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| NCT ID | NCT05388669 |
| Title | A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer (PALOMA-3) |
| Acronym | PALOMA-3 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Janssen Research & Development, LLC |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | ITA | ISR | GBR | FRA | ESP | DEU | CAN | BRA | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| City of Hope Duarte | Duarte | California | 91010 | United States | Details | |
| City of Hope Orange County Lennar Foundation Cancer Center | Irvine | California | 92618 | United States | Details | |
| City of Hope Long Beach Elm | Long Beach | California | 90813 | United States | Details | |
| National Jewish Health | Denver | Colorado | 80206 | United States | Details | |
| Baptist Lynn Cancer Institute | Boca Raton | Florida | 33486 | United States | Details | |
| Orlando Health | Orlando | Florida | 32806 | United States | Details | |
| University of Kansas | Kansas City | Kansas | 66160 | United States | Details | |
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | Details | |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | United States | Details | |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | United States | Details | |
| Montefiore Medical Center | Bronx | New York | 10461 | United States | Details | |
| NYU Langone Health Laura and Isaac Perlmutter Cancer Center | New York | New York | 10016 | United States | Details | |
| Providence Portland Medical Center | Portland | Oregon | 97213 | United States | Details | |
| Providence Oncology and Hematology Care Clinic Westside | Portland | Oregon | 97225 | United States | Details | |
| University of Pennsylvania Division of Hematology Oncology Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States | Details | |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | United States | Details | |
| CEMIC (Centro de Educación Médica e Investigaciones Clínicas) | Buenos Aires | 1431 | Argentina | Details | ||
| IADT Instituto Argentino de Diagnostico y Tratamiento | Caba | C1122 | Argentina | Details | ||
| Centro Oncológico Korben | Ciudad Autonoma de Buenos Aires | C1426AGE | Argentina | Details | ||
| Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica | Cordoba | 5000 | Argentina | Details | ||
| Sanatorio Allende | Cordoba | 5000 | Argentina | Details | ||
| Clínica Viedma | Viedma | R8500ACE | Argentina | Details | ||
| Cancer Research SA | Adelaide | 5000 | Australia | Details | ||
| Chris O'Brien Lifehouse | Camperdown | 2050 | Australia | Details | ||
| Peter MacCallum Cancer Centre | Melbourne | 3000 | Australia | Details | ||
| St John of God Hospital Murdoch | Murdoch | 6150 | Australia | Details | ||
| Westmead Hospital | Westmead | 2145 | Australia | Details | ||
| Princess Alexandra Hospital | Woolloongabba | 4102 | Australia | Details | ||
| Fundacao Pio XII | Barretos | 14784-400 | Brazil | Details | ||
| Cetus Oncologia | Belo Horizonte | 30110-017 | Brazil | Details | ||
| Instituto Cionc de Ensino e Pesquisa S/S | Curitiba | 80810-050 | Brazil | Details | ||
| Ynova Pesquisa Clinica | Florianopolis | 88020-210 | Brazil | Details | ||
| Fundacao Sao Francisco Xavier HMC Unidade de Oncologia | Ipatinga | 35162 189 | Brazil | Details | ||
| UPCO Unidade de Pesquisa Clinica em Oncologia | Pelotas | 96020 080 | Brazil | Details | ||
| Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS | Porto Alegre | 90610-000 | Brazil | Details | ||
| Impar Servicos Hospitalares S/A | Rio de Janeiro | 22061-080 | Brazil | Details | ||
| Oncoclinicas Rio de Janeiro S A | Rio de Janeiro | 22250 905 | Brazil | Details | ||
| Instituto D Or de Pesquisa e Ensino IDOR | Rio de Janeiro | 22281 100 | Brazil | Details | ||
| Nucleo de Oncologia da Bahia | Salvador | 40170 110 | Brazil | Details | ||
| CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia | Santo Andre | 09060-650 | Brazil | Details | ||
| Impar Servicos Hospitalares SA Hospital Nove de Julho | Sao Paulo | 01409-002 | Brazil | Details | ||
| Onco Star SP Oncologia Ltda | Sao Paulo | 04543-000 | Brazil | Details | ||
| Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein | Sao Paulo | 05652 900 | Brazil | Details | ||
| Núcleo de Pesquisa São Camilo | São Paulo | 04014-002 | Brazil | Details | ||
| The Ottawa Hospital Cancer Centre | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Princess Margaret Hospital | Toronto | Ontario | M5G 1Z5 | Canada | Details | |
| Beijing Shijitan Hospital, Capital Medical University | Beijing | 100038 | China | Details | ||
| Beijing Friendship Hospital Capital Medical University | Beijing | 100050 | China | Details | ||
| Peking University Third Hospital | Beijing | 100191 | China | Details | ||
| Beijing Chest hospital, Capital medical university | Beijing | 101149 | China | Details | ||
| Cancer Hospital Chinese Academy of Medical Sciences | Beijing | 200240 | China | Details | ||
| Jilin cancer hospital | Changchun | 130012 | China | Details | ||
| The First People's Hospital Of Changzhou | Changzhou | 213004 | China | Details | ||
| Sichuan Cancer Hospital | Chengdu | 610041 | China | Details | ||
| West China Hospital Sichuan University | Chengdu | 610047 | China | Details | ||
| Chongqing University Cancer Hospital | Chongqing | 400030 | China | Details | ||
| Southwest Hospital | ChongQing | 400038 | China | Details | ||
| First Affiliated Hospital of Gannan Medical University | Ganzhou | 341000 | China | Details | ||
| The First Affiliated Hospital Sun Yat sen University | Guang Zhou | 510080 | China | Details | ||
| Sun Yat-Sen Memorial Hospital Sun Yat-sen University | Guangzhou | 510000 | China | Details | ||
| Zhejiang Cancer Hospital | Hang Zhou | 310022 | China | Details | ||
| The Second Affiliated Hospital of Zhejiang University College of Medicine | Hangzhou | 310009 | China | Details | ||
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine | Hangzhou | 310016 | China | Details | ||
| Harbin medical university cancer hospital | Harbin | 150081 | China | Details | ||
| Huizhou Municipal Central Hospital | Huizhou | 516001 | China | Details | ||
| Huizhou First Hospital | Huizhou | 516003 | China | Details | ||
| Liuzhou people's Hospital | Liuzhou | 545026 | China | Details | ||
| Affiliated Hospital of North Sichuan Medical College | Nanchong | 637100 | China | Details | ||
| Fudan University Shanghai Cancer Center | Shanghai | 200032 | China | Details | ||
| Shenzhen People s Hospital | Shen Zhen Shi | 518001 | China | Details | ||
| Shengjing Hospital Of China Medical University | Shenyang | 110004 | China | Details | ||
| Shenzhen university General Hospital | Shenzhen | 518055 | China | Details | ||
| Tianjin Medical University Cancer Institute and Hospital | Tianjin | 300060 | China | Details | ||
| Union Hospital Tongji Medical College of Huazhong University of Science and Technology | Wuhan | 430022 | China | Details | ||
| The First Affiliated Hospital of Xian Jiaotong University | XI An | 710061 | China | Details | ||
| Xiangyang Central Hospital | Xiangyang | 441021 | China | Details | ||
| Yantai Yuhuangding Hospital | Yantai | 264000 | China | Details | ||
| Henan Cancer Hospital | Zhengzhou | 450008 | China | Details | ||
| CHU Grenoble | La Tronche | 38700 | France | Details | ||
| Institute Coeur Poumon | Lille | 59000 | France | Details | ||
| CHU de Limoges Hopital Dupuytren | Limoges | 87000 | France | Details | ||
| Hopital Nord | Marseille Cedex 20 | 13915 | France | Details | ||
| Evangelische Lungenklinik Berlin | Berlin | 13125 | Germany | Details | ||
| Niels-Stensen-Kliniken Franziskus-Hospital Harderberg | Georgsmarienhütte | 49124 | Germany | Details | ||
| Universitaetsklinikum Giessen und Marburg GmbH | Giessen | 35392 | Germany | Details | ||
| Munster University Hospital | Münster | 48149 | Germany | Details | ||
| Oncologianova GmbH | Recklinghausen | 45659 | Germany | Details | ||
| Onkologische Schwerpunktpraxis | Weinsberg | 74189 | Germany | Details | ||
| Rambam Medical Center | Haifa | 3109601 | Israel | Details | ||
| Shaare Zedek Medical Center | Jerusalem | 91031 | Israel | Details | ||
| Meir Medical Center | Kfar Saba | 44281 | Israel | Details | ||
| Rabin Medical Center | Petah-Tikva | 49100 | Israel | Details | ||
| Chaim Sheba Medical Center | Ramat Gan | 5262100 | Israel | Details | ||
| Oncologia Medica - Irccs - Istituto Tumori Giovanni Paolo II | Bari | 70124 | Italy | Details | ||
| A O U Sant Orsola Malpighi | Bologna | 40138 | Italy | Details | ||
| European Institute of Oncology | Milano | 20141 | Italy | Details | ||
| Aou San Luigi Gonzaga | Orbassano | 10043 | Italy | Details | ||
| Istituto Oncologico Veneto - IRCCS | Padova | 35128 | Italy | Details | ||
| Ospedale S. Maria Delle Croci | Ravenna | 48121 | Italy | Details | ||
| A.O. San Camillo Forlanini | Roma | 00152 | Italy | Details | ||
| Istituto Nazionale Tumori Regina Elena | Rome | 00144 | Italy | Details | ||
| Istituto Clinico Humanitas | Rozzano | 20089 | Italy | Details | ||
| National Cancer Center Hospital | Chuo Ku | 104 0045 | Japan | Details | ||
| National Hospital Organization Himeji Medical Center | Himeji | 670-8520 | Japan | Details | ||
| Kansai Medical University Hospital | Hirakata | 573-1191 | Japan | Details | ||
| Kanagawa Cancer Center | Kanagawa | 241-8515 | Japan | Details | ||
| Kurashiki Central Hospital | Kurashiki | 710-8602 | Japan | Details | ||
| Kurume University Hospital | Kurume | 830-0011 | Japan | Details | ||
| Matsusaka Municipal Hospital | Matsusaka | 515-8544 | Japan | Details | ||
| Niigata Cancer Center Hospital | Niigata | 951-8566 | Japan | Details | ||
| Okayama University Hospital | Okayama | 700-8558 | Japan | Details | ||
| Osaka International Cancer Institute | Osaka City | 541 8567 | Japan | Details | ||
| Hokkaido University Hospital | Sapporo-shi | 060-8648 | Japan | Details | ||
| Shizuoka Cancer Center | Shizuoka | 411 8777 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR | Tokyo | 135 8550 | Japan | Details | ||
| Fujita Health University Hospital | Toyoake | 470-1192 | Japan | Details | ||
| National Hospital Organization Osaka Toneyama Medical Center | Toyonaka-shi | 560-8552 | Japan | Details | ||
| Wakayama Medical University Hospital | Wakayama | 641 8510 | Japan | Details | ||
| National Hospital Organization Iwakuni Clinical Center | Yamaguchi | 740-8510 | Japan | Details | ||
| National Hospital Organization Yamaguchi Ube Medical Center | Yamaguchi | 755-0241 | Japan | Details | ||
| National Cancer Center | Gyeonggi-do | 10408 | Korea, Republic of | Details | ||
| CHA Bundang Medical Center, CHA University | Gyeonggi-do | 13496 | Korea, Republic of | Details | ||
| GyeongSang National University Hospital | Gyeongsangnam-do | 52727 | Korea, Republic of | Details | ||
| Chonnam National University Hwasun Hospital | Jeollanam-do | 58128 | Korea, Republic of | Details | ||
| Seoul National University Bundang Hospital | Seongnam-si | 13620 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Prince Court Medical Centre | Kuala Lumpur | 50450 | Malaysia | Details | ||
| Pantai Hospital Kuala Lumpur | Kuala Lumpur | 59100 | Malaysia | Details | ||
| University Malaya Medical Centre | Kuala Lumpur | 59100 | Malaysia | Details | ||
| Hospital Umum Sarawak | Kuching | 93586 | Malaysia | Details | ||
| Beacon Hospital Sdn Bhd | Petaling Jaya | 46050 | Malaysia | Details | ||
| Sunway Medical Centre | Petaling Jaya | 47500 | Malaysia | Details | ||
| Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy | Bydgoszcz | 85-796 | Poland | Details | ||
| Krakowski Szpital Specjalityczny im. Jana Pawla II | Krakow | 31-202 | Poland | Details | ||
| Mazowieckie Centrum Leczenia Chorob Pluc | Otwock | 05-400 | Poland | Details | ||
| Private Specialist Hospitals - MedPolonia | Poznan | 60-693 | Poland | Details | ||
| Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy | Warszawa | 02-781 | Poland | Details | ||
| Hospital de Braga | Braga | 4710-243 | Portugal | Details | ||
| Hospital da Luz, SA | Lisboa | 1500-650 | Portugal | Details | ||
| Hosp. Cuf Descobertas | Lisboa | 1998-018 | Portugal | Details | ||
| Hospital Pedro Hispano | Senhora da Hora, | 4464-513 | Portugal | Details | ||
| Hosp Univ A Coruna | A Coruna | 15006 | Spain | Details | ||
| Hosp. Gral. Univ. de Alicante | Alicante | 03010 | Spain | Details | ||
| Hosp Univ Vall D Hebron | Barcelona | 08035 | Spain | Details | ||
| Hosp Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| Hosp. Univ. Quiron Dexeus | Barcelona | 8028 | Spain | Details | ||
| Hosp Reina Sofia | Córdoba | 14004 | Spain | Details | ||
| Hosp. Univ. Insular de Gran Canaria | Las Palmas de Gran Canaria | 35016 | Spain | Details | ||
| Hosp. Univ. Lucus Augusti | Lugo | 27003 | Spain | Details | ||
| Hosp. Gral. Univ. Gregorio Maranon | Madrid | 28009 | Spain | Details | ||
| Hosp. Univ. La Paz | Madrid | 28046 | Spain | Details | ||
| Hosp. Univ. Pta. de Hierro Majadahonda | Majadahonda | 28222 | Spain | Details | ||
| Hosp Regional Univ de Malaga | Málaga | 29011 | Spain | Details | ||
| Hosp. Univ. Central de Asturias | Oviedo | 33011 | Spain | Details | ||
| Hosp. Univ. Son Espases | Palma de Mallorca | 07120 | Spain | Details | ||
| Hosp. Virgen Del Rocio | Sevilla | 41013 | Spain | Details | ||
| Hosp. Univ. I Politecni La Fe | Valencia | 46026 | Spain | Details | ||
| Changhua Christian Hospital | Changhua | 50006 | Taiwan | Details | ||
| Chang Kung Memorial Hospital | Kaohsiung City | 833 | Taiwan | Details | ||
| Kaohsiung Medical University Chung Ho Memorial Hospital | Kaohsiung | 80756 | Taiwan | Details | ||
| Chung Shan Medical University Hospital | Taichung | 403 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Tainan | 70403 | Taiwan | Details | ||
| National Taiwan University Cancer Center | Taipei City | 106 | Taiwan | Details | ||
| National Taiwan University Hospital | Taipei | 10048 | Taiwan | Details | ||
| Linkou Chang Gung Memorial Hospital | Taoyuan | 33382 | Taiwan | Details | ||
| Phramongkutklao Hospital and Medical College | Bangkok | 10400 | Thailand | Details | ||
| Siriraj Hospital | Bangkok | 10700 | Thailand | Details | ||
| Chiang Mai University | Chiangmai | 50200 | Thailand | Details | ||
| Adana City Hospital | Adana | 01060 | Turkey | Details | ||
| Adana Baskent Hospital | Adana | 01120 | Turkey | Details | ||
| Memorial Ankara Hastanesi | Ankara | 06520 | Turkey | Details | ||
| Gazi University Hospital | Ankara | 06560 | Turkey | Details | ||
| Ankara Bilkent City Hospital | Ankara | 06800 | Turkey | Details | ||
| Trakya University Medical Faculty | Edirne | 22030 | Turkey | Details | ||
| Istanbul University Cerrahpasa Medical Faculty | Istanbul | 34098 | Turkey | Details | ||
| Acıbadem Maslak Hospital | Istanbul | 34457 | Turkey | Details | ||
| Dokuz Eylul University Medical Faculty | Izmir | 35330 | Turkey | Details | ||
| IEU Medical Point Hospital | Izmir | 35575 | Turkey | Details | ||
| Medical Park Samsun Hastanesi | Samsun | 55200 | Turkey | Details | ||
| Birmingham Heartlands Hospital | Birmingham | B9 5SS | United Kingdom | Details | ||
| Imperial College Healthcare | London | W2 1NY | United Kingdom | Details | ||
| Newcastle Freeman Hospital | Newcastle Upon Tyne | NE7 7DN | United Kingdom | Details | ||
| Royal Marsden Hospital | Sutton | SM2 5PT | United Kingdom | Details |