thioureidobutyronitrile
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| Drug Name | thioureidobutyronitrile |
| Trade Name | |
| Synonyms | Kevetrin|NSC-525990 |
| Drug Descriptions |
Kevetrin (thioureidobutyronitrile) leads to stabilization of wild-type Tp53 and degradation of mutant Tp53, resulting in apoptosis and decreased growth of tumors with wild-type and mutant Tp53 (J Clin Oncol 31, 2013 (suppl; abstr TPS2627)). |
| DrugClasses | p53 Activator 12 |
| CAS Registry Number | 500863-50-3 |
| NCIT ID | C102881 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| thioureidobutyronitrile | thioureidobutyronitrile | 6 | 2 |
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