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| NCT ID | NCT05568095 |
| Title | A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body (STAR-221) |
| Acronym | STAR-221 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Arcus Biosciences, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | ROU | POL | LTU | ITA | ISR | HUN | GRC | GBR | FRA | ESP | CAN | BRA | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Aichi Cancer Center | Nagoya | Japan | Details | |||
| Ankara Üniversitesi Tıp Fakültesi - Cebeci Araştırma ve Uygulama Hastanesi | Mamak | Turkey | Details | |||
| Asan Medical Center | Seoul | Korea, Republic of | Details | |||
| Ataturk Universitesi Arastirma Hastanesi | Yakutiye | Turkey | Details | |||
| Azienda Ospedaliero - Universitaria Careggi | Firenze | Italy | Details | |||
| Azienda Sanitaria Universitaria Friuli Centrale ? P.O. Santa Maria della Misericordia | Udine | Italy | Details | |||
| Baguio General Hospital and Medical Center | Baguio | Philippines | Details | |||
| Barts Health NHS Trust | London | United Kingdom | Details | |||
| Baylor College of Medicine | Houston | Texas | 77054 | United States | Details | |
| Başkent Üniversitesi Adana Dr Turgut Noyan Uygulama ve Araştirma Merkezi | Yüreğir | Turkey | Details | |||
| BioClinic Thessaloniki | Thessaloniki | Greece | Details | |||
| Bradford Hill Centro de Investigaciones Clinicas | Recoleta | Chile | Details | |||
| Bács-Kiskun Megyei Oktatókórház - Kecskemét | Kecskemet | Hungary | Details | |||
| Cancer Inst Hosp of JFCR | Koto | Japan | Details | |||
| Cebu Doctors' University Hospital | Cebu City | Philippines | Details | |||
| Centre Armoricain de Radiothérapie, d'Imagerie Médicale et d'Oncologie | Plerin | France | Details | |||
| Centre de Lutte contre le Cancer - François Baclesse | Caen Cedex 5 | France | Details | |||
| Centre Hospitalier Universitaire de Poitiers | Poitiers | France | Details | |||
| Centre Léon Bérard | Lyon | France | Details | |||
| Centro de Atención e Investigación Clínica en Oncología | Merida | 97134 | Mexico | Details | ||
| Centro de Estudios Clínicos SAGA | Santiago | Chile | Details | |||
| Centro Especializado en Investigacion y Tratamiento Oncologicos SC | Mexico DF | 3100 | Mexico | Details | ||
| Centro Hemato - Oncológico Privado (CHOP) | Toluca de Lerdo | 50120 | Mexico | Details | ||
| Centro Hospitalar e Universitário de Coimbra | Coimbra | Portugal | Details | |||
| Centro Regional de Sub Especialidades Médicas (CRESEM) SA | Quetzaltenango | Guatemala | Details | |||
| Centrul de Oncologie Euroclinic | Iasi | Romania | Details | |||
| Centrul De Oncologie Sf Nectarie | Craiova | Romania | Details | |||
| Centrul de Radioterapie Amethyst Cluj | Florești | Romania | Details | |||
| Centrum Onkologii Ziemi Lubelskiej im. św. Jana z Dukli | Lublin | Poland | Details | |||
| Cha Bundang Medical Center | Seongnam | Korea, Republic of | Details | |||
| Chiba Cancer Center | Chiba | Japan | Details | |||
| CHUM | Montreal | Canada | Details | |||
| Cleavland Clin - Taussig Cancer Ctr | Cleveland | Ohio | 44106 | United States | Details | |
| Cleveland Clin - Fairview Hosp | Cleveland | Ohio | 44111 | United States | Details | |
| Cleveland Clin-Hillcrest Hosp | Mayfield Heights | Ohio | 44124 | United States | Details | |
| CLIMERS Clinical Medical Research | Colonia Centro | 94300 | Mexico | Details | ||
| Clinica SIGMedical | Suceava | Romania | Details | |||
| Clinical Center Kragujevac | Kragujevac | Serbia | Details | |||
| Clínica Privada Dr. Rixci Ramírez | Guatemala | Guatemala | Details | |||
| Clínica Universidad Católica del Maule - Talca | Talca | Chile | Details | |||
| Davidoff Cancer Center | Petah Tikva | Israel | Details | |||
| Dong-A University Hospital | Busan | Korea, Republic of | Details | |||
| Dr Pablo O. Torre Memorial Hospital - Riverside Medical Center | Bacolod City | Philippines | Details | |||
| Duke University Medical Center | Durham | North Carolina | 27710 | United States | Details | |
| Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet | Budapest | Hungary | Details | |||
| Evex Hospitals - Kutaisi Referral Hospital | Kutaisi | 4600 | Georgia | Details | ||
| Evgenidion Clinic SA - Agia Trias | Athens | Greece | Details | |||
| Faculty of Medicine Siriraj Hospital | Bang Phlat | Thailand | Details | |||
| Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location | Seattle | Washington | 98109 | United States | Details | |
| Froedtert Clinical Cancer Center | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud | Lisboa | Portugal | Details | |||
| Fundação Pio XII - Hospital de Câncer de Barretos - Hospital de Amor | Barretos | Brazil | Details | |||
| General Oncology Hospital of Kifisias "Agioi Anargyroi" | Nea Kifisia | Greece | Details | |||
| Genesis Cancer Center and Blood Institute - Hot Springs | Hot Springs | Arkansas | 71913 | United States | Details | |
| Georgetown Lombardi Comprehensive Cancer Center | Washington | District of Columbia | 22057 | United States | Details | |
| Gosford Hospital | Gosford | Australia | Details | |||
| Grupo Medico Angeles | Guatemala | Guatemala | Details | |||
| Gunma Prefectural Cancer Ctr | Ota-shi | Japan | Details | |||
| Hadassah University Hospital Ein Kerem | Jerusalem | Israel | Details | |||
| Harris Health System | Houston | Texas | 77054 | United States | Details | |
| HealthPartners Cancer Center at Regions Hospital | Saint Louis Park | Minnesota | 55426 | United States | Details | |
| Hong Kong Sanatorium and Hospital | Happy Valley | Hong Kong | Details | |||
| Hospital Británico de Buenos Aires | Buenos Aires | Argentina | Details | |||
| Hospital Clínico Universitario de Valencia | Valencia | Spain | Details | |||
| Hospital Ernesto Dornelles | Porto Alegre | Brazil | Details | |||
| Hospital General Universitario Gregorio Marañón | Madrid | Spain | Details | |||
| Hospital Kuala Lumpur | Kuala Lumpur | Malaysia | Details | |||
| Hospital Maria Auxiliadora | San Juan De Miraflores | Peru | Details | |||
| Hospital Nacional Daniel Alcides Carrión | Bellavista | Peru | Details | |||
| Hospital Puerto Montt | Puerto Montt | Chile | Details | |||
| Hospital Pulau Pinang | George Town | Malaysia | Details | |||
| Hospital Umum Sarawak | Kuching | Malaysia | Details | |||
| Hospital Universitari Vall d'Hebrón | Barcelona | Spain | Details | |||
| Hospital Universitario HM Sanchinarro | Madrid | Spain | Details | |||
| Hospital Universitario Marqués de Valdecilla | Santander | Spain | Details | |||
| Hospital Universitario Miguel Servet | Zaragoza | Spain | Details | |||
| Hospital Universitario Ramón y Cajal | Madrid | Spain | Details | |||
| Hospital Zambrano Hellion TecSalud | San Pedro Garza García | 66278 | Mexico | Details | ||
| Humanity & Health Clinical Trial Centre | Hong Kong | Hong Kong | Details | |||
| Hyogo Cancer Center | Akashi City | Japan | Details | |||
| Hôpital Claude Huriez | Lille Cedex | France | Details | |||
| Hôpital de la Timone | Marseille | France | Details | |||
| Hôpital Morvan | Brest | France | Details | |||
| Hôpital Notre-Dame | Montreal | Canada | Details | |||
| Icegclinic | La Florida | Chile | Details | |||
| Institut Bergonié | Bordeaux cedex | France | Details | |||
| Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet) | Barcelona | Spain | Details | |||
| Institut Gustave Roussy | Villejuif | France | Details | |||
| Institut Régional du Cancer de Montpellier | Montpellier | France | Details | |||
| Institute of Oncology and Radiology of Serbia (Institut za onkologiju i radiologiju Srbije) | Belgrade | Serbia | Details | |||
| Instituto de Investigaciones Clínicas Mar del Plata | Mar del Plata | Argentina | Details | |||
| Instituto Nacional de Câncer - Brazil | Rio de Janeiro | Brazil | Details | |||
| Instituto Nacional de Enfermedades Neoplásicas | Surquillo | Peru | Details | |||
| Instituto Português de Oncologia do Porto Francisco Gentil | Porto | Portugal | Details | |||
| Institutul Clinic Fundeni | Bucharest | Romania | Details | |||
| Institutul Oncologic Prof. Dr. Ion Chiricuta | Cluj-Napoca | Romania | Details | |||
| INTEGRA Cancer Institute | Guatemala | Guatemala | Details | |||
| Inönü Üniversitesi Turgut Özal Tıp Merkezi | Malatya | Turkey | Details | |||
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas | Rozzano | Italy | Details | |||
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele | Milan | Italy | Details | |||
| Istituto Europeo di Oncologia | Milano | Italy | Details | |||
| Kaiser Permanente - Los Angeles Medical Center | Los Angeles | California | 90027 | United States | Details | |
| Kanagawa Cancer Center | Yokohama-Shi | Japan | Details | |||
| Kauno Klinikos | Kaunas | Lithuania | Details | |||
| Kindai University Hospital | Osakasayama-shi | Japan | Details | |||
| Klaipedos Universitetine Ligonine | Klaipeda | Lithuania | Details | |||
| Kocaeli Üniversitesi Araştırma ve Uygulama Hastanesi | Izmit | Turkey | Details | |||
| Korea University Guro Hospital | Seoul | Korea, Republic of | Details | |||
| Kumamoto University Hospital | Kumamoto | Japan | Details | |||
| Kyungpook Nat Uni Chilgok | Daegu | Korea, Republic of | Details | |||
| Kyushu Cancer Center | Fukuoka-shi | Japan | Details | |||
| Liga Contra o Câncer - Centro Avançado de Oncologia | Natal | Brazil | Details | |||
| Liverpool Hospital | Liverpool | Australia | Details | |||
| LLC Todua Clinic | Tbilisi | 112 | Georgia | Details | ||
| Ltd Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic | Tbilisi | 144 | Georgia | Details | ||
| Manila Doctors Hospital | Manila | Philippines | Details | |||
| Mark H. Zangmeister Cancer Center | Columbus | Ohio | 43219 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Medi-k Cayalá | Guatemala city | Guatemala | Details | |||
| Medisprof | Cluj-Napoca | Romania | Details | |||
| Memorial Ankara Hastanesi | Ankara | Turkey | Details | |||
| Memorial Sloan Kettering Cancer Center - New York | New York | New York | 10065 | United States | Details | |
| Metropolitan Hospital | Neo Faliro | Greece | Details | |||
| Monash University | Clayton | Australia | Details | |||
| Multi-profile Clinic "New Hospitals" | Tbilisi | 186 | Georgia | Details | ||
| Nacionalinis Vėžio Institutas | Vilnius | Lithuania | Details | |||
| Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy | Warszawa | Poland | Details | |||
| Nat Cancer Ctr-Kashiwa Campus | Kashiwa-shi | Japan | Details | |||
| National Cancer Ctr Hosp | Tokyo | Japan | Details | |||
| New Vision University Hospital | Tbilisi | 159 | Georgia | Details | ||
| Niigata Cancer Center Hospital | Niigata | Japan | Details | |||
| Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| Norton Cancer Institute - Poplar Level Road | Louisville | Kentucky | 40217 | United States | Details | |
| Ochsner Cancer Institute | New Orleans | Louisiana | 70121 | United States | Details | |
| Oncology West - Murdoch | Murdoch | Australia | Details | |||
| ONCOSITE - Centro de Pesquisa Clinica Em Oncologia Ltda. | Ijuí | Brazil | Details | |||
| Oncovida - Santiago | Providencia | Chile | Details | |||
| Országos Onkológiai Intézet | Budapest | Hungary | Details | |||
| Osaka Prefectural Hosp Org | Osaka | Japan | Details | |||
| Ottawa Hospital - General Campus | Ottawa | Canada | Details | |||
| Oxford University Hospitals NHS Foundation Trust | Oxford | United Kingdom | Details | |||
| Perlmutter Cancer Center - 38th Street | New York | New York | 10016 | United States | Details | |
| Perlmutter Cancer Ctr NYU | Mineola | New York | 11501 | United States | Details | |
| Pontificia Universidad Catolica de Chile - Escuela De Medicina - Clinica UC San Carlos de Apoq | Santiago | Chile | Details | |||
| Princess Margaret Cancer Centre | Toronto | Canada | Details | |||
| Prisma Health Cancer Institute - Faris Road | Greenville | South Carolina | 29605 | United States | Details | |
| Prov Care Clinic - Westside | Portland | Oregon | 97225 | United States | Details | |
| Providence Cancer Center Oncology and Hematology Care Westside Portland | Portland | Oregon | 97225 | United States | Details | |
| Providence Cancer Institute | Portland | Oregon | 97225 | United States | Details | |
| Pusat Perubatan Universiti Malaya | Kuala Lumpur | Malaysia | Details | |||
| Pécsi Tudományegyetem Klinikai Központ | Pecs | Hungary | Details | |||
| Queen Elizabeth II Health Sciences Centre-Victoria General | Halifax | Canada | Details | |||
| Queen Mary Hospital - Hong Kong | Hong Kong | Hong Kong | Details | |||
| Regions Hospital | Saint Louis Park | Minnesota | 55426 | United States | Details | |
| Saitama Cancer Center | Ina | Japan | Details | |||
| Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie | Lublin | Poland | Details | |||
| Samsung Medical Center | Seoul | Korea, Republic of | Details | |||
| SANNA - Clínica El Golf | San Isidro | Peru | Details | |||
| Sarah Cannon Research Institute London | London | United Kingdom | Details | |||
| SCRI - Florida Cancer Specialists - East Region Research Office | West Palm Beach | Florida | 33401 | United States | Details | |
| SCRI - Florida Cancer Specialists - North Region Research Office | Saint Petersburg | Florida | 33705 | United States | Details | |
| SCRI - Florida Cancer Specialists - Panhandle Research Office | Tallahassee | Florida | 32308 | United States | Details | |
| SCRI - Florida Cancer Specialists - South Region Research Office | Fort Myers | Florida | 33901 | United States | Details | |
| Seoul Nat Uni Hospital | Seoul | Korea, Republic of | Details | |||
| Severance Hospital | Seoul | Korea, Republic of | Details | |||
| Shaare Zedek Medical Center | Jerusalem | Israel | Details | |||
| Shikoku Cancer Center | Matsuyama-Shi | Japan | Details | |||
| Shizuoka Cancer Center | Matsuyama-Shi | Japan | Details | |||
| Smillow Cancer Hosp | New Haven | Connecticut | 06520 | United States | Details | |
| Songklanagarind Hospital | Hat Yai | Thailand | Details | |||
| Spitalul Judetean de Urgenta | Baia Mare | Romania | Details | |||
| St. Marianna Uni Hosp | Kawasaki | Japan | Details | |||
| Sunnybrook Health Sciences Centre - Bayview Campus | Toronto | Canada | Details | |||
| Sunpasitthiprasong Hospital | Ubon Ratchathani | Thailand | Details | |||
| Szpital Miejski w Tychach | Tychy | Poland | Details | |||
| T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi | Istanbul | Turkey | Details | |||
| T.C. Saglik Bakanligi Adana Sehir Egitim ve Arastirma Hastanesi | Adana | Turkey | Details | |||
| Teine Keijinkai Hospital | Sapporo | Japan | Details | |||
| Tel Aviv Sourasky Medical Center | Tel Aviv | Israel | Details | |||
| Tennessee Oncology - Chattanooga - Memorial Plaza | Nashville | Tennessee | 37203 | United States | Details | |
| Tennessee Oncology - Nashville - Centennial | Nashville | Tennessee | 37203 | United States | Details | |
| The Center for Cancer & Blood Disorders - Fort Worth | Fort Worth | Texas | 76104 | United States | Details | |
| The Christie NHS Foundation Trust | Manchester | United Kingdom | Details | |||
| The Royal Marsden NHS Foundation Trust | London | United Kingdom | Details | |||
| The Royal Marsden NHS Foundation Trust | Sutton | United Kingdom | Details | |||
| Tokyo Metro Ctr | Bunkyō-Ku | Japan | Details | |||
| Trakya Universitesi Tip Fakultesi | Edirne | Turkey | Details | |||
| Tuen Mun Hospital | Tuen Mun | Hong Kong | Details | |||
| UCLA Health - Santa Monica Cancer Care | Santa Monica | California | 90404 | United States | Details | |
| UCLA Ronald Reagan Med Ctr | Santa Monica | California | 90404 | United States | Details | |
| University College London Hospitals NHS Foundation Trust | London | United Kingdom | Details | |||
| University Hospital Medical Center (KBC) Bezanijska Kosa | Belgrade | Serbia | Details | |||
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| University of California Irvine Health Chao Family Comprehensive Cancer Center | Orange | California | 92868 | United States | Details | |
| University of Louisville James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | United States | Details | |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | United States | Details | |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | United States | Details | |
| University of Tokyo Hospital | Bunkyo-ku | Japan | Details | |||
| USOR - Virginia Cancer Specialists - Fairfax Office | Fairfax | Virginia | 22031 | United States | Details | |
| Van Yüzüncü Yıl Üniversitesi Dursun Odabaş Tıp Merkezi | Van | Turkey | Details | |||
| Vanderbilt - Ingram Cancer Center | Nashville | Tennessee | 37232 | United States | Details | |
| Vilniaus Universiteto Ligoninė Santariškių Klinikos | Vilnius | Lithuania | Details | |||
| Yale Cancer Center | New Haven | Connecticut | 06520 | United States | Details |
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