AKT3: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

AKT3

Synonyms

Gene Description

AKT3, AKT serine/threonine kinase 3, is a serine-threonine protein kinase, which regulates cell proliferation and survival through PI3K signaling (PMID: 18955974) and has been shown to play a role in brain development (PMID: 15713641, PMID: 22500628). AKT3 mutations have been identified in melanoma (PMID: 18813315), altered expression has been observed in breast cancer (PMID: 31320990), AKT3 amplification has been identified in several tumor types, including glioblastoma (PMID: 25737557), and Akt3 is downregulated by several microRNAs to inhibit cell migration and invasion (PMID: 31383783, PMID: 31160577, PMID: 31074018, PMID: 30825222).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
10000	1	1q43-q44	NM_005465	Oncogene (PMID: 30606230)

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Gene Variants 54
Category Variants 3
Molecular Profiles 55
Evidence 18
Clinical Trials 13

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AKT3 - Gene Detail

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