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Gene Symbol | CHEK2 | ||||||||||
Synonyms | CDS1 | CHK2 | hCds1 | HuCds1 | LFS2 | PP1425 | RAD53 | TPDS4 | ||||||||||
Gene Description | CHEK2, checkpoint kinase 2, is a serine-threonine protein kinase and a putative tumor suppressor (PMID: 30562755) required for checkpoint-mediated cell cycle arrest and activation of DNA repair and apoptosis in response to DNA damage (PMID: 28553140). CHEK2 alterations are associated with predisposition to certain human cancers, including breast, prostate, kidney, and colon (PMID: 24880342; PMID: 24713400, PMID: 28553140). | ||||||||||
|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
CHEK2 A17S | no effect - predicted | |
CHEK2 A230P | loss of function - predicted | Olaparib |
CHEK2 A237T | loss of function - predicted | Olaparib |
CHEK2 A247D | loss of function | Olaparib |
CHEK2 A247T | unknown | |
CHEK2 A334T | no effect - predicted | |
CHEK2 A392P | loss of function - predicted | Olaparib |
CHEK2 A392S | loss of function - predicted | Olaparib |
CHEK2 A392V | loss of function | Olaparib |
CHEK2 A480T | unknown | |
CHEK2 A541G | unknown | |
CHEK2 amp | no effect | |
CHEK2 C108R | loss of function - predicted | Olaparib |
CHEK2 C243R | no effect | |
CHEK2 C284Y | loss of function | Olaparib |
CHEK2 C385R | loss of function - predicted | Olaparib |
CHEK2 C420T | loss of function - predicted | Olaparib |
CHEK2 D134H | no effect - predicted | |
CHEK2 D134Y | unknown | |
CHEK2 D162G | loss of function - predicted | Olaparib |
CHEK2 D203G | unknown | |
CHEK2 D207V | no effect - predicted | |
CHEK2 D265_H282del | loss of function | Olaparib |
CHEK2 D293fs | loss of function - predicted | Olaparib |
CHEK2 D311N | no effect - predicted | |
CHEK2 D347A | loss of function | Olaparib |
CHEK2 D347N | loss of function | Olaparib |
CHEK2 D409N | loss of function | Olaparib |
CHEK2 D438G | no effect - predicted | |
CHEK2 D438Y | unknown | Olaparib |
CHEK2 D490E | no effect - predicted | |
CHEK2 D497N | no effect - predicted | |
CHEK2 D82_E86del | loss of function - predicted | Olaparib |
CHEK2 dec exp | no effect | |
BRAF V600E CDKN2A loss CHEK2 dec exp RB1 pos | ||
CHEK2 del | loss of function | Olaparib |
CHEK2 E107_K197del | loss of function - predicted | Olaparib |
CHEK2 E122Dfs*8 | loss of function - predicted | Olaparib |
CHEK2 E149Ifs*6 | loss of function - predicted | Olaparib |
CHEK2 E161del | loss of function | Olaparib |
CHEK2 E239K | loss of function | Olaparib |
CHEK2 E239Q | no effect - predicted | |
CHEK2 E263Q | no effect - predicted | |
CHEK2 E273K | loss of function - predicted | Olaparib |
CHEK2 E275* | loss of function - predicted | Olaparib |
CHEK2 E275K | unknown | |
CHEK2 E305G | unknown | |
CHEK2 E321* | loss of function - predicted | Olaparib |
CHEK2 E321K | loss of function | Olaparib |
CHEK2 E351D | unknown | |
CHEK2 E351K | loss of function | Olaparib |
CHEK2 E377G | no effect - predicted | |
CHEK2 E394K | loss of function | Olaparib |
CHEK2 E454V | unknown | |
CHEK2 E501K | no effect - predicted | |
CHEK2 E504Q | no effect - predicted | |
CHEK2 E528K | no effect - predicted | |
CHEK2 E531Q | no effect - predicted | |
CHEK2 E64K | loss of function | Olaparib |
CHEK2 E87* | loss of function - predicted | Olaparib |
CHEK2 F103L | no effect - predicted | |
CHEK2 F125S | loss of function - predicted | Olaparib |
CHEK2 F169L | loss of function - predicted | Olaparib |
CHEK2 F169Lfs*2 | loss of function - predicted | Olaparib |
CHEK2 F202fs | loss of function - predicted | Olaparib |
CHEK2 F292fs | loss of function - predicted | Olaparib |
CHEK2 F475I | no effect - predicted | |
CHEK2 F475Lfs*7 | loss of function - predicted | Olaparib |
CHEK2 G102V | unknown | |
CHEK2 G116A | unknown | |
CHEK2 G14Afs*47 | loss of function - predicted | Olaparib |
CHEK2 G151C | no effect - predicted | |
CHEK2 G167R | loss of function | Olaparib |
CHEK2 G229D | unknown | |
CHEK2 G229S | loss of function - predicted | Olaparib |
CHEK2 G232R | unknown | |
CHEK2 G306A | loss of function | Olaparib |
CHEK2 G306E | loss of function - predicted | Olaparib |
CHEK2 G306W | unknown | |
CHEK2 G342S | no effect - predicted | |
CHEK2 G370E | loss of function - predicted | Olaparib |
CHEK2 G386R | loss of function - predicted | Olaparib |
CHEK2 G414E | loss of function - predicted | Olaparib |
CHEK2 H143R | loss of function - predicted | Olaparib |
CHEK2 H143Y | loss of function - predicted | Olaparib |
CHEK2 H282Y | unknown | |
CHEK2 H339Y | unknown | |
CHEK2 H371Y | unknown | Olaparib |
CHEK2 H483R | loss of function - predicted | Olaparib |
CHEK2 H54Pfs*6 | loss of function - predicted | Olaparib |
CHEK2 I157S | no effect - predicted | |
CHEK2 I157T | loss of function - predicted | Olaparib |
CHEK2 I160M | loss of function - predicted | Olaparib |
CHEK2 I160R | loss of function - predicted | Olaparib |
CHEK2 I160T | loss of function - predicted | Olaparib |
CHEK2 I189V | loss of function - predicted | Olaparib |
CHEK2 I221M | no effect - predicted | |
CHEK2 I221V | no effect - predicted | |
CHEK2 I251F | unknown | |
CHEK2 I251M | unknown | |
CHEK2 I276S | unknown | |
CHEK2 I364T | unknown | |
CHEK2 I448S | unknown | |
CHEK2 inact mut | loss of function | Olaparib |
CHEK2 K135Nfs*26 | loss of function - predicted | Olaparib |
CHEK2 K135T | unknown | |
CHEK2 K141T | unknown | |
CHEK2 K224E | loss of function - predicted | Olaparib |
CHEK2 K244R | no effect - predicted | Olaparib |
CHEK2 K249N | unknown | |
CHEK2 K249R | loss of function - predicted | Olaparib |
CHEK2 K253* | loss of function - predicted | Olaparib |
CHEK2 K279T | unknown | |
CHEK2 K287fs | loss of function - predicted | Olaparib |
CHEK2 K373E | loss of function | Olaparib |
CHEK2 K373R | no effect - predicted | |
CHEK2 K437E | no effect | |
CHEK2 L174F | no effect - predicted | |
CHEK2 L174V | loss of function - predicted | Olaparib |
CHEK2 L183F | loss of function - predicted | Olaparib |
CHEK2 L183S | loss of function - predicted | Olaparib |
CHEK2 L216* | loss of function - predicted | Olaparib |
CHEK2 L226F | unknown | |
CHEK2 L236P | loss of function - predicted | Olaparib |
CHEK2 L309P | loss of function - predicted | Olaparib |
CHEK2 L326P | loss of function - predicted | Olaparib |
CHEK2 L338F | no effect - predicted | |
CHEK2 L338R | unknown | |
CHEK2 L354V | unknown | |
CHEK2 L355P | unknown | |
CHEK2 L396V | unknown | |
CHEK2 L512V | no effect - predicted | |
CHEK2 L543S | unknown | |
CHEK2 loss | loss of function | Olaparib |
CHEK2 M222V | no effect - predicted | |
CHEK2 M304T | loss of function - predicted | Olaparib |
CHEK2 M381* | loss of function - predicted | Olaparib |
CHEK2 M381V | no effect - predicted | |
CHEK2 mutant | unknown | |
ATM mut CHEK2 mut | ||
CHEK2 N166S | loss of function - predicted | Olaparib |
CHEK2 N185fs | loss of function - predicted | Olaparib |
CHEK2 N185T | unknown | |
CHEK2 N186H | no effect | |
CHEK2 N281S | no effect - predicted | |
CHEK2 N290Ifs*15 | loss of function - predicted | Olaparib |
CHEK2 N352D | loss of function - predicted | Olaparib |
CHEK2 N405K | no effect - predicted | |
CHEK2 N446D | no effect | |
CHEK2 over exp | no effect | |
CHEK2 P182H | unknown | |
CHEK2 P182L | unknown | |
CHEK2 P182T | no effect - predicted | |
CHEK2 P21T | no effect - predicted | |
CHEK2 P425L | unknown | |
CHEK2 P426H | unknown | |
CHEK2 P426R | loss of function - predicted | Olaparib |
CHEK2 P484L | no effect - predicted | |
CHEK2 P484T | no effect - predicted | |
CHEK2 P509S | unknown | |
CHEK2 P536L | unknown | |
CHEK2 P80H | no effect - predicted | |
CHEK2 P85L | unknown | Olaparib |
CHEK2 P85R | loss of function - predicted | Olaparib |
CHEK2 P90S | unknown | |
CHEK2 Q10fs | loss of function - predicted | Olaparib |
CHEK2 Q209* | loss of function | Olaparib |
CHEK2 Q27* | loss of function - predicted | Olaparib |
CHEK2 Q34Vfs*42 | loss of function - predicted | Olaparib |
CHEK2 Q487R | unknown | |
CHEK2 R117A | loss of function | Olaparib |
CHEK2 R117G | loss of function | Olaparib |
CHEK2 R137Q | no effect - predicted | |
CHEK2 R145Q | no effect - predicted | |
CHEK2 R145W | loss of function | Olaparib |
CHEK2 R148G | loss of function - predicted | Olaparib |
CHEK2 R148T | no effect - predicted | |
CHEK2 R180C | unknown | |
CHEK2 R180H | loss of function - predicted | Olaparib |
CHEK2 R181C | unknown | Olaparib |
CHEK2 R181H | no effect | |
CHEK2 R318C | no effect - predicted | |
CHEK2 R318H | loss of function - predicted | Olaparib |
CHEK2 R346C | unknown | |
CHEK2 R346G | unknown | |
CHEK2 R346H | unknown | |
CHEK2 R346S | unknown | |
CHEK2 R382* | loss of function - predicted | Olaparib |
CHEK2 R3W | unknown | |
CHEK2 R406C | no effect - predicted | |
CHEK2 R406H | unknown | |
CHEK2 R406Vfs*8 | loss of function - predicted | Olaparib |
CHEK2 R474C | loss of function | Olaparib |
CHEK2 R474H | loss of function | Olaparib |
CHEK2 R474L | loss of function - predicted | Olaparib |
CHEK2 R519* | unknown | |
CHEK2 R519G | unknown | |
CHEK2 R521Q | unknown | |
CHEK2 R521W | unknown | |
CHEK2 R523C | no effect - predicted | |
CHEK2 R523fs | unknown | |
CHEK2 R95* | loss of function - predicted | Olaparib |
CHEK2 S140N | loss of function - predicted | Olaparib |
CHEK2 S24C | unknown | |
CHEK2 S357F | loss of function - predicted | Olaparib |
CHEK2 S372F | loss of function - predicted | Olaparib |
CHEK2 S372Y | loss of function - predicted | Olaparib |
CHEK2 S39F | no effect - predicted | |
CHEK2 S412R | loss of function - predicted | Olaparib |
CHEK2 S422Vfs*15 | loss of function - predicted | Olaparib |
CHEK2 S428F | loss of function - predicted | Olaparib |
CHEK2 S49F | unknown | |
CHEK2 S505T | no effect - predicted | |
CHEK2 S57F | no effect - predicted | |
CHEK2 S5L | no effect - predicted | |
CHEK2 T168I | unknown | |
CHEK2 T172A | no effect - predicted | |
CHEK2 T205S | no effect - predicted | |
CHEK2 T323P | unknown | Olaparib |
CHEK2 T366fs | loss of function - predicted | Olaparib |
CHEK2 T367fs | loss of function | Olaparib |
CHEK2 T367Mfs*15 | loss of function | Olaparib |
CHEK2 T378I | no effect - predicted | |
CHEK2 T387S | loss of function - predicted | Olaparib |
CHEK2 T410fs | loss of function | Olaparib |
CHEK2 T476K | loss of function - predicted | Olaparib |
CHEK2 T476M | loss of function | Olaparib |
CHEK2 T532I | unknown | |
CHEK2 T533A | no effect - predicted | |
CHEK2 T59K | loss of function - predicted | Olaparib |
CHEK2 V109A | unknown | |
CHEK2 V175A | no effect - predicted | |
CHEK2 V198Ffs*7 | loss of function - predicted | Olaparib |
CHEK2 V198I | unknown | |
CHEK2 V200A | unknown | |
CHEK2 V25I | unknown | |
CHEK2 V395L | unknown | |
CHEK2 W485G | loss of function - predicted | Olaparib |
CHEK2 W93Gfs*17 | loss of function - predicted | Olaparib |
CHEK2 W93R | loss of function - predicted | Olaparib |
CHEK2 wild-type | no effect | |
CHEK2 Y123C | no effect - predicted | |
CHEK2 Y139* | loss of function - predicted | Olaparib |
CHEK2 Y159H | no effect - predicted | |
CHEK2 Y327C | unknown | |
CHEK2 Y390C | loss of function | Olaparib |
CHEK2 Y390S | loss of function | Olaparib |
CHEK2 Y404C | unknown | |
CHEK2 Y424H | loss of function - predicted | Olaparib |