RNF139: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

RNF139

Synonyms

HRCA1 | RCA1 | TRC8

Gene Description

RNF139, ring finger protein 139, encodes an E3 ubiquitin ligase that is involved in multiple cellular processes via protein ubiquitination and degradation activity (PMID: 22689053, PMID: 22143767) including inhibition of cell growth (PMID: 12032852, PMID: 17016439), degradation of misfolded proteins through the ER-associated degradation pathway (PMID: 26210183, PMID: 19720873), and cholesterol homeostasis (PMID: 22143767, PMID: 22939900). Translocations in RNF139 have been identified in hereditary renal cell cancer (PMID: 9689122, PMID: 24813807) and dysgerminoma (PMID: 19642973).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
11236	8	8q24.13	NM_007218	Unknown

Additional content available in

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Gene Variants 0
Category Variants 0
Molecular Profiles 0
Evidence 0
Clinical Trials 0

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Gene Variants

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RNF139 - Gene Detail

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