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Gene Symbol CHEK2
Synonyms CDS1 | CHK2 | hCds1 | HuCds1 | LFS2 | PP1425 | RAD53 | TPDS4
Gene Description CHEK2, checkpoint kinase 2, is a serine-threonine protein kinase and a putative tumor suppressor (PMID: 30562755) required for checkpoint-mediated cell cycle arrest and activation of DNA repair and apoptosis in response to DNA damage (PMID: 28553140). CHEK2 alterations are associated with predisposition to certain human cancers, including breast, prostate, kidney, and colon (PMID: 24880342; PMID: 24713400, PMID: 28553140).

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Molecular Profile Protein Effect Treatment Approaches
CHEK2 A17S no effect - predicted
CHEK2 A230P loss of function - predicted Olaparib
CHEK2 A237T loss of function - predicted Olaparib
CHEK2 A247D loss of function Olaparib
CHEK2 A247T unknown
CHEK2 A334T no effect - predicted
CHEK2 A392P loss of function - predicted Olaparib
CHEK2 A392S loss of function - predicted Olaparib
CHEK2 A392V loss of function Olaparib
CHEK2 A480T unknown
CHEK2 A541G unknown
CHEK2 amp no effect
CHEK2 C108R loss of function - predicted Olaparib
CHEK2 C243R no effect
CHEK2 C284Y loss of function Olaparib
CHEK2 C385R loss of function - predicted Olaparib
CHEK2 C420T loss of function - predicted Olaparib
CHEK2 D134H no effect - predicted
CHEK2 D134Y unknown
CHEK2 D162G loss of function - predicted Olaparib
CHEK2 D203G unknown
CHEK2 D207V no effect - predicted
CHEK2 D265_H282del loss of function Olaparib
CHEK2 D293fs loss of function - predicted Olaparib
CHEK2 D311N no effect - predicted
CHEK2 D347A loss of function Olaparib
CHEK2 D347N loss of function Olaparib
CHEK2 D409N loss of function Olaparib
CHEK2 D438G no effect - predicted
CHEK2 D438Y unknown Olaparib
CHEK2 D490E no effect - predicted
CHEK2 D497N no effect - predicted
CHEK2 D82_E86del loss of function - predicted Olaparib
CHEK2 dec exp no effect
BRAF V600E CDKN2A loss CHEK2 dec exp RB1 pos
CHEK2 del loss of function Olaparib
CHEK2 E107_K197del loss of function - predicted Olaparib
CHEK2 E122Dfs*8 loss of function - predicted Olaparib
CHEK2 E149Ifs*6 loss of function - predicted Olaparib
CHEK2 E161del loss of function Olaparib
CHEK2 E239K loss of function Olaparib
CHEK2 E239Q no effect - predicted
CHEK2 E263Q no effect - predicted
CHEK2 E273K loss of function - predicted Olaparib
CHEK2 E275* loss of function - predicted Olaparib
CHEK2 E275K unknown
CHEK2 E305G unknown
CHEK2 E321* loss of function - predicted Olaparib
CHEK2 E321K loss of function Olaparib
CHEK2 E351D unknown
CHEK2 E351K loss of function Olaparib
CHEK2 E377G no effect - predicted
CHEK2 E394K loss of function Olaparib
CHEK2 E454V unknown
CHEK2 E501K no effect - predicted
CHEK2 E504Q no effect - predicted
CHEK2 E528K no effect - predicted
CHEK2 E531Q no effect - predicted
CHEK2 E64K loss of function Olaparib
CHEK2 E87* loss of function - predicted Olaparib
CHEK2 F103L no effect - predicted
CHEK2 F125S loss of function - predicted Olaparib
CHEK2 F169L loss of function - predicted Olaparib
CHEK2 F169Lfs*2 loss of function - predicted Olaparib
CHEK2 F202fs loss of function - predicted Olaparib
CHEK2 F292fs loss of function - predicted Olaparib
CHEK2 F475I no effect - predicted
CHEK2 F475Lfs*7 loss of function - predicted Olaparib
CHEK2 G102V unknown
CHEK2 G116A unknown
CHEK2 G14Afs*47 loss of function - predicted Olaparib
CHEK2 G151C no effect - predicted
CHEK2 G167R loss of function Olaparib
CHEK2 G229D unknown
CHEK2 G229S loss of function - predicted Olaparib
CHEK2 G232R unknown
CHEK2 G306A loss of function Olaparib
CHEK2 G306E loss of function - predicted Olaparib
CHEK2 G306W unknown
CHEK2 G342S no effect - predicted
CHEK2 G370E loss of function - predicted Olaparib
CHEK2 G386R loss of function - predicted Olaparib
CHEK2 G414E loss of function - predicted Olaparib
CHEK2 H143R loss of function - predicted Olaparib
CHEK2 H143Y loss of function - predicted Olaparib
CHEK2 H282Y unknown
CHEK2 H339Y unknown
CHEK2 H371Y unknown Olaparib
CHEK2 H483R loss of function - predicted Olaparib
CHEK2 H54Pfs*6 loss of function - predicted Olaparib
CHEK2 I157S no effect - predicted
CHEK2 I157T loss of function - predicted Olaparib
CHEK2 I160M loss of function - predicted Olaparib
CHEK2 I160R loss of function - predicted Olaparib
CHEK2 I160T loss of function - predicted Olaparib
CHEK2 I189V loss of function - predicted Olaparib
CHEK2 I221M no effect - predicted
CHEK2 I221V no effect - predicted
CHEK2 I251F unknown
CHEK2 I251M unknown
CHEK2 I276S unknown
CHEK2 I364T unknown
CHEK2 I448S unknown
CHEK2 inact mut loss of function Olaparib
CHEK2 K135Nfs*26 loss of function - predicted Olaparib
CHEK2 K135T unknown
CHEK2 K141T unknown
CHEK2 K224E loss of function - predicted Olaparib
CHEK2 K244R no effect - predicted Olaparib
CHEK2 K249N unknown
CHEK2 K249R loss of function - predicted Olaparib
CHEK2 K253* loss of function - predicted Olaparib
CHEK2 K279T unknown
CHEK2 K287fs loss of function - predicted Olaparib
CHEK2 K373E loss of function Olaparib
CHEK2 K373R no effect - predicted
CHEK2 K437E no effect
CHEK2 L174F no effect - predicted
CHEK2 L174V loss of function - predicted Olaparib
CHEK2 L183F loss of function - predicted Olaparib
CHEK2 L183S loss of function - predicted Olaparib
CHEK2 L216* loss of function - predicted Olaparib
CHEK2 L226F unknown
CHEK2 L236P loss of function - predicted Olaparib
CHEK2 L309P loss of function - predicted Olaparib
CHEK2 L326P loss of function - predicted Olaparib
CHEK2 L338F no effect - predicted
CHEK2 L338R unknown
CHEK2 L354V unknown
CHEK2 L355P unknown
CHEK2 L396V unknown
CHEK2 L512V no effect - predicted
CHEK2 L543S unknown
CHEK2 loss loss of function Olaparib
CHEK2 M222V no effect - predicted
CHEK2 M304T loss of function - predicted Olaparib
CHEK2 M381* loss of function - predicted Olaparib
CHEK2 M381V no effect - predicted
CHEK2 mutant unknown
ATM mut CHEK2 mut
CHEK2 N166S loss of function - predicted Olaparib
CHEK2 N185fs loss of function - predicted Olaparib
CHEK2 N185T unknown
CHEK2 N186H no effect
CHEK2 N281S no effect - predicted
CHEK2 N290Ifs*15 loss of function - predicted Olaparib
CHEK2 N352D loss of function - predicted Olaparib
CHEK2 N405K no effect - predicted
CHEK2 N446D no effect
CHEK2 over exp no effect
CHEK2 P182H unknown
CHEK2 P182L unknown
CHEK2 P182T no effect - predicted
CHEK2 P21T no effect - predicted
CHEK2 P425L unknown
CHEK2 P426H unknown
CHEK2 P426R loss of function - predicted Olaparib
CHEK2 P484L no effect - predicted
CHEK2 P484T no effect - predicted
CHEK2 P509S unknown
CHEK2 P536L unknown
CHEK2 P80H no effect - predicted
CHEK2 P85L unknown Olaparib
CHEK2 P85R loss of function - predicted Olaparib
CHEK2 P90S unknown
CHEK2 Q10fs loss of function - predicted Olaparib
CHEK2 Q209* loss of function Olaparib
CHEK2 Q27* loss of function - predicted Olaparib
CHEK2 Q34Vfs*42 loss of function - predicted Olaparib
CHEK2 Q487R unknown
CHEK2 R117A loss of function Olaparib
CHEK2 R117G loss of function Olaparib
CHEK2 R137Q no effect - predicted
CHEK2 R145Q no effect - predicted
CHEK2 R145W loss of function Olaparib
CHEK2 R148G loss of function - predicted Olaparib
CHEK2 R148T no effect - predicted
CHEK2 R180C unknown
CHEK2 R180H loss of function - predicted Olaparib
CHEK2 R181C unknown Olaparib
CHEK2 R181H no effect
CHEK2 R318C no effect - predicted
CHEK2 R318H loss of function - predicted Olaparib
CHEK2 R346C unknown
CHEK2 R346G unknown
CHEK2 R346H unknown
CHEK2 R346S unknown
CHEK2 R382* loss of function - predicted Olaparib
CHEK2 R3W unknown
CHEK2 R406C no effect - predicted
CHEK2 R406H unknown
CHEK2 R406Vfs*8 loss of function - predicted Olaparib
CHEK2 R474C loss of function Olaparib
CHEK2 R474H loss of function Olaparib
CHEK2 R474L loss of function - predicted Olaparib
CHEK2 R519* unknown
CHEK2 R519G unknown
CHEK2 R521Q unknown
CHEK2 R521W unknown
CHEK2 R523C no effect - predicted
CHEK2 R523fs unknown
CHEK2 R95* loss of function - predicted Olaparib
CHEK2 S140N loss of function - predicted Olaparib
CHEK2 S24C unknown
CHEK2 S357F loss of function - predicted Olaparib
CHEK2 S372F loss of function - predicted Olaparib
CHEK2 S372Y loss of function - predicted Olaparib
CHEK2 S39F no effect - predicted
CHEK2 S412R loss of function - predicted Olaparib
CHEK2 S422Vfs*15 loss of function - predicted Olaparib
CHEK2 S428F loss of function - predicted Olaparib
CHEK2 S49F unknown
CHEK2 S505T no effect - predicted
CHEK2 S57F no effect - predicted
CHEK2 S5L no effect - predicted
CHEK2 T168I unknown
CHEK2 T172A no effect - predicted
CHEK2 T205S no effect - predicted
CHEK2 T323P unknown Olaparib
CHEK2 T366fs loss of function - predicted Olaparib
CHEK2 T367fs loss of function Olaparib
CHEK2 T367Mfs*15 loss of function Olaparib
CHEK2 T378I no effect - predicted
CHEK2 T387S loss of function - predicted Olaparib
CHEK2 T410fs loss of function Olaparib
CHEK2 T476K loss of function - predicted Olaparib
CHEK2 T476M loss of function Olaparib
CHEK2 T532I unknown
CHEK2 T533A no effect - predicted
CHEK2 T59K loss of function - predicted Olaparib
CHEK2 V109A unknown
CHEK2 V175A no effect - predicted
CHEK2 V198Ffs*7 loss of function - predicted Olaparib
CHEK2 V198I unknown
CHEK2 V200A unknown
CHEK2 V25I unknown
CHEK2 V395L unknown
CHEK2 W485G loss of function - predicted Olaparib
CHEK2 W93Gfs*17 loss of function - predicted Olaparib
CHEK2 W93R loss of function - predicted Olaparib
CHEK2 wild-type no effect
CHEK2 Y123C no effect - predicted
CHEK2 Y139* loss of function - predicted Olaparib
CHEK2 Y159H no effect - predicted
CHEK2 Y327C unknown
CHEK2 Y390C loss of function Olaparib
CHEK2 Y390S loss of function Olaparib
CHEK2 Y404C unknown
CHEK2 Y424H loss of function - predicted Olaparib