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Gene Symbol CHEK1
Synonyms CHK1 | OZEMA21
Gene Description CHEK1, checkpoint kinase 1, is a serine/threonine kinase activated in response to DNA damage that is responsible for mediating checkpoint signaling from ATM and ATR (PMID: 23613359, PMID: 12781359). Overexpression of Chek1 has been observed in several tumor types, including gastric cancer, small cell lung cancer, T-cell leukemia (PMID: 25132270, PMID: 26867682, PMID: 28490518), and breast cancer (PMID: 31933717).

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Molecular Profile Protein Effect Treatment Approaches
CHEK1 act mut gain of function
CHEK1 D130Y unknown
CHEK1 D235N unknown
CHEK1 D235Y unknown
CHEK1 D336* gain of function
CHEK1 D336N unknown
CHEK1 D8N unknown
CHEK1 del loss of function Olaparib
CHEK1 E223_T226delinsA unknown
CHEK1 E309* unknown
CHEK1 E309K unknown
CHEK1 E32D unknown
CHEK1 F93V unknown
CHEK1 G169S unknown
CHEK1 G195R unknown
CHEK1 G21R unknown
CHEK1 G289* unknown
CHEK1 H122Y unknown
CHEK1 H243fs unknown
CHEK1 H352* gain of function
CHEK1 I234Sfs*6 unknown
CHEK1 inact mut loss of function Olaparib
CHEK1 K232N unknown
CHEK1 K233T unknown
CHEK1 K470* unknown
CHEK1 L136F unknown
CHEK1 L338S unknown
CHEK1 L360F unknown
CHEK1 M1? unknown
CHEK1 mutant unknown
CHEK1 over exp no effect
CHEK1 P238fs unknown
CHEK1 positive unknown
CHEK1 R141S unknown
CHEK1 R156W unknown
CHEK1 R160C unknown
CHEK1 R160H unknown
CHEK1 R379* gain of function - predicted Olaparib
CHEK1 R419S unknown
CHEK1 R442W unknown
CHEK1 S193Y unknown
CHEK1 S284* unknown
CHEK1 S284L unknown
CHEK1 S296F unknown
CHEK1 S366* gain of function
CHEK1 T226Hfs*14 unknown
CHEK1 T226Nfs*19 unknown
CHEK1 V312M unknown
CHEK1 V439L unknown
CHEK1 V46A unknown
CHEK1 Y390* gain of function