Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol CTCF
Synonyms CFAP108 | FAP108 | MRD21
Gene Description CTCF, CCCTC binding factor, is a zinc finger DNA-binding transcriptional repressor of numerous genes including MYC (PMID: 8649389) and TP53 (PMID: 21465478) and plays a role in chromatin organization (PMID: 29307136). Ctcf missense variants have been identified in endometrial cancer, prostate cancer, Wilms’ tumor, and breast cancer (PMID: 28648147) and altered expression has been observed in prostate cancer (PMID: 31736271).
Additional content available in CKB BOOST