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| NCT ID | NCT05658640 |
| Title | HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies (HEM-iSMART D) |
| Acronym | HEM-iSMART D |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase Ib/II |
| Variant Requirements | Yes |
| Sponsors | Princess Maxima Center for Pediatric Oncology |
| Indications | |
| Therapies | |
| Age Groups: | adult | child |
| Covered Countries | SWE | NOR | NLD | ITA | ISR | IRL | GBR | FRA | FIN | ESP | DNK | DEU | CHE | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| St. Anna Kinderspital | NOT_YET_RECRUITING | Vienna | 1090 | Austria | Details | |
| Universitair Ziekenhuis Gent | NOT_YET_RECRUITING | Gent | 9000 | Belgium | Details | |
| Rigshospitalet Copenhagen | RECRUITING | Copenhagen | DK-2100 | Denmark | Details | |
| Helsinki University Hospital, New Children's Hospital | NOT_YET_RECRUITING | Helsinki | FI00029 | Finland | Details | |
| Hôpital des Enfants GH Pellegrin - CHU de Bordeaux | NOT_YET_RECRUITING | Bordeaux | 33076 | France | Details | |
| CHRU Lille - Hôpital Jeanne de Flandre | NOT_YET_RECRUITING | Lille | 59037 | France | Details | |
| Centre Léon Bérard | NOT_YET_RECRUITING | Lyon | 69 373 | France | Details | |
| Hopital La Timone - Enfants | NOT_YET_RECRUITING | Marseille | 13005 | France | Details | |
| CHU Nantes Hôpital Mère-Enfant | NOT_YET_RECRUITING | Nantes | 44093 | France | Details | |
| Hôpital Robert Debré | NOT_YET_RECRUITING | Paris | 75019 | France | Details | |
| Universitätsklinikum Augsburg | NOT_YET_RECRUITING | Augsburg | 86156 | Germany | Details | |
| Charité Universitätsmedizin Berlin | RECRUITING | Berlin | 13353 | Germany | Details | |
| Universitätsklinikum Essen | NOT_YET_RECRUITING | Essen | 45147 | Germany | Details | |
| Universitätsklinikum Frankfurt | NOT_YET_RECRUITING | Frankfurt | 60590 | Germany | Details | |
| Universitätsklinikum Münster | NOT_YET_RECRUITING | Münster | 48149 | Germany | Details | |
| Our Lady's Hospital for Sick Children | NOT_YET_RECRUITING | Dublin | D12N512 | Ireland | Details | |
| Schneider's Children's Medical Center | NOT_YET_RECRUITING | Petach Tikva | 4920235 | Israel | Details | |
| Sheba Medical Center Hospital | NOT_YET_RECRUITING | Ramat Gan | 52621 | Israel | Details | |
| IRCCS Istituto Giannina Gaslini | NOT_YET_RECRUITING | Genova | 16147 | Italy | Details | |
| Fondazione MBBM c/o Centro ML Verga | NOT_YET_RECRUITING | Monza | 20900 | Italy | Details | |
| Padova Azienda Ospedaliera | NOT_YET_RECRUITING | Padova | 35128 | Italy | Details | |
| Ospedale Pediatrico Bambino Gesù, IRCCS | NOT_YET_RECRUITING | Roma | 0165 | Italy | Details | |
| Ospedale Infantile Regina Margherita | NOT_YET_RECRUITING | Turin | 10126 | Italy | Details | |
| Princess Máxima Center for Pediatric Oncology | RECRUITING | Utrecht | 3584CS | Netherlands | Details | |
| Oslo University Hospital | NOT_YET_RECRUITING | Oslo | 0373 | Norway | Details | |
| Hospital Vall d'Hebron | NOT_YET_RECRUITING | Barcelona | 08035 | Spain | Details | |
| Hospital Sant Joan de Déu de Barcelona | NOT_YET_RECRUITING | Barcelona | 08950 | Spain | Details | |
| Hospital Infantil Universitario Niño Jesús | NOT_YET_RECRUITING | Madrid | 28009 | Spain | Details | |
| La Fe | NOT_YET_RECRUITING | Valencia | 46026 | Spain | Details | |
| Karolinska university hospital | RECRUITING | Stockholm | 171 76 | Sweden | Details | |
| University Children's Hospital Zürich | NOT_YET_RECRUITING | Zürich | CH-8032 | Switzerland | Details | |
| Bristol Royal Hospital for Children | NOT_YET_RECRUITING | Bristol | B52 8BJ | United Kingdom | Details | |
| Great Ormond Street Hospital for Children NHS Trust | NOT_YET_RECRUITING | London | WC1N 2BH | United Kingdom | Details | |
| Royal Manchester Children's Hospital | NOT_YET_RECRUITING | Manchester | M13 9WL | United Kingdom | Details | |
| Great North Children's Hospital | NOT_YET_RECRUITING | Newcastle | NE1 4LP | United Kingdom | Details | |
| Royal Marsden NHS Trust | NOT_YET_RECRUITING | Sutton | SM2 5PT | United Kingdom | Details |