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| NCT ID | NCT05568095 |
| Title | A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body (STAR-221) |
| Acronym | STAR-221 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Arcus Biosciences, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | ROU | POL | LTU | ITA | ISR | HUN | GRC | GBR | FRA | ESP | CAN | BRA | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Genesis Cancer Center and Blood Institute - Hot Springs | Hot Springs | Arkansas | 71913 | United States | Details | |
| Kaiser Permanente - Los Angeles Medical Center | Los Angeles | California | 90027 | United States | Details | |
| Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | United States | Details | |
| University of California Irvine Health Chao Family Comprehensive Cancer Center | Orange | California | 92868 | United States | Details | |
| UCLA Health - Santa Monica Cancer Care | Santa Monica | California | 90404 | United States | Details | |
| UCLA Ronald Reagan Med Ctr | Santa Monica | California | 90404 | United States | Details | |
| Smillow Cancer Hosp | New Haven | Connecticut | 06520 | United States | Details | |
| Yale Cancer Center | New Haven | Connecticut | 06520 | United States | Details | |
| Georgetown Lombardi Comprehensive Cancer Center | Washington | District of Columbia | 22057 | United States | Details | |
| SCRI - Florida Cancer Specialists - South Region Research Office | Fort Myers | Florida | 33901 | United States | Details | |
| SCRI - Florida Cancer Specialists - North Region Research Office | Saint Petersburg | Florida | 33705 | United States | Details | |
| SCRI - Florida Cancer Specialists - Panhandle Research Office | Tallahassee | Florida | 32308 | United States | Details | |
| SCRI - Florida Cancer Specialists - East Region Research Office | West Palm Beach | Florida | 33401 | United States | Details | |
| University of Louisville James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | United States | Details | |
| Norton Cancer Institute - Poplar Level Road | Louisville | Kentucky | 40217 | United States | Details | |
| Ochsner Cancer Institute | New Orleans | Louisiana | 70121 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | United States | Details | |
| HealthPartners Cancer Center at Regions Hospital | Saint Louis Park | Minnesota | 55426 | United States | Details | |
| Regions Hospital | Saint Louis Park | Minnesota | 55426 | United States | Details | |
| Perlmutter Cancer Ctr NYU | Mineola | New York | 11501 | United States | Details | |
| Perlmutter Cancer Center - 38th Street | New York | New York | 10016 | United States | Details | |
| Memorial Sloan Kettering Cancer Center - New York | New York | New York | 10065 | United States | Details | |
| Duke University Medical Center | Durham | North Carolina | 27710 | United States | Details | |
| Cleavland Clin - Taussig Cancer Ctr | Cleveland | Ohio | 44106 | United States | Details | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | United States | Details | |
| Cleveland Clin - Fairview Hosp | Cleveland | Ohio | 44111 | United States | Details | |
| Mark H. Zangmeister Cancer Center | Columbus | Ohio | 43219 | United States | Details | |
| Cleveland Clin-Hillcrest Hosp | Mayfield Heights | Ohio | 44124 | United States | Details | |
| Prov Care Clinic - Westside | Portland | Oregon | 97225 | United States | Details | |
| Providence Cancer Center Oncology and Hematology Care Westside Portland | Portland | Oregon | 97225 | United States | Details | |
| Providence Cancer Institute | Portland | Oregon | 97225 | United States | Details | |
| Prisma Health Cancer Institute - Faris Road | Greenville | South Carolina | 29605 | United States | Details | |
| Tennessee Oncology - Chattanooga - Memorial Plaza | Nashville | Tennessee | 37203 | United States | Details | |
| Tennessee Oncology - Nashville - Centennial | Nashville | Tennessee | 37203 | United States | Details | |
| Vanderbilt - Ingram Cancer Center | Nashville | Tennessee | 37232 | United States | Details | |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | United States | Details | |
| The Center for Cancer & Blood Disorders - Fort Worth | Fort Worth | Texas | 76104 | United States | Details | |
| Baylor College of Medicine | Houston | Texas | 77054 | United States | Details | |
| Harris Health System | Houston | Texas | 77054 | United States | Details | |
| USOR - Virginia Cancer Specialists - Fairfax Office | Fairfax | Virginia | 22031 | United States | Details | |
| Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location | Seattle | Washington | 98109 | United States | Details | |
| Froedtert Clinical Cancer Center | Milwaukee | Wisconsin | 53226 | United States | Details | |
| Hospital Británico de Buenos Aires | Buenos Aires | Argentina | Details | |||
| Instituto de Investigaciones Clínicas Mar del Plata | Mar del Plata | Argentina | Details | |||
| Monash University | Clayton | Australia | Details | |||
| Gosford Hospital | Gosford | Australia | Details | |||
| Liverpool Hospital | Liverpool | Australia | Details | |||
| Oncology West - Murdoch | Murdoch | Australia | Details | |||
| Fundação Pio XII - Hospital de Câncer de Barretos - Hospital de Amor | Barretos | Brazil | Details | |||
| ONCOSITE - Centro de Pesquisa Clinica Em Oncologia Ltda. | Ijuí | Brazil | Details | |||
| Liga Contra o Câncer - Centro Avançado de Oncologia | Natal | Brazil | Details | |||
| Hospital Ernesto Dornelles | Porto Alegre | Brazil | Details | |||
| Instituto Nacional de Câncer - Brazil | Rio de Janeiro | Brazil | Details | |||
| Queen Elizabeth II Health Sciences Centre-Victoria General | Halifax | Canada | Details | |||
| CHUM | Montreal | Canada | Details | |||
| Hôpital Notre-Dame | Montreal | Canada | Details | |||
| Ottawa Hospital - General Campus | Ottawa | Canada | Details | |||
| Princess Margaret Cancer Centre | Toronto | Canada | Details | |||
| Sunnybrook Health Sciences Centre - Bayview Campus | Toronto | Canada | Details | |||
| Icegclinic | La Florida | Chile | Details | |||
| Oncovida - Santiago | Providencia | Chile | Details | |||
| Hospital Puerto Montt | Puerto Montt | Chile | Details | |||
| Bradford Hill Centro de Investigaciones Clinicas | Recoleta | Chile | Details | |||
| Centro de Estudios Clínicos SAGA | Santiago | Chile | Details | |||
| Pontificia Universidad Catolica de Chile - Escuela De Medicina - Clinica UC San Carlos de Apoq | Santiago | Chile | Details | |||
| Clínica Universidad Católica del Maule - Talca | Talca | Chile | Details | |||
| Institut Bergonié | Bordeaux cedex | France | Details | |||
| Hôpital Morvan | Brest | France | Details | |||
| Centre de Lutte contre le Cancer - François Baclesse | Caen Cedex 5 | France | Details | |||
| Hôpital Claude Huriez | Lille Cedex | France | Details | |||
| Centre Léon Bérard | Lyon | France | Details | |||
| Hôpital de la Timone | Marseille | France | Details | |||
| Institut Régional du Cancer de Montpellier | Montpellier | France | Details | |||
| Centre Armoricain de Radiothérapie, d'Imagerie Médicale et d'Oncologie | Plerin | France | Details | |||
| Centre Hospitalier Universitaire de Poitiers | Poitiers | France | Details | |||
| Institut Gustave Roussy | Villejuif | France | Details | |||
| Evex Hospitals - Kutaisi Referral Hospital | Kutaisi | 4600 | Georgia | Details | ||
| LLC Todua Clinic | Tbilisi | 112 | Georgia | Details | ||
| Ltd Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic | Tbilisi | 144 | Georgia | Details | ||
| New Vision University Hospital | Tbilisi | 159 | Georgia | Details | ||
| Multi-profile Clinic "New Hospitals" | Tbilisi | 186 | Georgia | Details | ||
| Evgenidion Clinic SA - Agia Trias | Athens | Greece | Details | |||
| General Oncology Hospital of Kifisias "Agioi Anargyroi" | Nea Kifisia | Greece | Details | |||
| Metropolitan Hospital | Neo Faliro | Greece | Details | |||
| BioClinic Thessaloniki | Thessaloniki | Greece | Details | |||
| Medi-k Cayalá | Guatemala city | Guatemala | Details | |||
| Clínica Privada Dr. Rixci Ramírez | Guatemala | Guatemala | Details | |||
| Grupo Medico Angeles | Guatemala | Guatemala | Details | |||
| INTEGRA Cancer Institute | Guatemala | Guatemala | Details | |||
| Centro Regional de Sub Especialidades Médicas (CRESEM) SA | Quetzaltenango | Guatemala | Details | |||
| Hong Kong Sanatorium and Hospital | Happy Valley | Hong Kong | Details | |||
| Humanity & Health Clinical Trial Centre | Hong Kong | Hong Kong | Details | |||
| Queen Mary Hospital - Hong Kong | Hong Kong | Hong Kong | Details | |||
| Tuen Mun Hospital | Tuen Mun | Hong Kong | Details | |||
| Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet | Budapest | Hungary | Details | |||
| Országos Onkológiai Intézet | Budapest | Hungary | Details | |||
| Bács-Kiskun Megyei Oktatókórház - Kecskemét | Kecskemet | Hungary | Details | |||
| Pécsi Tudományegyetem Klinikai Központ | Pecs | Hungary | Details | |||
| Hadassah University Hospital Ein Kerem | Jerusalem | Israel | Details | |||
| Shaare Zedek Medical Center | Jerusalem | Israel | Details | |||
| Davidoff Cancer Center | Petah Tikva | Israel | Details | |||
| Tel Aviv Sourasky Medical Center | Tel Aviv | Israel | Details | |||
| Azienda Ospedaliero - Universitaria Careggi | Firenze | Italy | Details | |||
| Istituto Europeo di Oncologia | Milano | Italy | Details | |||
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele | Milan | Italy | Details | |||
| Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas | Rozzano | Italy | Details | |||
| Azienda Sanitaria Universitaria Friuli Centrale ? P.O. Santa Maria della Misericordia | Udine | Italy | Details | |||
| Hyogo Cancer Center | Akashi City | Japan | Details | |||
| University of Tokyo Hospital | Bunkyo-ku | Japan | Details | |||
| Tokyo Metro Ctr | Bunkyō-Ku | Japan | Details | |||
| Chiba Cancer Center | Chiba | Japan | Details | |||
| Kyushu Cancer Center | Fukuoka-shi | Japan | Details | |||
| Saitama Cancer Center | Ina | Japan | Details | |||
| Nat Cancer Ctr-Kashiwa Campus | Kashiwa-shi | Japan | Details | |||
| St. Marianna Uni Hosp | Kawasaki | Japan | Details | |||
| Cancer Inst Hosp of JFCR | Koto | Japan | Details | |||
| Kumamoto University Hospital | Kumamoto | Japan | Details | |||
| Shikoku Cancer Center | Matsuyama-Shi | Japan | Details | |||
| Shizuoka Cancer Center | Matsuyama-Shi | Japan | Details | |||
| Aichi Cancer Center | Nagoya | Japan | Details | |||
| Niigata Cancer Center Hospital | Niigata | Japan | Details | |||
| Kindai University Hospital | Osakasayama-shi | Japan | Details | |||
| Osaka Prefectural Hosp Org | Osaka | Japan | Details | |||
| Gunma Prefectural Cancer Ctr | Ota-shi | Japan | Details | |||
| Teine Keijinkai Hospital | Sapporo | Japan | Details | |||
| National Cancer Ctr Hosp | Tokyo | Japan | Details | |||
| Kanagawa Cancer Center | Yokohama-Shi | Japan | Details | |||
| Dong-A University Hospital | Busan | Korea, Republic of | Details | |||
| Kyungpook Nat Uni Chilgok | Daegu | Korea, Republic of | Details | |||
| Cha Bundang Medical Center | Seongnam | Korea, Republic of | Details | |||
| Asan Medical Center | Seoul | Korea, Republic of | Details | |||
| Korea University Guro Hospital | Seoul | Korea, Republic of | Details | |||
| Samsung Medical Center | Seoul | Korea, Republic of | Details | |||
| Seoul Nat Uni Hospital | Seoul | Korea, Republic of | Details | |||
| Severance Hospital | Seoul | Korea, Republic of | Details | |||
| Kauno Klinikos | Kaunas | Lithuania | Details | |||
| Klaipedos Universitetine Ligonine | Klaipeda | Lithuania | Details | |||
| Nacionalinis Vėžio Institutas | Vilnius | Lithuania | Details | |||
| Vilniaus Universiteto Ligoninė Santariškių Klinikos | Vilnius | Lithuania | Details | |||
| Hospital Pulau Pinang | George Town | Malaysia | Details | |||
| Hospital Kuala Lumpur | Kuala Lumpur | Malaysia | Details | |||
| Pusat Perubatan Universiti Malaya | Kuala Lumpur | Malaysia | Details | |||
| Hospital Umum Sarawak | Kuching | Malaysia | Details | |||
| CLIMERS Clinical Medical Research | Colonia Centro | 94300 | Mexico | Details | ||
| Centro de Atención e Investigación Clínica en Oncología | Merida | 97134 | Mexico | Details | ||
| Centro Especializado en Investigacion y Tratamiento Oncologicos SC | Mexico DF | 3100 | Mexico | Details | ||
| Hospital Zambrano Hellion TecSalud | San Pedro Garza García | 66278 | Mexico | Details | ||
| Centro Hemato - Oncológico Privado (CHOP) | Toluca de Lerdo | 50120 | Mexico | Details | ||
| Hospital Nacional Daniel Alcides Carrión | Bellavista | Peru | Details | |||
| SANNA - Clínica El Golf | San Isidro | Peru | Details | |||
| Hospital Maria Auxiliadora | San Juan De Miraflores | Peru | Details | |||
| Instituto Nacional de Enfermedades Neoplásicas | Surquillo | Peru | Details | |||
| Dr Pablo O. Torre Memorial Hospital - Riverside Medical Center | Bacolod City | Philippines | Details | |||
| Baguio General Hospital and Medical Center | Baguio | Philippines | Details | |||
| Cebu Doctors' University Hospital | Cebu City | Philippines | Details | |||
| Manila Doctors Hospital | Manila | Philippines | Details | |||
| Centrum Onkologii Ziemi Lubelskiej im. św. Jana z Dukli | Lublin | Poland | Details | |||
| Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie | Lublin | Poland | Details | |||
| Szpital Miejski w Tychach | Tychy | Poland | Details | |||
| Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy | Warszawa | Poland | Details | |||
| Centro Hospitalar e Universitário de Coimbra | Coimbra | Portugal | Details | |||
| Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud | Lisboa | Portugal | Details | |||
| Instituto Português de Oncologia do Porto Francisco Gentil | Porto | Portugal | Details | |||
| Spitalul Judetean de Urgenta | Baia Mare | Romania | Details | |||
| Institutul Clinic Fundeni | Bucharest | Romania | Details | |||
| Institutul Oncologic Prof. Dr. Ion Chiricuta | Cluj-Napoca | Romania | Details | |||
| Medisprof | Cluj-Napoca | Romania | Details | |||
| Centrul De Oncologie Sf Nectarie | Craiova | Romania | Details | |||
| Centrul de Radioterapie Amethyst Cluj | Florești | Romania | Details | |||
| Centrul de Oncologie Euroclinic | Iasi | Romania | Details | |||
| Clinica SIGMedical | Suceava | Romania | Details | |||
| Institute of Oncology and Radiology of Serbia (Institut za onkologiju i radiologiju Srbije) | Belgrade | Serbia | Details | |||
| University Hospital Medical Center (KBC) Bezanijska Kosa | Belgrade | Serbia | Details | |||
| Clinical Center Kragujevac | Kragujevac | Serbia | Details | |||
| Hospital Universitari Vall d'Hebrón | Barcelona | Spain | Details | |||
| Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet) | Barcelona | Spain | Details | |||
| Hospital General Universitario Gregorio Marañón | Madrid | Spain | Details | |||
| Hospital Universitario HM Sanchinarro | Madrid | Spain | Details | |||
| Hospital Universitario Ramón y Cajal | Madrid | Spain | Details | |||
| Hospital Universitario Marqués de Valdecilla | Santander | Spain | Details | |||
| Hospital Clínico Universitario de Valencia | Valencia | Spain | Details | |||
| Hospital Universitario Miguel Servet | Zaragoza | Spain | Details | |||
| Faculty of Medicine Siriraj Hospital | Bang Phlat | Thailand | Details | |||
| Songklanagarind Hospital | Hat Yai | Thailand | Details | |||
| Sunpasitthiprasong Hospital | Ubon Ratchathani | Thailand | Details | |||
| T.C. Saglik Bakanligi Adana Sehir Egitim ve Arastirma Hastanesi | Adana | Turkey | Details | |||
| Memorial Ankara Hastanesi | Ankara | Turkey | Details | |||
| Trakya Universitesi Tip Fakultesi | Edirne | Turkey | Details | |||
| T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi | Istanbul | Turkey | Details | |||
| Kocaeli Üniversitesi Araştırma ve Uygulama Hastanesi | Izmit | Turkey | Details | |||
| Inönü Üniversitesi Turgut Özal Tıp Merkezi | Malatya | Turkey | Details | |||
| Ankara Üniversitesi Tıp Fakültesi - Cebeci Araştırma ve Uygulama Hastanesi | Mamak | Turkey | Details | |||
| Van Yüzüncü Yıl Üniversitesi Dursun Odabaş Tıp Merkezi | Van | Turkey | Details | |||
| Ataturk Universitesi Arastirma Hastanesi | Yakutiye | Turkey | Details | |||
| Başkent Üniversitesi Adana Dr Turgut Noyan Uygulama ve Araştirma Merkezi | Yüreğir | Turkey | Details | |||
| Barts Health NHS Trust | London | United Kingdom | Details | |||
| Sarah Cannon Research Institute London | London | United Kingdom | Details | |||
| The Royal Marsden NHS Foundation Trust | London | United Kingdom | Details | |||
| University College London Hospitals NHS Foundation Trust | London | United Kingdom | Details | |||
| The Christie NHS Foundation Trust | Manchester | United Kingdom | Details | |||
| Oxford University Hospitals NHS Foundation Trust | Oxford | United Kingdom | Details | |||
| The Royal Marsden NHS Foundation Trust | Sutton | United Kingdom | Details |