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| NCT ID | NCT06305754 |
| Title | Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) and Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009) |
| Acronym | MK-2870-009 |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme LLC |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | SWE | POL | ITA | FRA | ESP | CAN | ARG |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Kaiser Permanente - Oakland ( Site 0054) | Oakland | California | 94611 | United States | Details | |
| Kaiser Permanente - Roseville ( Site 0055) | Roseville | California | 95661 | United States | Details | |
| Kaiser Permanente - San Francisco ( Site 0056) | San Francisco | California | 94115 | United States | Details | |
| Kaiser Permanente - Santa Clara ( Site 0057) | Santa Clara | California | 95051 | United States | Details | |
| Kaiser Permanente-Kaiser Permanente ( Site 0036) | Vallejo | California | 94589 | United States | Details | |
| Kaiser Permanente - Walnut Creek ( Site 0058) | Walnut Creek | California | 94596 | United States | Details | |
| Mid Florida Hematology and Oncology Center ( Site 0005) | Orange City | Florida | 32763 | United States | Details | |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0003) | Marietta | Georgia | 30060 | United States | Details | |
| University of Michigan ( Site 0009) | Ann Arbor | Michigan | 48109 | United States | Details | |
| Cox Medical Center North - Cox Medical Center/ Hematology/Medical Oncology ( Site 0051) | Springfield | Missouri | 65807 | United States | Details | |
| Astera Cancer Care ( Site 0032) | East Brunswick | New Jersey | 08816 | United States | Details | |
| Stony Brook University-Cancer Center ( Site 0038) | Stony Brook | New York | 11794 | United States | Details | |
| Sanford Fargo Medical Center ( Site 0028) | Fargo | North Dakota | 58122 | United States | Details | |
| Sanford Cancer Center ( Site 0024) | Sioux Falls | South Dakota | 57104 | United States | Details | |
| John Peter Smith Hospital ( Site 0065) | Fort Worth | Texas | 76104 | United States | Details | |
| University of Texas MD Anderson ( Site 0063) | Houston | Texas | 77030 | United States | Details | |
| Millennium Research & Clinical Development ( Site 0035) | Houston | Texas | 77090 | United States | Details | |
| Clinica Adventista Belgrano-Oncology ( Site 0315) | Caba. | Buenos Aires | C1430EGF | Argentina | Details | |
| Instituto Alexander Fleming ( Site 0307) | Ciudad Autónoma de Buenos Aires | Buenos Aires | C1426ANZ | Argentina | Details | |
| Hospital Británico de Buenos Aires-Oncology ( Site 0304) | Buenos Aires | Buenos Aires F.D. | C1280AEB | Argentina | Details | |
| Centro Privado de RMI Río Cuarto S.A. II ( Site 0310) | Río Cuarto | Córdoba Province | X5800ALB | Argentina | Details | |
| Instituto de Oncología de Rosario ( Site 0301) | Rosario | Santa Fe Province | S2000KZE | Argentina | Details | |
| Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0303) | La Rioja | F5300COE | Argentina | Details | ||
| Cross Cancer Institute ( Site 0201) | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| Waterloo Regional Health Network (WRHN) ( Site 0207) | Kitchener | Ontario | N2G 1G3 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0203) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| McGill University Health Centre ( Site 0204) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| Anhui Provincial Cancer Hospital ( Site 3132) | Hefei | Anhui | 230031 | China | Details | |
| Beijing Cancer hospital ( Site 3100) | Beijing | Beijing Municipality | 100142 | China | Details | |
| Beijing Peking Union Medical College Hospital-pneumology department ( Site 3107) | Beijing | Beijing Municipality | 100730 | China | Details | |
| Chongqing University Cancer Hospital-Medical Oncology ( Site 3128) | Chongqing | Chongqing Municipality | 400030 | China | Details | |
| Fujian Cancer Hospital ( Site 3124) | Fuzhou | Fujian | 350014 | China | Details | |
| The First Affiliated hospital of Xiamen University ( Site 3125) | Xiamen | Fujian | 361003 | China | Details | |
| Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 3102) | Guangzhou | Guangdong | 510515 | China | Details | |
| Guangxi Medical University Affiliated Tumor Hospital-Respiratory Oncology ( Site 3103) | Nanning | Guangxi | 530021 | China | Details | |
| Harbin Medical University Cancer Hospital ( Site 3109) | Harbin | Heilongjiang | 150081 | China | Details | |
| Henan Cancer Hospital ( Site 3105) | Zhengzhou | Henan | 450008 | China | Details | |
| Tongji Hospital Tongji Medical,Science & Technology ( Site 3121) | Wuhan | Hubei | 430000 | China | Details | |
| Hubei Cancer Hospital ( Site 3122) | Wuhan | Hubei | 430079 | China | Details | |
| The Second Xiangya Hospital of Central South University-Oncology ( Site 3104) | Changsha | Hunan | 410011 | China | Details | |
| Nanjing Drum Tower Hospital JiangBei International Branch Hospital ( Site 3117) | Nanjing | Jiangsu | 210031 | China | Details | |
| The First Affiliated Hospital of Soochow University-Respiratory Department ( Site 3118) | Suzhou | Jiangsu | 215006 | China | Details | |
| The Second Affiliated Hospital of Nanchang University ( Site 3119) | Nanchang | Jiangxi | 330006 | China | Details | |
| The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 3130) | Xi'an | Shaanxi | 710004 | China | Details | |
| Jinan Central Hospital ( Site 3113) | Jinan | Shandong | 250013 | China | Details | |
| Shandong Cancer Hospital ( Site 3112) | Jinan | Shandong | 250117 | China | Details | |
| Zhongshan Hospital of Fudan University ( Site 3133) | Shanghai | Shanghai Municipality | 200032 | China | Details | |
| Shanxi Cancer Hospital ( Site 3114) | Taiyuan | Shanxi | 410013 | China | Details | |
| West China Hospital, Sichuan University ( Site 3126) | Chengdu | Sichuan | 610041 | China | Details | |
| Sichuan Cancer hospital. ( Site 3127) | Chengdu | Sichuan | 610042 | China | Details | |
| The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3101) | Hangzhou | Zhejiang | 310006 | China | Details | |
| Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 3106) | Hangzhou | Zhejiang | 310016 | China | Details | |
| The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 3120) | Wenzhou | Zhejiang | 325015 | China | Details | |
| FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0600) | Bogotá | Bogota D.C. | 110131 | Colombia | Details | |
| Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0606) | Bogotá | Bogota D.C. | 111321 | Colombia | Details | |
| Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0601) | Valledupar | Cesar Department | 200002 | Colombia | Details | |
| IMAT S.A.S ( Site 0602) | Montería | Departamento de Córdoba | 230002 | Colombia | Details | |
| Oncologos del Occidente ( Site 0604) | Pereira | Risaralda Department | 660001 | Colombia | Details | |
| Fundacion Valle del Lili- CIC-Oncology CIC ( Site 0605) | Cali | Valle del Cauca Department | 760032 | Colombia | Details | |
| Nouvel Hôpital Civil (NHC) ( Site 1302) | Strasbourg | Alsace | 67091 | France | Details | |
| Clinique Clairval ( Site 1306) | Marseille | Bouches-du-Rhone | 13009 | France | Details | |
| Hopitaux Universitaires Paris Centre-Hopital Cochin-Unité d'Oncologie Thoracique ( Site 1304) | Paris | 75014 | France | Details | ||
| Gustave Roussy ( Site 1303) | Villejuif | Île-de-France Region | 94805 | France | Details | |
| Artemis hospital ( Site 3307) | Gurugram | Haryana | 122001 | India | Details | |
| Tata Memorial Hospital-Medical Oncology ( Site 3304) | Mumbai | Maharashtra | 400012 | India | Details | |
| Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute-Centre for cancer ( Site 3302) | Mumbai | Maharashtra | 400053 | India | Details | |
| All India Institute of Medical Sciences-Department of medical oncology ( Site 3303) | New Delhi | National Capital Territory of Delhi | 110029 | India | Details | |
| Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3301) | New Delhi | National Capital Territory of Delhi | 110076 | India | Details | |
| Rajiv Gandhi Cancer Institute And Research Centre ( Site 3300) | New Delhi | National Capital Territory of Delhi | 110085 | India | Details | |
| Instituto Tumori Giovanni Paolo II-SSD Oncologia Medica per la Patologia Toracica ( Site 1802) | Bari | Apulia | 70124 | Italy | Details | |
| Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1800) | Milan | Lombardy | 20133 | Italy | Details | |
| Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1803) | Milan | Lombardy | 20141 | Italy | Details | |
| Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1804) | Florence | Tuscany | 50134 | Italy | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1801) | Roma | 00168 | Italy | Details | ||
| Fujita Health University Hospital ( Site 3409) | Toyoake | Aichi-ken | 470-1192 | Japan | Details | |
| Ehime University Hospital ( Site 3411) | Tōon | Ehime | 791-0295 | Japan | Details | |
| National Hospital Organization Kyushu Cancer Center ( Site 3401) | Fukuoka | Fukuoka | 811-1395 | Japan | Details | |
| Gunma Prefectural Cancer Center ( Site 3413) | Ōta | Gunma | 373-8550 | Japan | Details | |
| Kanazawa University Hospital ( Site 3402) | Kanazawa | Ishikawa-ken | 920-8641 | Japan | Details | |
| St. Marianna University Hospital ( Site 3415) | Kawasaki | Kanagawa | 216-8511 | Japan | Details | |
| Kanagawa Cancer Center ( Site 3416) | Yokohama | Kanagawa | 241-8515 | Japan | Details | |
| Miyagi Cancer Center ( Site 3406) | Natori-shi | Miyagi | 981-1293 | Japan | Details | |
| Kansai Medical University Hospital ( Site 3414) | Hirakata | Osaka | 573-1191 | Japan | Details | |
| Saitama Prefectural Cancer Center ( Site 3417) | Kitaadachi-gun | Saitama | 362-0806 | Japan | Details | |
| Shizuoka Cancer Center ( Site 3405) | Sunto-gun | Shizuoka | 411-8777 | Japan | Details | |
| National Cancer Center Hospital ( Site 3408) | Chūō | Tokyo | 104-0045 | Japan | Details | |
| Toho University Omori Medical Center ( Site 3407) | Ōta-ku | Tokyo | 143-8541 | Japan | Details | |
| Kyushu University Hospital ( Site 3400) | Fukuoka | 812-8582 | Japan | Details | ||
| Hiroshima City Hiroshima Citizens Hospital ( Site 3419) | Hiroshima | 730-8518 | Japan | Details | ||
| Niigata Cancer Center Hospital ( Site 3403) | Niigata | 951-8566 | Japan | Details | ||
| Okayama University Hospital ( Site 3404) | Okayama | 700-8558 | Japan | Details | ||
| Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 3410) | Osaka | 541-8567 | Japan | Details | ||
| Osaka Metropolitan University Hospital ( Site 3412) | Osaka | 545-0051 | Japan | Details | ||
| University Malaya Medical Centre ( Site 3507) | Lembah Pantai | Kuala Lumpur | 59100 | Malaysia | Details | |
| National Cancer Institute-Radiotherapy and Oncology ( Site 3504) | Putrajaya | Kuala Lumpur | 62250 | Malaysia | Details | |
| Hospital Tengku Ampuan Afzan ( Site 3506) | Kuantan | Pahang | 25100 | Malaysia | Details | |
| Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 3501) | George Town | Pulau Pinang | 10450 | Malaysia | Details | |
| Sarawak General Hospital-Radiotherapy Unit ( Site 3508) | Kuching | Sarawak | 93586 | Malaysia | Details | |
| CIO - Centro de Inmuno-Oncología de Occidente ( Site 0700) | Guadalajara | Jalisco | 44630 | Mexico | Details | |
| Arké SMO S.A. de C.V. ( Site 0706) | Mexico City | Mexico City | 06700 | Mexico | Details | |
| Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0705) | Monterrey | Nuevo León | 64460 | Mexico | Details | |
| Oaxaca Site Management Organization S.C. ( Site 0701) | Oaxaca City | 68000 | Mexico | Details | ||
| Centro de Investigacion Clinica de Oaxaca ( Site 0704) | Oaxaca City | 68020 | Mexico | Details | ||
| Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2003) | Bydgoszcz | Kuyavian-Pomeranian Voivodeship | 85-796 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2000) | Warsaw | Masovian Voivodeship | 02-781 | Poland | Details | |
| Bialostockie Centrum Onkologii ( Site 2010) | Bialystok | Podlaskie Voivodeship | 15-027 | Poland | Details | |
| Narodowy Instytut Onkologii - Oddzial w Gliwicach-II Klinika Radioterapi i Chemioterapii ( Site 2002) | Gliwice | Silesian Voivodeship | 44-102 | Poland | Details | |
| National Cancer Center ( Site 3803) | Goyang-si | Kyonggi-do | 10408 | South Korea | Details | |
| Seoul National University Bundang Hospital ( Site 3807) | Seongnam | Kyonggi-do | 13620 | South Korea | Details | |
| The Catholic University Of Korea St. Vincent's Hospital ( Site 3800) | Suwon | Kyonggi-do | 16247 | South Korea | Details | |
| Ajou University Hospital ( Site 3813) | Suwon | Kyonggi-do | 16499 | South Korea | Details | |
| Pusan National University Yangsan Hospital ( Site 3802) | Pusan | Kyongsangnam-do | 50612 | South Korea | Details | |
| Chungbuk National University Hospital ( Site 3804) | Cheongju-si | North Chungcheong | 28644 | South Korea | Details | |
| Pusan National University Hospital ( Site 3805) | Busan | Pusan-Kwangyokshi | 49241 | South Korea | Details | |
| Keimyung University Dongsan Hospital CRC room 1 ( Site 3814) | Daegu | Taegu-Kwangyokshi | 42601 | South Korea | Details | |
| Chungnam national university hospital ( Site 3806) | Junggu | Taejon-Kwangyokshi | 35015 | South Korea | Details | |
| The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3812) | Seoul | 03312 | South Korea | Details | ||
| Asan Medical Center ( Site 3810) | Seoul | 05505 | South Korea | Details | ||
| Samsung Medical Center ( Site 3811) | Seoul | 06351 | South Korea | Details | ||
| Korea University Guro Hospital ( Site 3808) | Seoul | 08308 | South Korea | Details | ||
| Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2321) | LHospitalet de Llobregat | Barcelona | 08908 | Spain | Details | |
| CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2322) | Santiago de Compostela | La Coruna | 15706 | Spain | Details | |
| Hospital Universitario Juan Ramon Jimenez-Oncología Medica ( Site 2323) | Huelva | 21005 | Spain | Details | ||
| Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2324) | Seville | 41009 | Spain | Details | ||
| Karolinska Universitetssjukhuset Solna ( Site 2401) | Stockholm | Stockholm County | 171 64 | Sweden | Details | |
| National Cheng Kung University Hospital ( Site 3901) | Tainan | Tainan | 704 | Taiwan | Details | |
| Chi Mei Hospital - Liouying Branch ( Site 3909) | Tainan | Tainan | 73657 | Taiwan | Details | |
| National Taiwan University Cancer Center (NTUCC) ( Site 3907) | Taipei City | Taipei | 106 | Taiwan | Details | |
| Changhua Christian Hospital ( Site 3904) | Changhua | 50006 | Taiwan | Details | ||
| National Taiwan University Hospital - Hsinchu branch ( Site 3900) | Hsinchu | 300 | Taiwan | Details | ||
| Chang Gung Memorial Hospital at Kaohsiung ( Site 3905) | Kaohsiung City | 83301 | Taiwan | Details | ||
| Far Eastern Memorial Hospital ( Site 3912) | New Taipei City | 220 | Taiwan | Details | ||
| Taichung Veterans General Hospital-Chest ( Site 3910) | Taichung | 40705 | Taiwan | Details | ||
| National Taiwan University Hospital-Oncology ( Site 3908) | Taipei | 10002 | Taiwan | Details | ||
| Mackay Memorial Hospital-Chest Medicine ( Site 3902) | Taipei | 10449 | Taiwan | Details | ||
| Taipei Medical University Hospital ( Site 3903) | Taipei | 110301 | Taiwan | Details | ||
| Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 3911) | Taoyuan | 333 | Taiwan | Details | ||
| Faculty of Medicine Siriraj Hospital ( Site 4004) | Bangkoknoi | Bangkok | 10700 | Thailand | Details | |
| Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 4006) | Dusit | Bangkok | 10300 | Thailand | Details | |
| Faculty of Medicine - Khon Kaen University ( Site 4002) | Muang | Changwat Khon Kaen | 40002 | Thailand | Details | |
| Lampang Cancer Hospital ( Site 4000) | Lampang | Changwat Lampang | 52000 | Thailand | Details | |
| Ramathibodi Hospital ( Site 4001) | Ratchathewi | Changwat Ratchaburi | 10400 | Thailand | Details | |
| Songklanagarind hospital ( Site 4003) | Hat Yai | Changwat Songkhla | 90110 | Thailand | Details | |
| Maharaj Nakorn Chiang Mai Hospital ( Site 4005) | Muang | Chiang Mai | 50200 | Thailand | Details | |
| Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2504) | Adana | 01140 | Turkey (Türkiye) | Details | ||
| Hacettepe Universite Hastaneleri-oncology hospital ( Site 2501) | Ankara | 06230 | Turkey (Türkiye) | Details | ||
| Memorial Ankara Hastanesi-Medical Oncology ( Site 2505) | Ankara | 06520 | Turkey (Türkiye) | Details | ||
| Ankara Bilkent Şehir Hastanesi ( Site 2500) | Ankara | 06800 | Turkey (Türkiye) | Details | ||
| I.E.U. Medical Point Hastanesi-Oncology ( Site 2503) | Izmir | 35575 | Turkey (Türkiye) | Details | ||
| Hanoi Oncology Hospital ( Site 4198) | Hanoi | Hanoi | 100000 | Vietnam | Details | |
| K Hospital - National Cancer Hospital ( Site 4193) | Hanoi | Hanoi | 100000 | Vietnam | Details | |
| National Lung Hospital-Oncology Department ( Site 4194) | Hanoi | Hanoi | 100000 | Vietnam | Details | |
| Oncology Hospital ( Site 4191) | Ho Chi Minh City | Ho Chi Minh | 700000 | Vietnam | Details | |
| Thong Nhat Hospital ( Site 4192) | Tan Binh District | Ho Chi Minh | 700000 | Vietnam | Details | |
| Cho Ray Hospital ( Site 4190) | Ho Chi Minh City | 700000 | Vietnam | Details | ||
| Tam Anh TP.HCM General Hospital ( Site 4196) | Ho Chi Minh City | 700000 | Vietnam | Details |