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| NCT ID | NCT05270044 |
| Title | Adjuvant Encorafenib and Binimetinib in High-risk Stage II Melanoma With a BRAF Mutation. (COLUMBUS-AD) |
| Acronym | COLUMBUS-AD |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Pierre Fabre Medicament |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | SWE | ROU | POL | NOR | NLD | ITA | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Centro Oncologico Korben | Caba | Buenos Aires | C1426 | Argentina | Details | |
| Centro de Investigaciones Medicas Mar del Plata | Mar Del Plata | Buenos Aires | B7600FYK | Argentina | Details | |
| Fundacion CIDEA | Ciudad Autonoma Bs As | Ciudad Autonoma Buenos Aires | C1121ABE | Argentina | Details | |
| Sanatorio Britanico S.A. | Rosario | Santa Fe | 2000 | Argentina | Details | |
| Instituto de Oncologia de Rosario | Rosario | Santa Fe | S2000KZE | Argentina | Details | |
| Hospital Aleman | Ciudad Autonoma Buenos Aires | C1118AAT | Argentina | Details | ||
| Instituto Medico Especializado Alexander Fleming | Ciudad Autonoma Buenos Aires | C1426ANZ | Argentina | Details | ||
| Clinica Adventista Belgrano | Ciudad Autonoma Buenos Aires | C1430EGF | Argentina | Details | ||
| Westmead Hospital | Sydney | New South Wales | 2145 | Australia | Details | |
| Melanoma Institute Australia | Wollstonecraft | New South Wales | 2065 | Australia | Details | |
| Princess Alexandra Hospital | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Adelaide Oncology & Haematolog, Calvary North Adelaide Hospital | North Adelaide | South Australia | 5006 | Australia | Details | |
| Box Hill Hospital | Box Hill | Victoria | 3128 | Australia | Details | |
| Austin Health | Heidelberg | Victoria | 3084 | Australia | Details | |
| The Alfred Hospital | Prahran | Victoria | 3181 | Australia | Details | |
| Hollywood Private Hospital | Nedlands | Western Australia | 6009 | Australia | Details | |
| Sir Charles Gairdner Hospital | Nedlands | Western Australia | 6009 | Australia | Details | |
| Landeskrankenhaus - Universitaetsklinikum Graz | Graz | 8036 | Austria | Details | ||
| Krankenhaus der Elisabethinen Linz | Linz | 4020 | Austria | Details | ||
| Universitätsklinikum St.Pölten-Lilienfeld | St. Pölten | 3100 | Austria | Details | ||
| AKH - Medizinische Universität Wien | Vienna | 1090 | Austria | Details | ||
| Institut Jules Bordet | Anderlecht | 1070 | Belgium | Details | ||
| ZNA Middelheim | Antwerpen | 2020 | Belgium | Details | ||
| Cliniques Universitaires Saint-Luc | Brussels | 1200 | Belgium | Details | ||
| Universitair Ziekenhuis Brussel | Brussel | 1090 | Belgium | Details | ||
| UZ Gent | Gent | 9000 | Belgium | Details | ||
| ZNA | Merksem | 2170 | Belgium | Details | ||
| Vitaz | Sint-Niklaas | 9100 | Belgium | Details | ||
| CHU UCL Namur | Yvoir | 5530 | Belgium | Details | ||
| AMO - Assistência Multidisciplinar em Oncologia | Salvador | Bahia | 41950-640 | Brazil | Details | |
| Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer | Curitiba | Paraná | 81520-060 | Brazil | Details | |
| Instituto de Cancer de Londrina | Londrina | Paraná | 86015-520 | Brazil | Details | |
| Hospital de Clínicas de Porto Alegre | Porto Alegre | Rio Grande Do Sul | 90035-903 | Brazil | Details | |
| HGB - Hospital Giovanni Battista - Mãe de Deus Center | Porto Alegre | Rio Grande Do Sul | 90110-270 | Brazil | Details | |
| Instituto de Oncologia Saint Gallen | Santa Cruz Do Sul | Rio Grande Do Sul | 96810-110 | Brazil | Details | |
| CEPON - Centro de Pesquisas Oncológicas de Santa Catarina | Florianópolis | Santa Catarina | 88034-000 | Brazil | Details | |
| Fundação Doutor Amaral Carvalho | Jaú | Sao Paulo | 17210-120 | Brazil | Details | |
| CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia | Santo André | Sao Paulo | 09060-870 | Brazil | Details | |
| A. C. Camargo Cancer Center | São Paulo | Sao Paulo | 01509-900 | Brazil | Details | |
| London Health Sciences Centre (LHSC) - Victoria Hospital | London | Ontario | N6A 5W9 | Canada | Details | |
| Toronto Sunnybrook Hospital | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| CIUSSS du Centre Ouest de l'lle de Montreal | Montréal | Quebec | H3T 1E2 | Canada | Details | |
| Fakultni nemocnice Hradec Kralove | Hradec Králové | 500 05 | Czechia | Details | ||
| Fakultni nemocnice Olomouc | Olomouc | 79900 | Czechia | Details | ||
| Fakultni nemocnice Ostrava | Ostrava - Poruba | 708 52 | Czechia | Details | ||
| Fakultni nemocnice Kralovske Vinohrady | Praha 10 | 100 34 | Czechia | Details | ||
| Vseobecna fakultni nemocnice v Praze | Praha 2 | 128 08 | Czechia | Details | ||
| CHU Nice - Hopital de l Archet 2 | Nice cedex 3 | Alpes Maritimes | 06202 | France | Details | |
| Hôpital de la Timone | Marseille cedex 5 | Bouches-du-Rhône | 13385 | France | Details | |
| CHU de Dijon - Hôpital du Bocage | Dijon | Cote dÝOr | 21079 | France | Details | |
| CHU de Bordeaux - Hôpital Saint André | Bordeaux | Gironde | 33075 | France | Details | |
| Institut Claudius Regaud - Oncopole | Toulouse | Haute Garonne | 31059 | France | Details | |
| Hôpital Ambroise Paré | Boulogne-Billancourt | Hauts De Seine | 92100 | France | Details | |
| CRLCC Eugene Marquis | Rennes cedex | Ille Et Vilaine | 35042 | France | Details | |
| CHU Tours - Hôpital Trousseau | Chambray-lès-Tours | Indre Et Loire | 37170 | France | Details | |
| CHU de Grenoble - Hôpital André Michallon | La Tronche | Isere | 38700 | France | Details | |
| CHU Nantes - Hôtel Dieu | Nantes Cedex 1 | Loire Atlantique | 44093 | France | Details | |
| CHU Saint Etienne - Hôpital Nord | Saint Etienne Cedex 2 | Loire | 42055 | France | Details | |
| Hopital Claude Huriez - CHU Lille | Lille cedex | Nord | 59037 | France | Details | |
| Hôpital Saint-Louis | Paris Cedex 10 | Paris | 75010 | France | Details | |
| CAC Clermont-Ferrand Centre Jean Perrin | Clermont-Ferrand | Puy De Dome | 63000 | France | Details | |
| Centre Hospitalier de Pau - Hôpital François Mitterrand | Pau cedex | Pyrenees Atlantiques | 64046 | France | Details | |
| Centre Hospitalier Lyon Sud | Pierre Bénite cedex | Rhone | 69495 | France | Details | |
| CHU de Rouen - Hôpital Charles Nicolle | Rouen | Seine Maritime | 76031 | France | Details | |
| Institut Gustave Roussy | Villejuif cedex | Val De Marne | 94805 | France | Details | |
| CHU Poitiers - Hôpital la Milétrie | Poitiers | Vienne | 86021 | France | Details | |
| Universitaetsklinikum Heidelberg | Heidelberg | Baden Wuerttemberg | 69120 | Germany | Details | |
| Universitaetsklinikum Wuerzburg | Wuerzburg | Bayern | 97080 | Germany | Details | |
| Elbekliniken Buxtehude GmbH | Buxtehude | Niedersachsen | 21614 | Germany | Details | |
| Universitaetsklinikum Carl Gustav Carus TU Dresden | Dresden | Sachsen | 01307 | Germany | Details | |
| Universitaetsklinikum Schleswig-Holstein | Kiel | Schleswig Holstein | 24105 | Germany | Details | |
| Universitaetsklinikum Hamburg-Eppendorf | Hamburg | 20246 | Germany | Details | ||
| General Hospital of Athens Laiko | Athens | 11527 | Greece | Details | ||
| Metropolitan Hospital | Néo Fáliro | 18547 | Greece | Details | ||
| Bioclinic Thessaloniki | Thessaloníki | 54622 | Greece | Details | ||
| Anticancer Hospital of Thessaloniki " Theagenio" | Thessaloníki | 54639 | Greece | Details | ||
| Interbalkan Hospital of Thessaloniki | Thessaloníki | 57001 | Greece | Details | ||
| Semmelweis Egyetem | Budapest | 1085 | Hungary | Details | ||
| Orszagos Onkologiai Intezet | Budapest | 1122 | Hungary | Details | ||
| Debreceni Egyetem | Debrecen | 4032 | Hungary | Details | ||
| Petz Aladar Egyetemi Oktato Korhaz | Győr | 9023 | Hungary | Details | ||
| Pecsi Tudomanyegyetem | Pécs | 7632 | Hungary | Details | ||
| Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont | Szeged | 6720 | Hungary | Details | ||
| IRCCS Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori "Dino Amadori" - IRST | Meldola | Forli - Cesena | 47014 | Italy | Details | |
| Ospedale San Vincenzo | Taormina | Messina | 98039 | Italy | Details | |
| Istituto Nazionale Tumori Fondazione G. Pascale | Naples | Napoli | 80131 | Italy | Details | |
| IRCCS Centro di Riferimento Oncologico | Aviano | Pordenone | 33081 | Italy | Details | |
| Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari | Bari | 70124 | Italy | Details | ||
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII) | Bergamo | 24127 | Italy | Details | ||
| Azienda Sanitaria Ospedaliera S.Croce e Carle | Cuneo | 12100 | Italy | Details | ||
| IRCCS Ospedale Policlinico San Martino | Genova | 16132 | Italy | Details | ||
| Ospedale San Raffaele | Milano | 20132 | Italy | Details | ||
| Fondazione IRCCS Istituto Nazionale dei Tumori | Milano | 20133 | Italy | Details | ||
| IEO Istituto Europeo di Oncologia | Milano | 20141 | Italy | Details | ||
| IOV - Istituto Oncologico Veneto IRCCS | Padova | 35128 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone | Palermo | 90127 | Italy | Details | ||
| Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia | Perugia | 06156 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Pisana | Pisa | 56126 | Italy | Details | ||
| Istituto Nazionale Tumori Regina Elena IRCCS | Roma | 00144 | Italy | Details | ||
| IDI-Istituto Dermopatico dell'Immacolata IRCCS | Roma | 00167 | Italy | Details | ||
| Policlinico Universitario di Sassari | Sassari | 07100 | Italy | Details | ||
| A.O.U. Senese Policlinico Santa Maria alle Scotte | Siena | 53100 | Italy | Details | ||
| Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino | Torino | 10126 | Italy | Details | ||
| Azienda Sanitaria Universitaria Friuli Centrale | Udine | 33100 | Italy | Details | ||
| Antoni van Leeuwenhoek | Amsterdam | 1066 CX | Netherlands | Details | ||
| Universitair Medisch Centrum Groningen (UMCG) | Groningen | 9713 GZ | Netherlands | Details | ||
| Leids Universitair Medisch Centrum | Leiden | 2333 ZA | Netherlands | Details | ||
| Maastricht University Medical Center | Maastricht | 6202 AZ | Netherlands | Details | ||
| Radboudumc | Nijmegen | 6525 GA | Netherlands | Details | ||
| Erasmus MC | Rotterdam | 3015 GD | Netherlands | Details | ||
| UMC Utrecht | Utrecht | 3508 GA | Netherlands | Details | ||
| Isala | Zwolle | 8025 AB | Netherlands | Details | ||
| Oslo University Hospital | Oslo | 0424 | Norway | Details | ||
| Ålesund Hospital | Ålesund | 6017 | Norway | Details | ||
| Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie - Panstwowy Instytut Badawczy | Gliwice | 44-102 | Poland | Details | ||
| Przychodnia Lekarska Komed | Konin | 62-500 | Poland | Details | ||
| Centrum Onkologii-Instytut im. M. Sklodowskiej-Curie | Kraków | 31-115 | Poland | Details | ||
| Wielkopolskie Centrum Onkologii | Poznań | 61-866 | Poland | Details | ||
| Centrum Medyczne Pratia Poznan | Skórzewo | 60-185 | Poland | Details | ||
| Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy | Warszawa | 02-781 | Poland | Details | ||
| Dolnoslaskie Centrum Onkologii | Wrocław | 53-413 | Poland | Details | ||
| Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE | Lisboa | 1099-023 | Portugal | Details | ||
| Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria | Lisboa | 1649-035 | Portugal | Details | ||
| Instituto Português de Oncologia do Porto Francisco Gentil, EPE | Porto | 4200-072 | Portugal | Details | ||
| S.C Medisprof S.R.L | Cluj-Napoca | 400641 | Romania | Details | ||
| S.C Centrul de Oncologie Sf. Nectarie S.R.L | Craiova | 200542 | Romania | Details | ||
| Institutul Regional de Oncologie Iasi | Iasi | 700483 | Romania | Details | ||
| Clinical Center "Bezanijska kosa" | Belgrade | 11000 | Serbia | Details | ||
| Institute of Oncology and Radiology of Serbia | Belgrade | 11000 | Serbia | Details | ||
| Military Medical Academy | Belgrade | 11000 | Serbia | Details | ||
| Clinical Center Kragujevac | Kragujevac | 34000 | Serbia | Details | ||
| Clinical Center Nis | Niš | 18000 | Serbia | Details | ||
| Oncology Institute of Vojvodina | Sremska Kamenica | 21204 | Serbia | Details | ||
| National Hospital Oncology | Bloemfontein | Free State | 9301 | South Africa | Details | |
| Johese Clinical Research: Midstream | Centurion | Gauteng | 1692 | South Africa | Details | |
| Sandton Oncology Medical Group | Johannesburg | Gauteng | 2196 | South Africa | Details | |
| ICO Badalona - Hospital Universitari Germans Trias i Pujol | Badalona | Barcelona | 08916 | Spain | Details | |
| ICO l'Hospitalet - Hospital Duran i Reynals | L'Hospitalet De Llobregat | Barcelona | 08908 | Spain | Details | |
| Hospital Universitario Virgen de la Arrixaca | El Palmar | Murcia | 30120 | Spain | Details | |
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hospital Universitario Reina Sofia | Córdoba | 14004 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Centro Integral Oncologico Clara Campal | Madrid | 28050 | Spain | Details | ||
| Hospital Regional Universitario de Malaga | Málaga | 29010 | Spain | Details | ||
| Hospital Clinico Universitario de Valencia | Valencia | 46010 | Spain | Details | ||
| Hospital General Universitario de Valencia | Valencia | 46014 | Spain | Details | ||
| Karolinska University Hospital | Stockholm | 17176 | Sweden | Details | ||
| Norrlands Universitetssjukhus | Umeå | 901 87 | Sweden | Details | ||
| Universitaetsspital Zuerich | Zuerich | 8091 | Switzerland | Details | ||
| Royal Preston Hospital | Preston | Lancashire | PR2 9HT | United Kingdom | Details | |
| Northern Centre for Cancer Care | Newcastle Upon Tyne | Tyne & Wear | NE7 7DN | United Kingdom | Details |