Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol CDKN2B
Synonyms CDK4I | INK4B | MTS2 | P15 | p15INK4b | TP15
Gene Description CDKN2B, cyclin dependent kinase inhibitor 2B, regulates G1-S phase cell cycle arrest via specific inhibition of CDK4 and CDK6 kinases to function as a tumor suppressor (PMID: 27030077). CDKN2B deletion and/or promoter hypermethylation is commonly observed in acute lymphoblastic leukemia (PMID: 30635552, PMID: 30592434) and CDKN2B deletions have also been reported in liposarcoma (PMID: 21910158), renal cell carcinoma (PMID: 23898052), and glioma (PMID: 30558563).
Additional content available in CKB BOOST