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Gene Symbol POLQ
Synonyms PRO0327
Gene Description POLQ, DNA polymerase theta, is a promiscuous DNA polymerase that regulates microhomology-mediated end-joining in response to double-stranded DNA breaks (PMID: 25642963, PMID: 31537809). POLQ expression is elevated in epithelial ovarian cancers and is associated with homologous recombination activity (PMID: 25642963).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
10721 3 3q13.33 NM_199420 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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