RSPO1 - Gene Detail
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| Gene Symbol | RSPO1 | ||||||||||||
| Synonyms | CRISTIN3 | RSPO | ||||||||||||
| Gene Description | RSPO1, R-spondin 1, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling and ovarian development (PMID: 27270435). RSPO1 amplification has been identified in ovarian cancer and loss of function mutations in squamous cell carcinoma (PMID: 27270435), and increased Rspo1 expression has been associated with increased survival in lung adenocarcinoma (PMID: 31579414). | ||||||||||||
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