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| NCT ID | NCT06989112 |
| Title | DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer (DE-01) |
| Acronym | DE-01 |
| Recruitment | Recruiting |
| Gender | female |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | AstraZeneca |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | SWE | POL | NOR | NLD | ITA | HUN | GBR | FRA | FIN | ESP | DNK | DEU | CHE | CAN | BRA | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Research Site | WITHDRAWN | Tucson | Arizona | 85704 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Little Rock | Arkansas | 72205 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Duarte | California | 91010 | United States | Details |
| Research Site | NOT_YET_RECRUITING | La Jolla | California | 92037 | United States | Details |
| Research Site | WITHDRAWN | Palo Alto | California | 94304 | United States | Details |
| Research Site | NOT_YET_RECRUITING | San Francisco | California | 94143 | United States | Details |
| Research Site | WITHDRAWN | Sylmar | California | 91342 | United States | Details |
| Research Site | RECRUITING | Fort Myers | Florida | 33901 | United States | Details |
| Research Site | RECRUITING | Miami Beach | Florida | 33140 | United States | Details |
| Research Site | RECRUITING | St. Petersburg | Florida | 33705 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Tampa | Florida | 33612 | United States | Details |
| Research Site | RECRUITING | West Palm Beach | Florida | 33401 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Augusta | Georgia | 30912 | United States | Details |
| Research Site | WITHDRAWN | Honolulu | Hawaii | 96813 | United States | Details |
| Research Site | RECRUITING | Arlington Heights | Illinois | 60005 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Evanston | Illinois | 60201 | United States | Details |
| Research Site | RECRUITING | Shreveport | Louisiana | 71103 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Baltimore | Maryland | 21201 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Boston | Massachusetts | 02111 | United States | Details |
| Research Site | WITHDRAWN | Worcester | Massachusetts | 01655 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Ann Arbor | Michigan | 48109 | United States | Details |
| Research Site | WITHDRAWN | Detroit | Michigan | 48201 | United States | Details |
| Research Site | RECRUITING | Minneapolis | Minnesota | 55455 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Rochester | Minnesota | 55905 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Jackson | Mississippi | 39216 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Springfield | Missouri | 65804 | United States | Details |
| Research Site | NOT_YET_RECRUITING | St Louis | Missouri | 63141 | United States | Details |
| Research Site | WITHDRAWN | Las Vegas | Nevada | 89169 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Hackensack | New Jersey | 07601 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Albuquerque | New Mexico | 87109 | United States | Details |
| Research Site | WITHDRAWN | New York | New York | 10016 | United States | Details |
| Research Site | RECRUITING | New York | New York | 10065 | United States | Details |
| Research Site | WITHDRAWN | New York | New York | 10075 | United States | Details |
| Research Site | RECRUITING | Charlotte | North Carolina | 28204 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Charlotte | North Carolina | 28204 | United States | Details |
| Research Site | RECRUITING | Winston-Salem | North Carolina | 27103 | United States | Details |
| Research Site | RECRUITING | Cincinnati | Ohio | 45220 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Columbus | Ohio | 43210 | United States | Details |
| Research Site | WITHDRAWN | Tulsa | Oklahoma | 74134 | United States | Details |
| Research Site | RECRUITING | Eugene | Oregon | 97401 | United States | Details |
| Research Site | WITHDRAWN | Abington | Pennsylvania | 19001 | United States | Details |
| Research Site | WITHDRAWN | Hershey | Pennsylvania | 17033 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Philadelphia | Pennsylvania | 19111 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Pittsburgh | Pennsylvania | 15224 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Providence | Rhode Island | 02905 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Charleston | South Carolina | 29425 | United States | Details |
| Research Site | RECRUITING | Sioux Falls | South Dakota | 57105 | United States | Details |
| Research Site | RECRUITING | Austin | Texas | 78758 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Fort Worth | Texas | 76104 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Houston | Texas | 77030 | United States | Details |
| Research Site | RECRUITING | San Antonio | Texas | 78240 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Saint Johnsbury | Vermont | 05819 | United States | Details |
| Research Site | RECRUITING | Charlottesville | Virginia | 22908 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Fairfax | Virginia | 22031 | United States | Details |
| Research Site | WITHDRAWN | Seattle | Washington | 98133 | United States | Details |
| Research Site | NOT_YET_RECRUITING | Madison | Wisconsin | 53705 | United States | Details |
| Research Site | RECRUITING | Blacktown | 2148 | Australia | Details | |
| Research Site | RECRUITING | East Melbourne | 3002 | Australia | Details | |
| Research Site | RECRUITING | Nedlands | 6009 | Australia | Details | |
| Research Site | RECRUITING | South Brisbane | 4101 | Australia | Details | |
| Research Site | NOT_YET_RECRUITING | Innsbruck | 6020 | Austria | Details | |
| Research Site | NOT_YET_RECRUITING | Linz | 4021 | Austria | Details | |
| Research Site | NOT_YET_RECRUITING | Vienna | 1090 | Austria | Details | |
| Research Site | NOT_YET_RECRUITING | Wein | 1130 | Austria | Details | |
| Research Site | NOT_YET_RECRUITING | Anderlecht | 1070 | Belgium | Details | |
| Research Site | NOT_YET_RECRUITING | Brussels | 1200 | Belgium | Details | |
| Research Site | WITHDRAWN | Charleroi | 6060 | Belgium | Details | |
| Research Site | NOT_YET_RECRUITING | Ghent | 9000 | Belgium | Details | |
| Research Site | NOT_YET_RECRUITING | Leuven | 3000 | Belgium | Details | |
| Research Site | NOT_YET_RECRUITING | Liège | 4000 | Belgium | Details | |
| Research Site | NOT_YET_RECRUITING | Barretos | 14784-057 | Brazil | Details | |
| Research Site | NOT_YET_RECRUITING | Belo Horizonte | 30130 100 | Brazil | Details | |
| Research Site | RECRUITING | Goiânia | 74000-000 | Brazil | Details | |
| Research Site | RECRUITING | Londrina | 86015-520 | Brazil | Details | |
| Research Site | NOT_YET_RECRUITING | Porto Alegre | 90020-090 | Brazil | Details | |
| Research Site | RECRUITING | Porto Alegre | 90610000 | Brazil | Details | |
| Research Site | NOT_YET_RECRUITING | Rio de Janeiro | 20220-410 | Brazil | Details | |
| Research Site | NOT_YET_RECRUITING | Salvador | 41.950-610 | Brazil | Details | |
| Research Site | NOT_YET_RECRUITING | São Paulo | 01246-000 | Brazil | Details | |
| Research Site | RECRUITING | São Paulo | 01317-001 | Brazil | Details | |
| Research Site | NOT_YET_RECRUITING | São Paulo | 1409 | Brazil | Details | |
| Research Site | NOT_YET_RECRUITING | Teresina | 64049-200 | Brazil | Details | |
| Research Site | RECRUITING | Calgary | Alberta | T2N 5G2 | Canada | Details |
| Research Site | NOT_YET_RECRUITING | Edmonton | Alberta | T6G 1Z2 | Canada | Details |
| Research Site | NOT_YET_RECRUITING | Winnipeg | Manitoba | R3E 0V9 | Canada | Details |
| Research Site | WITHDRAWN | Halifax | Nova Scotia | B3H 2Y9 | Canada | Details |
| Research Site | RECRUITING | London | Ontario | N6A 4L6 | Canada | Details |
| Research Site | NOT_YET_RECRUITING | Toronto | Ontario | M4N 3M5 | Canada | Details |
| Research Site | RECRUITING | Toronto | Ontario | M5G 2M9 | Canada | Details |
| Research Site | RECRUITING | Montreal | Quebec | H1T 2M4 | Canada | Details |
| Research Site | RECRUITING | Montreal | Quebec | H2X 0A9 | Canada | Details |
| Research Site | RECRUITING | Montreal | Quebec | H3G 1A4 | Canada | Details |
| Research Site | RECRUITING | Québec | Quebec | G1J 1Z4 | Canada | Details |
| Research Site | RECRUITING | Beijing | 100142 | China | Details | |
| Research Site | RECRUITING | Changchun | 130021 | China | Details | |
| Research Site | RECRUITING | Changsha | 410013 | China | Details | |
| Research Site | RECRUITING | Chengdu | 610041 | China | Details | |
| Research Site | RECRUITING | Chengdu | 610072 | China | Details | |
| Research Site | RECRUITING | Chongqing | 400030 | China | Details | |
| Research Site | RECRUITING | Fuzhou | 350001 | China | Details | |
| Research Site | NOT_YET_RECRUITING | Fuzhou | 350014 | China | Details | |
| Research Site | RECRUITING | Guangzhou | 510060 | China | Details | |
| Research Site | RECRUITING | Guangzhou | 510080 | China | Details | |
| Research Site | RECRUITING | Guangzhou | 510120 | China | Details | |
| Research Site | RECRUITING | Haikou | 570311 | China | Details | |
| Research Site | RECRUITING | Hangzhou | 310022 | China | Details | |
| Research Site | RECRUITING | Harbin | 150049 | China | Details | |
| Research Site | RECRUITING | Hefei | 230001 | China | Details | |
| Research Site | RECRUITING | Jinan | 250021 | China | Details | |
| Research Site | RECRUITING | Jinan | 250117 | China | Details | |
| Research Site | RECRUITING | Jining | 272029 | China | Details | |
| Research Site | RECRUITING | Kunming | 650118 | China | Details | |
| Research Site | RECRUITING | Lanzhou | 730030 | China | Details | |
| Research Site | RECRUITING | Nanchang | 330006 | China | Details | |
| Research Site | RECRUITING | Nanning | 530021 | China | Details | |
| Research Site | RECRUITING | Shanghai | 200011 | China | Details | |
| Research Site | RECRUITING | Shanghai | 201318 | China | Details | |
| Research Site | RECRUITING | Shantou | China | Details | ||
| Research Site | RECRUITING | Shenyang | 110004 | China | Details | |
| Research Site | NOT_YET_RECRUITING | Shenyang | 110042 | China | Details | |
| Research Site | RECRUITING | Taiyuan | 030001 | China | Details | |
| Research Site | RECRUITING | Tianjin | 300060 | China | Details | |
| Research Site | WITHDRAWN | Ürümqi | 830000 | China | Details | |
| Research Site | RECRUITING | Wuhan | 430000 | China | Details | |
| Research Site | RECRUITING | Wuhan | 430022 | China | Details | |
| Research Site | RECRUITING | Xi'an | 710061 | China | Details | |
| Research Site | RECRUITING | Xuzhou | 221009 | China | Details | |
| Research Site | WITHDRAWN | Yibin | 610500 | China | Details | |
| Research Site | NOT_YET_RECRUITING | Aalborg | 9100 | Denmark | Details | |
| Research Site | WITHDRAWN | Herlev | 2730 | Denmark | Details | |
| Research Site | NOT_YET_RECRUITING | København Ø | 2100 | Denmark | Details | |
| Research Site | NOT_YET_RECRUITING | Odense | 5000 | Denmark | Details | |
| Research Site | NOT_YET_RECRUITING | Helsinki | 00290 | Finland | Details | |
| Research Site | NOT_YET_RECRUITING | Oulu | 90029 | Finland | Details | |
| Research Site | NOT_YET_RECRUITING | Tampere | 33520 | Finland | Details | |
| Research Site | NOT_YET_RECRUITING | Turku | 20520 | Finland | Details | |
| Research Site | NOT_YET_RECRUITING | Besançon | 25030 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Bordeaux | 33076 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Caen | 14076 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Clermont-Ferrand | 63000 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Lyon | 69373 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Montpellier | 34298 | France | Details | |
| Research Site | RECRUITING | Nice | 06100 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Paris | 75015 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Plérin | 22190 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Poitiers | 86021 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Saint-Herblain | 44805 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Toulouse | 31059 | France | Details | |
| Research Site | NOT_YET_RECRUITING | Berlin | 13353 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Chemnitz | 09116 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Dessau | 06847 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Dresden | 01307 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Essen | 45147 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Hamburg | 20246 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Kassel | 34125 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Leipzig | 04103 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Mannheim | 68167 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Marburg | 35043 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Münster | 48149 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Saarbrücken | 66113 | Germany | Details | |
| Research Site | NOT_YET_RECRUITING | Budapest | 1088 | Hungary | Details | |
| Research Site | RECRUITING | Budapest | 1122 | Hungary | Details | |
| Research Site | RECRUITING | Debrecen | 4032 | Hungary | Details | |
| Research Site | NOT_YET_RECRUITING | Catania | 95100 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Florence | 50134 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Milan | 20141 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Milan | 20159 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Milan | 20162 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Monza | 20900 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Napoli | 80131 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Reggio Emilia | 422122 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Roma | 00144 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Rome | 00168 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Torino | 10128 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Turin | 10128 | Italy | Details | |
| Research Site | NOT_YET_RECRUITING | Akashi-shi | 673-8558 | Japan | Details | |
| Research Site | RECRUITING | Ginowan-shi | 901-2725 | Japan | Details | |
| Research Site | RECRUITING | Hidaka-shi | 350-1298 | Japan | Details | |
| Research Site | RECRUITING | Isehara-shi | 259-1193 | Japan | Details | |
| Research Site | NOT_YET_RECRUITING | Kashiwa | 227-8577 | Japan | Details | |
| Research Site | NOT_YET_RECRUITING | Kashiwa-shi | 277-8567 | Japan | Details | |
| Research Site | RECRUITING | Kobe | 650-0047 | Japan | Details | |
| Research Site | RECRUITING | Kōtoku | 135-8550 | Japan | Details | |
| Research Site | RECRUITING | Kurume-shi | 830-0011 | Japan | Details | |
| Research Site | RECRUITING | Matsuyama | 791-0280 | Japan | Details | |
| Research Site | RECRUITING | Morioka | 028-3695 | Japan | Details | |
| Research Site | NOT_YET_RECRUITING | Nagoya | 464-8681 | Japan | Details | |
| Research Site | RECRUITING | Niigata | 951-8520 | Japan | Details | |
| Research Site | NOT_YET_RECRUITING | Osaka | 541-8567 | Japan | Details | |
| Research Site | RECRUITING | Ota-shi | 373-8550 | Japan | Details | |
| Research Site | RECRUITING | Sapporo | 060-8638 | Japan | Details | |
| Research Site | NOT_YET_RECRUITING | Sendai | 980-8574 | Japan | Details | |
| Research Site | RECRUITING | Shinjuku-ku | 160-8582 | Japan | Details | |
| Research Site | RECRUITING | Sunto-gun | 411-8777 | Japan | Details | |
| Research Site | RECRUITING | Tokyo | 104-0045 | Japan | Details | |
| Research Site | WITHDRAWN | Amsterdam | 1066CX | Netherlands | Details | |
| Research Site | WITHDRAWN | Leiden | 2333 ZA | Netherlands | Details | |
| Research Site | WITHDRAWN | Nijmegen | 6525 GA | Netherlands | Details | |
| Research Site | WITHDRAWN | Rotterdam | 3015 GD | Netherlands | Details | |
| Research Site | NOT_YET_RECRUITING | Oslo | 0379 | Norway | Details | |
| Research Site | NOT_YET_RECRUITING | Stavanger | 4011 | Norway | Details | |
| Research Site | NOT_YET_RECRUITING | Bialystok | 15-027 | Poland | Details | |
| Research Site | NOT_YET_RECRUITING | Gdansk | 80-214 | Poland | Details | |
| Research Site | NOT_YET_RECRUITING | Lodz | 93-338 | Poland | Details | |
| Research Site | NOT_YET_RECRUITING | Poznan | 60-569 | Poland | Details | |
| Research Site | NOT_YET_RECRUITING | Siedlce | 08-110 | Poland | Details | |
| Research Site | NOT_YET_RECRUITING | Szczecin | 70-111 | Poland | Details | |
| Research Site | RECRUITING | Goyang-si | 10408 | South Korea | Details | |
| Research Site | RECRUITING | Seoul | 03080 | South Korea | Details | |
| Research Site | RECRUITING | Seoul | 03722 | South Korea | Details | |
| Research Site | RECRUITING | Seoul | 05505 | South Korea | Details | |
| Research Site | RECRUITING | Seoul | 06351 | South Korea | Details | |
| Research Site | RECRUITING | Suwon | 16499 | South Korea | Details | |
| Research Site | NOT_YET_RECRUITING | A Coruña | 15009 | Spain | Details | |
| Research Site | RECRUITING | Córdoba | 14004 | Spain | Details | |
| Research Site | RECRUITING | Donostia / San Sebastian | 20014 | Spain | Details | |
| Research Site | RECRUITING | El Palmar | 30120 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | L'Hospitalet de Llobregat | 08908 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | Madrid | 28034 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | Madrid | 28041 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | Palma de Mallorca | 07010 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | Valencia | 46006 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | Valencia | 46009 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | Zaragoza | 50009 | Spain | Details | |
| Research Site | NOT_YET_RECRUITING | Linköping | 581 85 | Sweden | Details | |
| Research Site | NOT_YET_RECRUITING | Lund | 22185 | Sweden | Details | |
| Research Site | NOT_YET_RECRUITING | Stockholm | 17164 | Sweden | Details | |
| Research Site | NOT_YET_RECRUITING | Uppsala | 751 85 | Sweden | Details | |
| Research Site | WITHDRAWN | Frauenfeld | 8501 | Switzerland | Details | |
| Research Site | NOT_YET_RECRUITING | Liestal | CH- 4410 | Switzerland | Details | |
| Research Site | NOT_YET_RECRUITING | Sankt Gallen | 9007 | Switzerland | Details | |
| Research Site | NOT_YET_RECRUITING | Zurich | 8091 | Switzerland | Details | |
| Research Site | RECRUITING | Changhua | 500 | Taiwan | Details | |
| Research Site | RECRUITING | Kaohsiung City | 81362 | Taiwan | Details | |
| Research Site | RECRUITING | New Taipei City | 220 | Taiwan | Details | |
| Research Site | RECRUITING | Taichung | 40705 | Taiwan | Details | |
| Research Site | RECRUITING | Tainan | 704 | Taiwan | Details | |
| Research Site | RECRUITING | Taipei | 10449 | Taiwan | Details | |
| Research Site | NOT_YET_RECRUITING | Bath | BA1 3NG | United Kingdom | Details | |
| Research Site | NOT_YET_RECRUITING | Cambridge | CB2 0QQ | United Kingdom | Details | |
| Research Site | NOT_YET_RECRUITING | Leeds | LS9 7TF | United Kingdom | Details | |
| Research Site | NOT_YET_RECRUITING | London | EC1A 7BE | United Kingdom | Details | |
| Research Site | NOT_YET_RECRUITING | Manchester | M20 4BX | United Kingdom | Details | |
| Research Site | NOT_YET_RECRUITING | Northwood | HA6 2RN | United Kingdom | Details | |
| Research Site | NOT_YET_RECRUITING | Taunton | TA1 5DA | United Kingdom | Details |