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Gene Symbol SH2B3
Synonyms IDDM20 | LNK
Gene Description SH2B3 (LNK), SH2B adapter protein 3, is an adaptor protein that integrates signaling molecules to JAK and RTK pathways and thereby negatively regulating hematopoiesis and endothelial cell physiology (PMID: 21723852). Loss of functional SH2B3 (LNK) has been associated with acute lymphoblastic leukemia (PMID: 23908464, PMID: 30103202), B-cell precursor acute lymphoblastic leukaemia (PMID: 30816328), and myeloproliferative neoplasms (PMID: 26522763), while SH2B3 (LNK) overexpression has been observed in ovarian cancer (PMID: 24704825).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
10019 12 12q24.12 NM_005475 Tumor suppressor (PMID: 30606230)
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