CCR9 - Gene Detail
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| Gene Symbol | CCR9 | ||||||||||||
| Synonyms | CC-CKR-9 | CDw199 | GPR-9-6 | GPR28 | ||||||||||||
| Gene Description | CCR9, C-C motif chemokine receptor 9, is a G protein-coupled receptor that mediates lymphocyte homing to the thymus and small intestine (PMID: 10602049, PMID: 15485630), and promotes tumor proliferation (PMID: 24481516), invasion (PMID: 20649989), organ-specific metastasis (PMID: 18245522), and chemoresistance through anti-apoptotic signaling, beta-catenin activation, and drug efflux (PMID: 26879872). Increased CCR9 expression has been identified in various tumor types (PMID: 26879872), including non-small cell lung cancer (PMID: 25296976, PMID: 26168791), breast cancer (PMID: 21344163), hepatocellular carcinoma (PMID: 24481516), ovarian carcinoma (PMID: 21637913), and T-cell acute lymphoblastic leukemia (PMID: 35507686, PMID: 40598348). | ||||||||||||
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