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Gene Symbol | MERTK | ||||||||||
Synonyms | c-Eyk | c-mer | MER | RP38 | Tyro12 | ||||||||||
Gene Description | MERTK, MER proto-oncogene, tyrosine kinase, binds ligands, LGALS3, TUB, TULP1 and GAS6, to activate downstream signaling pathways including ERK and AKT (PMID: 29554921) and plays a role in phagocytosis of apoptotic cells (PMID: 28369510). MERTK overexpression has been observed in mantle cell lymphoma (PMID: 29554921), glioblastoma multiforme (PMID: 29553850), gastric cancer (PMID: 29285287), and is associated with resistance to Braf inhibition in Braf mutant melanoma (PMID: 29050198). | ||||||||||
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Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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act mut | unknown | gain of function | MERTK act mut indicates that this variant results in a gain of function in the Mertk protein. However, the specific amino acid change has not been identified. | |
amp | none | no effect | MERTK amplification indicates an increased number of copies of the MERTK gene. However, the mechanism causing the increase is unspecified. | |
over exp | none | no effect | MERTK over exp indicates an over expression of the Mertk protein and/or mRNA. However, the mechanism causing the over expression is unspecified. | Y |
positive | unknown | unknown | MERTK positive indicates the presence of the MERTK gene, mRNA, and/or protein. |