CDK9: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CDK9

Synonyms

C-2k | CDC2L4 | CTK1 | PITALRE | TAK

Gene Description

CDK9, cyclin dependent kinase 9, interacts with cyclin-T1 (CCNT1) to form the positive transcription elongation factor B (P-TEFb) complex, which regulates transcription and mRNA processing (PMID: 28722178). Overexpression of Cdk9 in osteosarcoma correlates with poor prognosis (PMID: 30579871), may also play a role in mTOR driven acute myeloid leukemia (PMID: 30587525) and AKT2 driven cervical cancer (PMID: 30536701), and is overexpressed in chordoma (PMID: 31892980).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
1025	9	9q34.11	NM_001261	Unknown

Additional content available in

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Gene Variants 2
Category Variants 1
Molecular Profiles 2
Evidence 0
Clinical Trials 1

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Variant Tier Coding
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CDK9 - Gene Detail

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