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PSIP1 - Gene Detail

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Gene Symbol PSIP1
Synonyms DFS70 | LEDGF | p52 | p75 | PAIP | PSIP2
Gene Description PSIP1, PC4 and SRSF1 interacting protein 1, encodes a chromatin-binding protein that produces a long isoform (PMID: 22773103), which plays a role in homologous recombination and double strand DNA break repair (PMID: 22773103, PMID: 34541330), activation of stress-related and pro-survival signaling (PMID: 11350077, PMID: 22275515), and viral entry and infection (PMID: 18092005, PMID: 17639082, PMID: 16959972), and a short isoform (PMID: 9885563), which binds to splicing factors, playing a role in alternate splicing (PMID: 22615581). Increased expression of PSIP1 has been identified in several tumor types (PMID: 22276150), including cervical cancer (PMID: 29953789) and prostate cancer (PMID: 15389814).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
11168 9 9p22.3 NM_033222 Unknown
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