AXL - Gene Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol AXL
Synonyms ARK | AXL3 | JTK11 | Tyro7 | UFO
Gene Description AXL, AXL receptor tyrosine kinase, is a receptor tyrosine kinase, which promotes growth, migration, and survival of tumor cells through activation of Mapk signaling (PMID: 28072762). Activation and overexpression of AXL has been associated with resistance to chemotherapeutic agents and targeted therapies (PMID: 28251492), in both solid and hematological tumors (PMID: 32148495).
NCBI Gene ID Chromosome Map Location Canonical Transcript MANE Select Gene Role
558 19 19q13.2 NM_021913 Y Unknown

Filtering

  • Case-insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Spaces will be interpreted literally in the search. Use the percentage character '%' as a wildcard to search for multiple values
  • When searching for values delimited by '%', searches are ordered by their appearance in the text. (i.e. 'A%C' will likely return different results than 'C%A')
  • Precede text with a caret '^' to indicate search should "start with" the text
  • Follow text with a dollar sign '$' to indicate search should "end with" the preceding text

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries