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| NCT ID | NCT05580562 |
| Title | ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) (ACTION) |
| Acronym | ACTION |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Chimerix |
| Indications | |
| Therapies | |
| Age Groups: | adult | child | senior |
| Covered Countries | USA | NLD | ITA | ISR | GBR | ESP | DNK | DEU | CHE | CAN | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Barrow Neurological Institute | RECRUITING | Phoenix | Arizona | 085013 | United States | Details |
| Banner MD Anderson Cancer Center | RECRUITING | Phoenix | Arizona | 85006 | United States | Details |
| Phoenix Childrens Hospital | RECRUITING | Phoenix | Arizona | 85016 | United States | Details |
| Mayo Clinic Arizona | RECRUITING | Phoenix | Arizona | 85054 | United States | Details |
| University of California Irvine | RECRUITING | Costa Mesa | California | 92628 | United States | Details |
| UC San Diego Moores Cancer Center | RECRUITING | La Jolla | California | 92093 | United States | Details |
| Kaiser Permanente Los Angeles Medical Center | RECRUITING | Los Angeles | California | 90027 | United States | Details |
| UCLA University of California Los Angeles | RECRUITING | Los Angeles | California | 90095 | United States | Details |
| Children's Hospital of Orange County | RECRUITING | Orange | California | 92868 | United States | Details |
| UCSF Benioff Children's Hospital | RECRUITING | San Francisco | California | 94143 | United States | Details |
| University of California San Francisco | RECRUITING | San Francisco | California | 94143 | United States | Details |
| Providence Saint John's Cancer Institute | RECRUITING | Santa Monica | California | 90404 | United States | Details |
| Stanford Cancer Center | RECRUITING | Stanford | California | 94350 | United States | Details |
| Yale University | RECRUITING | Fairfield | Connecticut | 06824 | United States | Details |
| MedStar Georgetown University Hospital | RECRUITING | Washington | District of Columbia | 20007 | United States | Details |
| Mayo Clinic Jacksonville | RECRUITING | Jacksonville | Florida | 32224 | United States | Details |
| Miami Cancer Institute | RECRUITING | Miami | Florida | 33176 | United States | Details |
| St Joseph's Children's Hospital of Tampa | RECRUITING | Tampa | Florida | 33607 | United States | Details |
| Moffitt Cancer Center | RECRUITING | Tampa | Florida | 33612 | United States | Details |
| Children's Healthcare of Atlanta | RECRUITING | Atlanta | Georgia | 30342 | United States | Details |
| Kapi'olani Medical Center for Women and Children | RECRUITING | Honolulu | Hawaii | 96826 | United States | Details |
| Feinberg School of Medicine Northwestern University | RECRUITING | Chicago | Illinois | 60611 | United States | Details |
| Indiana University School of Medicine - Indianapolis | RECRUITING | Indianapolis | Indiana | 46202 | United States | Details |
| University of Iowa Hospitals & Clinics | RECRUITING | Iowa City | Iowa | 52242 | United States | Details |
| Norton Healthcare | RECRUITING | Louisville | Kentucky | 40241 | United States | Details |
| Ochsner Medical Center - New Orleans | RECRUITING | New Orleans | Louisiana | 70121 | United States | Details |
| University of Maryland School of Medicine | RECRUITING | Baltimore | Maryland | 21201 | United States | Details |
| Massachusetts General Hospital Cancer Center | RECRUITING | Boston | Massachusetts | 02114 | United States | Details |
| Dana Farber Cancer Institute | RECRUITING | Boston | Massachusetts | 02215 | United States | Details |
| University of Michigan Hospital | RECRUITING | Ann Arbor | Michigan | 48109 | United States | Details |
| University of Minnesota | RECRUITING | Minneapolis | Minnesota | 55455 | United States | Details |
| Mayo Clinic - Cancer Center - Rochester | RECRUITING | Rochester | Minnesota | 55905 | United States | Details |
| Washington University School of Medicine | RECRUITING | Saint Louis | Missouri | 63110 | United States | Details |
| Benefis Hospital Sletten Cancer Institute | WITHDRAWN | Great Falls | Montana | 59405 | United States | Details |
| University of Nebraska Medical Center | RECRUITING | Omaha | Nebraska | 68114 | United States | Details |
| Jersey Shore University Medical Center | RECRUITING | Neptune | New Jersey | 07753 | United States | Details |
| Overlook Medical Center | RECRUITING | Summit | New Jersey | 07901 | United States | Details |
| Albany Medical Center | RECRUITING | Albany | New York | 12208 | United States | Details |
| Children's Hospital at Montefiore Medical Center | RECRUITING | New York | New York | 10029 | United States | Details |
| Montefiore Medical Park | RECRUITING | New York | New York | 10029 | United States | Details |
| Laura & Isaac Perlmutter Cancer Center - NYU ACC | RECRUITING | New York | New York | 10032-3726 | United States | Details |
| Columbia University Medical Center | RECRUITING | New York | New York | 10032 | United States | Details |
| Columbia University Medical Center | RECRUITING | New York | New York | 10032 | United States | Details |
| Lenox Hill Hospital | RECRUITING | New York | New York | 10075 | United States | Details |
| University of Rochester Medical Center | RECRUITING | Rochester | New York | 14642 | United States | Details |
| Levine Cancer Institute/ Atrium Health | RECRUITING | Charlotte | North Carolina | 28204 | United States | Details |
| Duke Cancer Institute | RECRUITING | Durham | North Carolina | 27710 | United States | Details |
| Cincinnati Children's Hospital Medical Center | RECRUITING | Cincinnati | Ohio | 45229 | United States | Details |
| Cleveland Clinic | RECRUITING | Cleveland | Ohio | 44195 | United States | Details |
| Ohio Statue University | RECRUITING | Columbus | Ohio | 43210 | United States | Details |
| University of Oklahoma Peggy and Charles Stephenson Cancer Center | RECRUITING | Oklahoma City | Oklahoma | 73104 | United States | Details |
| Providence Health and Services St. Vincent Medical Center | RECRUITING | Portland | Oregon | 97239 | United States | Details |
| University of Pennsylvania | RECRUITING | Philadelphia | Pennsylvania | 19104 | United States | Details |
| Thomas Jefferson University | RECRUITING | Philadelphia | Pennsylvania | 19107 | United States | Details |
| UPMC Hillman Cancer Center | RECRUITING | Pittsburgh | Pennsylvania | 15232 | United States | Details |
| Dell Children's Medical Center of Central Texas | RECRUITING | Austin | Texas | 78723 | United States | Details |
| Neuro-Oncology Associates | RECRUITING | Dallas | Texas | 75246 | United States | Details |
| University of Texas Southwestern Medical Center | RECRUITING | Dallas | Texas | 75390 | United States | Details |
| University of Texas MD Anderson Cancer Center | RECRUITING | Houston | Texas | 77030 | United States | Details |
| UT Health Science Center Houston Department of Neurosurgery | RECRUITING | Houston | Texas | 77030 | United States | Details |
| University of Texas - San Antonio - Health Science Center | RECRUITING | San Antonio | Texas | 78229 | United States | Details |
| University of Utah - Huntsman Cancer Institute | RECRUITING | Salt Lake City | Utah | 84112 | United States | Details |
| Inova Schar Cancer Institute | RECRUITING | Fairfax | Virginia | 22031 | United States | Details |
| Children's Hospital of The King's Daughter | RECRUITING | Norfolk | Virginia | 23507 | United States | Details |
| University of Washington | RECRUITING | Seattle | Washington | 98195 | United States | Details |
| University Of Wisconsin - Madison | RECRUITING | Madison | Wisconsin | 53792 | United States | Details |
| Sydney Children's Hospital | RECRUITING | Randwick | New South Wales | 2031 | Australia | Details |
| Royal North Shore Hospital | RECRUITING | Sydney | New South Wales | 2065 | Australia | Details |
| Royal Brisbane and Women's Hospital | RECRUITING | Herston | Queensland | Australia | Details | |
| Royal Hobart Hospital | RECRUITING | Hobart | Tasmania | 7000 | Australia | Details |
| Olivia Newton-John Cancer Research Institute (ONJCRI) | RECRUITING | Heidelberg | Victoria | 3084 | Australia | Details |
| Perth Children's Hospital | RECRUITING | Nedlands | Western Australia | 6009 | Australia | Details |
| Medical University of Vienna - Adults | RECRUITING | Vienna | Wien | 01090 | Austria | Details |
| Medical University of Vienna - Pediatrics | RECRUITING | Vienna | Wien | Austria | Details | |
| Tom Baker Cancer Cetre | RECRUITING | Calgary | Alberta | T2N 2T9 | Canada | Details |
| BC Cancer - The Vancouver Center | RECRUITING | Vancouver | British Columbia | V5Z 4E6 | Canada | Details |
| Children's & Women's Health Care of BC | RECRUITING | Vancouver | British Columbia | V6H 0B3 | Canada | Details |
| London Health Sciences Centre | RECRUITING | London | Ontario | N6A 5W9 | Canada | Details |
| Childrens Hospital of Eastern Ontario | RECRUITING | Ottawa | Ontario | K1H 8L1 | Canada | Details |
| Sunnybrook Health Sciences Centre | RECRUITING | Toronto | Ontario | M4N 3M5 | Canada | Details |
| Princess Margaret Hospital | RECRUITING | Toronto | Ontario | M5G 1X8 | Canada | Details |
| Hopital Notre Dame, Lachapelle | RECRUITING | Montréal | Quebec | H2X 3E4 | Canada | Details |
| Copenhagen University Hospital | RECRUITING | Copenhagen | Capital | 2100 | Denmark | Details |
| Aalborg Universitetshospital | RECRUITING | Aalborg | Nordjylland | 9000 | Denmark | Details |
| F345 H.C. Andersen's Children's Hospital | RECRUITING | Odense | South Denmark | 5000 | Denmark | Details |
| Odense Universitetshospital | RECRUITING | Odense | South Denmark | 5000 | Denmark | Details |
| University Clinic Heidelberg | RECRUITING | Heidelberg | Baden-Württemberg | 69120 | Germany | Details |
| Universitätsklinikum Heidelberg | RECRUITING | Heidelberg | Baden-Württemberg | 69120 | Germany | Details |
| Universitätsklinikum Augsburg | RECRUITING | Augsburg | Bayern | 86156 | Germany | Details |
| University Clinic Regensburg | RECRUITING | Regensburg | Bayern | 93053 | Germany | Details |
| Klinikum der Johann-Wolfgang Goethe-Universitat | RECRUITING | Frankfurt am Main | Hessen | 60528 | Germany | Details |
| Universitätsklinikum Bonn | RECRUITING | Bonn | Nordrhein-Westfalen | 53127 | Germany | Details |
| Universitätsklinikum Essen | RECRUITING | Essen | Nordrhein-Westfalen | 45147 | Germany | Details |
| Uniklinik Köln | RECRUITING | Köln | Nordrhein-Westfalen | 50937 | Germany | Details |
| Vivantes Klinikum Neukölln | RECRUITING | Berlin | 12351 | Germany | Details | |
| Klinikum Mannheim Universitätsklinikum gGmbH | RECRUITING | Manheim | 68167 | Germany | Details | |
| Universitätsklinikum Tübingen | RECRUITING | Tübingen | 72076 | Germany | Details | |
| Queen Mary Hospital | RECRUITING | Hong Kong | 999077 | Hong Kong | Details | |
| Sheba Medical Center | RECRUITING | Ramat Gan | Tel-Aviv | 5262100 | Israel | Details |
| Soroka University Medical Centre | RECRUITING | Be'er Sheva | 50937 | Israel | Details | |
| Rambam Medical Center | RECRUITING | Haifa | 31096 | Israel | Details | |
| Hadassah Ein Kerem Medical Center | RECRUITING | Jerusalem | 91120 | Israel | Details | |
| Schneider Children's Medical Center of Israel | RECRUITING | Petah Tikvah | 4920235 | Israel | Details | |
| Rabin Medical Center | RECRUITING | Petah Tikva | 49372 | Israel | Details | |
| Tel Aviv Sourasky Medical Center | RECRUITING | Tel Aviv | 64239 | Israel | Details | |
| Ospedale Bellaria | RECRUITING | Bologna | Emilia-Romagna | 40139 | Italy | Details |
| Istituto Nazionale Tumori Regina Elena | RECRUITING | Roma | Lazio | 00144 | Italy | Details |
| Ospedale San Raffaele S.r.l. | RECRUITING | Milano | Lombardia | 20132 | Italy | Details |
| Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo Besta | RECRUITING | Milano | Lombardia | 20133 | Italy | Details |
| Istituto Clinico Humanitas | RECRUITING | Rozzano | Lombardia | 20089 | Italy | Details |
| Azienda Ospedaliera Città della Salute e della Scienza di Torino | RECRUITING | Torino | Piemonte | 10126 | Italy | Details |
| Istituto Oncologico Veneto | RECRUITING | Padova | Veneto | 35128 | Italy | Details |
| National Cancer Center Hospital | RECRUITING | Chuo City | 104-0045 | Japan | Details | |
| Osaka City General Hospital | RECRUITING | Osaka | 534-0021 | Japan | Details | |
| Hokkaido University Hospital | RECRUITING | Sapporo | 060-8648 | Japan | Details | |
| CHA Bundang Medical Center | RECRUITING | Bundang-Gu, Seongnam-Si | Gyeonggido | 13496 | Korea, Republic of | Details |
| National Cancer Center | RECRUITING | Ilsandong-Gu, Goyang-Si | Gyeonggido | 10408 | Korea, Republic of | Details |
| Samsung Medical Center | RECRUITING | Gangnam-Gu | Seoul Teugbyeolsi | 06351 | Korea, Republic of | Details |
| Gangnam Severance Hospital, Yonsei University Health System | RECRUITING | Gangnam | Seoul Teugbyeolsi | 06273 | Korea, Republic of | Details |
| Seoul National University Hospital | RECRUITING | Jongno-Gu | Seoul Teugbyeolsi | 03080 | Korea, Republic of | Details |
| Asan Medical Center | RECRUITING | Seoul | Seoul Teugbyeolsi | 5505 | Korea, Republic of | Details |
| Severance Hospital Yonsei University Health System | RECRUITING | Seoul | 03722 | Korea, Republic of | Details | |
| The Catholic University of Korea, Seoul St. Mary's Hospital | RECRUITING | Seoul | 6591 | Korea, Republic of | Details | |
| Erasmus MC | RECRUITING | Rotterdam | Zuid-Holland | 3015 GD | Netherlands | Details |
| Universitair Medisch Centrum Utrecht Cancer Center | RECRUITING | Utrecht | 3584 CX | Netherlands | Details | |
| Hospital Sant Joan de Deu | RECRUITING | Esplugues De Llobregat | Barcelona | 8950 | Spain | Details |
| Clinica Universidad Navarra | RECRUITING | Pamplona | Navarra | 31008 | Spain | Details |
| Hospital Clinic de Barcelona | RECRUITING | Barcelona | 08036 | Spain | Details | |
| Hospital Universitario Vall d'Hebron | RECRUITING | Barcelona | 8035 | Spain | Details | |
| Hospital Infantil Universitario Niño Jesus | RECRUITING | Madrid | 28009 | Spain | Details | |
| Hospital Universitario 12 de Octubre | RECRUITING | Madrid | 28041 | Spain | Details | |
| Hospital Universitario HM Sanchinarro | RECRUITING | Madrid | 28050 | Spain | Details | |
| Complejo Asistencial Universitario de Salamanca - H. Clinico | RECRUITING | Salamanca | 37007 | Spain | Details | |
| Hospital Universitari i Politecnic La Fe de Valencia | RECRUITING | Valencia | 46026 | Spain | Details | |
| Hospital Universitari i Politecnic La Fe de Valencia | RECRUITING | Valencia | 46026 | Spain | Details | |
| Centre Hospitalier Universitaire Vaudois | RECRUITING | Lausanne | Vaud | 1011 | Switzerland | Details |
| Universitätsspital Zürich | RECRUITING | Zürich | 8091 | Switzerland | Details | |
| Addenbrooke's Hospital | RECRUITING | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details |
| Beatson West of Scotland Cancer Centre | RECRUITING | Glasgow | Lanarkshire | G12 0YN | United Kingdom | Details |
| Royal Hospital for Children (Glasgow) | RECRUITING | Glasgow | Lanarkshire | G51 4TF | United Kingdom | Details |
| Clatterbridge Cancer Centre - Liverpool | RECRUITING | Liverpool | Lancashire | L7 8YA | United Kingdom | Details |
| The Christie NHS Foundation Trust | RECRUITING | Manchester | Lancashire | M20 4BX | United Kingdom | Details |
| The Royal Marsden in Sutton, Surrey | RECRUITING | Sutton | Surrey | SM2 5PT | United Kingdom | Details |
| Royal Victoria Infirmary | RECRUITING | Newcastle Upon Tyne | Tyne And Wear | NE1 4LP | United Kingdom | Details |
| Freeman Hospital | RECRUITING | Newcastle Upon Tyne | Tyne And Wear | NE7 7DN | United Kingdom | Details |
| St James University Hospital | RECRUITING | Leeds | West Yorkshire | LS9 7TF | United Kingdom | Details |
| The Leeds Teaching Hospitals NHS Trust, Leeds General Infimary | RECRUITING | Leeds | LS1 3EX | United Kingdom | Details | |
| Guy's Hospital | RECRUITING | London | SE19RT | United Kingdom | Details | |
| Churchill Hospital | RECRUITING | Oxford | Ox3 7LE | United Kingdom | Details |