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| NCT ID | NCT05099172 |
| Title | First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2) |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase I |
| Variant Requirements | No |
| Sponsors | Bayer |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | POL | NLD | ITA | ISR | FRA | ESP | BRA | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Banner MD Anderson Cancer Center at Banner Gateway Medical Center | COMPLETED | Gilbert | Arizona | 85234 | United States | Details |
| City of Hope - Duarte Cancer Center | COMPLETED | Duarte | California | 91010 | United States | Details |
| Emory Winship Cancer Institute | ACTIVE_NOT_RECRUITING | Atlanta | Georgia | 30322 | United States | Details |
| The Center for Cancer and Blood Disorders | WITHDRAWN | Bethesda | Maryland | 20817 | United States | Details |
| Dana-Farber Cancer Institute - Oncology Department | COMPLETED | Boston | Massachusetts | 02215 | United States | Details |
| Brigette Harris Cancer Pavilion at Henry Ford Cancer Center - Detroit | COMPLETED | Detroit | Michigan | 48202 | United States | Details |
| Roswell Park Comprehensive Cancer Center | WITHDRAWN | Buffalo | New York | 14263 | United States | Details |
| Tennessee Oncology - Nashville Centennial Clinic | RECRUITING | Nashville | Tennessee | 37203 | United States | Details |
| The University of Texas MD Anderson Cancer Center - Texas Medical Center | ACTIVE_NOT_RECRUITING | Houston | Texas | 77030 | United States | Details |
| Inova Schar Cancer Insitute - Inova Fairfax Hospital | WITHDRAWN | Fairfax | Washington | 22031 | United States | Details |
| Virginia Cancer Specialists, PC - Fairfax | COMPLETED | Fairfax | Washington | 22031 | United States | Details |
| UZ Leuven Gasthuisberg - Pneumology Department | ACTIVE_NOT_RECRUITING | Leuven | Flemish Brabant | 3000 | Belgium | Details |
| AZ Delta | Clinical Trial Center - Pneumology | ACTIVE_NOT_RECRUITING | Roeselare | West Flanders | 8800 | Belgium | Details |
| Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica | ACTIVE_NOT_RECRUITING | Natal | Rio Grande do Norte | 59040-000 | Brazil | Details |
| Hospital de Base | Funfarme - Centro Integrado de Pesquisa - Cardiologia | WITHDRAWN | São José do Rio Preto | São Paulo | 15090-000 | Brazil | Details |
| Hospital Israelita Albert Einstein | Morumbi - Clinical Research Department | WITHDRAWN | São Paulo | 05651-901 | Brazil | Details | |
| Beijing Cancer Hospital - Oncology Department | ACTIVE_NOT_RECRUITING | Beijing | Beijing Municipality | 100142 | China | Details |
| Beijing Hospital | ACTIVE_NOT_RECRUITING | Beijing | Beijing Municipality | 100730 | China | Details |
| Fujian Cancer Hospital | ACTIVE_NOT_RECRUITING | Fuzhou | Fujian | 350014 | China | Details |
| Harbin Medical University Cancer Hospital | TERMINATED | Harbin | Heilongjiang | 150000 | China | Details |
| Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech | ACTIVE_NOT_RECRUITING | Wuhan | Hubei | 430023 | China | Details |
| Hunan Cancer Hospital - Oncology Department | ACTIVE_NOT_RECRUITING | Changsha | Hunan | 410013 | China | Details |
| Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School | ACTIVE_NOT_RECRUITING | Nanjing | Jiangsu | 210008 | China | Details |
| Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province | ACTIVE_NOT_RECRUITING | Taizhou | Jiangsu | 317000 | China | Details |
| Qilu Hospital of Shandong University | TERMINATED | Jinan | Shandong | 250012 | China | Details |
| Shandong University - Shandong Cancer Hospital | ACTIVE_NOT_RECRUITING | Jinan | Shandong | 250117 | China | Details |
| Shanghai Chest Hospital, Shanghai Jiaotong University | ACTIVE_NOT_RECRUITING | Shanghai | Shanghai Municipality | 200030 | China | Details |
| West China Hospital Sichuan University | ACTIVE_NOT_RECRUITING | Chengdu | Sichuan | 610041 | China | Details |
| Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department | ACTIVE_NOT_RECRUITING | Hangzhou | Zhejiang | 310016 | China | Details |
| Zhejiang Cancer Hospital | ACTIVE_NOT_RECRUITING | Hangzhou | Zhejiang | 310022 | China | Details |
| UNICANCER - Centre Leon-Berard (CLB) - Medical oncology | ACTIVE_NOT_RECRUITING | Lyon | Auvergne-Rhône-Alpes | 69373 | France | Details |
| Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale | COMPLETED | Bordeaux | New Aquitaine | 33000 | France | Details |
| Hopital Nord Laennec - Oncologie medicale thoracique et digestive | ACTIVE_NOT_RECRUITING | Nantes | Pays de la Loire Region | 44093 | France | Details |
| Institut de Cancerologie Ouest - Saint Herblain - Oncologie medicale | ACTIVE_NOT_RECRUITING | Saint-Herblain | Pays de la Loire Region | 44800 | France | Details |
| AP-HM - Hopital de la Timone - Centre d'Essais en Cancerologie | WITHDRAWN | Marseille | Provence-Alpes-Côte d'Azur Region | 13005 | France | Details |
| Institut Curie - Paris - Oncologie medicale | COMPLETED | Paris | Île-de-France Region | 75248 | France | Details |
| Gustave Roussy - Departement Oncologie-Radiotherapie | COMPLETED | Villejuif | Île-de-France Region | 94805 | France | Details |
| Prince of Wales Hospital | ACTIVE_NOT_RECRUITING | Hong Kong | Hong Kong SAR | 00000 | Hong Kong | Details |
| Queen Mary Hospital | ACTIVE_NOT_RECRUITING | Hong Kong | Hong Kong SAR | 00000 | Hong Kong | Details |
| Hong Kong United Oncology Centre | RECRUITING | Kowloon | 00000 | Hong Kong | Details | |
| Rabin Medical Center | Beilinson Campus | COMPLETED | Petah Tikva | Central District | 4941492 | Israel | Details |
| Chaim Sheba Medical Center | COMPLETED | Ramat Gan | Tel Aviv | 5262000 | Israel | Details |
| IRCCS Istituto Nazionale Tumori Fondazione Pascale | WITHDRAWN | Naples | Campania | 80131 | Italy | Details |
| Azienda Ospedaliero Universitaria Parma - SC Oncologia Medica | ACTIVE_NOT_RECRUITING | Parma | Emilia-Romagna | 43126 | Italy | Details |
| Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati | ACTIVE_NOT_RECRUITING | Aviano | Friuli Venezia Giulia | 33081 | Italy | Details |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Fase I | ACTIVE_NOT_RECRUITING | Rome | Lazio | 00128 | Italy | Details |
| Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1 | ACTIVE_NOT_RECRUITING | Milan | Lombardy | 20133 | Italy | Details |
| Istituto Europeo di Oncologia s.r.l - Sviluppo di nuovi farmaci per Terapie Innovative | COMPLETED | Milan | Lombardy | 20141 | Italy | Details |
| Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia | ACTIVE_NOT_RECRUITING | Rozzano | Lombardy | 20089 | Italy | Details |
| Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica | ACTIVE_NOT_RECRUITING | Orbassano | Piedmont | 10043 | Italy | Details |
| Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia | COMPLETED | Verona | Veneto | 37134 | Italy | Details |
| Aichi Cancer Center Hospital | ACTIVE_NOT_RECRUITING | Nagoya | Aichi-ken | 464-8681 | Japan | Details |
| National Cancer Center Hospital East | ACTIVE_NOT_RECRUITING | Kashiwa | Chiba | 277-8577 | Japan | Details |
| National Hospital Organization Shikoku Cancer Center | COMPLETED | Matsuyama | Ehime | 791-0280 | Japan | Details |
| Hokkaido University Hospital | ACTIVE_NOT_RECRUITING | Sapporo | Hokkaido | 060-8648 | Japan | Details |
| Kanagawa Cancer Center | ACTIVE_NOT_RECRUITING | Yokohama | Kanagawa | 241-8515 | Japan | Details |
| Kindai University Hospital | ACTIVE_NOT_RECRUITING | Sakai | Osaka | 590-0197 | Japan | Details |
| Shizuoka Cancer Center | COMPLETED | Sunto | Shizuoka | 411-8777 | Japan | Details |
| National Cancer Center Hospital | ACTIVE_NOT_RECRUITING | Chuo-ku | Tokyo | 104-0045 | Japan | Details |
| Tottori University Hospital | COMPLETED | Yonago | Tottori | 683-8504 | Japan | Details |
| Okayama University Hospital | TERMINATED | Okayama | 700-8558 | Japan | Details | |
| Osaka International Cancer Institute | ACTIVE_NOT_RECRUITING | Osaka | 541-8567 | Japan | Details | |
| Radboud University Medical Center | Afdeling Interne Geneeskunde | WITHDRAWN | Nijmegen | Gelderland | 6500 HB | Netherlands | Details |
| Nederlands Kanker Instituut | ACTIVE_NOT_RECRUITING | Amsterdam | North Holland | 1066 CX | Netherlands | Details |
| Erasmus University Medical Center | Research Department - Lung Diseases | COMPLETED | Rotterdam | South Holland | 3015 GD | Netherlands | Details |
| Uniwersyteckie Centrum Kliniczne | WITHDRAWN | Gdansk | Pomeranian Voivodeship | 80-214 | Poland | Details |
| Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Łodzi | WITHDRAWN | Lodz | Łódź Voivodeship | 92-213 | Poland | Details |
| START Research Portugal | WITHDRAWN | Lisbon | 1649-028 | Portugal | Details | |
| Hospital Santa Maria | Centro de Investigacao Clinica | WITHDRAWN | Lisbon | 1649-035 | Portugal | Details | |
| IPO Porto | RECRUITING | Porto | 4200-072 | Portugal | Details | |
| National University Hospital Medical Centre | ACTIVE_NOT_RECRUITING | Singapore | 119074 | Singapore | Details | |
| National Cancer Center Singapore - Oncology Department | ACTIVE_NOT_RECRUITING | Singapore | 168583 | Singapore | Details | |
| Curie Oncology | Mount Elizabeth Novena | ACTIVE_NOT_RECRUITING | Singapore | 329563 | Singapore | Details | |
| Seoul National University Bundang Hospital | Hematology and Medical Oncology | COMPLETED | Seongnam-si | Gyeonggi-do | 13620 | South Korea | Details |
| St Vincent's Hospital | Oncology | ACTIVE_NOT_RECRUITING | Suwon | Gyeonggi-do | 16247 | South Korea | Details |
| Chungbuk National University Hospital | Hematology and Oncology | ACTIVE_NOT_RECRUITING | Chungcheongbuk-do | North Chungcheong | 28644 | South Korea | Details |
| Seoul National University Hospital | Oncology | ACTIVE_NOT_RECRUITING | Jongno -Gu | Seoul | 03080 | South Korea | Details |
| Severance Hospital | Oncology | ACTIVE_NOT_RECRUITING | Seoul | 03722 | South Korea | Details | |
| Asan Medical Center | Oncology | ACTIVE_NOT_RECRUITING | Seoul | 05505 | South Korea | Details | |
| Samsung Medical Center | Oncology | ACTIVE_NOT_RECRUITING | Seoul | 06351 | South Korea | Details | |
| Institut Catala D'oncologia | Hospitalet | Oncologia | ACTIVE_NOT_RECRUITING | L'Hospitalet de Llobregat | Barcelona | 08908 | Spain | Details |
| Hospital Universitari Dexeus Grupo Quironsalud | Oncologia | ACTIVE_NOT_RECRUITING | Barcelona | 08028 | Spain | Details | |
| Hospital Universitari Vall D Hebron | Oncologia | ACTIVE_NOT_RECRUITING | Barcelona | 08035 | Spain | Details | |
| Hospital Universitario Fundacion Jimenez Diaz | Oncologia | ACTIVE_NOT_RECRUITING | Madrid | 28040 | Spain | Details | |
| Hospital Universitario Hm Sanchinarro | Oncologia | COMPLETED | Madrid | 28050 | Spain | Details | |
| Hospital Universitario Virgen De La Victoria | Oncologia | WITHDRAWN | Málaga | 29010 | Spain | Details | |
| Hospital Universitario Y Politecnico La Fe | Oncologia | ACTIVE_NOT_RECRUITING | Valencia | 46026 | Spain | Details | |
| Chung Shan Medical University Hospital | WITHDRAWN | Taichung | 402306 | Taiwan | Details | |
| Taichung Veterans General Hospital | ACTIVE_NOT_RECRUITING | Taichung | 40705 | Taiwan | Details | |
| National Cheng Kung University Hospital | ACTIVE_NOT_RECRUITING | Tainan | 704 | Taiwan | Details | |
| Chi-Mei Medical Center, Liouyine | ACTIVE_NOT_RECRUITING | Tainan | 73657 | Taiwan | Details | |
| National Taiwan University Hospital | ACTIVE_NOT_RECRUITING | Taipei | 100 | Taiwan | Details | |
| Taipei Medical University (TMU) - Shuang Ho Hospital (SHH) | WITHDRAWN | Taipei | 23561 | Taiwan | Details | |
| Chang Gung Memorial Hospital at Linkou | ACTIVE_NOT_RECRUITING | Taoyuan | 33305 | Taiwan | Details |