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Gene Symbol NDRG1
Synonyms CAP43 | CMT4D | DRG-1 | DRG1 | GC4 | HMSNL | NDR1 | NMSL | PROXY1 | RIT42 | RTP | TARG1 | TDD5
Gene Description NDRG1, N-myc downstream regulated 1, is a member of the NDRG family and may play a role in multiple biological functions including tumor suppression, cell differentiation, cell growth, lipid biosynthesis, stress response, myelination (PMID: 25712528, PMID: 31132412), and autophagy (PMID: 32335136). A NDRG1-ERG fusion was observed to be overexpressed in prostate cancer (PMID: 19649210) and a NDRG1-PLAG1 fusion has been identified in chondroid syringoma (PMID: 32345665), and overexpression of Ndrg1 has been associated with poor prognosis in esophageal squamous cell carcinoma (PMID: 32106831) and altered expression has been observed in gastric cancer (PMID: 31384305).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
10397 8 8q24.22 NM_001135242 Tumor suppressor (PMID: 30606230)
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