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| NCT ID | NCT06662786 |
| Title | A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (OrigAMI-2) |
| Acronym | OrigAMI-2 |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Janssen Research & Development, LLC |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | TUR | SWE | POL | NLD | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CAN | BRA | BEL |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Adana City Hospital | RECRUITING | Adana | 01060 | Turkey | Details | |
| Addenbrooke's Hospital | RECRUITING | Cambridge | CB2 0QQ | United Kingdom | Details | |
| Aichi Cancer Center | RECRUITING | Nagoya Shi | 464 8681 | Japan | Details | |
| Antoni van Leeuwenhoek | RECRUITING | Amsterdam | 1066 CX | Netherlands | Details | |
| Arthur J E Child Comprehensive Cancer Centre | RECRUITING | Calgary | Alberta | T2N 5G2 | Canada | Details |
| Asan Medical Center | RECRUITING | Seoul | 05505 | Korea, Republic of | Details | |
| Asklepios Klinik Altona | RECRUITING | Hamburg | 22763 | Germany | Details | |
| Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia | RECRUITING | Vitoria | 29043 260 | Brazil | Details | |
| Assuta MC | RECRUITING | Tel Aviv Yafo | 69710 | Israel | Details | |
| Astera Cancer Care | RECRUITING | East Brunswick | New Jersey | 08816 | United States | Details |
| Az Groeninge | RECRUITING | Kortrijk | 8500 | Belgium | Details | |
| AZ Maria Middelares | RECRUITING | Gent | 9000 | Belgium | Details | |
| Azienda Ospedaliero Universitaria Pisana | RECRUITING | Pisa | 56126 | Italy | Details | |
| B P Poddar Hospital and Medical research Limited | RECRUITING | Kolkata | 700053 | India | Details | |
| Bakirkoy Training and Research Hospital | RECRUITING | Istanbul | 34147 | Turkey | Details | |
| Baylor Scott and White Health | RECRUITING | Temple | Texas | 76508 | United States | Details |
| Beijing Cancer Hospital | RECRUITING | Beijing | 100142 | China | Details | |
| Beijing Friendship Hospital Capital Medical University | RECRUITING | Beijing | 100050 | China | Details | |
| Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku | RECRUITING | Bialystok | 15 027 | Poland | Details | |
| Cancer and Blood Specialty Clinic | RECRUITING | Los Alamitos | California | 90720 | United States | Details |
| Castle Hill Hospital | RECRUITING | Hull | HU16 5JQ | United Kingdom | Details | |
| CBCC Global Research | RECRUITING | Bakersfield | California | 93309 | United States | Details |
| Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie | RECRUITING | Warszawa | 02 781 | Poland | Details | |
| Charite Universitatsmedizin Berlin Campus Virchow Klinikum | RECRUITING | Berlin | 13353 | Germany | Details | |
| Chiba Cancer Center | RECRUITING | Chiba | 260 0801 | Japan | Details | |
| CHU De Poitiers | RECRUITING | Poitiers Cedex | 86000 | France | Details | |
| CHU Nantes | RECRUITING | Nantes Cedex 1 | 44000 | France | Details | |
| Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion | RECRUITING | Cleveland | Ohio | 44111 | United States | Details |
| Cleveland Clinic Cancer Center Hillcrest Hospital | RECRUITING | Mayfield Heights | Ohio | 44124 | United States | Details |
| Cleveland Clinic Cancer Center Independence Family Health Center | RECRUITING | Independence | Ohio | 44131 | United States | Details |
| Cleveland Clinic Cancer Center Mansfield | RECRUITING | Mansfield | Ohio | 44906 | United States | Details |
| Cleveland Clinic Cancer Center South Pointe Hospital | RECRUITING | Warrensville Heights | Ohio | 44122 | United States | Details |
| Cleveland Clinic Cancer Center Strongsville | RECRUITING | Strongsville | Ohio | 44136 | United States | Details |
| Cleveland Clinic Cancer Centers Sandusky | RECRUITING | Sandusky | Ohio | 44870 | United States | Details |
| Clinica de Hematologia e Oncologia Viver Ltda | RECRUITING | Santa Maria | 97015 450 | Brazil | Details | |
| Clinica Univ. de Navarra | RECRUITING | Pamplona | 31008 | Spain | Details | |
| Comprehensive Cancer Centers of Nevada | RECRUITING | Las Vegas | Nevada | 89169 | United States | Details |
| Deenanath Mangeshkar Hospital and Research Centre | RECRUITING | Pune | 411004 | India | Details | |
| Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital | RECRUITING | Ankara | 06200 | Turkey | Details | |
| Elisabeth-TweeSteden Ziekenhuis | RECRUITING | Tilburg | 5022 GC | Netherlands | Details | |
| Erasmus MC | RECRUITING | Rotterdam | 3015 GD | Netherlands | Details | |
| Essen University Hospital | RECRUITING | Essen | 45147 | Germany | Details | |
| First Hospital of Shanxi Medical University | RECRUITING | Taiyuan | 030001 | China | Details | |
| Florida Cancer Specialists East | RECRUITING | West Palm Beach | Florida | 33401-3406 | United States | Details |
| Florida Cancer Specialists North Region | RECRUITING | Saint Petersburg | Florida | 33705 | United States | Details |
| Florida Cancer Specialists South | RECRUITING | Fort Myers | Florida | 33901 | United States | Details |
| Fort Wayne Medical Oncology & Hematology | RECRUITING | Fort Wayne | Indiana | 46804 | United States | Details |
| Fox Chase Cancer Center | RECRUITING | Philadelphia | Pennsylvania | 19111 | United States | Details |
| Fudan University Shanghai Cancer Center | RECRUITING | Shanghai | 200032 | China | Details | |
| Fundacao Antonio Prudente A C Camargo Cancer Center | RECRUITING | Sao Paulo | 01509 900 | Brazil | Details | |
| Fundacao Doutor Amaral Carvalho | RECRUITING | Jau | 17210 080 | Brazil | Details | |
| Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base | RECRUITING | Sao Jose do Rio Preto | 15090 000 | Brazil | Details | |
| Fundacao Pio XII | RECRUITING | Barretos | 14780 070 | Brazil | Details | |
| Fundacao Universidade de Caxias do Sul | RECRUITING | Caxias do Sul | 95070 560 | Brazil | Details | |
| Gazi University Hospital | RECRUITING | Ankara | 06560 | Turkey | Details | |
| Georgetown Univ Medical Center Lombardi Cancer Center | RECRUITING | Washington | District of Columbia | 20007 | United States | Details |
| Grady Memorial Hospital | RECRUITING | Atlanta | Georgia | 30303 | United States | Details |
| Guangdong Provincial People's Hospital | RECRUITING | Guangzhou | 519041 | China | Details | |
| Gulhane Egitim ve Arastirma Hastanesi | RECRUITING | Ankara | 06010 | Turkey | Details | |
| Gustave Roussy | RECRUITING | Villejuif | 94805 | France | Details | |
| Hadassah University Hospita Ein Kerem | RECRUITING | Jerusalem | 9112001 | Israel | Details | |
| Harbin medical university cancer hospital | RECRUITING | Harbin | 150081 | China | Details | |
| Hattiesburg Clinic | RECRUITING | Hattiesburg | Mississippi | 39401 | United States | Details |
| Herbert Irving Comprehensive Cancer Center Columbia University Medical Center | RECRUITING | New York | New York | 10032 | United States | Details |
| Hopital Claude Huriez | RECRUITING | Lille | 59000 | France | Details | |
| Hopital de Jolimont | RECRUITING | Haine Saint Paul La Louviere | 7100 | Belgium | Details | |
| Hopital Haut Leveque | RECRUITING | Pessac | 33604 | France | Details | |
| Hopital Prive Jean Mermoz | RECRUITING | Lyon | 69008 | France | Details | |
| Hopital Saint Antoine | RECRUITING | Paris | 75571 | France | Details | |
| Hosp Univ Vall D Hebron | RECRUITING | Barcelona | 08035 | Spain | Details | |
| Hosp. Clinico Univ. de Valencia | RECRUITING | Valencia | 46010 | Spain | Details | |
| Hosp. de La Santa Creu I Sant Pau | RECRUITING | Barcelona | 08025 | Spain | Details | |
| Hosp. Gral. Univ. Gregorio Maranon | RECRUITING | Madrid | 28007 | Spain | Details | |
| Hosp. Univ. 12 de Octubre | RECRUITING | Madrid | 28041 | Spain | Details | |
| Hosp. Univ. Ramon Y Cajal | RECRUITING | Madrid | 28034 | Spain | Details | |
| Hosp. Virgen Del Rocio | RECRUITING | Sevilla | 41013 | Spain | Details | |
| Hospital Canselor Tuanku Muhriz UKM | RECRUITING | Cheras | 56000 | Malaysia | Details | |
| Hospital Kuala Lumpur | RECRUITING | Kuala Lumpur | 50586 | Malaysia | Details | |
| Hospital Pulau Pinang | RECRUITING | Georgetown | 10450 | Malaysia | Details | |
| Hospital Raja Permaisuri Bainun | RECRUITING | Ipoh | 30450 | Malaysia | Details | |
| Hospital Santa Izabel Santa Casa de Misericordia da Bahia | RECRUITING | Salvador | 40050 410 | Brazil | Details | |
| Hospital Umum Sarawak | RECRUITING | Kuching | 93586 | Malaysia | Details | |
| Hubei Cancer Hospital | RECRUITING | Wuhan | 430079 | China | Details | |
| Huizhou Central People's Hospital | RECRUITING | Huizhou | 516001 | China | Details | |
| Institut du Cancer de Montpellier | RECRUITING | Montpellier | 34298 | France | Details | |
| Institut Jules Bordet | RECRUITING | Anderlecht | 1070 | Belgium | Details | |
| Institut Sainte Catherine | RECRUITING | Avignon Cedex 9 | 84918 | France | Details | |
| Instytut Centrum Zdrowia Matki Polki | RECRUITING | Lodz | 93 339 | Poland | Details | |
| Istituto Clinico Humanitas | RECRUITING | Rozzano | 20089 | Italy | Details | |
| Istituto Dei Tumori Di Milano | RECRUITING | Milano | 20133 | Italy | Details | |
| Istituto Oncologico Veneto - IRCCS | RECRUITING | Padova | 35128 | Italy | Details | |
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori | RECRUITING | Meldola | 47014 | Italy | Details | |
| Kaohsiung Chang Gung Memorial Hospital | RECRUITING | Kaohsiung | 83301 | Taiwan | Details | |
| Kaohsiung Medical University Chung Ho Memorial Hospital | RECRUITING | Kaohsiung | 80756 | Taiwan | Details | |
| Karolinska Universitetssjukhuset | RECRUITING | Stockholm | 171 76 | Sweden | Details | |
| Klinikum der Universitaet Muenchen | RECRUITING | Munich | 81377 | Germany | Details | |
| Krankenhaus NorthWest | RECRUITING | Frankfurt am Main | 60488 | Germany | Details | |
| Kyungpook National University Chilgok Hospital | RECRUITING | Daegu | 41404 | Korea, Republic of | Details | |
| Linkou Chang Gung Memorial Hospital | RECRUITING | Taoyuan | 333 | Taiwan | Details | |
| Los Angeles Cancer Network | RECRUITING | Glendale | California | 91204 | United States | Details |
| Mahamana Pandit Madan Mohan Malviya Cancer Centre | RECRUITING | Varanasi | 221005 | India | Details | |
| Markhot Ferenc Oktatokorhaz es Rendelointezet | RECRUITING | Eger | 3300 | Hungary | Details | |
| Marmara University Pendik Training Hospital | RECRUITING | İstanbul | 34899 | Turkey | Details | |
| MD Anderson Cancer Center | RECRUITING | Houston | Texas | 77030 | United States | Details |
| Meander Medisch Centrum | RECRUITING | Amersfoort | 3813 TZ | Netherlands | Details | |
| MedStar Franklin Square Medical Center | RECRUITING | Baltimore | Maryland | 21237 | United States | Details |
| Montefiore Einstein Comprehensive Cancer Center | RECRUITING | Bronx | New York | 10461 | United States | Details |
| Mount Sinai | RECRUITING | New York | New York | 10003 | United States | Details |
| Mount Sinai West | RECRUITING | New York | New York | 10009 | United States | Details |
| Mount Vernon Cancer Centre | RECRUITING | Northwood | HA6 2RN | United Kingdom | Details | |
| Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach | RECRUITING | Gliwice | 44 100 | Poland | Details | |
| National Cancer Center Hospital | RECRUITING | Chuo Ku | 104 0045 | Japan | Details | |
| National Cancer Center Hospital East | RECRUITING | Kashiwa | 277 8577 | Japan | Details | |
| National Cancer Institute | RECRUITING | Putrajaya | 62250 | Malaysia | Details | |
| National Cheng Kung University Hospital | RECRUITING | Tainan | 704 | Taiwan | Details | |
| National Hospital Organization Osaka National Hospital | RECRUITING | Osaka-Shi | 540 0006 | Japan | Details | |
| National Taiwan University Hospital | RECRUITING | Taipei | 10043 | Taiwan | Details | |
| Nebraska Cancer Specialists Midwest Cancer Center | RECRUITING | Omaha | Nebraska | 68130 | United States | Details |
| Necmettin Erbakan University Meram Medical Faculty | RECRUITING | Konya | 42090 | Turkey | Details | |
| New York Cancer and Blood Specialists | RECRUITING | Shirley | New York | 11967 | United States | Details |
| Osaka International Cancer Institute | RECRUITING | Osaka City | 541 8567 | Japan | Details | |
| Osaka University Hospital | RECRUITING | Suita | 565 0871 | Japan | Details | |
| Ottawa Hospital | RECRUITING | Ottawa | Ontario | K1H 8L6 | Canada | Details |
| Pan American Center for Oncology Trials LLC | RECRUITING | Barrio Monacillos | 00935 | Puerto Rico | Details | |
| Pecsi Tudomanyegyetem | RECRUITING | Pecs | 7624 | Hungary | Details | |
| Peking University First Hospital | RECRUITING | Beijing | 100034 | China | Details | |
| Peking University Shenzhen Hospital | RECRUITING | Shenzhen | 518036 | China | Details | |
| Peking University Third Hospital | RECRUITING | Beijing | 100191 | China | Details | |
| Praxis fur interdisziplinare Onkologie & Hamatologie GbR | RECRUITING | Freiburg | 79110 | Germany | Details | |
| Princess Margaret Cancer Centre | RECRUITING | Toronto | Ontario | M5G1X6 | Canada | Details |
| Providence Medical Foundation | RECRUITING | Santa Rosa | California | 95403 | United States | Details |
| Rabin Medical Center | RECRUITING | Petah Tikva | 4941492 | Israel | Details | |
| Radboud University Medical Center | RECRUITING | Nijmegen | 6525 GA | Netherlands | Details | |
| Rajiv Gandhi Cancer Institute and Research Centre | RECRUITING | Delhi | 110085 | India | Details | |
| Rambam Medical Center | RECRUITING | Haifa | 3109601 | Israel | Details | |
| Rocky Mountain Cancer Centers | RECRUITING | Denver | Colorado | 80218 | United States | Details |
| Royal Marsden Hospital (Sutton) | RECRUITING | Sutton | SM2 5PT | United Kingdom | Details | |
| Rutgers Cancer Institute | RECRUITING | New Brunswick | New Jersey | 08901 | United States | Details |
| Sahlgrenska University Hospital | RECRUITING | Goteborg | 413 45 | Sweden | Details | |
| Sakarya University Training and Research Hospital | RECRUITING | Sakarya | 54290 | Turkey | Details | |
| Samsung Medical Center | RECRUITING | Seoul | 06351 | Korea, Republic of | Details | |
| SCRI Oncology Partners | RECRUITING | Nashville | Tennessee | 37203 | United States | Details |
| Semmelweis Egyetem | RECRUITING | Budapest | 1082 | Hungary | Details | |
| Seoul National University Hospital | RECRUITING | Seoul | 03080 | Korea, Republic of | Details | |
| Severance Hospital Yonsei University Health System | RECRUITING | Seoul | 03722 | Korea, Republic of | Details | |
| Sheba Medical Center | RECRUITING | Ramat Gan | 52621 | Israel | Details | |
| Shizuoka Cancer Center | RECRUITING | Shizuoka | 411 8777 | Japan | Details | |
| Skanes universitetssjukhus | RECRUITING | Lund | 222 42 | Sweden | Details | |
| Sodersjukhuset | RECRUITING | Stockholm | 118 83 | Sweden | Details | |
| SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie | RECRUITING | Olsztyn | 10 228 | Poland | Details | |
| SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego | RECRUITING | Opole | 45 061 | Poland | Details | |
| St Bartholomew's Hospital | RECRUITING | London | EC1A 7BE | United Kingdom | Details | |
| St James University Hospital | RECRUITING | Leeds | LS9 7TF | United Kingdom | Details | |
| St. Bernard's Medical Center | RECRUITING | Jonesboro | Arkansas | 72401 | United States | Details |
| Sun Yat Sen University Cancer Center | RECRUITING | Guangzhou | 510062 | China | Details | |
| Swedish Cancer Institute | RECRUITING | Edmonds | Washington | 98026 | United States | Details |
| Swedish Cancer Institute | RECRUITING | Issaquah | Washington | 98029 | United States | Details |
| Swedish Cancer Institute | RECRUITING | Seattle | Washington | 98104 | United States | Details |
| Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza | RECRUITING | Brzozow | 36 200 | Poland | Details | |
| Tata Memorial Hospital | RECRUITING | Mumbai | 400012 | India | Details | |
| Taussig Cancer Insititute Cleveland Clinic | RECRUITING | Cleveland | Ohio | 44195 | United States | Details |
| Tel Aviv Sourasky Medical Center | RECRUITING | Tel Aviv Yafo | 6423906 | Israel | Details | |
| Texas Oncology - San Antonio | RECRUITING | San Antonio | Texas | 78240 | United States | Details |
| Texas Oncology DFW | RECRUITING | Dallas | Texas | 75246 | United States | Details |
| Texas Oncology West Texas | RECRUITING | Abilene | Texas | 79606 | United States | Details |
| The Cancer Institute Hospital of JFCR | RECRUITING | Tokyo | 135 8550 | Japan | Details | |
| The Catholic University of Korea Seoul St Marys Hospital | RECRUITING | Seoul | 06591 | Korea, Republic of | Details | |
| The First Affiliated Hospital of NanChang University | RECRUITING | Nanchang | 330006 | China | Details | |
| The First Affiliated Hospital Zhejiang University College of Medicine | RECRUITING | Hangzhou | 310003 | China | Details | |
| The First Bethune Hospital of Jilin University | RECRUITING | Changchun | 130021 | China | Details | |
| The Second Affiliated Hospital of Zhejiang University College of Medicine | RECRUITING | Hangzhou | 310009 | China | Details | |
| The Sixth Affiliated Hospital Sun Yat sen University | RECRUITING | Guangzhou | 510655 | China | Details | |
| Tianjin Medical University Cancer Institute and Hospital | RECRUITING | Tianjin | 300060 | China | Details | |
| Torrance Memorial Physicians Network | RECRUITING | Torrance | California | 90505 | United States | Details |
| UMC Utrecht | RECRUITING | Utrecht | 3584 CX | Netherlands | Details | |
| Universitaetsklinikum Carl Gustav Carus TU Dresden | RECRUITING | Dresden | 01307 | Germany | Details | |
| Universitair Ziekenhuis Antwerpen | RECRUITING | Edegem | 2650 | Belgium | Details | |
| Universitair Ziekenhuis Leuven | RECRUITING | Leuven | 3000 | Belgium | Details | |
| Universitatsklinikum Ulm | RECRUITING | Ulm | 89081 | Germany | Details | |
| Universitatsmedizin der Johannes Gutenberg Universitat Mainz | RECRUITING | Mainz | 55131 | Germany | Details | |
| University College Hospital | RECRUITING | London | NW1 2BU | United Kingdom | Details | |
| University Malaya Medical Centre | RECRUITING | Kuala Lumpur | 59100 | Malaysia | Details | |
| University of New Mexico Cancer Center | RECRUITING | Albuquerque | New Mexico | 87102 | United States | Details |
| University of North Carolina at Chapel Hill | RECRUITING | Chapel Hill | North Carolina | 27516 | United States | Details |
| Uniwersyteckie Centrum Kliniczne | RECRUITING | Gdansk | 80 214 | Poland | Details | |
| Uppsala University | RECRUITING | Uppsala | SE 751 85 | Sweden | Details | |
| USC Norris Comprehensive Cancer Center | RECRUITING | Los Angeles | California | 90033 | United States | Details |
| VA Ann Arbor Healthcare System | RECRUITING | Ann Arbor | Michigan | 48105 | United States | Details |
| Washington University School Of Medicine | RECRUITING | Saint Louis | Missouri | 63110 | United States | Details |
| West China Hospital of Sichuan University | RECRUITING | Sichuan | 610044 | China | Details | |
| Western General Hospital | RECRUITING | Edinburgh | EH4 2XU | United Kingdom | Details | |
| Winship Cancer Institute Emory University | RECRUITING | Atlanta | Georgia | 30322 | United States | Details |
| Wojewodzki Szpital Specjalistyczny | RECRUITING | Biala Podlaska | 21 500 | Poland | Details | |
| Wooster Milltown Specialty and Surgery Center | RECRUITING | Wooster | Ohio | 44691 | United States | Details |
| Yale University School Of Medicine | RECRUITING | New Haven | Connecticut | 06519 | United States | Details |
| Yitzhak Shamir Medical Center | RECRUITING | Beer Yaakov | 70300 | Israel | Details | |
| Zhejiang Cancer Hospital | RECRUITING | Hangzhou | 310022 | China | Details |
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