BRCA1 - Gene Detail
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| Gene Symbol | BRCA1 | ||||||||||||
| Synonyms | BRCAI | BRCC1 | BROVCA1 | FANCS | IRIS | PNCA4 | PPP1R53 | PSCP | RNF53 | ||||||||||||
| Gene Description | BRCA1, BRCA1 DNA repair associated, is a tumor suppressor (PMID: 30562755) involved in the DNA damage response and DNA repair (PMID: 21203981). BRCA1 germline mutations increase the risk of developing ovarian and/or breast cancer (PMID: 21285145) and somatic mutations are highest in NSCLC, pancreatic, and colon cancers (PMID: 27283171). | ||||||||||||
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