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| Gene Symbol | SORBS1 | ||||||||||
| Synonyms | CAP | FLAF2 | R85FL | SH3D5 | SH3P12 | SORB1 | ||||||||||
| Gene Description | SORBS1, sorbin and SH3 domain containing 1, also known as CAP/ponsin is an adaptor protein that regulates insulin signaling, cell adhesion, and cell motility (PMID: 27791200). Decreased expression in breast cancer may promote tumorigenesis and decreased sensitivity to cisplatin (PMID: 27791200), and an FGFR2-SORBS1 fusion has been reported in intrahepatic cholangiocarcinoma (PMID: 31109923). | ||||||||||
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