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| Gene Symbol | PBRM1 | ||||||||||||
| Synonyms | BAF180 | PB1 | RCC | SMARCH1 | ||||||||||||
| Gene Description | PBRM1, polybromo 1, is a member of the PBAF subunit (PMID: 32303701) of the SWI/SNF complex, which functions in chromatin remodeling to modulate gene expression (PMID: 23867514). PBRM1 is frequently mutated in clear cell renal cell carcinoma (PMID: 19084573, PMID: 31861590). | ||||||||||||
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| Variant | Impact | Protein Effect | Variant Description | Associated With Drug Resistance |
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| Variant | Impact | Protein Effect | Variant Description | Associated With Drug Resistance |
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| Molecular Profile | Protein Effect | Treatment Approaches |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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