingdom | Details | ||
| Newcastle upon Tyne Hospitals Foundation Trust | Newcastle upon Tyne | NE7 7DN | United Kingdom | Details | ||
| Oxford University Hospitals NHS Foundation Trust, Churchill Hospital | Oxford | OX3 7LE | United Kingdom | Details | ||
| South Warwickshire University NHS Foundation Trust | Warwick | CV34 5BW | United Kingdom | Details | ||
| The Royal Wolverhampton NHS Trust | Wolverhampton | WV10 0QP | United Kingdom | Details |