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| NCT ID | NCT05215340 |
| Title | Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations (TROPION-Lung08) |
| Acronym | TROPION-Lung08 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Daiichi Sankyo, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | ROU | POL | NLD | ITA | HUN | GRC | GBR | FRA | ESP | DEU | CHE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Ironwood Cancer and Research Center | Chandler | Arizona | 85224 | United States | Details | |
| UCLA HemOnc - Clinical Research Unit | Los Angeles | California | 90095 | United States | Details | |
| Ridley-Tree Cancer Center | Santa Barbara | California | 93105 | United States | Details | |
| PIH Health Whittier Hospital | Whittier | California | 90602 | United States | Details | |
| The Oncology Institute of Hope and Innovation | Whittier | California | 90603 | United States | Details | |
| Uch-Mhs D/B/A Memorial Health System | Colorado Springs | Colorado | 80909 | United States | Details | |
| Johns Hopkins University | Baltimore | Maryland | 21205 | United States | Details | |
| American Oncology Partners of Maryland | Bethesda | Maryland | 20817 | United States | Details | |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02115 | United States | Details | |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | United States | Details | |
| Dana Farber Cancer Institute - Foxborough | Foxborough | Massachusetts | 02035 | United States | Details | |
| DFCI - South Shore Hospital | South Weymouth | Massachusetts | 02190 | United States | Details | |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03766 | United States | Details | |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | United States | Details | |
| Regional Cancer Care Associates LLC | Freehold | New Jersey | 07728 | United States | Details | |
| Cooperman Barnabas Medical Center | New Brunswick | New Jersey | 08901 | United States | Details | |
| The Valley Hospital | Paramus | New Jersey | 07652 | United States | Details | |
| Montefiore Medical Center | The Bronx | New York | 10461 | United States | Details | |
| Arizona Oncology NAHOA | Irving | Texas | 75063 | United States | Details | |
| Cancer Care Center of Brevard | Irving | Texas | 75063 | United States | Details | |
| Illinois Cancer Specialists | Irving | Texas | 75063 | United States | Details | |
| Maryland Oncology Hematology | Irving | Texas | 75063 | United States | Details | |
| Southern Cancer Center | Irving | Texas | 75063 | United States | Details | |
| Texas Oncology - Northeast Texas | Irving | Texas | 75063 | United States | Details | |
| Texas Oncology Gulf Coast | Irving | Texas | 75063 | United States | Details | |
| Texas Oncology McAllen | Irving | Texas | 75063 | United States | Details | |
| University of Texas Health Science Center San Antonio | San Antonio | Texas | 78229 | United States | Details | |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | United States | Details | |
| Providence Regional Cancer System | Lacey | Washington | 98503 | United States | Details | |
| VA Puget Sound Health Care System - VAPSHCS | Seattle | Washington | 98108 | United States | Details | |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Centro de Investigaciones Medicas y Desarrollo LC S.R.L. (LC Investigacion) | Buenos Aires | Argentina | Details | |||
| Fundacion CENIT para la investigación en Neurociencias | Ciudad Autonoma de Buenos Aire | 1125 | Argentina | Details | ||
| Hospital Privado de la Comunidad | Mar del Plata | B7602CBM | Argentina | Details | ||
| Centro de Investigación Pergamino S. A. | Pergamino | 2700 | Argentina | Details | ||
| Instituto de Oncología de Rosario | Rosario | S2000 | Argentina | Details | ||
| Sanatorio Parque | Rosario | S2001 | Argentina | Details | ||
| Sanatorio Británico de Rosario | Rosario | S2002 | Argentina | Details | ||
| CER SAN JUAN - Centro Polivalente de Asistencia e Investigación Clínica | San Juan | 5400 | Argentina | Details | ||
| Clinica Viedma SA | Viedma | 8500 | Argentina | Details | ||
| Austin Hospital | Heidelberg | Victoria | 3084 | Australia | Details | |
| Peninsula and South Eastern Haematology and Oncology Group | Mount Waverley | Victoria | 3149 | Australia | Details | |
| Chris Obrien Lifehouse | Camperdown | 2050 | Australia | Details | ||
| The Queen Elizabeth Hospital | Woodville South | 5011 | Australia | Details | ||
| Klinikum Klagenfurt am Wörthersee Abteilung für Lungenkrankheiten | Klagenfurt | Austria | Details | |||
| Karl-Landsteiner Institute for Lung Research and Pulmonary Oncology c/o Klinik Floridsdorf | Vienna | 1090 | Austria | Details | ||
| Onze-Lieve-Vrouwziekenhuis Olvz - Campus Aalst | Aalst | 9300 | Belgium | Details | ||
| Grand Hopital de Charleroi - Hopital Saint Joseph | Charleroi | 6000 | Belgium | Details | ||
| Az Maria Middelares - Campus Maria Middelares | Ghent | 9000 | Belgium | Details | ||
| AZ Nikolaas | Sint-Niklaas | 9100 | Belgium | Details | ||
| Instituto de Pesquisas em Saúde - IPS | Caxias do Sul | 95020-972 | Brazil | Details | ||
| Hospital Erasto Gaertner | Curitiba | 81520-060 | Brazil | Details | ||
| Oncosite - Centro de Pesquisa Clinica Oncologia | Ijuí | 98700-000 | Brazil | Details | ||
| Clínica de Neoplasias Litoral | Itajaí | 88301-220 | Brazil | Details | ||
| UPCO - Unidade de Pesquisas Clínicas em Oncologia - Clinica Lacks | Pelotas | 96020-080 | Brazil | Details | ||
| Santa Casa de Misericordia de Porto Alegre | Porto Alegre | 90050-170 | Brazil | Details | ||
| Instituto Nacional de Câncer - INCA | Rio de Janeiro | 20231-050 | Brazil | Details | ||
| Centro de Estudos e Pesquisa de Hematologia e Oncologia - CEPHO | Santo André | 09060-870 | Brazil | Details | ||
| Instituto de Ensino e Pesquisas Sao Lucas | São Paulo | 01236-030 | Brazil | Details | ||
| Instituto do Cancer Brasil - Unidade Taubate | Taubaté | Brazil | Details | |||
| McGill University Health Centre | Montreal | H4A 3J2 | Canada | Details | ||
| Centro de Estudios Clínicos SAGA | Santiago | Santiago Metropolitan | 7500653 | Chile | Details | |
| Oncovida | Santiago | 7500000 | Chile | Details | ||
| Fundación Arturo Pérez López | Santiago | 7500921 | Chile | Details | ||
| Orlandi Oncología | Santiago | 7501010 | Chile | Details | ||
| Centro de Investigaciones Clinicas Vina Del Mar | Viña del Mar | 254-0488 | Chile | Details | ||
| Guangxi Medical University Affiliated Tumor Hospital | Nanning | Guangxi | 530021 | China | Details | |
| Henan Cancer Hospital | Zhengzhou | Henan | 450008 | China | Details | |
| Jilin Cancer Hospital | Changchun | Jilin | 130012 | China | Details | |
| Sichuan Cancer Hospital | Chengdu | Sichuan | 610049 | China | Details | |
| Peking University Peoples Hospital | Beijing | 100044 | China | Details | ||
| Peking University Cancer Hospital | Beijing | 100142 | China | Details | ||
| Cangzhou People's Hospital | Cangzhou | 610001 | China | Details | ||
| Hunan Cancer Hospital | Changsha | 410013 | China | Details | ||
| Army Medical Center of PLA | Chongqing | 400042 | China | Details | ||
| Affiliated Cancer Hospital and Institute of Guangzhou Medical University | Guangzhou | 510095 | China | Details | ||
| Haikou People's Hospital | Haikou | 570208 | China | Details | ||
| The First Affiliated Hospital of College of Medicine Zhejiang University | Hanghzou | 310003 | China | Details | ||
| Harbin Medical University Cancer Hospital | Harbin | 150081 | China | Details | ||
| Inner Mongolia Medical University- the Affiliated Hospital | Hohhot | 10050 | China | Details | ||
| Jiamusi Tumor and Tuberculosis Hospital | Jiamusi | 154007 | China | Details | ||
| Yunnan Cancer Hospital | Kunming | 650118 | China | Details | ||
| Linyi Cancer Hospital | Linyi | 276000 | China | Details | ||
| The First Affiliated Hospital of Nanchang University | Nanchang | 330006 | China | Details | ||
| Jiangsu Province Hospital | Nanjing | 210029 | China | Details | ||
| The Second People's Hospital of Neijiang | Neijiang | 641000 | China | Details | ||
| Shanghai Pulmonary Hospital | Shanghai | 200433 | China | Details | ||
| Fudan University Shanghai Cancer Center | Shanghai Shi | 200032 | China | Details | ||
| The First Hospital of China Medical University | Shenyang | 110001 | China | Details | ||
| Liaoning Cancer Hospital& Institute | Shenyang | 110801 | China | Details | ||
| Tianjin Medical University General Hospital | Tianjin | 300052 | China | Details | ||
| Xinjiang Tumor Hospital | Ürümqi | 830000 | China | Details | ||
| Union Hospital Affiliated With Tongji Medical College Huazhong University of Science and Technology | Wuhan | 430022 | China | Details | ||
| Hubei Cancer Hospital | Wuhan | 430079 | China | Details | ||
| The First Affiliate Hospitalof Xi'An Jiaotong University | Xi'an | 710061 | China | Details | ||
| The First Affiliated Hospital Xiamen University | Xiamen | 361001 | China | Details | ||
| Xiangyang Central Hospital- 5 Lumen Avenue | Xiangyang | 441000 | China | Details | ||
| Sainte-Catherine Institut du Cancer Avignon-Provence (ICAP) | Avignon | 84000 | France | Details | ||
| Bordeaux University Hospital - Hopital Saint Andre | Bordeaux | 33075 | France | Details | ||
| Institut Bergonie | Bordeaux | 33076 | France | Details | ||
| Centre Hospitalier Universitaire de Lille | Lille | 59000 | France | Details | ||
| Centre Leon Berard | Lyon | 69008 | France | Details | ||
| APHM - Hopital Nord | Marseille | 13015 | France | Details | ||
| Institut Paoli-Calmettes | Marseille | 13273 | France | Details | ||
| Centre Hospitalier Universitaire de Montpellier | Montpellier | 34295 | France | Details | ||
| CHU de Nantes | Nantes | 44093 | France | Details | ||
| Hopital prive du Confluent | Nantes | 44277 | France | Details | ||
| AP-HP - Hopital Tenon | Paris | 75970 | France | Details | ||
| CHU de Poitier Pole Regional de Cancerologie | Poitiers | 86000 | France | Details | ||
| Hopital FOCH | Suresnes | 92150 | France | Details | ||
| Evangelische Lungenklinik Berlin | Berlin | 13125 | Germany | Details | ||
| Klinikum Esslingen GmbH | Esslingen am Neckar | 73730 | Germany | Details | ||
| LungenClinic Grosshansdorf | Großhansdorf | 22927 | Germany | Details | ||
| Klinikum der Universitaet Muenchen | München | 80336 | Germany | Details | ||
| Metropolitan Hospital | Neo Faliro | Athens | 14564 | Greece | Details | |
| Sotiria General Hosptial of Chest Diseases | Athens | 11527 | Greece | Details | ||
| University Hospital of Ioannina Uhi | Ioannina | 45500 | Greece | Details | ||
| Metropolitan Hospital | Neo Faliro | 18547 | Greece | Details | ||
| Metropolitan Hospital | Piraeus | 18547 | Greece | Details | ||
| Bioclinic Thessaloniki | Thessaloniki | 54622 | Greece | Details | ||
| St. Luke's Hospital | Thessaloniki | 55236 | Greece | Details | ||
| Prince of Wales Hospital / The Chinese University of Hong Kong 99999 | Hong Kong | 99999 | Hong Kong | Details | ||
| Queen Elizabeth Hospital | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital | Pok Fu Lam | 999077 | Hong Kong | Details | ||
| Semmelweis University Department of Pulmonology | Budapest | 1083 | Hungary | Details | ||
| Veszprem Megyei Tudogyogyintezet Farkasgyepu | Farkasgyepű | 8582 | Hungary | Details | ||
| Bkmk Hospital | KecskemĂŠt | 6000 | Hungary | Details | ||
| Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Székesfehérvár | 8000 | Hungary | Details | ||
| Pulmonology Hospital Torokbalint | Törökbálint | 2045 | Hungary | Details | ||
| IRCCS Istituto Oncologico Giovanni Paolo II | Bari | 70124 | Italy | Details | ||
| UOC Oncologia | Chieti | 66100 | Italy | Details | ||
| Ospedale San Luca | Lucca | 55100 | Italy | Details | ||
| IRCCS Ospedale San Raffaele | Milan | 20132 | Italy | Details | ||
| Irccs Istituto Europeo Di Oncologia | Milan | 20141 | Italy | Details | ||
| Azienda Ospedaliera dei Colli | Naples | 80131 | Italy | Details | ||
| A.O. Perugia Santa Maria della Misericordia | Perugia | 06132 | Italy | Details | ||
| Policlinico Tor Vergata | Rome | 133 | Italy | Details | ||
| Ifo Regina Elena | Rome | 144 | Italy | Details | ||
| Asst Sette Laghi Ospedale di Circolo e Fondazione Macchi | Varese | 21100 | Italy | Details | ||
| Aomori Prefectural Central Hospital | Aomori | Aomori | 030-8553 | Japan | Details | |
| National Cancer Center Hospital East | Kashiwa-shi | Chiba | 277-8577 | Japan | Details | |
| NHO Shikoku Cancer Center | Matsuyama | Ehime | 791-0280 | Japan | Details | |
| National Hospital Organization Kyushu Cancer Center | Fukuoka | Fukuoka | 811-1395 | Japan | Details | |
| Kyushu University Hospital | Fukuoka | Fukuoka | 812-8582 | Japan | Details | |
| Kurume University Hospital | Kurume-shi | Fukuoka | 830-0011 | Japan | Details | |
| Kanazawa University Hospital | Kanazawa | Ishikawa-ken | 920-8641 | Japan | Details | |
| Kanagawa Cancer Center | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Saiseikai Kumamoto Hospital | Kumamoto | Kumamoto | 861- 4193 | Japan | Details | |
| Matsusaka Municipal Hospital | Matsusaka-shi | Mie-ken | 515-8544 | Japan | Details | |
| Sendai Kousei Hospital | Sendai | Miyagi | 980-0873 | Japan | Details | |
| Niigata Cancer Center Hospital | Niigata | Niigata | 961-8566 | Japan | Details | |
| Kansai Medical University Hospital | Hirakata-shi | Osaka | 573-1191 | Japan | Details | |
| Osaka International Cancer Institute | Osaka | Osaka | 541-8567 | Japan | Details | |
| NHO Kinki-Chuo Chest Medical Center | Sakai-shi | Osaka | 591-8555 | Japan | Details | |
| Dokkyo Medical University Hospital | Shimotsuga-gun | Tochigi | 321-0293 | Japan | Details | |
| Juntendo University Hospital | Bunkyo-ku | Tokyo | 113-8431 | Japan | Details | |
| Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital | Bunkyō-Ku | Tokyo | 113-8677 | Japan | Details | |
| The Cancer Institute Hospital of JFCR | Kōtoku | Toyko | 135-8550 | Japan | Details | |
| Toho University Omori Medical Center | Ōta-ku | Toyko | 143-8541 | Japan | Details | |
| NHO Iwakuni Clinical Center | Iwakuni-shi | Yamaguchi | 740-8510 | Japan | Details | |
| Yamaguchi-Ube Medical Center | Ube-shi | Yamaguchi | 755-0241 | Japan | Details | |
| Yamanashi Prefectural Central Hospital | Kofu | Japan | Details | |||
| University Hospital Kyoto Prefectural University of Medicine | Kyoto | 602-8566 | Japan | Details | ||
| Osaka Toneyama Medical Center | Osaka | 560-8552 | Japan | Details | ||
| Teine Keijinkai Hospital | Sapporo | 006-8555 | Japan | Details | ||
| Cryptex Investigacion Clinica Sa de Cv | Cuauhtémoc | 06100 | Mexico | Details | ||
| Hospital Civil de Guadalajara Fray Antonio Alcalde | Guadalajara | 44280 | Mexico | Details | ||
| Hospital Universitario Dr. Jose Eleuterio Gonzalez | Monterrey | 64460 | Mexico | Details | ||
| Centro de Investigacion Clinica de Oaxaca (CICLO) | Oaxaca City | 68020 | Mexico | Details | ||
| Oncologico Potosino | San Luis Potosí City | 78209 | Mexico | Details | ||
| Rijnstate Ziekenhuis | Arnhem | Gelderland | 6815 AD | Netherlands | Details | |
| Jeroen Bosch Ziekenhuis J BZ Hieronymus Bosch Hospital | 's-Hertogenbosch | 5223 GZ | Netherlands | Details | ||
| Amsterdam Umc, Location Vumc | Amsterdam | 1081 HZ | Netherlands | Details | ||
| Leiden University Medical Center | Leiden | 2333 ZA | Netherlands | Details | ||
| Instytut Centrum Zdrowia Matki Polki | Lodz | Iodzkie | 93-338 | Poland | Details | |
| Szpitale Pomorskie Sp. z o.o. | Gdynia | Pomeranian Voivodeship | 81-519 | Poland | Details | |
| Dom Lekarski SA | Szczecin | West Pomeranian Voivodeship | 70-784 | Poland | Details | |
| II Klinika Chorob Pluc I Gruzlicy | Bialystok | 15-450 | Poland | Details | ||
| MS Pneumed Janusz Milanowski, Katarzyna Szmygin-Milanowska Sp. Jawna | Lublin | 20-064 | Poland | Details | ||
| Centro Clinico Champalimau | Lisbon | 1400-038 | Portugal | Details | ||
| Centro Hospitalar e Universitário do Porto | Porto | 4099-001 | Portugal | Details | ||
| Hospital CUF Porto | Porto | 4100-180 | Portugal | Details | ||
| Instituto Portuguas de Oncologia do Porto Francisco Gentil | Porto | 4200-072 | Portugal | Details | ||
| Centro Hospitalar Universitário de São João | Porto | 4200-319 | Portugal | Details | ||
| Onco Clinic Consult SA | Craiova | 200094 | Romania | Details | ||
| Centrul de Oncologie Sf Nectarie S.R.L. | Craiova | 200542 | Romania | Details | ||
| Sc Sigmedical Services Srl | Suceava | 720214 | Romania | Details | ||
| Oncocenter-Oncologie Clinica SRL | Timișoara | 300166 | Romania | Details | ||
| SC Oncomed SRL | Timișoara | 300239 | Romania | Details | ||
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | South Korea | Details | |
| Gyeongsang National University Hospital | Jinju | Gyeongsangnam-do | 52727 | South Korea | Details | |
| Chungbuk National University Hospital | Cheongju-si | North Chungcheong | 28644 | South Korea | Details | |
| Kyungpook National University Chilgok Hospital | Daegu | 42119 | South Korea | Details | ||
| National Cancer Center | Goyang-si | 10408 | South Korea | Details | ||
| Samsung Medical Center | Seoul | 6351 | South Korea | Details | ||
| The Catholic Univ. of Korea, Seoul St. Mary'S Hospital | Seoul | 6591 | South Korea | Details | ||
| Asan Medical Center | Songpa-gu | 5505 | South Korea | Details | ||
| Hospital Clinic i Provincial de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital Universitari Vall D'Hebron | Barcelona | 8035 | Spain | Details | ||
| Hospital Universitario Arnau de Vilanova - Lleida | Lleida | 25198 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Hospital Clinico San Carlos | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Fundacion Jimenez Diaz | Madrid | 28040 | Spain | Details | ||
| Hospital Regional Universitario Malaga | Málaga | 29010 | Spain | Details | ||
| CHUO | Ourense | 32005 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Seville | 41009 | Spain | Details | ||
| Hospital Universitario de Valme | Seville | 41014 | Spain | Details | ||
| Hospital Universitari i Politècnic La Fe | Valencia | 46026 | Spain | Details | ||
| Hospital Universitario Miguel Servet | Zaragoza | 50009 | Spain | Details | ||
| Kantonsspital Baden | Baden | 5404 | Switzerland | Details | ||
| University Hospital Basel | Basel | 4031 | Switzerland | Details | ||
| Kantonsspital Baselland | Liestal | A4410 | Switzerland | Details | ||
| Kantonsspital St. Gallen | Sankt Gallen | Switzerland | Details | |||
| E-Da Hospital | Kaohsiung City | 824 | Taiwan | Details | ||
| Chang Gung Memorial Hospital Cgmh - Kaohsiung Branch | Kaohsiung City | 833 | Taiwan | Details | ||
| Chung Shan Medical University Hospital | Taichung | 40201 | Taiwan | Details | ||
| Taichung Veterans General Hospital | Taichung | 40705 | Taiwan | Details | ||
| National Cheng Kung University Hospital Nckuh | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 100 | Taiwan | Details | ||
| Taipei Veterans General Hospital | Taipei | 11217 | Taiwan | Details | ||
| Koo Foundation Sun Yat-Sen Cancer Center | Taipei | 112 | Taiwan | Details | ||
| Chang Gung Memorial Hospital LinKou | Taoyuan | 333 | Taiwan | Details | ||
| Srinagarind Hospital | Muaeng | Changwat Khon Kaen | 40002 | Thailand | Details | |
| Prince of Songkla University PSU - Faculty of Medicine | Hat Yai | Changwat Songkhla | 90110 | Thailand | Details | |
| Faculty of Medicine Chulalongkorn University | Bangkok | 10330 | Thailand | Details | ||
| Siriraj Hospital | Bangkok | 10700 | Thailand | Details | ||
| Adana Acibadem Hospital | Adana | 1130 | Turkey (Türkiye) | Details | ||
| Akdeniz University Hospital | Antalya | 7070 | Turkey (Türkiye) | Details | ||
| Ege University | Bornova-İzmir | 35100 | Turkey (Türkiye) | Details | ||
| Memorial Ankara Hospital Ankara | Çankaya | 06520 | Turkey (Türkiye) | Details | ||
| Goztepe Prof. Dr. Suleyman Yalcin City Hospital | Istanbul | 34772 | Turkey (Türkiye) | Details | ||
| Medical Park Seyhan Hospital | Seyhan /Adana | 1140 | Turkey (Türkiye) | Details | ||
| Birmingham Heartlands Hospital | Birmingham | B9 5SS | United Kingdom | Details | ||
| Nottingham University Hospitals | Nottingham | NG5 1PB | United Kingdom | Details |