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| NCT ID | NCT05904886 |
| Title | A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152) (SKYSCRAPER-14) |
| Acronym | SKYSCRAPER-14 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | POL | NZL | ITA | GBR | FRA | ESP | DEU | CAN | BRA | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Genesis Cancer Center | Hot Springs | Arkansas | 71913 | United States | Details | |
| UCSF Fresno at Community Cancer Institute | Clovis | California | 93611 | United States | Details | |
| City of Hope Cancer Center | Duarte | California | 91010 | United States | Details | |
| University of California San Diego Moores Cancer Center | La Jolla | California | 92037 | United States | Details | |
| University of Southern California | Los Angeles | California | 90033 | United States | Details | |
| Stanford Cancer Center | Palo Alto | California | 94304 | United States | Details | |
| Va Palo Alto Health Care System | Palo Alto | California | 94304 | United States | Details | |
| UCLA Cancer Center | Santa Monica | California | 90404 | United States | Details | |
| Hartford Healthcare Cancer Institute at Hartford Hospital | Hartford | Connecticut | 06106 | United States | Details | |
| MedStar Washington Hosp Center | Washington | District of Columbia | 20010 | United States | Details | |
| Florida Cancer Specialists - Fort Myers (Broadway) | Fort Myers | Florida | 33901 | United States | Details | |
| Miami VA Healthcare System | Miami | Florida | 33125 | United States | Details | |
| Florida Cancer Specialist, North Region | Saint Petersburg | Florida | 33705 | United States | Details | |
| University of Illinois | Chicago | Illinois | 60612 | United States | Details | |
| Norton Cancer Institute - Audubon | Louisville | Kentucky | 40217 | United States | Details | |
| Ochsner Cancer Inst. | New Orleans | Louisiana | 70121 | United States | Details | |
| Mercy Medical Center | Baltimore | Maryland | 21202 | United States | Details | |
| Henry Ford Health System | Detroit | Michigan | 48202 | United States | Details | |
| Cancer & Hematology Centers of Western Michigan | Grand Rapids | Michigan | 49503 | United States | Details | |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | United States | Details | |
| Minnesota Oncology Hematology Woodbury | Woodbury | Minnesota | 55125 | United States | Details | |
| Washington Uni School of Medicine | Saint Louis | Missouri | 63110 | United States | Details | |
| Montefiore Medical Center | Bronx | New York | 10461 | United States | Details | |
| James J Peters VA Hospital / Mental Illness Research Education and Clinic Center | Bronx | New York | 10468 | United States | Details | |
| NYU Langone | New York | New York | 10016 | United States | Details | |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | United States | Details | |
| Columbia University | New York | New York | 10032-3725 | United States | Details | |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | United States | Details | |
| Thomas Jefferson Uni | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| North Texas VA Medical Center | Dallas | Texas | 75216 | United States | Details | |
| Kelsey Seybold Clnic | Houston | Texas | 77005 | United States | Details | |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | United States | Details | |
| Swedish Cancer Inst. | Seattle | Washington | 98104 | United States | Details | |
| Univ of Wisconsin-Madison | Madison | Wisconsin | 53705 | United States | Details | |
| Cliniques Universitaires St-Luc | Bruxelles | 1200 | Belgium | Details | ||
| UZ Antwerpen | Edegem | 2650 | Belgium | Details | ||
| AZ Delta (Campus Rumbeke) | Roeselare | 8800 | Belgium | Details | ||
| CEDOES - Diagnóstico e Pesquisa | Vitoria | Espírito Santo | 29055-450 | Brazil | Details | |
| Oncoclínicas do Brasil - BELO HORIZONTE | Belo Horizonte | Minas Gerais | 30170-080 | Brazil | Details | |
| Hospital do Cancer de Pernambuco - HCP | Recife | Pernambuco | 50040-000 | Brazil | Details | |
| Santa Casa de Misericordia de Porto Alegre | Porto Alegre | Rio Grande Do Sul | 90020-090 | Brazil | Details | |
| Hospital Sao Lucas - PUCRS | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details | |
| Hospital de Cancer de Barretos | Barretos | São Paulo | 14784-400 | Brazil | Details | |
| Instituto do Cancer do Estado de Sao Paulo - ICESP | Sao Paulo | São Paulo | 01246-000 | Brazil | Details | |
| Clinicas Oncologicas Integradas - COI | Rio De Janeiro | 22290-160 | Brazil | Details | ||
| Juravinski Hospital | Hamilton | Ontario | L8V 1C3 | Canada | Details | |
| Sunnybrook Health Sciences Centre | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Jewish General Hospital | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| McGill University Health Centre - Glen Site | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Baoji Central Hospital | Baoji City | 721008 | China | Details | ||
| Beijing Cancer Hospital | Beijing | 100142 | China | Details | ||
| The First Hospital of Jilin University | Changchun City | 130021 | China | Details | ||
| Hunan Cancer Hospital | Changsha CITY | 410013 | China | Details | ||
| Peoples Hospital of Hunan Province | Changsha | 410007 | China | Details | ||
| West China Hospital - Sichuan University | Chengdu City | 610047 | China | Details | ||
| The First Affliated Hospital Of Fujian Medical University | Fuzhou City | 350005 | China | Details | ||
| Mengchao Hepatobiliary Hospital Of Fujian Medical University | Fuzhou City | 350025 | China | Details | ||
| Nanfang Hospital, Southern Medical University | Guangzhou | 510515 | China | Details | ||
| Sun yat-sen University Cancer Center | Guangzhou | China | Details | |||
| The First Affiliated Hospital of College of Medicine, Zhejiang University | Hangzhou | 310003 | China | Details | ||
| Zhejiang Provincial People?s Hospital | Hangzhou | 310014 | China | Details | ||
| Harbin Medical University Cancer Hospital | Harbin | 150081 | China | Details | ||
| The Second Affiliated Hospital of Anhui Medical University | Hefei City | 230601 | China | Details | ||
| Anhui Provincial Hospital | Hefei | 230001 | China | Details | ||
| Lishui Central Hospital | Lishui City | 323000 | China | Details | ||
| Zhongshan Hospital Fudan Unvierstiy | Shanghai City | 200032 | China | Details | ||
| Renji Hospital Shanghai Jiaotong University School of Medicine | Shanghai City | 200127 | China | Details | ||
| Shengjing Hospital of China Medical University | ShenYang | 110004 | China | Details | ||
| Tianjin Cancer Hospital | Tianjin | 300060 | China | Details | ||
| Tongji Hospital Tongji Medical College Huazhong University of Science and Technology | Wuhan City | 430030 | China | Details | ||
| First Affiliated Hospital of Medical College of Xi'an Jiaotong University | Xi'an | 710061 | China | Details | ||
| Xi'an Inernational Medical Center Hospital | Xi'an | 710119 | China | Details | ||
| Polyclinique Internationale Sainte Anne- Marie (PISAM) | Abidjan | BP 1463 Abidjan | Côte D'Ivoire | Details | ||
| Centre National d'Oncologie Médicale et de Radiothérapie Alassane Ouattara (CNRAO) | Abidjan | Côte D'Ivoire | Details | |||
| CHU CAEN - Hôpital de la Côte de Nacre | Caen Cedex | 14033 | France | Details | ||
| CHRU de Lille - Hopital Claude Huriez | Lille | 59037 | France | Details | ||
| Hopital Dupuytren | Limoges | 87042 | France | Details | ||
| Fondation Hopital Saint Joseph | Marseille | 13285 | France | Details | ||
| Hopital Hotel Dieu Et Hme | Nantes | 44093 | France | Details | ||
| APHP - Hopital Saint Antoine | Paris | 75571 | France | Details | ||
| Hopital Robert Debre | Reims | 51092 | France | Details | ||
| Centre Hospitalier Valence | Valence | 26953 | France | Details | ||
| Hopitaux de Brabois - Gastro-Entereologie | Vandoeuvre-les-nancy | 54511 | France | Details | ||
| Hopital Paul Brousse | Villejuif | 94804 | France | Details | ||
| Klinikum Esslingen | Esslingen | 73730 | Germany | Details | ||
| Universitätsklinikum Magdeburg Klinik für Gastroenterologie und Hepatologie | Magdeburg | 39120 | Germany | Details | ||
| Uniklinik Mainz | Mainz | 55131 | Germany | Details | ||
| Universität Tübingen | Tübingen | 72076 | Germany | Details | ||
| KBTH | Accra | 0000 | Ghana | Details | ||
| Sweden Ghana Medical Center | Accra | Ghana | Details | |||
| Queen Mary Hospital | Hong Kong | Hong Kong | Details | |||
| Prince of Wales Hosp | Shatin | Hong Kong | Details | |||
| A.O. S. Orsola Malpighi | Bologna | Emilia-Romagna | 40138 | Italy | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Roma | Lazio | 00168 | Italy | Details | |
| Az. Osp. Uni Ria San Martino | Genova | Liguria | 16132 | Italy | Details | |
| IRCCS Istituto Clinico Humanitas | Rozzano | Lombardia | 20089 | Italy | Details | |
| Az. Osp. G. Panico | Tricase | Puglia | Italy | Details | ||
| A.O.U. Policlinico Paolo Giaccone | Palermo | Sicilia | 90127 | Italy | Details | |
| A.O.U.I. Verona-Ospedale Policlinico G.B. Rossi Borgo Roma | Verona | Veneto | 37134 | Italy | Details | |
| Fujita Health University Hospital | Aichi | 470-1192 | Japan | Details | ||
| Chiba University Hospital | Chiba | 260-8677 | Japan | Details | ||
| National Cancer Center Hospital East | Chiba | 277-8577 | Japan | Details | ||
| Ehime Prefectural Central Hospital | Ehime | 790-0024 | Japan | Details | ||
| Kurume University Hospital | Fukuoka | 830-0011 | Japan | Details | ||
| Hiroshima University Hospital | Hiroshima | 734-8551 | Japan | Details | ||
| Sapporo Kosei General Hospital | Hokkaido | 060-0033 | Japan | Details | ||
| Hokkaido University Hospital | Hokkaido | 060-8648 | Japan | Details | ||
| Kanazawa University Hospital | Ishikawa | 920-8641 | Japan | Details | ||
| Iwate Medical University Hospital | Iwate | 028-3695 | Japan | Details | ||
| Toranomon Branch Hospital | Kanagawa | 213-8587 | Japan | Details | ||
| Kanagawa Cancer Center | Kanagawa | 241-8515 | Japan | Details | ||
| Kitasato University Hospital | Kanagawa | 252-0375 | Japan | Details | ||
| University Hospital Kyoto Prefectural University of Medicine | Kyoto | 602-8566 | Japan | Details | ||
| Kyoto University Hospital | Kyoto | 606-8507 | Japan | Details | ||
| Osaka University Hospital | Osaka | 565-0871 | Japan | Details | ||
| Kindai University Hospital | Osaka | 589-8511 | Japan | Details | ||
| Jichi Medical University Hospital | Tochigi | 329-0498 | Japan | Details | ||
| Toranomon Hospital | Tokyo | 105-8470 | Japan | Details | ||
| Japanese Red Cross Musashino Hospital | Tokyo | 180-8610 | Japan | Details | ||
| University of Nairobi - Institute of Tropical and Infectious Diseases | Nairobi | Kenya | Details | |||
| National Cancer Center | Goyang-si | 10408 | Korea, Republic of | Details | ||
| CHA Bundang Medical Center | Gyeonggi-do | 13496 | Korea, Republic of | Details | ||
| Chonnam National University Hwasun Hospital | Jeollanam-do | 58128 | Korea, Republic of | Details | ||
| Severance Hospital, Yonsei University Health System | Seoul | 003-722 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Seoul | 03080 | Korea, Republic of | Details | ||
| Asan Medical Center | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center | Seoul | 135-710 | Korea, Republic of | Details | ||
| Ulsan University Hosiptal | Ulsan | 44033 | Korea, Republic of | Details | ||
| OncoMed | Ciudad de México | Mexico CITY (federal District) | 03100 | Mexico | Details | |
| Centro Medico Nacional Siglo Xxi - Imss | Mexico City | Mexico CITY (federal District) | 06720 | Mexico | Details | |
| Instituto Nacional de Ciencias Médicas Y de Nutricion Salvador Zubirán | Mexico DF | Mexico CITY (federal District) | 14000 | Mexico | Details | |
| Centro de Investigacion Clinica de Oaxaca | Oaxaca de Juárez | Oaxaca | 68020 | Mexico | Details | |
| Auckland City Hospital | Auckland | 1023 | New Zealand | Details | ||
| Christchurch Hospital | Christchurch | 8011 | New Zealand | Details | ||
| Wellington Hospital | Wellington | 6021 | New Zealand | Details | ||
| Jos University Teaching Hospital | JOS | 930232 | Nigeria | Details | ||
| Lagos University Teaching Hospital Lagos (LUTH), Lagos State | Lagos | Nigeria | Details | |||
| Copernicus Podmiot Medyczny Sp. z o.o. Wojewodzkie Centrum Onkologii | Gdansk | 80-219 | Poland | Details | ||
| ID Clinic | Myslowice | 41-400 | Poland | Details | ||
| NIO im Marii Sklodowskiej-Curie | Warszawa | 02-034 | Poland | Details | ||
| PanOncology Trials | San Juan | 00935 | Puerto Rico | Details | ||
| National Cancer Centre | Singapore | 168583 | Singapore | Details | ||
| Charlotte Maxeke Johannesburg Academic Hospital | Johannesburg | 2193 | South Africa | Details | ||
| Limpopo Cancer Research Institute | Polokwane | 0700 | South Africa | Details | ||
| Hospital Universitario Central de Asturias | Oviedo | Asturias | 33011 | Spain | Details | |
| Clinica Universitaria de Navarra | Pamplona/iruña | Navarra | 31008 | Spain | Details | |
| Hospital Universitari Vall d'Hebron | Barcelona | 08035 | Spain | Details | ||
| Hospital Duran i Reynals | Barcelona | 08907 | Spain | Details | ||
| Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico | Jaen | 23007 | Spain | Details | ||
| Hospital General Universitario Gregorio Marañon | Madrid | 28007 | Spain | Details | ||
| Clinica Universitaria de Navarra de Madrid;Servicio de Hepatologia | Madrid | 28027 | Spain | Details | ||
| Hospital Clinico San Carlos | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario Puerta de Hierro | Madrid | 28222 | Spain | Details | ||
| Hospital de Navarra | Navarra | 31008 | Spain | Details | ||
| Hospital Clinico de Valencia | Valencia | 46010 | Spain | Details | ||
| China Medical University Hospital | Taichung | 404 | Taiwan | Details | ||
| National Cheng Kung University Hospital | Tainan | 00704 | Taiwan | Details | ||
| Chi-Mei Medical Centre | Tainan | 710 | Taiwan | Details | ||
| National Taiwan Uni Hospital | Taipei | 100 | Taiwan | Details | ||
| Chang Gung Medical Foundation - Linkou | Taoyuan | 333 | Taiwan | Details | ||
| Chulalongkorn Hospital | Bangkok | 10330 | Thailand | Details | ||
| Ramathibodi Hospital | Bangkok | 10400 | Thailand | Details | ||
| Maharaj Nakorn Chiang Mai Hospital | ChiangMai | 50200 | Thailand | Details | ||
| Khon Kaen Uni | Khon Kaen | 40002 | Thailand | Details | ||
| Adana Baskent University Medical Faculty | Adana | 01220 | Turkey | Details | ||
| Ankara Bilkent City Hospital | Ankara | 06490 | Turkey | Details | ||
| Gazi Uni Medical Faculty Hospital | Ankara | 06500 | Turkey | Details | ||
| Dicle University Faculty of Medicine | Diyarbakir | 21080 | Turkey | Details | ||
| Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi | Edirne | 22030 | Turkey | Details | ||
| ?zmir Medical Point | Kar?iyaka | 35575 | Turkey | Details | ||
| Uganda Cancer Institute | Kampala | Uganda | Details | |||
| Western General Hospital | Edinburgh | EH4 2XU | United Kingdom | Details | ||
| Royal Free Hospital | London | NW3 2QG | United Kingdom | Details | ||
| Hammersmith Hospital | London | W12 0HS | United Kingdom | Details |