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| NCT ID | NCT05254743 |
| Title | A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN-CLL-314) |
| Acronym | BRUIN-CLL-314 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | NZL | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Genesis Cancer Center | Hot Springs | Arkansas | 71913 | United States | Details | |
| Pacific Cancer Medical Center, Inc | Anaheim | California | 92801 | United States | Details | |
| Alta Bates Summit Medical Center | Berkeley | California | 94705 | United States | Details | |
| TOI Clinical Research | Cerritos | California | 90703 | United States | Details | |
| Stanford School of Medicine-Cancer Clinical Trials Office | Palo Alto | California | 94304 | United States | Details | |
| Eisenhower Army Medical Center | Rancho Mirage | California | 92270 | United States | Details | |
| Sharp Memorial Hospital | San Diego | California | 92123 | United States | Details | |
| California Cancer Associates for Research and Excellence | San Marcos | California | 92069 | United States | Details | |
| Eastern Connecticut Hematology/Oncology Assoc. | Norwich | Connecticut | 06360 | United States | Details | |
| Asclepes Research Centers Florida | Brooksville | Florida | 34613 | United States | Details | |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | United States | Details | |
| Cancer Specialists of North Florida -St Augustine | Jacksonville | Florida | 32256 | United States | Details | |
| Lakeland Regional Health Systems Inc | Lakeland | Florida | 33805 | United States | Details | |
| Florida Cancer Specialists | Saint Petersburg | Florida | 33705 | United States | Details | |
| Florida Cancer Specialists East | West Palm Beach | Florida | 33401 | United States | Details | |
| Summit Cancer Care, P.C. | Savannah | Georgia | 31405 | United States | Details | |
| Baptist Healthcare System, Inc. | Louisville | Kentucky | 40207 | United States | Details | |
| Hematology Oncology Clinic | Baton Rouge | Louisiana | 70809 | United States | Details | |
| Tulane Cancer Center Office of Clinical Research | New Orleans | Louisiana | 70112 | United States | Details | |
| American Oncology Partners of Maryland, PA | Bethesda | Maryland | 20817 | United States | Details | |
| TidalHealth Peninsula Regional, Inc. | Salisbury | Maryland | 21801 | United States | Details | |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | United States | Details | |
| Westchester Medical Center | Hawthorne | New York | 10532 | United States | Details | |
| Novant Cancer Institute Charlotte | Charlotte | North Carolina | 28204 | United States | Details | |
| The James Cancer Hospital | Columbus | Ohio | 43210 | United States | Details | |
| Cancer Care Associates of York | York | Pennsylvania | 17403 | United States | Details | |
| Lifespan Cancer Institute | Providence | Rhode Island | 02903 | United States | Details | |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29615 | United States | Details | |
| Sarah Cannon Research Institute SCRI | Chattanooga | Tennessee | 37404 | United States | Details | |
| Kelsey Research Foundation | Houston | Texas | 77025 | United States | Details | |
| Houston Methodist Hospital Cancer Center | Houston | Texas | 77030 | United States | Details | |
| Lumi Research | Kingwood | Texas | 77339 | United States | Details | |
| Baylor Scott & White Health | Round Rock | Texas | 78665 | United States | Details | |
| Virginia Cancer Institute | Richmond | Virginia | 23228 | United States | Details | |
| Summit Cancer Treatment Center | Spokane | Washington | 99208 | United States | Details | |
| MultiCare Health System Institute for Research and Innovation | Spokane | Washington | 99218 | United States | Details | |
| Hospital Privado De Comunidad | Mar Del Plata | Buenos Aires | 7600 | Argentina | Details | |
| Hospital Italiano de Buenos Aires | ABB | Ciudad Autónoma De Buenos Aire | 1199 | Argentina | Details | |
| Instituto Alexander Fleming | Ciudad Autonoma Buenos Aires | C1426ANZ | Argentina | Details | ||
| Clínica de Nefrología, Urología y Enfermedades Cardiovasculares | Santa Fe | 3000 | Argentina | Details | ||
| Sunshine Hospital | St Albans | Victoria | 3021 | Australia | Details | |
| One Clinical Research | Nedlands | Western Australia | 6009 | Australia | Details | |
| The Perth Blood Institute | West Perth | 6005 | Australia | Details | ||
| Ordensklinikum Linz | Linz | Oberösterreich | 4020 | Austria | Details | |
| Hanusch Krankenhaus | Vienna | 1400 | Austria | Details | ||
| VITAZ | Sint-Niklaas | Oost-Vlaanderen | 9100 | Belgium | Details | |
| AZ Delta | Roeselare | West Flanders | 8800 | Belgium | Details | |
| Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| Centro Integrado de Oncologia de Curitiba | Curitiba | Paraná | 80810-050 | Brazil | Details | |
| Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer | Curitiba | Paraná | 81520-060 | Brazil | Details | |
| Instituto do Câncer - Hospital São Vicente de Paulo | Passo Fundo | Rio Grande Do Sul | 99010-080 | Brazil | Details | |
| Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus | Porto Alegre | Rio Grande Do Sul | 90110-270 | Brazil | Details | |
| UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu | Botucatu | Sao Paulo | 18618-686 | Brazil | Details | |
| Centro de Hematologia e Hemoterapia - Hemocentro de Campinas - UNICAMP | Campinas | Sao Paulo | 13083-878 | Brazil | Details | |
| Fundação Faculdade Regional de Medicina de São José do Rio Preto | Sao Jose Rio Preto | Sao Paulo | 15090-000 | Brazil | Details | |
| Fundação Pio XII - Hospital de Câncer de Barretos | Barretos | São Paulo | 14784-400 | Brazil | Details | |
| Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) - HCFMRP | Ribeirão Preto | São Paulo | 14051-140 | Brazil | Details | |
| CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia | Santo André | São Paulo | 09060-650 | Brazil | Details | |
| Hospital Uopeccan - Centro de Pesquisa Clinica | Cascavel | 85806-300 | Brazil | Details | ||
| Hospital Beneficência Portuguesa de São Paulo | Sao Paulo | 01323-001 | Brazil | Details | ||
| Hospital Santa Marcelina | Sao Paulo | 08270-070 | Brazil | Details | ||
| Hospital das Clínicas da Faculdade de Medicina da USP | São Paulo | 05402-000 | Brazil | Details | ||
| Cancer Care Manitoba | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Royal Victoria Regional Health Centre | Barrie | Ontario | L4M 6M2 | Canada | Details | |
| Hopital de L'Enfant Jesus | Québec | G1J 1Z4 | Canada | Details | ||
| Sociedad de Investigaciones Médicas Limitada | Temuco | IX Región | 4780000 | Chile | Details | |
| CeCim Biocinetic | Santiago | Región Metropolitana | 8320000 | Chile | Details | |
| Centro de Estudios Clinicos SAGA | Providencia | Santiago | 7500653 | Chile | Details | |
| Centro de Investigaciones Clínicas Viña del Mar (CIC) | Viña del Mar | Valparaíso | 2520000 | Chile | Details | |
| Anhui Provincial Hospital | Hefei | Anhui | 230001 | China | Details | |
| The Second Hospital of Anhui Medical University | Hefei | Anhui | 231200 | China | Details | |
| Sun Yat-sen University Cancer Center | Guangzhou | Guangdong | 510000 | China | Details | |
| Southern Medical University Nanfang Hospital | Guangzhou | Guangdong | 510515 | China | Details | |
| Guangxi Medical University Affiliated Tumor Hospital | Nanning | Guangxi | 530021 | China | Details | |
| Wu Han Tongji Hospital | Wuhan City | Hubei | 430030 | China | Details | |
| The 2nd Xiangya Hospital of Central South University | Changsha | Hunan | 410011 | China | Details | |
| Hunan Cancer Hospital | Changsha | Hunan | 410013 | China | Details | |
| The First Affiliated Hospital of Nanchang University | Nanchang | Jiangxi | 330006 | China | Details | |
| Jiangxi Provincial Cancer Hospital | Nanchang | Jiangxi | 330029 | China | Details | |
| Fudan University Shanghai Cancer Center | Shanghai | Shanghai | 200030 | China | Details | |
| Blood Institute of the Chinese Academy of Medical science | Tianjin | Tianjin | 300020 | China | Details | |
| Tianjin Medical University General Hospital | Tianjin | Tianjin | 300052 | China | Details | |
| The Affiliated Cancer Hospital of Xinjiang Medical university | Urumqi | Xinjiang | 830000 | China | Details | |
| The Second Affiliated Hospital of Zhejiang University School of Medicine | Hangzhou | Zhejiang | 310009 | China | Details | |
| The Fourth Affiliated Hospital Zhejiang University School of Medicine | Yiwu | Zhejiang | 322000 | China | Details | |
| Hainan General Hospital | Haikou | 570311 | China | Details | ||
| First Affiliated Hosp of College of Med, Zhejiang University | Hangzhou | 310003 | China | Details | ||
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | Wuhan | 430022 | China | Details | ||
| Fakultni nemocnice Brno | Brno | 62500 | Czechia | Details | ||
| Fakultni nemocnice Hradec Kralove | Hradec Kralove | 50005 | Czechia | Details | ||
| Fakultni Nemocnice Ostrava | Ostrava-Poruba | 708 52 | Czechia | Details | ||
| Fakultni Nemocnice Plzen | Plzen - Lochotin | 30460 | Czechia | Details | ||
| Fakultni nemocnice Kralovske Vinohrady | Praha 10 | 100 34 | Czechia | Details | ||
| Vseobecna fakultni nemocnice v Praze | Praha 2 | 12808 | Czechia | Details | ||
| Hopital de la Pitie Salpetriere | Paris | Cedex 13 | 75651 | France | Details | |
| CHU de Nantes - Hotel Dieu | Nantes | Cedex 1 | 44093 | France | Details | |
| Hôpital de Pontchaillou | Rennes | Cedex 9 | 35033 | France | Details | |
| Centre Hospitalier Lyon Sud | Pierre Benite | Cedex | 69495 | France | Details | |
| Centre Antoine Lacassagne | Nice | Nice Cedex 2 | 06189 | France | Details | |
| CHRU De Tours | Tours | Tours Cedex 9 | 37044 | France | Details | |
| CHD Vendee | La Roche sur Yon | 85000 | France | Details | ||
| Centre Hospitalier du Mans | Le Mans | 72000 | France | Details | ||
| Centre Hospitalier Universitaire (Limoges) (CHU DUPUYTREN 1) | Limoges | 87042 | France | Details | ||
| Centre Henri Becquerel | Rouen Cedex | 76038 | France | Details | ||
| Universitaetsklinikum Ulm | Ulm | Baden | 89081 | Germany | Details | |
| Uniklinik Köln | Kerpener | Köln | 50937 | Germany | Details | |
| GEFOS (Gesellschaft für onkologische Studien) Dortmund mbH | Dortmund | Nordrhein Westfalen | 44263 | Germany | Details | |
| Gemeinschaftspraxis Haematologie und Onkologie | Dresden | Sachsen Anhalt | 01307 | Germany | Details | |
| Universitaetsklinikum Carl Gustav Carus TU Dresden | Dresden | Sachsen | 01307 | Germany | Details | |
| Debreceni Egyetem | Debrecen | 4032 | Hungary | Details | ||
| Markusovszky Egyetemi Oktatokorhaz | Szombathely | 9700 | Hungary | Details | ||
| Hadassah Medical Center | Jerusalem | 9112001 | Israel | Details | ||
| Rabin Medical Center-Beilinson Campus | Petach-Tikva | 4941492 | Israel | Details | ||
| Chaim Sheba Medical Center | Ramat Gan | 5262100 | Israel | Details | ||
| Tel Aviv Sourasky Medical Center | Tel Aviv | 6423906 | Israel | Details | ||
| IRCCS Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori "Dino Amadori" - IRST | Meldola | Forlì-Cesena | 47014 | Italy | Details | |
| A.O.U. Citta' della Salute e della Scienza di Torino | Torino | Otago | 10126 | Italy | Details | |
| Fondazione del Piemonte per l'Oncologia IRCCS Candiolo | Candiolo | Torino | 10060 | Italy | Details | |
| Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo | Alessandria | 15121 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS | Bologna | 40138 | Italy | Details | ||
| Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico | Milano | 20122 | Italy | Details | ||
| IRCCS Ospedale San Raffaele | Milano | 20132 | Italy | Details | ||
| IEO Istituto Europeo di Oncologia | Milano | 20141 | Italy | Details | ||
| Azienda Unita Sanitaria Locale di Reggio Emilia | Reggio Emilia | 42122 | Italy | Details | ||
| Centro Ricerche Cliniche di Verona s.r.l. | Verona | 37134 | Italy | Details | ||
| Tokai University Hospital- Isehara Campus | Isehara | Kanagawa | 259-1143 | Japan | Details | |
| Kumamoto University Hospital | Kumamoto | 860-8556 | Japan | Details | ||
| Yamagata University Hospital | Yamagata | 990-2331 | Japan | Details | ||
| Seoul National University Hospital | Seoul | Seoul, Korea | 03080 | Korea, Republic of | Details | |
| The Catholic University of Korea-Seoul St. Mary's Hospital | Seocho-Gu | Seoul | 06591 | Korea, Republic of | Details | |
| Inje Univ Busan Paik Hospital | Busan | 47392 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| P3 Research | Newtown | Wellington | 6021 | New Zealand | Details | |
| Dunedin Hospital | Dunedin | 9016 | New Zealand | Details | ||
| Waikato Hospital | Hamilton | 3200 | New Zealand | Details | ||
| Middlemore Hospital | Otahuhu | 2025 | New Zealand | Details | ||
| Uniwersyteckie Centrum Kliniczne | Gdansk | Pomorskie | 80214 | Poland | Details | |
| Centrum Medyczne Pratia Poznan | Skorzewo | Poznan | 60 185 | Poland | Details | |
| KO-MED Centra Kliniczne | Biała Podlaska | 21500 | Poland | Details | ||
| Szpital Uniwersytecki nr 2 im. dr Jana Biziela w BydgoszczyKlinika Hematologii | Bydgoszcz | 85-168 | Poland | Details | ||
| Pratia Onkologia Katowice | Katowice | 40-519 | Poland | Details | ||
| Pratia MCM Krakow | Krakow | 30-510 | Poland | Details | ||
| Klinika Hematoonkologii i Transplantacji Szpiku | Lublin | 20-081 | Poland | Details | ||
| Szpital Wojewodzki w Opolu | Opole | 45-061 | Poland | Details | ||
| Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu Klinika Hematologii | Wrocław | 50-367 | Poland | Details | ||
| Institut Català d'Oncologia de Girona (ICO Girona) | Girona | Cataluna | 17007 | Spain | Details | |
| Hospital Germans Trias i Pujol | Badalona | Catalunya [Cataluña] | 08916 | Spain | Details | |
| Hospital Universitari Vall d'Hebron | Barcelona | Cataluña | 08035 | Spain | Details | |
| Hospital Universitario Puerta de Hierro Majadahonda | Majadahonda | Madrid, Comunidad De | 28222 | Spain | Details | |
| Hospital Costa Del Sol | Marbella | Malaga | 29603 | Spain | Details | |
| Hospital De Navarra | Pamplona | Navarra | 31008 | Spain | Details | |
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital de la Santa Creu i Sant Pau | Barcelona | 08041 | Spain | Details | ||
| Hospital Duran i Reynals | L'Hospitalet de Llobregat | 08908 | Spain | Details | ||
| Hospital De Gran Canaria Dr. Negrin | Las Palmas de Gran Canaria | 35010 | Spain | Details | ||
| Clinica Universitaria De Navarra | Madrid | 28027 | Spain | Details | ||
| Hospital Universitario Infanta Leonor | Madrid | 28031 | Spain | Details | ||
| Hospital Universitario Ramón y Cajal | Madrid | Spain | Details | |||
| Hospital Universitario Marqués de Valdecilla | Santander | 39008 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hospital Universitario Virgen Del Rocio | Sevilla | 41013 | Spain | Details | ||
| Chang Gung Memorial Hospital - Chiayi | Putz | Chiayi Hsien | 61363 | Taiwan | Details | |
| Chang Bing Show Chwan Memorial Hospital | Changhua | 50544 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Tainan | 704 | Taiwan | Details | ||
| Koo Foundation Sun Yan-Sen Cancer Center | Taipei | 11259 | Taiwan | Details | ||
| Ankara University Medicine Hospital | Mamak | Ankara | 06590 | Turkey | Details | |
| 9 Eylul University Hospital | Balçova | İzmir | 35100 | Turkey | Details | |
| Ege University Medical Faculty | Bornova | Izmir | 35040 | Turkey | Details | |
| Gazi University Faculty of Medicine | Ankara | Yenimahalle | 06560 | Turkey | Details | |
| Koc University American Hospital | Istanbul | 34365 | Turkey | Details | ||
| Acıbadem Maslak Hastanesi | Istanbul | 34457 | Turkey | Details | ||
| Istanbul University Istanbul Medical Faculty | Istanbul | 34732 | Turkey | Details | ||
| Bristol Haematology and Oncology Centre | Bristol | Bristol, City Of | BS2 8ED | United Kingdom | Details | |
| Castle Hill Hospital | Hull | East Riding Of Yorkshire | HU16 5JQ | United Kingdom | Details | |
| Leicester Royal Infirmary | Leicester | Leicestershire | LE1 5WW | United Kingdom | Details | |
| St Bartholomew's Hospital | London | London, City Of | EC1A 7BE | United Kingdom | Details | |
| Singleton Hospital | Swansea | SA2 8QA | United Kingdom | Details |