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| NCT ID | NCT07075016 |
| Title | Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy (EVOLVE 1) |
| Acronym | EVOLVE 1 |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Stichting Hemato-Oncologie voor Volwassenen Nederland |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | SWE | NOR | NLD | LTU | ITA | IRL | GBR | FRA | FIN | EST | ESP | DNK | DEU | CHE | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| AT-Feldkirch-IKHF | NOT_YET_RECRUITING | Feldkirch | Austria | Details | ||
| AT-Salzburg-SALK | NOT_YET_RECRUITING | Salzburg | Austria | Details | ||
| AT-Vienna-HANUSCH | NOT_YET_RECRUITING | Vienna | Austria | Details | ||
| BE-Antwerpen-ZAS | NOT_YET_RECRUITING | Antwerp | Belgium | Details | ||
| BE-Brussel-BORDET | NOT_YET_RECRUITING | Brussels | Belgium | Details | ||
| BE-Brussel-UZBRUSSEL | NOT_YET_RECRUITING | Brussels | Belgium | Details | ||
| BE-Bruxelles-STLUC | NOT_YET_RECRUITING | Brussels | Belgium | Details | ||
| BE-Gent-UZGENT | NOT_YET_RECRUITING | Ghent | Belgium | Details | ||
| BE-Leuven-UZLEUVEN | NOT_YET_RECRUITING | Leuven | Belgium | Details | ||
| BE-Liege-CHULIEGE | NOT_YET_RECRUITING | Liège | Belgium | Details | ||
| BE-Yvoir-MONTGODINNE | RECRUITING | Yvoir | Belgium | Details | ||
| DK-Aalborg-AALBORGUH | NOT_YET_RECRUITING | Aalborg | Denmark | Details | ||
| DK-Aarhus N-AUH | NOT_YET_RECRUITING | Aarhus N | Denmark | Details | ||
| DK-Copenhagen-RIGSHOSPITALET | NOT_YET_RECRUITING | Copenhagen | Denmark | Details | ||
| DK-Odense-OUH | NOT_YET_RECRUITING | Odense | Denmark | Details | ||
| DK-Roskilde-ROSKILDE | NOT_YET_RECRUITING | Roskilde | Denmark | Details | ||
| EE-Tallinn-REGIONAALHAIGLA | NOT_YET_RECRUITING | Tallinn | Estonia | Details | ||
| EE-Tartu-TARTU | NOT_YET_RECRUITING | Tartu | Estonia | Details | ||
| FI-Helsinki-HUS | NOT_YET_RECRUITING | Helsinki | Finland | Details | ||
| FI-Tampere-TAYS | NOT_YET_RECRUITING | Tampere | Finland | Details | ||
| FR-Angers-CHUANGERS | NOT_YET_RECRUITING | Angers | France | Details | ||
| FR-Pessac Cedex-CHUBORDEAUX | NOT_YET_RECRUITING | Bordeaux | France | Details | ||
| FR-Caen-CHUCAEN | NOT_YET_RECRUITING | Caen | France | Details | ||
| FR-Créteil cedex-CHUMONDOR | NOT_YET_RECRUITING | Créteil | France | Details | ||
| FR-Grenoble cedex 9-CHUGRENOBLE | NOT_YET_RECRUITING | Grenoble | France | Details | ||
| FR-Lille-CHULILLE | NOT_YET_RECRUITING | Lille | France | Details | ||
| FR-Lyon Pierre Benite cedex-LYONSUD | NOT_YET_RECRUITING | Lyon | France | Details | ||
| FR-Montpellier-CHUSAINTELOIS | NOT_YET_RECRUITING | Montpellier | France | Details | ||
| FR-Nantes-CHUNANTES | NOT_YET_RECRUITING | Nantes | France | Details | ||
| FR-Nice-LARCHET | NOT_YET_RECRUITING | Nice | France | Details | ||
| FR-Rennes cedex 9-CHURENNES | NOT_YET_RECRUITING | Rennes | France | Details | ||
| FR-Rouen cedex-BECQUEREL | NOT_YET_RECRUITING | Rouen | France | Details | ||
| FR-Saint-Priest-en-Jarez-STETIENNE | NOT_YET_RECRUITING | Saint-Etienne | France | Details | ||
| FR-Le Chesnay cedex-CHVERSAILLES | NOT_YET_RECRUITING | Versailles | France | Details | ||
| DE-Berlin-CAMPUSBENFRANKLIN | NOT_YET_RECRUITING | Berlin | Germany | Details | ||
| DE-Berlin-CAMPUSVIRCHOW | NOT_YET_RECRUITING | Berlin | Germany | Details | ||
| DE-Berlin-VIVANTESNEUKOLLN | NOT_YET_RECRUITING | Berlin | Germany | Details | ||
| DE-Bochum-RUB | NOT_YET_RECRUITING | Bochum | Germany | Details | ||
| DE-Bonn-UNIBONN | NOT_YET_RECRUITING | Bonn | Germany | Details | ||
| DE-Braunschweig-KLINIKUMBRAUNSCHWEIG | NOT_YET_RECRUITING | Braunschweig | Germany | Details | ||
| DE-Bremen-KBM | NOT_YET_RECRUITING | Bremen | Germany | Details | ||
| DE-Darmstadt-KLINIKUMDARMSTADT | NOT_YET_RECRUITING | Darmstadt | Germany | Details | ||
| DE-Flensburg-MALTESER | NOT_YET_RECRUITING | Flensburg | Germany | Details | ||
| DE-Freiburg-UNIKLINIKFREIBURG | NOT_YET_RECRUITING | Freiburg im Breisgau | Germany | Details | ||
| DE-Greifswald-UNIGREIFSWALD | NOT_YET_RECRUITING | Greifswald | Germany | Details | ||
| DE-Halle-UMH | NOT_YET_RECRUITING | Halle | Germany | Details | ||
| DE-Hamburg-ASKLEPIOSSTGEORG | NOT_YET_RECRUITING | Hamburg | Germany | Details | ||
| DE-Hamburg-UKE | NOT_YET_RECRUITING | Hamburg | Germany | Details | ||
| DE-Hannover-MHHANNOVER | NOT_YET_RECRUITING | Hanover | Germany | Details | ||
| DE-Hannover-SILOAHKRH | NOT_YET_RECRUITING | Hanover | Germany | Details | ||
| DE-Heilbronn-SLK | NOT_YET_RECRUITING | Heilbronn | Germany | Details | ||
| DE-Karlsruhe-KLINIKUMKARLSRUHE | NOT_YET_RECRUITING | Karlsruhe | Germany | Details | ||
| DE-Mainz-UNIMEDIZINMAINZ | NOT_YET_RECRUITING | Mainz | Germany | Details | ||
| DE-Minden-MUEHLENKREISKLINKEN | NOT_YET_RECRUITING | Minden | Germany | Details | ||
| DE-München-IRZTUM | NOT_YET_RECRUITING | München | Germany | Details | ||
| DE-Oldenburg-KLINIKUMOLDENBURG | NOT_YET_RECRUITING | Oldenburg | Germany | Details | ||
| DE-Regensburg-UKR | NOT_YET_RECRUITING | Regensburg | Germany | Details | ||
| DE-Stuttgart-KLINIKUMSTUTTGART | NOT_YET_RECRUITING | Stuttgart | Germany | Details | ||
| DE-Tübingen-MEDUNITUEBINGEN | NOT_YET_RECRUITING | Tübingen | Germany | Details | ||
| DE-Ulm-UNIKLINKULM | NOT_YET_RECRUITING | Ulm | Germany | Details | ||
| IE-Cork-CUH | NOT_YET_RECRUITING | Cork | Ireland | Details | ||
| IE-Dublin 7-MATER | NOT_YET_RECRUITING | Dublin | Ireland | Details | ||
| IE-Dublin 8-ST JAMES | NOT_YET_RECRUITING | Dublin | Ireland | Details | ||
| IE-Galway-UHGALWAY | NOT_YET_RECRUITING | Galway | Ireland | Details | ||
| IT-Bologna-MALPHIGI | NOT_YET_RECRUITING | Bologna | Italy | Details | ||
| IT-Milano-NIGUARDA | NOT_YET_RECRUITING | Milan | Italy | Details | ||
| IT-Roma-SAPIENZA | NOT_YET_RECRUITING | Roma | Italy | Details | ||
| IT-Roma-TORVERGATA | NOT_YET_RECRUITING | Roma | Italy | Details | ||
| IT-Torino-CITTADELLASALUTE | NOT_YET_RECRUITING | Torino | Italy | Details | ||
| LT-Vilnius-SANTA | NOT_YET_RECRUITING | Vilnius | Lithuania | Details | ||
| NL-Den Bosch-JBZ | NOT_YET_RECRUITING | 's-Hertogenbosch | Netherlands | Details | ||
| NL-Amsterdam-VUMC | NOT_YET_RECRUITING | Amsterdam | Netherlands | Details | ||
| NL-Arnhem-RIJNSTATE | NOT_YET_RECRUITING | Arnhem | Netherlands | Details | ||
| NL-Breda-AMPHIA | NOT_YET_RECRUITING | Breda | Netherlands | Details | ||
| NL-Dordrecht-ASZ | NOT_YET_RECRUITING | Dordrecht | Netherlands | Details | ||
| NL-Eindhoven-CATHARINA | NOT_YET_RECRUITING | Eindhoven | Netherlands | Details | ||
| NL-Enschede-MST | NOT_YET_RECRUITING | Enschede | Netherlands | Details | ||
| NL-Sittard-Geleen-ZUYDERLAND | NOT_YET_RECRUITING | Geleen | Netherlands | Details | ||
| NL-Groningen-UMCG | RECRUITING | Groningen | Netherlands | Details | ||
| NL-Nijmegen-RADBOUDUMC | NOT_YET_RECRUITING | Nijmegen | Netherlands | Details | ||
| NL-Rotterdam-ERASMUSMC | NOT_YET_RECRUITING | Rotterdam | Netherlands | Details | ||
| NL-DenHaag-HAGA | NOT_YET_RECRUITING | The Hague | Netherlands | Details | ||
| NL-Utrecht-UMCU | NOT_YET_RECRUITING | Utrecht | Netherlands | Details | ||
| NL-Zwolle-ISALA | NOT_YET_RECRUITING | Zwolle | Netherlands | Details | ||
| NO-Bergen-HELSEBERGEN | NOT_YET_RECRUITING | Bergen | Norway | Details | ||
| NO-Oslo-OSLOUH | NOT_YET_RECRUITING | Oslo | Norway | Details | ||
| NO-Tromsø-NORTHNOORWEGEN | NOT_YET_RECRUITING | Tromsø | Norway | Details | ||
| NO-Trondheim-STOLAV | NOT_YET_RECRUITING | Trondheim | Norway | Details | ||
| ES-Barcelona-CLINICUB | NOT_YET_RECRUITING | Barcelona | Spain | Details | ||
| ES-Barcelona-GERMANTRIALS | NOT_YET_RECRUITING | Barcelona | Spain | Details | ||
| ES-Barcelona-SANTPAU | NOT_YET_RECRUITING | Barcelona | Spain | Details | ||
| ES-Girona-ICSTRUETA | NOT_YET_RECRUITING | Girona | Spain | Details | ||
| ES-Valencia-MALVARROSA | NOT_YET_RECRUITING | Valencia | Spain | Details | ||
| SE-Goteborg-SAHLGRENSKA | NOT_YET_RECRUITING | Gothenburg | Sweden | Details | ||
| SE-Lund-SUH | NOT_YET_RECRUITING | Lund | Sweden | Details | ||
| SE-Stockholm-KAROLINSKAHUDDINGE | NOT_YET_RECRUITING | Stockholm | Sweden | Details | ||
| SE-Uppsala-UPPSALAUH | NOT_YET_RECRUITING | Uppsala | Sweden | Details | ||
| CH-Basel-USB | NOT_YET_RECRUITING | Basel | Switzerland | Details | ||
| CH-Bellinzona-IOSI | NOT_YET_RECRUITING | Bellinzona | Switzerland | Details | ||
| CH-Bern-INSEL | NOT_YET_RECRUITING | Bern | Switzerland | Details | ||
| CH-Zurich-USZ | NOT_YET_RECRUITING | Zurich | Switzerland | Details | ||
| UK-Birmingham-QE | NOT_YET_RECRUITING | Birmingham | United Kingdom | Details | ||
| UK-Blackpool-BLACKPOOLVICTORIA | NOT_YET_RECRUITING | Blackpool | United Kingdom | Details | ||
| UK-Bristol-BRISTOLCENTRE | NOT_YET_RECRUITING | Bristol | United Kingdom | Details | ||
| UK-Cardiff-UHW | NOT_YET_RECRUITING | Cardiff | United Kingdom | Details | ||
| UK-Glasgow-BEATSON | NOT_YET_RECRUITING | Glasgow | United Kingdom | Details | ||
| UK-Leeds-STJAMESUH | NOT_YET_RECRUITING | Leeds | United Kingdom | Details | ||
| UK-Leicester-LEICESTERRI | NOT_YET_RECRUITING | Leicester | United Kingdom | Details | ||
| UK-London-KCH | NOT_YET_RECRUITING | London | United Kingdom | Details | ||
| UK-London-ROYALMARSDEN | NOT_YET_RECRUITING | London | United Kingdom | Details | ||
| UK-London-UNICOLLEGEHOSP | NOT_YET_RECRUITING | London | United Kingdom | Details | ||
| UK-Manchester-CHRISTIE | NOT_YET_RECRUITING | Manchester | United Kingdom | Details | ||
| UK-Manchester-ROYALINFIRMARY | NOT_YET_RECRUITING | Manchester | United Kingdom | Details | ||
| UK-Newcastle on Tyne-FREEMAN | NOT_YET_RECRUITING | Newcastle upon Tyne | United Kingdom | Details | ||
| UK-Nottingham-NOTTINGHAMCH | NOT_YET_RECRUITING | Nottingham | United Kingdom | Details | ||
| UK-Oxford-CHURCHILL | NOT_YET_RECRUITING | Oxford | United Kingdom | Details | ||
| UK-Portsmouth-QUEENALEXANDRA | NOT_YET_RECRUITING | Portsmouth | United Kingdom | Details | ||
| UK-Southampton-SOUTHAMPTONGH | NOT_YET_RECRUITING | Southampton | United Kingdom | Details | ||
| UK-Wolverhampton-NEWCROSSH | NOT_YET_RECRUITING | Wolverhampton | United Kingdom | Details |