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| NCT ID | NCT06016738 |
| Title | OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer (OPERA-01) |
| Acronym | OPERA-01 |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Olema Pharmaceuticals, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ROU | POL | NLD | ITA | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BGR | BEL | AUS | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Clinical Trial Site | RECRUITING | Tucson | Arizona | 85724 | United States | Details |
| Clinical Trial Site | RECRUITING | Fountain Valley | California | 92708 | United States | Details |
| Clinical Trial Site | RECRUITING | La Jolla | California | 92093 | United States | Details |
| Clinical Trial Site | RECRUITING | Los Angeles | California | 90027 | United States | Details |
| Clinical Trial Site | RECRUITING | Whittier | California | 90602 | United States | Details |
| Clinical Trial Site | RECRUITING | Aurora | Colorado | 80045 | United States | Details |
| Clinical Trial Site | RECRUITING | Denver | Colorado | 80218 | United States | Details |
| Clinical Trial Site | RECRUITING | Golden | Colorado | 80401 | United States | Details |
| Clinical Trial Site | RECRUITING | Grand Junction | Colorado | 81505 | United States | Details |
| Clinical Trial Site | RECRUITING | Danbury | Connecticut | 06810 | United States | Details |
| Clinical Trial Site | RECRUITING | Newark | Delaware | 19713 | United States | Details |
| Clinical Trials Site | RECRUITING | Jacksonville | Florida | 32223 | United States | Details |
| Clinical Trial Site | RECRUITING | Margate | Florida | 33063 | United States | Details |
| Clinical Trial Site | RECRUITING | Orlando | Florida | 32804 | United States | Details |
| Clinical Trial Site | RECRUITING | Plantation | Florida | 33324 | United States | Details |
| Clinical Trial Site | RECRUITING | Tamarac | Florida | 33321 | United States | Details |
| Clinical Trial Site | RECRUITING | Atlanta | Georgia | 30322 | United States | Details |
| Clinical Trial Site | RECRUITING | Chicago | Illinois | 60616-2315 | United States | Details |
| Clinical Trial Site | RECRUITING | Chicago | Illinois | 60637 | United States | Details |
| Clinical Trial Site | RECRUITING | Urbana | Illinois | 61801 | United States | Details |
| Clinical Trial Site | RECRUITING | Baton Rouge | Louisiana | 70809 | United States | Details |
| Clinical Trial Site | RECRUITING | Baltimore | Maryland | 21201 | United States | Details |
| Clinical Trial Site | RECRUITING | Boston | Massachusetts | 02111 | United States | Details |
| Clinical Trial Site | RECRUITING | Saint Louis Park | Minnesota | 55426 | United States | Details |
| Clinical Trial Site | RECRUITING | Lincoln | Nebraska | 68510-2496 | United States | Details |
| Clinical Trial Site | RECRUITING | Farmington | New Mexico | 87401 | United States | Details |
| Clinical Trial Site | RECRUITING | New York | New York | 10032 | United States | Details |
| Clinical Trial Site | RECRUITING | Port Jefferson Station | New York | 11776 | United States | Details |
| Clinical Trial Site | RECRUITING | Dayton | Ohio | 45409 | United States | Details |
| Clinical Trial Site | RECRUITING | Toledo | Ohio | 43623 | United States | Details |
| Clinical Trial Site | RECRUITING | Portland | Oregon | 97239 | United States | Details |
| Clinical Trial Site | RECRUITING | Nashville | Tennessee | 37203 | United States | Details |
| Clinical Trial Site | RECRUITING | Nashville | Tennessee | 37208 | United States | Details |
| Clinical Trial Site | RECRUITING | Dallas | Texas | 75246 | United States | Details |
| Clinical Trial Site | RECRUITING | Dallas | Texas | 75390 | United States | Details |
| Clinical Trial Site | RECRUITING | Houston | Texas | 77030 | United States | Details |
| Clinical Trial Site | RECRUITING | Spokane | Washington | 99204 | United States | Details |
| Clinical Trial Site | RECRUITING | Spokane | Washington | 99218 | United States | Details |
| Clinical Trial Site | RECRUITING | San Salvador De Jujuy | Jujuy | 4600 | Argentina | Details |
| Clinical Trial Site | RECRUITING | Viedma | Río Negro | R8500ACE | Argentina | Details |
| Clinical Trial Site | RECRUITING | Rosario | Santa Fe | S2013DTC | Argentina | Details |
| Clinical Trial Site | RECRUITING | Rosario | Santa Fe | S2013KDS | Argentina | Details |
| Clinical Trial Site | RECRUITING | San Miguel De Tucumán | Tucumán | 4000 | Argentina | Details |
| Clinical Trial Site | RECRUITING | Buenos Aires | C14626ABP | Argentina | Details | |
| Clinical Trial Site | RECRUITING | Córdoba | X5000HHW | Argentina | Details | |
| Clinical Trial Site | RECRUITING | Córdoba | X5008HHW | Argentina | Details | |
| Clinical Trial Site | RECRUITING | La Rioja | 5300 | Argentina | Details | |
| Clinical Trial Site | RECRUITING | Gosford | New South Wales | 2250 | Australia | Details |
| Clinical Trial Site | RECRUITING | Westmead | New South Wales | 2145 | Australia | Details |
| Clinical Trial Site | RECRUITING | Adelaide | South Australia | 5000 | Australia | Details |
| Clinical Trial Site | RECRUITING | Ballarat Central | Victoria | 3355 | Australia | Details |
| Clinical Trial Site | RECRUITING | Clayton | Victoria | 3168 | Australia | Details |
| Clinical Trial Site | RECRUITING | Shepparton | Victoria | 3630 | Australia | Details |
| Clinical Trial Site | RECRUITING | Nedlands | Western Australia | 6009 | Australia | Details |
| Clinical Trial Site | RECRUITING | Edegem | Antwerpen | 2650 | Belgium | Details |
| Clinical Trial Site | RECRUITING | Woluwe-Saint-Lambert | Brussels | 1200 | Belgium | Details |
| Clinical Trial Site | RECRUITING | Charleroi | Hainaut | 6000 | Belgium | Details |
| Clinical Trial Site | RECRUITING | Leuven | Vlaams Brabant | Belgium | Details | |
| Clinical Trial Site | RECRUITING | Salvador | Bahia | 40050-410 | Brazil | Details |
| Clinical Trial Site | RECRUITING | Belo Horizonte | Minas Gerais | 30150-221 | Brazil | Details |
| Clinical Trial Site | RECRUITING | Recife | Pernambuco | 50070-480 | Brazil | Details |
| Clinical Trial Site | RECRUITING | Porto Alegre | Rio Grande Do Sul | 90035-903 | Brazil | Details |
| Clinical Trial Site | RECRUITING | Porto Alegre | Rio Grande Do Sul | 90050-170 | Brazil | Details |
| Clinical Trial Site | RECRUITING | Itajaí | Santa Catarina | 88301-220 | Brazil | Details |
| Clinical Trial Site | RECRUITING | Sorocaba | São Paulo | 18060-105 | Brazil | Details |
| Clinical Trial Site | RECRUITING | Rio De Janeiro | 20560-120 | Brazil | Details | |
| Clinical Trial Site | RECRUITING | Panagyurishte | Pazardzhik | 4500 | Bulgaria | Details |
| Clinical Trial Site | RECRUITING | Sofia | Sofia-Grad | 1407 | Bulgaria | Details |
| Clinical Trial Site | RECRUITING | Vratsa | 3000 | Bulgaria | Details | |
| Clinical Trial Site | RECRUITING | Calgary | Alberta | T2N 4N2 | Canada | Details |
| Clinical Trial Site | RECRUITING | Montréal | Quebec | H4A 3J1 | Canada | Details |
| Clinical Trial Site | RECRUITING | Hradec Králové | Královéhradecký Kraj | 500 12 | Czechia | Details |
| Clinical Trial Site | RECRUITING | Nový Jičín | Moravskoslezský Kraj | 741 01 | Czechia | Details |
| Clinical Trial Site | RECRUITING | Olomouc | Olomoucký Kraj | 799 00 | Czechia | Details |
| Clinical Trial Site | RECRUITING | Bourg-en-Bresse | Ain | 01012 | France | Details |
| Clinical Trial Site | RECRUITING | Besançon | Doubs | 25030 | France | Details |
| Clinical Trial Site | RECRUITING | Nantes | Loire-Atlantique | 44805 | France | Details |
| Clinical Trial Site | RECRUITING | Compiègne | Oise | 60200 | France | Details |
| Clinical Trial Site | RECRUITING | Clermont-Ferrand | Puy-de-Dôme | 63011 | France | Details |
| Clinical Trial Site | RECRUITING | Le Mans | Sarthe | 72015 | France | Details |
| Clinical Trial Site | RECRUITING | Villejuif | Val-de-Marne | 94085 | France | Details |
| Clinical Trial Site | RECRUITING | Montpellier | 34070 | France | Details | |
| Clinical Trial Site | RECRUITING | Karlsruhe | Baden-Württemberg | 76135 | Germany | Details |
| Clinical Trial Site | RECRUITING | Krefeld | Nordrhein-Westfalen | 47805 | Germany | Details |
| Clinical Trial Site | RECRUITING | Velbert | Nordrhein-Westfalen | 42551 | Germany | Details |
| Clinical Trial Site | RECRUITING | Dresden | Sachsen | 01307 | Germany | Details |
| Clinical Trial Site | RECRUITING | Central | 100176 | Hong Kong | Details | |
| Clinical Trial Site | RECRUITING | Central | 999077 | Hong Kong | Details | |
| Clinical Trial Site | RECRUITING | Hong Kong | 999077 | Hong Kong | Details | |
| Clinical Trials Site | RECRUITING | Hong Kong | 999077 | Hong Kong | Details | |
| Clinical Trial Site | RECRUITING | Kowloon | 999077 | Hong Kong | Details | |
| Clinical Trial Site | RECRUITING | Pécs | Baranya | 7624 | Hungary | Details |
| Clinical Trial Site | RECRUITING | Kecskemét | Bács-Kiskun | 6000 | Hungary | Details |
| Clinical Trial Site | RECRUITING | Debrecen | Hajdú-Bihar | 4032 | Hungary | Details |
| Clinical Trial Site | RECRUITING | Avellino | Campania | 83100 | Italy | Details |
| Clinical Trial Site | RECRUITING | Bologna | Emilia-Romagna | 40138 | Italy | Details |
| Clinical Trial Site | RECRUITING | Meldola | Emilia-Romagna | 47014 | Italy | Details |
| Clinical Trial Site | RECRUITING | Modena | Emilia-Romagna | 41124 | Italy | Details |
| Clinical Trial Site | RECRUITING | Reggio Emilia | Emilia-Romagna | 42100 | Italy | Details |
| Clinical Trial Site | RECRUITING | Udine | Friuli-Venezia Giulia | 33100 | Italy | Details |
| Clinical Trial Site | RECRUITING | Roma | Lazio | 00144 | Italy | Details |
| Clinical Trial Site | RECRUITING | Roma | Lazio | 00168 | Italy | Details |
| Clinical Trial Site | RECRUITING | Milano | Lombardia | 20141 | Italy | Details |
| Clinical Trial Site | RECRUITING | Rozzano | Lombardia | 20089 | Italy | Details |
| Clinical Trial Site | RECRUITING | Alessandria | Piemonte | 15121 | Italy | Details |
| Clinical Trial Site | RECRUITING | Pavia | 27100 | Italy | Details | |
| Clinical Trial Site | RECRUITING | Suwon-si | Gyeonggi-do | 16247 | Korea, Republic of | Details |
| Clinical Trial Site | RECRUITING | Busan | 49201 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Seoul | 2841 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Seoul | 3080 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Seoul | 3722 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Seoul | 5505 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Seoul | 6273 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Seoul | 6591 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Seoul | 8308 | Korea, Republic of | Details | |
| Clinical Trial Site | RECRUITING | Suwon | 16499 | Korea, Republic of | Details | |
| Clinical Trials Site | RECRUITING | Sungai Petani | Kedah | 8000 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | Kota Bharu | Kelantan | 16150 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | George Town | Penang | 10450 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | Ipoh | Perak | 30450 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | Putrajaya | Putramya | 62250 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | Kuching | Sarawak | 93586 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | Petaling Jaya | Selangor | 46050 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | Kuala Lumpur | WP | 59100 | Malaysia | Details |
| Clinical Trial Site | RECRUITING | Zapopan | Jalisco | 45070 | Mexico | Details |
| Clinical Trial Site | RECRUITING | Monterrey | 64116 | Mexico | Details | |
| Clinical Trial Site | RECRUITING | Oaxaca | 68020 | Mexico | Details | |
| Clinical Trial Site | RECRUITING | Sinaloa | 80230 | Mexico | Details | |
| Clinical Trial Site | RECRUITING | Rotterdam | Zuid-Holland | 3083 AN | Netherlands | Details |
| Clinical Trial Site | RECRUITING | Łódź | Lódzkie | 90-349 | Poland | Details |
| Clinical Trial Site | RECRUITING | Otwock | Mazowieckie | 05-400 | Poland | Details |
| Clinical Trial Site | RECRUITING | Brzozów | Podkarpackie | 36-200 | Poland | Details |
| Clinical Trial Site | RECRUITING | Rzeszów | Podkarpackie | 35-922 | Poland | Details |
| Clinical Trial Site | RECRUITING | Gdynia | Pomorskie | 81-519 | Poland | Details |
| Clinical Trial Site | RECRUITING | Skórzewo | Wielkopolskie | 60-185 | Poland | Details |
| Clinical Trial Site | RECRUITING | Wrocław | 50-450 | Poland | Details | |
| Clinical Trial Site | RECRUITING | Matosinhos | Porto | 4454-509 | Portugal | Details |
| Clinical Trial Site | RECRUITING | Coimbra | 3000-075 | Portugal | Details | |
| Clinical Trial Site | RECRUITING | Lisboa | 1099-023 | Portugal | Details | |
| Clinical Trial Site | RECRUITING | Lisboa | 1500-473 | Portugal | Details | |
| Clinical Trial Site | RECRUITING | Porto | 4050-428 | Portugal | Details | |
| Clinical Trial Site | RECRUITING | Mayaguez | 00682-6391 | Puerto Rico | Details | |
| Clinical Trial Site | RECRUITING | Oradea | Bihor | 410469 | Romania | Details |
| Clinical Trial Site | RECRUITING | București | Bucuresti | 014141 | Romania | Details |
| Clinical Trial Site | RECRUITING | Cluj-Napoca | Cluj | 400015 | Romania | Details |
| Clinical Trial Site | RECRUITING | Craiova | Dolj | 200385 | Romania | Details |
| Clinical Trial Site | RECRUITING | Timisoara | Timis | 300239 | Romania | Details |
| Clinical Trial Site | RECRUITING | Brașov | 500152 | Romania | Details | |
| Clinical Trial Site | RECRUITING | Iași | 700106 | Romania | Details | |
| Clinical Trial Site | RECRUITING | Pamplona | Navarra | 31008 | Spain | Details |
| Clinical Trial Site | RECRUITING | Alicante | 03015 | Spain | Details | |
| Clinical Trial Site | RECRUITING | Badajoz | 06080 | Spain | Details | |
| Clinical Trial Site | RECRUITING | León | 24071 | Spain | Details | |
| Clinical Trial Site | RECRUITING | Lleida | 25198 | Spain | Details | |
| Clinical Trial Site | RECRUITING | Madrid | 28033 | Spain | Details | |
| Clinical Trial Site | RECRUITING | Madrid | 28050 | Spain | Details | |
| Clinical Trial Site | RECRUITING | Santiago De Compostela | 15706 | Spain | Details | |
| Clinical Trial Site | RECRUITING | Valencia | 46010 | Spain | Details | |
| Clinical Trial Site | RECRUITING | Changhua | 500 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Kaohsiung | 80756 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Taichung | 40447 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Taichung | 433 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Tainan City | 736 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Taipei city | 111 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Taipei city | 114 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Taipei | 100 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Taipei | 11217 | Taiwan | Details | |
| Clinical Trial Site | RECRUITING | Bangkok | 10300 | Thailand | Details | |
| Clinical Trial Site | RECRUITING | Bangkok | 10330 | Thailand | Details | |
| Clinical Trial Site | RECRUITING | Bangkok | 10700 | Thailand | Details | |
| Clinical Trial Site | RECRUITING | Chiang Mai | 50180 | Thailand | Details | |
| Clinical Trial Site | RECRUITING | Samut Sakhon | 74120 | Thailand | Details | |
| Clinical Trial Site | RECRUITING | Songkhla | 90110 | Thailand | Details | |
| Clinical Trial Site | RECRUITING | London | EC1M 6BQ | United Kingdom | Details |