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| NCT ID | NCT07185997 |
| Title | Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | ArriVent BioPharma, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | TUR | ITA | GRC | GBR | FRA | ESP | CAN | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| St. Jude Medical Center | RECRUITING | Fullerton | California | 92835 | United States | Details |
| USC/Norris Comprehensive Cancer Center | RECRUITING | Los Angeles | California | 90033 | United States | Details |
| Providence St. Joseph Hospital | RECRUITING | Orange | California | 92868 | United States | Details |
| University of California Davis Comprehensive Cancer Center | RECRUITING | Sacramento | California | 95817 | United States | Details |
| UCSF Medical Center-Mission Bay | RECRUITING | San Francisco | California | 94158 | United States | Details |
| Kaiser Permanente Medical Center | RECRUITING | Vallejo | California | 94589 | United States | Details |
| University of Colorado Health | RECRUITING | Aurora | Colorado | 80045 | United States | Details |
| Illinois Cancer Specialists | RECRUITING | Arlington Heights | Illinois | 60005 | United States | Details |
| University of Illinois Hospital and Health Sciences Systems | RECRUITING | Chicago | Illinois | 60612 | United States | Details |
| Henry Ford Cancer Institute | RECRUITING | Detroit | Michigan | 48202 | United States | Details |
| Northwell Health/R.J. Zuckerberg Cancer Center | RECRUITING | Lake Success | New York | 11042 | United States | Details |
| Laura & Isaac Perlmutter Cancer Center at NYU Langone Health | RECRUITING | New York | New York | 10016 | United States | Details |
| Columbia University Medical Center | RECRUITING | New York | New York | 10032 | United States | Details |
| Ohio State University Hospitals | RECRUITING | Columbus | Ohio | 43210 | United States | Details |
| Fox Chase Cancer Center | RECRUITING | Philadelphia | Pennsylvania | 19111 | United States | Details |
| Texas Oncology | RECRUITING | Dallas | Texas | 75246 | United States | Details |
| The University of Texas MD Anderson Cancer Center | RECRUITING | Houston | Texas | 77030 | United States | Details |
| University of Virginia | RECRUITING | Charlottesville | Virginia | 22903 | United States | Details |
| Virginia Cancer Specialists | RECRUITING | Fairfax | Virginia | 22031 | United States | Details |
| Shenandoah Oncology, P.C. | RECRUITING | Winchester | Virginia | 22601 | United States | Details |
| Swedish Cancer Institute | RECRUITING | Edmonds | Washington | 98026 | United States | Details |
| Blacktown Cancer and Haematology Centre | RECRUITING | Blacktown | New South Wales | 2148 | Australia | Details |
| Chris O'Brien Lifehouse | RECRUITING | Camperdown | New South Wales | 2050 | Australia | Details |
| GenesisCare North Shore Health Hub | RECRUITING | St Leonards | New South Wales | 2065 | Australia | Details |
| Austin Health | RECRUITING | Heidelberg | Victoria | 3084 | Australia | Details |
| Alberta Health Services, Tom Baker Cancer Centre | RECRUITING | Calgary | Alberta | T2N 4N2 | Canada | Details |
| University of Alberta - Cross Cancer Institute (CCI) | RECRUITING | Edmonton | Alberta | T6G 1Z2 | Canada | Details |
| BC Cancer Vancouver Centre | RECRUITING | Vancouver | British Columbia | V5Z 4E6 | Canada | Details |
| Brampton Civic Hospital, William Osler Health Centre | RECRUITING | Brampton | Ontario | L6R 3J7 | Canada | Details |
| The Ottawa Hospital Cancer Centre | RECRUITING | Ottawa | Ontario | K1H 8L6 | Canada | Details |
| Sunnybrook Research Institute | RECRUITING | Toronto | Ontario | M4N 3M5 | Canada | Details |
| Princess Margaret Cancer Centre - University Health Network | RECRUITING | Toronto | Ontario | M5G 2M9 | Canada | Details |
| Anhui Provincial Hospital | RECRUITING | Hefei | Anhui | 230036 | China | Details |
| Peking University People's Hospital | RECRUITING | Beijing | Beijing Municipality | 100044 | China | Details |
| Peking University Cancer Hospital (PKUCH)/Beijing Cancer Hospital | RECRUITING | Beijing | Beijing Municipality | 101142 | China | Details |
| Beijing Chest Hospital, Capital Medical University | RECRUITING | Beijing | Beijing Municipality | 101149 | China | Details |
| The First Affiliated Hospital of Chongqing Medical University | RECRUITING | Chongqing | Chongqing Municipality | 400020 | China | Details |
| Fujian Cancer Hospital | RECRUITING | Fuzhou | Fujian | 350014 | China | Details |
| Zhongshan Hospital Xiamen University | RECRUITING | Xiamen | Fujian | 361004 | China | Details |
| The First People's Hospital of Foshan | RECRUITING | Foshan | Guangdong | 528000 | China | Details |
| The First Affiliated Hospital, Sun Yat-sen University | RECRUITING | Guangzhou | Guangdong | 510080 | China | Details |
| Nanfang Hospital, Southern Medical University | RECRUITING | Guangzhou | Guangdong | 510515 | China | Details |
| Cancer Hospital of Shantou University Medical College | RECRUITING | Shantou | Guangdong | 515000 | China | Details |
| Guangxi Medical University Cancer Hospital | RECRUITING | Nanning | Guangxi | 530012 | China | Details |
| The Fourth Hospital of Hebei Medical University | RECRUITING | Shijiazhuang | Hebei | 50011 | China | Details |
| Harbin Medical University Cancer Hospital | RECRUITING | Harbin | Heilongjiang | 150081 | China | Details |
| The First Affiliated Hospital of Henan University of Science & Technology | RECRUITING | Luoyang | Henan | 47100 | China | Details |
| The First Affiliated Hospital of Henan Medical University | RECRUITING | Xinxiang | Henan | 453100 | China | Details |
| Henan Cancer Center | RECRUITING | Zhengzhou | Henan | 450000 | China | Details |
| The First Affiliated Hospital of Zhengzhou University | RECRUITING | Zhengzhou | Henan | 450008 | China | Details |
| Union Hospital Tongji Medical College Huazhong University Of Science And Technology | RECRUITING | Wuhan | Hubei | 430000 | China | Details |
| Xiangya Hospital of Central South University | RECRUITING | Changsha | Hunan | 410008 | China | Details |
| Hunan Cancer Hospital | RECRUITING | Changsha | Hunan | 410013 | China | Details |
| Profile of The Third Xiangya Hospital of Central South University | RECRUITING | Changsha | Hunan | 410013 | China | Details |
| The Affiliated Hospital of Inner Mongolia Medical University | RECRUITING | Hohhot | Inner Mongolia | 010030 | China | Details |
| Jiangsu Province Hospital | RECRUITING | Nanjing | Jiangsu | 210029 | China | Details |
| Nanjing Drum Tower Hospital | RECRUITING | Nanjing | Jiangsu | 210031 | China | Details |
| Affiliated Hospital of Nantong University | RECRUITING | Nantong | Jiangsu | 226001 | China | Details |
| The First Affiliated Hospital of Nanchang University | RECRUITING | Nanchang | Jiangxi | 330200 | China | Details |
| The First Hospital of China Medical University | RECRUITING | Shenyang | Liaoning | 110001 | China | Details |
| Cancer hospital of Dalian university of technology | RECRUITING | Shenyang | Liaoning | 110042 | China | Details |
| China shenyang the tenth People's Hospital | RECRUITING | Shenyang | Liaoning | 110044 | China | Details |
| Jinan Central Hospital | RECRUITING | Jinan | Shandong | 250013 | China | Details |
| Linyi Cancer Hospital | RECRUITING | Linyi | Shandong | 276001 | China | Details |
| The Affiliated Hospital of Qingdao University | RECRUITING | Qingdao | Shandong | 276001 | China | Details |
| Weifang People's Hospital | RECRUITING | Weifang | Shandong | 261057 | China | Details |
| Shanghai Geriatric Medical Center | RECRUITING | Shanghai | Shanghai Municipality | 200000 | China | Details |
| Shanghai Chest Hospital | RECRUITING | Shanghai | Shanghai Municipality | 20030 | China | Details |
| Shanghai Pulmonary Hospital | RECRUITING | Shanghai | Shanghai Municipality | 200433 | China | Details |
| Shanxi Cancer Hospital | RECRUITING | Taiyuan | Shanxi | 30009 | China | Details |
| Sichuan Cancer Hospital | RECRUITING | Chengdu | Sichuan | 610213 | China | Details |
| West China Hospital of Sichuan University | RECRUITING | Chengdu | Sichuan | 611135 | China | Details |
| Yibin Second People's Hospital | RECRUITING | Yibin | Sichuan | 644000 | China | Details |
| Tianjin Chest Hospital | RECRUITING | Tianjin | Tianjin Municipality | 300222 | China | Details |
| Tianjin Medical University Cancer Institute & Hospital | RECRUITING | Tianjin | Tianjin Municipality | 300222 | China | Details |
| Yunnan Cancer Hospital | RECRUITING | Kunming | Yunnan | 650118 | China | Details |
| The First Affiliated Hospital,Zhejiang University School of Medicine | RECRUITING | Hangzhou | Zhejiang | 310006 | China | Details |
| Zhejiang Cancer Hospital | RECRUITING | Hangzhou | Zhejiang | 310022 | China | Details |
| Hospices Civil de Lyon | RECRUITING | Bron | Auvergne-Rhône-Alpes | 69500 | France | Details |
| Hospital Nord de Marseille | RECRUITING | Marseille | Bouches-du-Rhone | 13915 | France | Details |
| Centre Francois Baclesse | RECRUITING | Caen | Calvados | 14076 | France | Details |
| Hopital Larrey | RECRUITING | Toulouse | Occitanie | 31059 | France | Details |
| Centre Leon-Berard | RECRUITING | Lyon | 69373 | France | Details | |
| Hopital Nord Guilaume-et-Rene-Laennec CHU de Nantes | RECRUITING | Saint-Herblain | 44093 | France | Details | |
| Insitut de Canderologie d I'Ouest | RECRUITING | Saint-Herblain | 44805 | France | Details | |
| Henry Dunant Hospital Center | RECRUITING | Athens | 115 26 | Greece | Details | |
| University General Hospital Attikon - General Hospital of West Attica H AGIA VARVARA | RECRUITING | Athens | 124 62 | Greece | Details | |
| Athens Medical Center S.A., European Interbalkan Medical Center | RECRUITING | Thessaloniki | 570 01 | Greece | Details | |
| Thoracic General Hospital of Athens I Sotiria | RECRUITING | Thessaloniki | 570 01 | Greece | Details | |
| Queen Mary Hospital | RECRUITING | Hong Kong | Hong Kong | 000000 | Hong Kong | Details |
| Prince of Wales Hospital | RECRUITING | Shatin | New Territories | Hong Kong | Details | |
| Humanity and Health Clinical Trial Centre | RECRUITING | Central | Hong Kong | Details | ||
| SOC Oncologia Medica e dei Tumori Immuno-correlati | RECRUITING | Aviano | 33081 | Italy | Details | |
| Istituto Europeo di Oncologia (IEO) | RECRUITING | Milan | 20141 | Italy | Details | |
| Aichi Cancer Center | RECRUITING | Nagoya | Aichi-ken | 464-8681 | Japan | Details |
| Fujita Health University Hospital | RECRUITING | Toyoake | Aichi-ken | 470-1192 | Japan | Details |
| National Cancer Center Hospital East | RECRUITING | Kashiwa | Chiba | 277-8577 | Japan | Details |
| Kurume University Hospital | RECRUITING | Kurume-Shi | Fukuoka | 830-0011 | Japan | Details |
| National Hospital Organization Hokkaido Cancer Center | RECRUITING | Sapporo | Hokkaido | 003-0804 | Japan | Details |
| Hyogo Cancer Center | RECRUITING | Akashi-shi | Hyōgo | 673-8558 | Japan | Details |
| Miyagi Cancer Center | RECRUITING | Natori-shi | Miyagi | 981-1293 | Japan | Details |
| Niigata Cancer Center Hospital | RECRUITING | Niigata | Niigata | 951-8566 | Japan | Details |
| Kansai Medical University Hospital | RECRUITING | Hirakata-shi | Osaka | 573-1191 | Japan | Details |
| Nippon Medical School Hospital | RECRUITING | Bunkyo-ku | Tokyo | 113-8603 | Japan | Details |
| Tokyo Metropolitan Komagome Hospital | RECRUITING | Bunkyō-Ku | Tokyo | 113-8677 | Japan | Details |
| National Cancer Center Hospital | RECRUITING | Chuo-ku | Tokyo | 104-0045 | Japan | Details |
| OncoCar Cancer Centre | RECRUITING | Petaling Jaya | Selangor | 47810 | Malaysia | Details |
| Hospital Kuala Lumpur | RECRUITING | Kuala Lumpur | WP Kuala Lumpur | 50586 | Malaysia | Details |
| National Cancer Centre Singapore | RECRUITING | Singapore | 168583 | Singapore | Details | |
| Curie Oncology (Farrer) | RECRUITING | Singapore | 217562 | Singapore | Details | |
| Tan Tok Seng Hospital | RECRUITING | Singapore | 308433 | Singapore | Details | |
| The Catholic University of Korea, St. Vincent's Hospital | RECRUITING | Suwon | Gyeonggi-do | 16247 | South Korea | Details |
| Chonnam National University Hwasun Hospital | RECRUITING | Hwasun | Jeollanam-do | 58128 | South Korea | Details |
| Gachon University Gil Medical Center | RECRUITING | Incheon | 21565 | South Korea | Details | |
| Kyung Hee University Hospital | RECRUITING | Seoul | 02447 | South Korea | Details | |
| Kangbuk Samsung Hospital | RECRUITING | Seoul | 03181 | South Korea | Details | |
| Asan Medical Center | RECRUITING | Seoul | 05505 | South Korea | Details | |
| Samsung Medical Center | RECRUITING | Seoul | 06351 | South Korea | Details | |
| Hospital Universitari Son Espases | RECRUITING | Palma | Balearic Islands | 07120 | Spain | Details |
| Hospital Clinic de Barcelona | RECRUITING | Barcelona | 08036 | Spain | Details | |
| Hospital QuironSalud Malaga | RECRUITING | Málaga | 29004 | Spain | Details | |
| Hospital Universitario Central de Asturias | RECRUITING | Oviedo | 33011 | Spain | Details | |
| Hospital Universitario y Politecnico La Fe | RECRUITING | Valencia | 46026 | Spain | Details | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital | RECRUITING | Kaohsiung City | 807 | Taiwan | Details | |
| Taichung Veterans General Hospital | RECRUITING | Taichung | 407219 | Taiwan | Details | |
| National Taiwan University Cancer Center | RECRUITING | Taipei | 106 | Taiwan | Details | |
| Taipei Veterans General Hospital | RECRUITING | Taipei | 11217 | Taiwan | Details | |
| Mahidol University - Siriraj Hospital | RECRUITING | Bangkoknoi | Bangkok | 10700 | Thailand | Details |
| Chulabhorn Hospital | RECRUITING | Lak Si | Bangkok | 10210 | Thailand | Details |
| Prince of Songkla Hospital | RECRUITING | Hat Yai | Changwat Songkhla | 90110 | Thailand | Details |
| Faculty of Medicine Vajira Hospital, Navamindradhiraj University | RECRUITING | Bangkok | 10300 | Thailand | Details | |
| Memorial Ankara Hospital | RECRUITING | Ankara | Ankara | 06520 | Turkey (Türkiye) | Details |
| Gulhane Training and Research Hospital | RECRUITING | Ankara | 06010 | Turkey (Türkiye) | Details | |
| Anatalya Province | RECRUITING | Antalya | 07050 | Turkey (Türkiye) | Details | |
| Medical Park Florya Hospital | RECRUITING | Istanbul | 34295 | Turkey (Türkiye) | Details | |
| Istinye University Bahcesehir Liv Hospital | RECRUITING | Istanbul | 34517 | Turkey (Türkiye) | Details | |
| University College London Hospitals NHS Foundation Trust | RECRUITING | London | England | NW1 2PG | United Kingdom | Details |
| The Christie NHS Foundation Trust | RECRUITING | Manchester | England | M20 4BX | United Kingdom | Details |
| The Royal Marsden NHS Foundation Trust | RECRUITING | London | SW3 6JJ | United Kingdom | Details |