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| NCT ID | NCT05646862 |
| Title | A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy (INAVO121) |
| Acronym | INAVO121 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | ITA | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Marin Cancer Care Inc | Greenbrae | California | 94904 | United States | Details | |
| Cancer Blood and Specialty Clinic | Los Alamitos | California | 90720 | United States | Details | |
| Los Angeles Cancer Network | Los Angeles | California | 90017-4803 | United States | Details | |
| University of California, Irvine Medical Center | Orange | California | 92868 | United States | Details | |
| UC Davis Comprehensive Cancer Center | Sacramento | California | 95817 | United States | Details | |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80220 | United States | Details | |
| Eastern CT Hematology and Oncology Associates | Norwich | Connecticut | 06360-2740 | United States | Details | |
| Cancer Care Centers of Brevard | Palm Bay | Florida | 32901 | United States | Details | |
| Cleveland Clinic Florida | Weston | Florida | 33331 | United States | Details | |
| Grady Health System | Atlanta | Georgia | 30303 | United States | Details | |
| Midtown West Medical | Atlanta | Georgia | 30318 | United States | Details | |
| Emory University Hospital | Atlanta | Georgia | 30322 | United States | Details | |
| Winship Cancer Institute at Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Karmanos Cancer Institute. | Detroit | Michigan | 48201 | United States | Details | |
| Cancer & Hematology Centers of Western Michigan | Grand Rapids | Michigan | 49503 | United States | Details | |
| Minnesota Oncology Hematology | Saint Paul | Minnesota | 55102 | United States | Details | |
| Gabrail Cancer Center | Canton | Ohio | 44718 | United States | Details | |
| Asante Rogue Regional Medical Center | Medford | Oregon | 97504-8332 | United States | Details | |
| WellSpan Oncology Research | York | Pennsylvania | 17403 | United States | Details | |
| Texas Oncology - Dallas Presbyterian Hospital | Dallas | Texas | 75231 | United States | Details | |
| Texas Tech University Health Sciences Center | El Paso | Texas | 79905 | United States | Details | |
| Fundación CENIT para la Investigación en Neurociencias | Buenos Aires | C1125ABD | Argentina | Details | ||
| Centro Oncologico Korben | Ciudad Autonoma Buenos Aires | C1426AGE | Argentina | Details | ||
| Fundacion CORI para la Investigacion y Prevencion del Cancer | La Rioja | F5300COE | Argentina | Details | ||
| Instituto de Oncología de Rosario | Rosario | S2000KZE | Argentina | Details | ||
| Sanatorio Parque S.A. | Rosario | S2000QGB | Argentina | Details | ||
| Hosp Provincial D. Centenarios | Rosario | S2002KDS | Argentina | Details | ||
| CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica | San Juan | J5400DIL | Argentina | Details | ||
| Clinica Viedma S.A. | Viedma | R8500ACE | Argentina | Details | ||
| Campbelltown Hospital | Campbelltown | New South Wales | 2560 | Australia | Details | |
| Coffs Harbour Health Campus | Coffs Harbour | New South Wales | 2450 | Australia | Details | |
| Concord Repatriation General Hospital | Concord | New South Wales | 2139 | Australia | Details | |
| Kinghorn Cancer Centre | Darlinghurst | New South Wales | 2010 | Australia | Details | |
| Gosford Hospital | Gosford | New South Wales | 2250 | Australia | Details | |
| Icon Cancer Care Wesley | Auchenflower | Queensland | 4066 | Australia | Details | |
| University of the Sunshine Coast | Sippy Downs | Queensland | 4556 | Australia | Details | |
| Bendigo Cancer Centre | Bendigo | Victoria | 3550 | Australia | Details | |
| Sir Charles Gairdner Hospital | Perth | Western Australia | 6009 | Australia | Details | |
| Cliniques Universitaires St-Luc | Bruxelles | 1200 | Belgium | Details | ||
| GHdC Site Notre Dame | Charleroi | 6000 | Belgium | Details | ||
| UZ Antwerpen | Edegem | 2650 | Belgium | Details | ||
| UZ Gent | Gent | 9000 | Belgium | Details | ||
| UZ Leuven Gasthuisberg | Leuven | 3000 | Belgium | Details | ||
| Clinique Ste-Elisabeth | Namur | 5000 | Belgium | Details | ||
| Hospital da Bahia | Salvador | Bahia | 41810-011 | Brazil | Details | |
| Instituto D?Or de Pesquisa e Ensino ? Hospital DF STAR | Brasilia | Distrito Federal | 70390-140 | Brazil | Details | |
| NUPEC | Belo Horizonte | Minas Gerais | 30210-090 | Brazil | Details | |
| Hospital Santa Cruz / Centro de Oncologia D'Or | Curitiba | Paraná | 80420-090 | Brazil | Details | |
| Hospital do Cancer de Pernambuco - HCP | Recife | Pernambuco | 50040-000 | Brazil | Details | |
| Instituto D?Or de Pesquisa e Ensino ? Hospital Esperança Recife | Recife | Pernambuco | Brazil | Details | ||
| Vencer Oncoclínica - Centro de Pesquisa do Piauí | Teresina | Piauí | 64049-200 | Brazil | Details | |
| Liga Norte Riograndense Contra O Câncer | Natal | Rio Grande Do Norte | 59040150 | Brazil | Details | |
| Santa Casa de Misericordia de Porto Alegre | Porto Alegre | Rio Grande Do Sul | 90050-170 | Brazil | Details | |
| Hospital Sao Lucas - PUCRS | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details | |
| Hospital de Base de Sao Jose do Rio Preto | Sao Jose do Rio Preto | São Paulo | 15090-000 | Brazil | Details | |
| Hospital Sírio-Libanês | Sao Paulo | São Paulo | 01308-050 | Brazil | Details | |
| Arthur J.E. Child Comprehensive Cancer Center-Calgary | Calgary | Alberta | T2N 5G2 | Canada | Details | |
| Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| BC Cancer ? Vancouver | Vancouver | British Columbia | V5Z 4E6 | Canada | Details | |
| The Moncton Hospital | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| Juravinski Hospital | Hamilton | Ontario | L8V 5C2 | Canada | Details | |
| The Ottawa Hospital - General Campus | Ottawa | Ontario | K1Y 4E9 | Canada | Details | |
| CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont | Montreal | Quebec | H1T 2M4 | Canada | Details | |
| Centre Hospitalier de l'Universite de Montreal (CHUM) | Montreal | Quebec | H2X 0C2 | Canada | Details | |
| Jewish General Hospital | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| Hôpital du Sacré-Coeur de Montreal | Montreal | Quebec | H4J 1C5 | Canada | Details | |
| The First Hospital of Jilin University | Changchun City | 130021 | China | Details | ||
| Sichuan Provincial Cancer Hospital | Chengdu | 610041 | China | Details | ||
| The First Affiliated Hospital, Chongqing Medical University | Chongqing | 400016 | China | Details | ||
| Guangdong Provincial People's Hospital | Guangzhou City | 510180 | China | Details | ||
| Sun yat-sen University Cancer Center | Guangzhou | 510060 | China | Details | ||
| The Second Affiliated Hospital of Zhejiang University School of Medicine | Hangzhou City | 310009 | China | Details | ||
| Sir Run Run Shaw Hospital Zhejiang University | Hangzhou City | 310016 | China | Details | ||
| Harbin Medical University Tumor Hospital | Harbin | 150049 | China | Details | ||
| Shandong Cancer Hospital | Jinan | 250117 | China | Details | ||
| The Second Affiliated Hospital to Nanchang University | Nanchang | 330006 | China | Details | ||
| Jiangsu Cancer Hospital | Nanjing City | 211100 | China | Details | ||
| Tianjin Cancer Hospital | Tianjin | 300000 | China | Details | ||
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | Wuhan City | 430023 | China | Details | ||
| Hubei Cancer Hospital | Wuhan | 430079 | China | Details | ||
| First Affiliated Hospital of Medical College of Xi'an Jiaotong University | Xi'an | 710061 | China | Details | ||
| Zhejiang Cancer Hospital | Zhejiang | 310022 | China | Details | ||
| Institut Sainte Catherine | Avignon | 84082 | France | Details | ||
| Centre Hospitalier de La Cote Basque | Bayonne | 64109 | France | Details | ||
| Polyclinique Bordeaux Nord | Bordeaux | 33300 | France | Details | ||
| Centre Leon Berard | Lyon | 69008 | France | Details | ||
| ICM | Montpellier cedex 5 | 34298 | France | Details | ||
| Centre Eugene Marquis | Rennes | 35042 | France | Details | ||
| IUCT Oncopole | Toulouse | 31100 | France | Details | ||
| Uniklinik RWTH Aachen Klinik für Gynäkologie und Geburtsmedizin | Aachen | 52074 | Germany | Details | ||
| Universitätsklinikum Essen | Essen | 45122 | Germany | Details | ||
| Praxis für Interdisziplinäre Onkologie und Hämatologie GbR | Freiburg | 79110 | Germany | Details | ||
| Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH | Georgsmarienhütte | 49124 | Germany | Details | ||
| Universitätsmedizin Göttingen Georg-August-Universität | Göttingen | 37075 | Germany | Details | ||
| Mammazentrum Hamburg am Krankenhaus Jerusalem | Hamburg | 20357 | Germany | Details | ||
| Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie | Hannover | 30625 | Germany | Details | ||
| Nationales Centrum für Tumorerkrankungen (NCT) | Heidelberg | 69120 | Germany | Details | ||
| Brustzentrum Rhein-Ruhr Servicegesellschaft mbH | Mönchengladbach | 41061 | Germany | Details | ||
| Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt | München | 80336 | Germany | Details | ||
| St. Vincenz-Krankenhaus GmbH Paderborn Frauen- und Kinderklinik St. Louise | Paderborn | 33098 | Germany | Details | ||
| A.O. S. Anna e San Sebastiano | Caserta | Campania | 81100 | Italy | Details | |
| IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola | Meldola | Emilia-Romagna | 47014 | Italy | Details | |
| AUSL della Romagna | Ravenna | Emilia-Romagna | 48121 | Italy | Details | |
| Irccs Centro Di Riferimento Oncologico (CRO) | Aviano | Friuli-Venezia Giulia | 33081 | Italy | Details | |
| Ospedale San Raffaele | Milano | Lombardia | 20132 | Italy | Details | |
| Ospedale Di Macerata | Macerata | Marche | 62100 | Italy | Details | |
| ASL AL - Azienda Sanitaria Locale AL | Alessandria | Piemonte | 15121 | Italy | Details | |
| AOU Città della Salute e della Scienza di Torino | Torino | Piemonte | 10126 | Italy | Details | |
| Humanitas Centro Catanese Di Oncologia | Misterbianco (CT) | Sicilia | 95045 | Italy | Details | |
| Ospedale S. Giuseppe | Empoli (FI) | Toscana | 50053 | Italy | Details | |
| Ospedale Santa Chiara | Trento | Trentino-Alto Adige | 38100 | Italy | Details | |
| Kyungpook National University Chilgok Hospital | Daegu | 41404 | Korea, Republic of | Details | ||
| National Cancer Center | Goyang-si | 10408 | Korea, Republic of | Details | ||
| CHA Bundang Medical Center | Gyeonggi-do | 13496 | Korea, Republic of | Details | ||
| Catholic Univ. of Incheon St.Mary's Hospital | Incheon | 21431 | Korea, Republic of | Details | ||
| Inha University Hospital | Incheon | 22332 | Korea, Republic of | Details | ||
| Korea University Anam Hospital | Seoul | 02841 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 03722 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Gangnam Severance Hospital | Seoul | 06273 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 06351 | Korea, Republic of | Details | ||
| Seoul St Mary's Hospital | Seoul | 06591 | Korea, Republic of | Details | ||
| Panamerican Clinical Research S.A de C.V. | Guadalajara | Jalisco | 44670 | Mexico | Details | |
| RENATI INNOVATION S.A.P.I. de C.V | Guadalajara | Jalisco | 44680 | Mexico | Details | |
| Health Pharma Professional Research | Cdmx | Mexico CITY (federal District) | 03100 | Mexico | Details | |
| COI Centro Oncologico Internacional Santa Fe | Ciudad de México | Mexico CITY (federal District) | 01330 | Mexico | Details | |
| OncoMed | Ciudad de México | Mexico CITY (federal District) | 03100 | Mexico | Details | |
| ARKE Estudios Clínicos S.A. de C.V. | Mexico City | Mexico CITY (federal District) | 06700 | Mexico | Details | |
| Instituto Nacional de Cancerologia | Distrito Federal | 14080 | Mexico | Details | ||
| CENEIT Oncologicos | Mexico City | 03100 | Mexico | Details | ||
| Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde | Morelia | 58260 | Mexico | Details | ||
| Centrum Onkologii im. Prof. Franciszka ?ukaszczyka | Bydgoszcz | 85-796 | Poland | Details | ||
| Szpital Morski im.PCK | Gdynia | 81-519 | Poland | Details | ||
| Narodowy Instytut Onkologii Odzia? w Gliwicach | Gliwice | 44-102 | Poland | Details | ||
| Przychodnia Lekarska KOMED, Roman Karaszewski | Konin | 62-500 | Poland | Details | ||
| Szpital Wojewódzki im. Miko?aja Kopernika | Koszalin | 75-581 | Poland | Details | ||
| Szpital Uniwersytecki w Krakowie | Kraków | 31-501 | Poland | Details | ||
| MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie | Rzeszow | 35-021 | Poland | Details | ||
| Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie | Warszawa | 02-781 | Poland | Details | ||
| Dr. W.M. Szpak Incorporated trading as Rainbow Oncology | Durban | 4126 | South Africa | Details | ||
| Hopelands Cancer Centre | Hilton | 3245 | South Africa | Details | ||
| Medical Oncology Centre of Rosebank | Johannesburg | 2196 | South Africa | Details | ||
| Richards Bay Oncology Centre | KwaZulu Natal | 3900 | South Africa | Details | ||
| Mountain View Oncology | Paarl | 7646 | South Africa | Details | ||
| ICO L'Hospitalet | L Hospitalet De Llobregat | Barcelona | 08908 | Spain | Details | |
| Hospital Universitario de Canarias | La Laguna | Tenerife | 38320 | Spain | Details | |
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital San Pedro De Alcantara | Caceres | 10003 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Hospital Ramon y Cajal | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario 12 de Octubre | Madrid | 28041 | Spain | Details | ||
| Hospital Regional Universitario Carlos Haya | Malaga | 29011 | Spain | Details | ||
| Hospital Universitario Virgen de Arrixaca | Murcia | 30120 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| China Medical University Hospital | Taichung | 404 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Tainan | 70457 | Taiwan | Details | ||
| Taipei Veterans General Hospital | Taipei City | 11217 | Taiwan | Details | ||
| Chang Gung Memorial Hosipital at Linkou | Taoyuan City | 333 | Taiwan | Details | ||
| Veterans General Hospital - Taichung | Xitun Dist. | 40705 | Taiwan | Details | ||
| National Taiwan University Hospital | Zhongzheng Dist. | 10048 | Taiwan | Details | ||
| Chulalongkorn Hospital | Bangkok | 10330 | Thailand | Details | ||
| Maharaj Nakorn Chiang Mai Hospital | ChiangMai | 50200 | Thailand | Details | ||
| Chulabhorn Hospital | Lak Si | 10210 | Thailand | Details | ||
| Songklanagarind Hospital | Songkhla | 90110 | Thailand | Details | ||
| Gulhane Training and Applicaton Hospital | Ankara | 06010 | Turkey | Details | ||
| Memorial Ankara Hastanesi | Ankara | 06520 | Turkey | Details | ||
| Dicle University Faculty of Medicine | Diyarbakir | 21280 | Turkey | Details | ||
| Trakya University Medical Faculty | Edirne | 22030 | Turkey | Details | ||
| Medipol Mega Üniversite Hastanesi Göztepe | Istanbul | 34214 | Turkey | Details | ||
| Marmara Uni Faculty of Medicine | Istanbul | 34890 | Turkey | Details | ||
| Ege Uni Medical Faculty Hospital | Izmir | 35100 | Turkey | Details | ||
| Katip Celebi University Ataturk Training and Research Hospital | Izmir | 35360 | Turkey | Details | ||
| Goztepe Prof.Dr. Suleyman Yalcin City Hospital | Kadiköy | 34722 | Turkey | Details | ||
| Medical Park Seyhan Hospital | Seyhan | 01140 | Turkey | Details | ||
| Hacettepe Uni Medical Faculty Hospital | Sihhiye/Ankara | 06230 | Turkey | Details | ||
| Basingstoke and North Hampshire Hospital | Basingstoke | RG24 9NA | United Kingdom | Details | ||
| Blackpool Victoria Hospital | Blackpool | FY3 8NR | United Kingdom | Details | ||
| Dumfries and Galloway Royal Infirmary | Dumfries | DG1 4AP | United Kingdom | Details | ||
| Western General Hospital | Edinburgh | EH4 2XU | United Kingdom | Details | ||
| Princess Alexandra Hospital | Harlow | CM20 1QX | United Kingdom | Details | ||
| St John's Hospital | Livingston | EH54 6PP | United Kingdom | Details | ||
| St Bartholomew's Hospital | London | EC1M 6BQ | United Kingdom | Details | ||
| Maidstone & Tonbridge Wells Hospital | Maidstone | ME16 9QQ | United Kingdom | Details | ||
| Mount Vernon & Watford Trust Hospital | Northwood | HA6 2RN | United Kingdom | Details | ||
| Churchill Hospital | Oxford | OX3 7LE | United Kingdom | Details | ||
| Royal Preston Hosptial | Preston | PR2 9HT | United Kingdom | Details | ||
| Royal Hampshire County Hospital | Winchester | SO22 5DG | United Kingdom | Details |